LOCUS       NM_023729               1740 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus ankyrin repeat, SAM and basic leucine zipper domain
            containing 1 (Asz1), mRNA.
ACCESSION   NM_023729
VERSION     NM_023729.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1740)
  AUTHORS   Ikeda,S., Tanaka,K., Ohtani,R., Kanda,A., Sotomaru,Y., Kono,T. and
            Obata,Y.
  TITLE     Disruption of piRNA machinery by deletion of ASZ1/GASZ results in
            the expression of aberrant chimeric transcripts in gonocytes
  JOURNAL   J Reprod Dev 68 (2), 125-136 (2022)
   PUBMED   35095021
  REMARK    GeneRIF: Disruption of piRNA machinery by deletion of ASZ1/GASZ
            results in the expression of aberrant chimeric transcripts in
            gonocytes.
REFERENCE   2  (bases 1 to 1740)
  AUTHORS   Zhang,J., Wang,Q., Wang,M., Jiang,M., Wang,Y., Sun,Y., Wang,J.,
            Xie,T., Tang,C., Tang,N., Song,H., Cui,D., Chao,R., Ding,S., Ni,B.,
            Chen,X. and Wang,Y.
  TITLE     GASZ and mitofusin-mediated mitochondrial functions are crucial for
            spermatogenesis
  JOURNAL   EMBO Rep 17 (2), 220-234 (2016)
   PUBMED   26711429
  REMARK    GeneRIF: GASZ interacts with itself at the outer membrane of
            mitochondria and promotes mitofusion in a mitofusin/MFN-dependent
            manner.  GASZ contains a functional mitochondrial targeting signal
            .
REFERENCE   3  (bases 1 to 1740)
  AUTHORS   Auclair,G., Borgel,J., Sanz,L.A., Vallet,J., Guibert,S., Dumas,M.,
            Cavelier,P., Girardot,M., Forne,T., Feil,R. and Weber,M.
  TITLE     EHMT2 directs DNA methylation for efficient gene silencing in mouse
            embryos
  JOURNAL   Genome Res 26 (2), 192-202 (2016)
   PUBMED   26576615
REFERENCE   4  (bases 1 to 1740)
  AUTHORS   Zylicz,J.J., Dietmann,S., Gunesdogan,U., Hackett,J.A., Cougot,D.,
            Lee,C. and Surani,M.A.
  TITLE     Chromatin dynamics and the role of G9a in gene regulation and
            enhancer silencing during early mouse development
  JOURNAL   Elife 4, e09571 (2015)
   PUBMED   26551560
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1740)
  AUTHORS   Lim,A.K., Lorthongpanich,C., Chew,T.G., Tan,C.W., Shue,Y.T.,
            Balu,S., Gounko,N., Kuramochi-Miyagawa,S., Matzuk,M.M., Chuma,S.,
            Messerschmidt,D.M., Solter,D. and Knowles,B.B.
  TITLE     The nuage mediates retrotransposon silencing in mouse primordial
            ovarian follicles
  JOURNAL   Development 140 (18), 3819-3825 (2013)
   PUBMED   23924633
REFERENCE   6  (bases 1 to 1740)
  AUTHORS   Ma,L., Buchold,G.M., Greenbaum,M.P., Roy,A., Burns,K.H., Zhu,H.,
            Han,D.Y., Harris,R.A., Coarfa,C., Gunaratne,P.H., Yan,W. and
            Matzuk,M.M.
  TITLE     GASZ is essential for male meiosis and suppression of
            retrotransposon expression in the male germline
  JOURNAL   PLoS Genet 5 (9), e1000635 (2009)
   PUBMED   19730684
  REMARK    GeneRIF: GASZ is essential for meiosis and suppression of
            retrotransposon expression in the male germ cells.
            Erratum:[PLoS Genet. 2009 Dec;5(12). doi:
            10.1371/annotation/20bf08d1-07e9-451e-b079-166832ebe158]
REFERENCE   7  (bases 1 to 1740)
  AUTHORS   Greenbaum,M.P., Iwamori,N., Agno,J.E. and Matzuk,M.M.
