LOCUS       NM_027435               5673 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus ATPase family, AAA domain containing 2 (Atad2),
            transcript variant 1, mRNA.
ACCESSION   NM_027435 XM_974897 XM_975041 XM_975107 XM_977653 XM_977793
            XM_977863 XM_986850 XM_986886 XM_986920 XM_986957 XM_986994
            XM_987027 XM_987064 XM_987087
VERSION     NM_027435.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5673)
  AUTHORS   Tong,Y., Li,J., Peng,M., Qian,Q., Shi,W., Chen,Z. and Liu,B.
  TITLE     ATAD2 drives colorectal cancer progression by regulating TRIM25
            expression via a positive feedback loop with E2F transcriptional
            factors
  JOURNAL   Biochem Biophys Res Commun 594, 146-152 (2022)
   PUBMED   35085891
  REMARK    GeneRIF: ATAD2 drives colorectal cancer progression by regulating
            TRIM25 expression via a positive feedback loop with E2F
            transcriptional factors.
REFERENCE   2  (bases 1 to 5673)
  AUTHORS   Wang,T., Perazza,D., Boussouar,F., Cattaneo,M., Bougdour,A.,
            Chuffart,F., Barral,S., Vargas,A., Liakopoulou,A., Puthier,D.,
            Bargier,L., Morozumi,Y., Jamshidikia,M., Garcia-Saez,I., Petosa,C.,
            Rousseaux,S., Verdel,A. and Khochbin,S.
  TITLE     ATAD2 controls chromatin-bound HIRA turnover
  JOURNAL   Life Sci Alliance 4 (12), e202101151 (2021)
   PUBMED   34580178
  REMARK    GeneRIF: ATAD2 controls chromatin-bound HIRA turnover.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5673)
  AUTHORS   Li,N., Yu,Y. and Wang,B.
  TITLE     Downregulation of AAA-domain-containing protein 2 restrains cancer
            stem cell properties in esophageal squamous cell carcinoma via
            blockade of the Hedgehog signaling pathway
  JOURNAL   Am J Physiol Cell Physiol 319 (1), C93-C104 (2020)
   PUBMED   31747529
  REMARK    GeneRIF: Downregulation of AAA-domain-containing protein 2
            restrains cancer stem cell properties in esophageal squamous cell
            carcinoma via blockade of the Hedgehog signaling pathway.
REFERENCE   4  (bases 1 to 5673)
  AUTHORS   Wu,G., Lu,X., Wang,Y., He,H., Meng,X., Xia,S., Zhen,K. and Liu,Y.
  TITLE     Epigenetic high regulation of ATAD2 regulates the Hh pathway in
            human hepatocellular carcinoma
  JOURNAL   Int J Oncol 45 (1), 351-361 (2014)
   PUBMED   24805933
  REMARK    GeneRIF: Results found that ATAD2 is highly expressed in
            hepatocellular carcinoma tissues and could affect the expression of
            hedghog pathway.
REFERENCE   5  (bases 1 to 5673)
  AUTHORS   Duan,Z., Zou,J.X., Yang,P., Wang,Y., Borowsky,A.D., Gao,A.C. and
            Chen,H.W.
  TITLE     Developmental and androgenic regulation of chromatin regulators
            EZH2 and ANCCA/ATAD2 in the prostate Via MLL histone methylase
            complex
  JOURNAL   Prostate 73 (5), 455-466 (2013)
   PUBMED   23038103
  REMARK    GeneRIF: EZH2 and ANCCA are androgen regulated and strongly
            expressed in early prostate morphogenesis and during puberty,
            suggesting their important role in prostate development.
REFERENCE   6  (bases 1 to 5673)
  AUTHORS   Caron,C., Lestrat,C., Marsal,S., Escoffier,E., Curtet,S.,
            Virolle,V., Barbry,P., Debernardi,A., Brambilla,C., Brambilla,E.,
            Rousseaux,S. and Khochbin,S.
  TITLE     Functional characterization of ATAD2 as a new cancer/testis factor
            and a predictor of poor prognosis in breast and lung cancers
  JOURNAL   Oncogene 29 (37), 5171-5181 (2010)
   PUBMED   20581866
REFERENCE   7  (bases 1 to 5673)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (bases 1 to 5673)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5673)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113292.6.
