LOCUS       NM_026487               2813 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ATPase family, AAA domain containing 1 (Atad1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_026487
VERSION     NM_026487.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2813)
  AUTHORS   Zhang,H., Cai,M., Gao,F., Yang,J., Li,C., Han,J., Wang,Y., Xu,Y.,
            Hu,Y., Chen,H., He,W. and Zhang,J.
  TITLE     Thorase deficiency causes both Abeta accumulation and tau
            hyperphosphorylation in mouse brain
  JOURNAL   Alzheimers Dement 20 (12), 8769-8786 (2024)
   PUBMED   39535463
REFERENCE   2  (bases 1 to 2813)
  AUTHORS   Li,C., Zhang,H., Tong,K., Cai,M., Gao,F., Yang,J., Xu,Y., Wang,H.,
            Chen,H., Hu,Y., He,W. and Zhang,J.
  TITLE     Genetic Deletion of Thorase Causes Purkinje Cell Loss and Impaired
            Motor Coordination Behavior
  JOURNAL   Cells 12 (16), 2032 (2023)
   PUBMED   37626842
  REMARK    GeneRIF: Genetic Deletion of Thorase Causes Purkinje Cell Loss and
            Impaired Motor Coordination Behavior.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2813)
  AUTHORS   Gao,F., Zhang,H., Yang,J., Cai,M., Yang,Q., Wang,H., Xu,Y.,
            Chen,H., Hu,Y., He,W. and Zhang,J.
  TITLE     ATPase Thorase Deficiency Causes alpha-Synucleinopathy and
            Parkinson's Disease-like Behavior
  JOURNAL   Cells 11 (19), 2990 (2022)
   PUBMED   36230952
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2813)
  AUTHORS   Umanah,G.K.E., Ghasemi,M., Yin,X., Chang,M., Kim,J.W., Zhang,J.,
            Ma,E., Scarffe,L.A., Lee,Y.I., Chen,R., Tangella,K., McNamara,A.,
            Abalde-Atristain,L., Dar,M.A., Bennett,S., Cortes,M., Andrabi,S.A.,
            Doulias,P.T., Ischiropoulos,H., Dawson,T.M. and Dawson,V.L.
  TITLE     AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of
            Thorase and Transnitrosylation of NSF
  JOURNAL   Cell Rep 33 (5), 108329 (2020)
   PUBMED   33147468
  REMARK    GeneRIF: AMPA Receptor Surface Expression Is Regulated by
            S-Nitrosylation of Thorase and Transnitrosylation of NSF.
REFERENCE   5  (bases 1 to 2813)
  AUTHORS   Zhang,J., Yang,J., Wang,H., Sherbini,O., Keuss,M.J., Umanah,G.K.,
            Pai,E.L., Chi,Z., Paldanius,K.M., He,W., Wang,H., Andrabi,S.A.,
            Dawson,T.M. and Dawson,V.L.
  TITLE     The AAA + ATPase Thorase is neuroprotective against ischemic injury
  JOURNAL   J Cereb Blood Flow Metab 39 (9), 1836-1848 (2019)
   PUBMED   29658368
  REMARK    GeneRIF: Thorase provides neuroprotection in an ATP-dependent
            manner against oxygen-glucose deprivation (OGD) neurotoxicity or
            glutamate N-Methyl-D-aspartate (NMDA) receptor-mediated
            excitotoxicity in vitro.
REFERENCE   6  (bases 1 to 2813)
  AUTHORS   Prendergast,J., Umanah,G.K., Yoo,S.W., Lagerlof,O., Motari,M.G.,
            Cole,R.N., Huganir,R.L., Dawson,T.M., Dawson,V.L. and Schnaar,R.L.
  TITLE     Ganglioside regulation of AMPA receptor trafficking
  JOURNAL   J Neurosci 34 (39), 13246-13258 (2014)
   PUBMED   25253868
REFERENCE   7  (bases 1 to 2813)
  AUTHORS   Chen,Y.C., Umanah,G.K., Dephoure,N., Andrabi,S.A., Gygi,S.P.,
            Dawson,T.M., Dawson,V.L. and Rutter,J.
  TITLE     Msp1/ATAD1 maintains mitochondrial function by facilitating the
            degradation of mislocalized tail-anchored proteins
  JOURNAL   EMBO J 33 (14), 1548-1564 (2014)
   PUBMED   24843043
  REMARK    GeneRIF: Yeast Msp1 and mammalian ATAD1 are conserved members of
            the mitochondrial protein quality control system that might promote
            the extraction and degradation of mislocalized TA proteins to
            maintain mitochondrial integrity.