  TITLE     Mouse TEX14 is required for embryonic germ cell intercellular
            bridges but not female fertility
  JOURNAL   Biol Reprod 80 (3), 449-457 (2009)
   PUBMED   19020301
REFERENCE   8  (bases 1 to 1740)
  AUTHORS   Thomas,J.W., Touchman,J.W., Blakesley,R.W., Bouffard,G.G.,
            Beckstrom-Sternberg,S.M., Margulies,E.H., Blanchette,M.,
            Siepel,A.C., Thomas,P.J., McDowell,J.C., Maskeri,B., Hansen,N.F.,
            Schwartz,M.S., Weber,R.J., Kent,W.J., Karolchik,D., Bruen,T.C.,
            Bevan,R., Cutler,D.J., Schwartz,S., Elnitski,L., Idol,J.R.,
            Prasad,A.B., Lee-Lin,S.Q., Maduro,V.V., Summers,T.J., Portnoy,M.E.,
            Dietrich,N.L., Akhter,N., Ayele,K., Benjamin,B., Cariaga,K.,
            Brinkley,C.P., Brooks,S.Y., Granite,S., Guan,X., Gupta,J.,
            Haghighi,P., Ho,S.L., Huang,M.C., Karlins,E., Laric,P.L.,
            Legaspi,R., Lim,M.J., Maduro,Q.L., Masiello,C.A., Mastrian,S.D.,
            McCloskey,J.C., Pearson,R., Stantripop,S., Tiongson,E.E.,
            Tran,J.T., Tsurgeon,C., Vogt,J.L., Walker,M.A., Wetherby,K.D.,
            Wiggins,L.S., Young,A.C., Zhang,L.H., Osoegawa,K., Zhu,B., Zhao,B.,
            Shu,C.L., De Jong,P.J., Lawrence,C.E., Smit,A.F., Chakravarti,A.,
            Haussler,D., Green,P., Miller,W. and Green,E.D.
  TITLE     Comparative analyses of multi-species sequences from targeted
            genomic regions
  JOURNAL   Nature 424 (6950), 788-793 (2003)
   PUBMED   12917688
REFERENCE   9  (bases 1 to 1740)
  AUTHORS   Yan,W., Rajkovic,A., Viveiros,M.M., Burns,K.H., Eppig,J.J. and
            Matzuk,M.M.
  TITLE     Identification of Gasz, an evolutionarily conserved gene expressed
            exclusively in germ cells and encoding a protein with four ankyrin
            repeats, a sterile-alpha motif, and a basic leucine zipper
  JOURNAL   Mol Endocrinol 16 (6), 1168-1184 (2002)
   PUBMED   12040005
REFERENCE   10 (bases 1 to 1740)
  AUTHORS   Ellsworth,R.E., Jamison,D.C., Touchman,J.W., Chissoe,S.L., Braden
            Maduro,V.V., Bouffard,G.G., Dietrich,N.L.,
            Beckstrom-Sternberg,S.M., Iyer,L.M., Weintraub,L.A., Cotton,M.,
            Courtney,L., Edwards,J., Maupin,R., Ozersky,P., Rohlfing,T.,
            Wohldmann,P., Miner,T., Kemp,K., Kramer,J., Korf,I., Pepin,K.,
            Antonacci-Fulton,L., Fulton,R.S., Minx,P., Hillier,L.W.,
            Wilson,R.K., Waterston,R.H., Miller,W. and Green,E.D.
  TITLE     Comparative genomic sequence analysis of the human and mouse cystic
            fibrosis transmembrane conductance regulator genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1172-1177 (2000)
   PUBMED   10655503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG088136.2, BC058859.1, AF459789.1 and BB020038.1.
            
            On Sep 1, 2009 this sequence version replaced NM_023729.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF459789.1, AK016595.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BG088136.2         1-4
            5-769               BC058859.1         14-778
            770-1732            AF459789.1         764-1726
            1733-1740           BB020038.1         237-244
FEATURES             Location/Qualifiers
     source          1..1740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 8.09 cM"
     gene            1..1740
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /note="ankyrin repeat, SAM and basic leucine zipper domain
                     containing 1"
                     /db_xref="GeneID:74068"
                     /db_xref="MGI:MGI:1921318"
     exon            1..130
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1453
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /note="germ cell-specific ankyrin, SAM and basic leucine
                     zipper domain containing protein"
                     /codon_start=1
                     /product="ankyrin repeat, SAM and basic leucine zipper
                     domain-containing protein 1"
                     /protein_id="NP_076218.3"
                     /db_xref="CCDS:CCDS19929.1"
                     /db_xref="GeneID:74068"
                     /db_xref="MGI:MGI:1921318"
                     /translation="MAAGTLRGLAVAGGGESSDSEDDGWDIGYLDRSSQKLKRSLPVE