            
            On Apr 14, 2022 this sequence version replaced NM_027435.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.16105.1,
                                           SRR17253011.10328586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               AC113292.6         160595-160857       c
            264-412             AC113292.6         157981-158129       c
            413-459             AC113292.6         153997-154043       c
            460-625             AC113292.6         152337-152502       c
            626-728             AC113292.6         151836-151938       c
            729-816             AC113292.6         151530-151617       c
            817-966             AC113292.6         148241-148390       c
            967-1084            AC113292.6         146730-146847       c
            1085-1189           AC113292.6         144133-144237       c
            1190-1298           AC113292.6         143026-143134       c
            1299-1414           AC113292.6         142556-142671       c
            1415-1589           AC113292.6         141460-141634       c
            1590-1678           AC113292.6         139958-140046       c
            1679-1838           AC113292.6         136905-137064       c
            1839-1929           AC113292.6         135736-135826       c
            1930-2244           AC113292.6         134091-134405       c
            2245-2359           AC113292.6         133869-133983       c
            2360-2546           AC113292.6         132513-132699       c
            2547-2732           AC113292.6         131265-131450       c
            2733-2868           AC113292.6         130219-130354       c
            2869-3065           AC113292.6         128986-129182       c
            3066-3225           AC113292.6         128165-128324       c
            3226-3348           AC113292.6         125755-125877       c
            3349-3492           AC113292.6         125499-125642       c
            3493-3882           AC113292.6         124147-124536       c
            3883-4016           AC113292.6         123040-123173       c
            4017-4145           AC113292.6         122365-122493       c
            4146-5673           AC113292.6         119832-121359       c
FEATURES             Location/Qualifiers
     source          1..5673
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 24.32 cM"
     gene            1..5673
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /note="ATPase family, AAA domain containing 2"
                     /db_xref="GeneID:70472"
                     /db_xref="MGI:MGI:1917722"
     exon            1..263
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..4190
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /EC_number="3.6.1.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATPase family AAA domain-containing protein 2"
                     /codon_start=1
                     /product="ATPase family AAA domain-containing protein 2
                     isoform 1"
                     /protein_id="NP_081711.2"
                     /db_xref="CCDS:CCDS37079.1"
                     /db_xref="GeneID:70472"
                     /db_xref="MGI:MGI:1917722"
                     /translation="MVVLRSSLELHSRSTTSSATDSLDLSSEFLSLQDSGGRRPRLRR
                     AGRKSTASKAAGDGFTVKGAETYHNTRSLRSLRNQAQTSSESSFDKNVDRTEKYSNGR
                     HFTRQFARQQADKKEECKEDKVIPVIRSLRNRNIAPTAEHLHEQSGDVEVRRSCRIRS
                     RYSTMNQSVLFDKLITNTAEAVLQKMDDMKKMRRQRMKKLEDLGVFNETEESNLTMYT