REFERENCE   8  (bases 1 to 2813)
  AUTHORS   Zhang,J., Wang,Y., Chi,Z., Keuss,M.J., Pai,Y.M., Kang,H.C.,
            Shin,J.H., Bugayenko,A., Wang,H., Xiong,Y., Pletnikov,M.V.,
            Mattson,M.P., Dawson,T.M. and Dawson,V.L.
  TITLE     The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic
            plasticity and behavior
  JOURNAL   Cell 145 (2), 284-299 (2011)
   PUBMED   21496646
REFERENCE   9  (bases 1 to 2813)
  AUTHORS   Lee,J., Xu,Y., Chen,Y., Sprung,R., Kim,S.C., Xie,S. and Zhao,Y.
  TITLE     Mitochondrial phosphoproteome revealed by an improved IMAC method
            and MS/MS/MS
  JOURNAL   Mol Cell Proteomics 6 (4), 669-676 (2007)
   PUBMED   17208939
REFERENCE   10 (bases 1 to 2813)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162887.5.
            
            On Nov 17, 2006 this sequence version replaced NM_026487.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029085.1, AK033639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC162887.5         49747-49779
            34-208              AC162887.5         55036-55210
            209-307             AC162887.5         59407-59505
            308-428             AC162887.5         60405-60525
            429-629             AC162887.5         63405-63605
            630-736             AC162887.5         66147-66253
            737-826             AC162887.5         74723-74812
            827-877             AC162887.5         77993-78043
            878-1011            AC162887.5         85195-85328
            1012-2813           AC162887.5         87681-89482
FEATURES             Location/Qualifiers
     source          1..2813
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 27.55 cM"
     gene            1..2813
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /note="ATPase family, AAA domain containing 1"
                     /db_xref="GeneID:67979"
                     /db_xref="MGI:MGI:1915229"
     exon            1..33
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /inference="alignment:Splign:2.1.0"
     exon            34..208
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1132
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /EC_number="3.6.1.3"
                     /note="ATPase family AAA domain-containing protein 1"
                     /codon_start=1
                     /product="outer mitochondrial transmembrane helix
                     translocase"
                     /protein_id="NP_080763.2"
                     /db_xref="CCDS:CCDS29752.1"
                     /db_xref="GeneID:67979"
                     /db_xref="MGI:MGI:1915229"
                     /translation="MVHAEAFSRPLSRNEVVGLIFRLTIFGAVTYFTIKWMVDAIDPT
                     RKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHLVDPLNMHVTWSDIAGLDDVITD
                     LKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPS
                     TLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMS
                     LWDGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQREAILKLILKNE
                     NVDRHVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNSTSEESHDEDEIRPVQQQ
                     DLHRAIEKMKKSKDAAFQNVLTHVCLD"
     exon            209..307
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /inference="alignment:Splign:2.1.0"
     exon            308..428
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /inference="alignment:Splign:2.1.0"
     exon            429..629
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /inference="alignment:Splign:2.1.0"
     exon            630..736
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /inference="alignment:Splign:2.1.0"
     exon            737..826
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /inference="alignment:Splign:2.1.0"
     exon            827..877
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1011
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..2813
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2275..2280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /note="hexamer: ATTAAA"