                     EKNETFKKALTTGDISLVKELLDSGINVDSSFRYGWTPLMYAASVANAELVRFLLDRG
                     ANASFDKDKLTILISACSARGSEEQVLKCVELLLSRNADPNTACRRLMTPIMYAARDG
                     HTQVVALLVAHGAEVNAQDENGYTALTWAARQGHKNVILKLLELGANKMLQTKDGRTP
                     SEIAKRNKHLEIFNFLSLTLNPLEGKLQQLTKEETICKLLATDSDKEKDHIFSPYTAF
                     GDLEIFLHGLGLEHMTDSLKEKDITLRHLLTMKKDELTKNGIASKDQQKILAALKELE
                     VEEINFGKLPEVTKLEISGDEFLNFLLKLNKQCGHLITAVQNIITELPVNSHKIVLEW
                     ASPRNFTSVCEELVSNVEDLNEEVCRLKELIQKMQNERENDPTHIPLVEEVSTWKTRI
                     LKRSAVTVCGFGLLLFIGKLTLQRK"
     exon            131..230
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /inference="alignment:Splign:2.1.0"
     exon            231..353
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /inference="alignment:Splign:2.1.0"
     exon            354..465
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /inference="alignment:Splign:2.1.0"
     exon            466..577
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /inference="alignment:Splign:2.1.0"
     exon            578..712
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /inference="alignment:Splign:2.1.0"
     exon            713..837
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /inference="alignment:Splign:2.1.0"
     exon            838..913
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /inference="alignment:Splign:2.1.0"
     exon            914..970
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1080
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1186
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1300
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1740
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1712..1717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /note="hexamer: AATAAA"
     polyA_site      1733
                     /gene="Asz1"
                     /gene_synonym="4933400N19Rik; Gasz; ORF3"
                     /note="major polyA site"
ORIGIN      
        1 ggcaccggaa gaacagcttg gagccatggc agcgggcaca ctgaggggct tggcagtggc
       61 tggtggaggc gagagcagcg atagtgagga tgacggctgg gatattgggt atctcgaccg
      121 gtcctctcag aaattaaaaa ggtctttacc cgttgaagag aagaacgaga catttaagaa
      181 agcactgacc accggagata tttctttagt taaagaactc ctggattctg gcattaatgt
      241 ggactccagc ttccgctatg gatggacccc tcttatgtat gccgctagtg tggccaatgc
      301 agagctggtt cgcttccttt tggacagagg tgctaatgcc agctttgata aggacaagtt
      361 aaccattttg ataagtgctt gttctgctcg tggctcagag gagcaagtct tgaaatgtgt
      421 agagttacta ctttcaagaa atgcggaccc aaatactgct tgtaggagac ttatgacgcc
      481 aatcatgtat gctgcccgag acggtcatac tcaggttgtg gctctgcttg tggctcacgg
      541 agccgaagtt aacgcccagg atgagaatgg ttatactgcc ttaacatggg cagcacggca
      601 gggtcataaa aatgtaattc tgaagttgct tgaactggga gctaataaaa tgctacagac
      661 caaagatggc agaacaccaa gcgagattgc aaaaagaaat aaacatcttg agatcttcaa
      721 ctttctttct ctgactctaa atccattgga aggaaaactt cagcagctaa ccaaagaaga
      781 gaccatttgt aaactgttgg ccacagattc tgataaagaa aaagatcaca tatttagccc
      841 gtatacagcg tttggagatc tggaaatatt tttacatggc cttggacttg aacatatgac
      901 agactcatta aaggaaaagg atataacttt aagacacctt ctgaccatga agaaagacga
      961 gcttacaaag aatggaattg ctagtaaaga tcaacagaaa atcttggctg ctcttaagga
     1021 actagaagta gaagagataa attttggaaa attacctgaa gtgacaaagt tggaaatcag
     1081 tggtgatgag ttcctcaact ttcttttgaa attaaataag cagtgtggcc atttaatcac
     1141 agctgtgcag aatatcatta ccgagttgcc tgtaaattct cacaagatag tactggagtg
     1201 ggcttctccc agaaatttta cttcagtttg tgaagaactg gttagtaatg ttgaagattt
     1261 gaatgaagag gtctgcagac tgaaggagtt gattcagaag atgcagaatg agcgggaaaa
     1321 tgacccaact catatcccac tagtagaaga ggtctctaca tggaagactc gaattctgaa
     1381 gaggtcagca gttacagtgt gtggattcgg gctgctgctt ttcatcggca agctaacttt
     1441 gcagagaaaa taatagtact atttatttaa gttctgtatg tccatcttct tctgagtgtc
     1501 ctagcatggc ttctaatcat ttgtggtaca gcatagcttt atttccttgc ctgtactcca
     1561 aaggaacaat tatgatacta taaagtacag ttttccttta gaacatgact tcagtttgaa
     1621 ttatatagtt tattacattt ttatgttcct ttcaatcaag aagtaaatta tggttaattc
     1681 tttcatttaa acctgactaa atcacatgca aaataaatgt ttggtattct ttacattcag
//