                     RGKLKAIQRADEETTDNQDGSVESSEEGEEQEDDDGEDEDDEDEEEGEEDNQKRYYLR
                     QRKTTVYYQSPLESKPRHQRKPNMFYSGPASPARPRFRLSSTGPRSPYCKRMSRRRHA
                     IHSSDSTSSSSSEDDCFERRTKRNRNRAINRCLPLNFRKDEIRGIYKDRMKIGASLAD
                     VDPMQLDTSVRFDSVGGLSSHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGT
                     GKTLVARALANECSRGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPAIIF
                     FDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRP
                     GRFDREFLFSLPDKNARKEILKIHTRDWNPKPVDMFLEELAEHCVGYCGADIKSICAE
                     AALCALRRRYPQIYTTSEKLQLDLSSITISAKDFEAALQKIRPASQRAVTSPGQALSA
                     IVKPLLQNTVHRILDALQKVFPHVEVGTNKSLNSDVSCPFLESDLAYSDDDTPSVYEN
                     GLSQKENLNFLHLNRNACYQPMSFRPRLLIVGEPGFGQSSHLAPAVIHALEKFTVYTL
                     DIPVLFGISTTSPEEACSQMIREAKRTAPSIVYVPHIHLWWEIVGPTLKATFTTLLQT
                     IPSFAPVLLLATSEKPYSALPEEVQELFTHDYGEIFNVQLPDKEERTKFFEDLILKQA
                     SKPPVSQKKAVLQALEVLPVAPPPEPRPLTAEEVKRLEEQEEDTFRELRIFLRNVTHR
                     LAIDKRFRVFTKPVDPDEVPDYVTVIKQPMDLSSVISKIDLHKYLTVKDYLKDIDLIC
                     SNALEYNPDRDPGDRLIRHRACALRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSS
                     SKYAPSYYHVMPKQNSPPVGDKKPDQEQNEKLKVPCTPVACSTPAQLKRKFHKKSKWH
                     VGTKIKRRKISQAKDNSLNAMNSSSRSDTEDSQHTHAEHTEPGNTDESSVEESDKQNR
                     LESNIDLKNNSSSSNIENELEEPKETTEGTELRKDRIVCRGDASASQVTDIPEDSESK
                     EMDFLRMTLARGSQVEQQELISMEQALAILSQPTPSLVLDHKQLTNILKTVVKKSQKY
                     NIFQLENLYAVISQCIYEHRRDYDKTALVQKMEQAVENFNCSRS"
     exon            264..412
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            413..459
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            460..625
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            626..728
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            729..816
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            817..966
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1084
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1189
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1298
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1414
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1589
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1678
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1838
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1929
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2244
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2359
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2546
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2732
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2868
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..3065
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3225
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3348
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3492
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3882
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..4016
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4017..4145
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..5673
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5647..5652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5662
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
     polyA_site      5673
                     /gene="Atad2"
                     /gene_synonym="2610509G12Rik"
                     /note="major polyA site"
ORIGIN      