     polyA_site      2287
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /note="major polyA site"
     regulatory      2533..2538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /note="hexamer: AATAAA"
     polyA_site      2554
                     /gene="Atad1"
                     /gene_synonym="4921525H23Rik; Thorase"
                     /note="major polyA site"
ORIGIN      
        1 cggctctccc atcgtctctg gtcctgcctc tgggttaaca atcaagatgg tacatgctga
       61 agccttttct cgtccattga gtcggaatga agttgtcggt ttaattttcc gtttaacaat
      121 atttggtgca gtaacgtact tcactattaa atggatggta gatgccattg accccaccag
      181 gaagcagaag gtagaagctc agaaacaggc ggaaaaactg atgaagcaaa ttggtgtgaa
      241 aaatgtgaag ctttcagaat atgaaatgag tattgctgct catctagtag accctcttaa
      301 tatgcatgtt acttggagtg atatagcagg tttagatgac gtcattacag atctgaaaga
      361 cacagtcatc ttacctatca aaaagaagca tttgtttgag aattccagac tactgcagcc
      421 tccaaaaggt gttcttctgt atggacctcc aggctgtggg aaaacattaa ttgccaaagc
      481 aacagccaaa gaagcaggct gtcggttcat taacctccag ccttcgacac tgactgataa
      541 gtggtatgga gaatctcaaa aactggctgc tgctgttttc tcccttgcca taaagctaca
      601 gccttctatc atatttattg atgaaataga ctctttccta cgaaatcgtt ccagttctga
      661 ccacgaagct acagcgatga tgaaagctca gtttatgagt ctctgggatg gactggacac
      721 tgatcacagc tgccaggtta tagtaatggg agctaccaat cgccctcaag accttgactc
      781 cgctataatg cgaagaatgc ctacacgatt tcatattaac cagcctgctc taaaacaaag
      841 agaagcaatt ttaaagctca tcttgaaaaa tgaaaatgtg gatagacacg tagatcttct
      901 agaagttgcc caggaaactg atggattttc aggaagtgac ctaaaagaaa tgtgtcggga
      961 tgccgccctc ctctgtgtca gggaatatgt caattctaca tcagaagaga gtcacgatga
     1021 agatgaaatc cggcctgtgc aacagcagga cctgcatcgg gcaattgaaa agatgaagaa
     1081 gtcaaaggat gcagcctttc agaatgttct aactcacgtt tgtttagatt aggagttgag
     1141 gatcatttgt gctgtccagt gctcccgtct gcacagcagt gagggaaatc caggcttggg
     1201 tcatattctc agatctttgc tctgttatat aaacggtgtt attgcttgtc agaaatcatg
     1261 cggaggaaac tgagtgcagc ctgagtgtgg gtgcttgtct gaccttttta gccatatgct
     1321 gttatagcct tatagagtct aagctggtct taatggagta aatgatttgt cattagtgag
     1381 gaatggggtg tggttaggtg ctggtttcta gacacgtgag tatgaatgtg agtgtgtgtg
     1441 tatgagtgta tatcaaatgt atatatccac tttttttaaa tattctgtag ataggtttga
     1501 attcagaagc ttttttcccc ccaactactg aatccaaaag caccagatag tctgtagcaa
     1561 aactgggatt taaggcagga tttgacaggt ccagggagat tcagccattc ctaggtgtca
     1621 ctaggtgttt gggcagtttt tttaagttga acatttttct ctgcggttgg ttgaatcaac
     1681 tacatctgaa tatgcacgtg tctcaagtat agtggttgtc aggagaatca gatgacaaac
     1741 acagtttgct cagtgatcag cagggattat tccacctcat cctgctgtga caccgagtag
     1801 actttttgaa gttttacact gaattacatt aagaaggatt aaaaaccttt caaaagaatg
     1861 ggtttaagaa acctcagtcc tctttaatac gtgtacataa ttctcagtgt aacaggtctg
     1921 taactgtatt aatgttgttt gaaagttata tgttctttaa ttatgttcaa atttcatttg
     1981 gtcacccaaa caaaatgata gtttatataa atagtcacta ctaaatgtgc taaaaaatac
     2041 tcactttgta acttaaattt aaaatttttc tcatttataa atgtgttcaa ataatacaca
     2101 tcaaaattct tgtgttgtat ctgtagtcac ttgatgctat gtgaaccaca tataaaactc
     2161 ttcttttttc aaacctccag tagccagact tctgattcag gcaccttgac atgtgacaga
     2221 actagagtac agtgccacag cacagtccta aggtgcctct gagtcaccag agagattaaa
     2281 cgacgacggg ttttattatt tgttttattt ctttgaaaac taaattttcc tatgtttact
     2341 gagttaattt ctctagtaat gtgtctcaca agaaccttct agacactttc ttcctccatt
     2401 tgtgttttgg ggttatagat tgcgggagac tacttaggat aacaaaaagc aagctgggca
     2461 agattgtaaa gatgatggga aatgaatgct aatacaagac gccaagaaac atatcctgtt
     2521 tttataattt acaataaaag tcctttcctt ttgattcttt tttccccact tagttcttga
     2581 ttgttttcag ttgcttggat tgcggatttt gttgtttata agatttgtgt ttgggcagtt
     2641 tttatattgc agttgacatt tcacattttt atagcagaca ttttaatatt gatttattct
     2701 gtttaaatat gagttttagt aatttaattt taatgtaatg gcatgttcag aaatgattga
     2761 tgtgtatatt tctttgtgtc tttttcatct tctattaaat tcaatagaat tta
//