        1 agaattcaga gcgcgtgagc gcctgagcag cctcctccgg agccaggttc tccacttccc
       61 ccgcctcggg ttccggcttc tgcaagcggg gcaccatggt ggtcctccgc agcagcctgg
      121 agctgcacag tcgctccacc acctcctcgg ccaccgactc tctggacctg tccagtgagt
      181 tcctcagcct gcaggacagc ggcgggaggc ggcccagatt gcgccgagcc gggaggaaat
      241 cgacggcgtc caaggcggcg ggcgatggat tcacagttaa gggagctgaa acctaccaca
      301 acacgcgctc tttaaggtct ctgagaaacc aagcacaaac ttcttcagag tctagttttg
      361 acaagaacgt ggacagaaca gagaaatact ccaatggcag acatttcaca aggcaatttg
      421 ctcgacagca ggctgataaa aaagaagagt gcaaagaaga caaagttatt ccagttattc
      481 gctcattgag gaatagaaac attgctccaa ctgcagaaca tttgcacgaa caaagtggag
      541 atgttgaagt tcgaagaagt tgcaggatta gaagtcgtta cagtaccatg aaccagtctg
      601 tgctatttga caagcttata acaaacactg ctgaagctgt acttcaaaag atggatgaca
      661 tgaaaaagat gcgcagacag cggatgaaga agcttgaaga cttgggagta ttcaatgaaa
      721 cagaagagag taatctcact atgtacacaa gaggaaaact aaaggctatc cagcgagctg
      781 atgaagaaac aactgataac caggacggca gtgtggaatc atctgaagag ggggaagagc
      841 aagaggatga tgatggcgaa gatgaagatg atgaagatga agaagaggga gaagaagata
      901 atcaaaaaag atactatctt aggcagagaa aaacaacggt ttactaccag tctccactgg
      961 aaagtaaacc tcgtcaccag agaaagccca acatgtttta tagtggccca gcttctcctg
     1021 caagaccaag attccgcttg tcttctacgg gaccaagaag tccctattgt aaacgaatga
     1081 gcaggcgaag gcatgccatc cacagcagtg actctacttc ctcctcctcc tctgaagacg
     1141 actgttttga gaggagaaca aaaaggaacc gaaatagagc tattaacagg tgcctcccac
     1201 taaattttcg gaaagatgaa ataagaggga tttataaaga tcgaatgaaa attggagcaa
     1261 gccttgctga tgttgaccca atgcaactag atacttcagt gcgctttgac agtgttggcg
     1321 gcctgtccag tcacattgca gctctaaaag agatggtggt gtttccctta ctttatccag
     1381 aagtcttcga aaagtttaaa attcaacccc caagaggttg tttgttttat ggaccacctg
     1441 gaactggaaa aaccctggtt gctagagcac ttgccaatga gtgcagccga ggggataaga
     1501 gagtggcgtt cttcatgagg aaaggtgctg actgcctgag taaatgggta ggagaatctg
     1561 agagacagct tcggttgcta tttgaccagg cctatcagat gcgcccagca attatattct
     1621 ttgatgaaat tgatggtttg gctccagtac gatctagcag gcaagatcag attcacagtt
     1681 ctattgtttc aaccctgtta gctcttatgg atggtttgga cagcagagga gaaattgtgg
     1741 tcattggagc taccaaccgg ctagattcca tagaccctgc tttacggagg cccggtcggt
     1801 ttgacagaga attccttttt agtctacctg ataaaaatgc tcgaaaagag attctgaaga
     1861 ttcatacaag agattggaat ccaaagccag tggacatgtt tctagaagaa ctagcagaac
     1921 actgtgttgg ctactgtggt gcggatatta agtcaatctg tgctgaagct gctttgtgcg
     1981 ccctgcgtcg acggtacccg cagatctaca ccaccagcga gaagcttcag ctggatctct
     2041 cttcaattac catctcagct aaggattttg aggcagctct gcagaaaata agaccagctt
     2101 cccagagagc tgtgacatca cccggacagg cactgtctgc cattgtgaaa ccacttctgc
     2161 aaaatactgt tcataggatc ttagacgccc tacagaaagt atttccacat gtggaagttg
     2221 gaacaaacaa atctttaaat tcagatgttt cttgcccttt tctagaaagt gatttggcat
     2281 acagtgatga tgatacacca tctgtgtatg aaaatggact ttctcaaaaa gaaaatttaa
     2341 attttcttca tttaaataga aatgcctgtt accagcctat gtcttttcga ccaagactat
     2401 tgatagtggg agaaccagga tttggacaga gttctcactt ggcaccagct gtcatccatg
     2461 ctttggaaaa atttactgta tatacattag acattcctgt tctttttggc atcagtacaa
     2521 catctcctga agaggcatgt tcccaaatga ttcgtgaagc taagagaaca gcacccagca
     2581 tagtctatgt cccacatatc catttgtggt gggaaatagt tggaccgaca ctcaaagcca
     2641 catttacaac attattacag actatacctt catttgctcc agttttatta cttgcaactt
     2701 ctgagaaacc atactcagct ttgccggaag aggtacaaga attgtttacc catgattatg
     2761 gagaaatttt taatgtacag ttaccagata aagaagaacg aaccaaattt tttgaagact
     2821 taattttaaa acaagcttca aagcctcctg tgtcacaaaa gaaagcagtt ctgcaggcct
     2881 tggaggtgct cccagtcgca ccaccgcctg aaccaagacc actgacagca gaggaagtta
     2941 aacggcttga agaacaagaa gaagatacat tcagagaact caggattttc ttaagaaatg
     3001 tcacacatag acttgctatt gataagcgat tccgagtctt tactaagcct gttgaccctg
     3061 atgaggttcc tgattatgtc actgtcataa agcaaccaat ggacctttca tctgtaatca
     3121 gtaaaattga tttacataaa tatctcactg tgaaagacta tttgaaggat attgatctaa
     3181 tctgtagtaa tgctttagaa tacaatccag atagagatcc tggagatcgt cttattaggc
     3241 atagagcttg tgctttgaga gacactgctt atgcaataat taaagaggag cttgatgaag
     3301 actttgagca gctctgtgaa gaaattcagg aatctcggaa gaagagaggt tgtagctcct
     3361 ccaaatacgc accatcttat taccacgtca tgccaaagca aaattctcct cctgttggtg
     3421 ataaaaagcc agatcaagag cagaatgaga agctaaaggt accgtgcact cctgtggcgt
     3481 gcagcacacc tgctcagttg aaaagaaaat tccataaaaa gtcaaagtgg catgtaggca
     3541 ccaaaataaa gcgaaggaaa atttcacaag ctaaagacaa cagcttgaat gctatgaaca
     3601 gttcaagcag gagcgacaca gaagacagcc agcacacaca tgcagagcac acggagcctg
     3661 gaaacacgga cgagtcctcg gtagaagaaa gtgacaagca aaatagactt gaaagcaaca
     3721 tagacttgaa aaataactca agttcctcta atattgagaa tgaacttgaa gagcctaagg
     3781 aaactacgga gggcacagaa ctgagaaaag acaggattgt ttgcaggggt gatgcctctg
     3841 cctcccaggt cacagacatt cccgaagaca gtgaatcaaa agaaatggat tttctgcgga
     3901 tgactctagc tagaggttcc caggtagagc agcaggagct catcagtatg gagcaggctc
     3961 tggccatcct ctctcagccg acaccctcac ttgtgctgga ccacaagcag ttaacaaata
     4021 ttttgaagac ggttgttaaa aaaagtcaga aatataatat attccaactg gagaatttgt
     4081 atgcagtaat cagccagtgt atttatgagc accgcaggga ctatgacaaa acagcgcttg
     4141 ttcagaaaat ggagcaagca gtagaaaact tcaattgttc cagatcatag tcgatacatt
     4201 caagtacttt atcttcagtt cctatttaat tgtcttcaga tatatcatca taactgatgc
     4261 aagataaggt gaaatcttgc atcttcaaga aaagattaaa atagtaaaag tatcttaaat
     4321 ttcctgatat ttatgtacat atagtaagat aactgataag tcttagatgt ttgagtgaag
     4381 cactgctaca atagtaatag tttggctaga tcttaaagct gttttggtaa ttaatgtctt
     4441 gtgacattta ataatgactt agcaagcatt ggattttttt tttttgttgt tcttgttagc
     4501 taaagcactt ttagttttat ccttccctag taggttattg tatcagacta gaattatatc
     4561 tgttatattt tgctgtcttt gttttccttt gtctttctcc tgtttgccaa aattcaattc
     4621 aagttgtgat tttcaagagg acctcaaaac aattctgtac ttaatataaa aatcaatgtc
     4681 tttagataaa tactttcata gttctaattt gggttaatat ttttaaatgt attgtttact
     4741 tttgtaatta tatacacaac aaatattagt gactagtttt tgtatttgac aactgtttac
     4801 cattgtgttt aggttatatt ctataaatac tctttatatg catatatatg gctataaata
     4861 taaattttgt attactggta ccaaaaacac tttttttttt ttttccagca gggtttctct
     4921 gtgtagccct ggctgtcctg gaactcactt tgtagaccag gctggcctcg aactcagaaa
     4981 tctgcctgcc tctgcctccc aagtgctggg attaaaggcg tgggccacca cgcccggctc
     5041 aaaaatacat ttcttaaagt tgaaatcatt tgcttcttcc ataatgggac gttgaaactt
     5101 ctgctttcgg aacagcgtgt gttggaaagc ttgtttgaga atggctacta gagtttaaga
     5161 ggctatgtat ggagtttgtt ggggatgtag tgatggtggt aaggatcaga cctagggccc
     5221 agtgtacact taagcacatg cctaactcaa gagtttagat tttagtatag tttaaagttg
     5281 agctgccttt tcttatgtag ctatttaaaa tatttctgaa gttcagtaat ttggatgcct
     5341 tcattagtag atgctgtcct atatacctat taaaaatgcc aaacactgat aacattgaac
     5401 atgttcatat tgatagagat aatattgtat aggtctagtg tgtatggatc tgggatctcc
     5461 gcccttgagg cagagacggg aagatcagga gttcaaggtc ttagctacat agtaagtttg
     5521 aagccagcct ggctacttga gactctgtct cacaaaagca aataaacaaa ggattatgct
     5581 taatagtttt cattgaagtt tattataact tatttcagat gtgtcctttt attgtacatt
     5641 ttgtataata aatgttgaag ttgaaaactg tta
//
