LOCUS       NM_001167777           11697 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ASXL transcriptional regulator 3 (Asxl3), mRNA.
ACCESSION   NM_001167777 XM_001474902 XM_140204
VERSION     NM_001167777.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11697)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 11697)
  AUTHORS   Alderman,P.J., Saxon,D., Torrijos-Saiz,L.I., Sharief,M., Page,C.E.,
            Baroudi,J.K., Biagiotti,S.W., Butyrkin,V.A., Melamed,A., Kuo,C.T.,
            Vicini,S., Garcia-Verdugo,J.M., Herranz-Perez,V., Corbin,J.G. and
            Sorrells,S.F.
  TITLE     Delayed maturation and migration of excitatory neurons in the
            juvenile mouse paralaminar amygdala
  JOURNAL   Neuron 112 (4), 574-592 (2024)
   PUBMED   38086370
REFERENCE   3  (bases 1 to 11697)
  AUTHORS   Wang,X., Zhang,Y., Yu,J., Ma,Y., Xu,Y., Shi,J., Qi,Z. and Liu,X.
  TITLE     Identification and analysis of key circRNAs in the mouse embryonic
            ovary provides insight into primordial follicle development
  JOURNAL   BMC Genomics 25 (1), 139 (2024)
   PUBMED   38310234
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11697)
  AUTHORS   Szakats,S., McAtamney,A., Cross,H. and Wilson,M.J.
  TITLE     Sex-biased gene and microRNA expression in the developing mouse
            brain is associated with neurodevelopmental functions and
            neurological phenotypes
  JOURNAL   Biol Sex Differ 14 (1), 57 (2023)
   PUBMED   37679839
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11697)
  AUTHORS   Siguero-Alvarez,M., Salguero-Jimenez,A., Grego-Bessa,J., de la
            Barrera,J., MacGrogan,D., Prados,B., Sanchez-Saez,F.,
            Pineiro-Sabaris,R., Felipe-Medina,N., Torroja,C., Gomez,M.J.,
            Sabater-Molina,M., Escriba,R., Richaud-Patin,I.,
            Iglesias-Garcia,O., Sbroggio,M., Callejas,S., O'Regan,D.P.,
            McGurk,K.A., Dopazo,A., Giovinazzo,G., Ibanez,B., Monserrat,L.,
            Perez-Pomares,J.M., Sanchez-Cabo,F., Pendas,A.M., Raya,A.,
            Gimeno-Blanes,J.R. and de la Pompa,J.L.
  TITLE     A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With
            Bicuspid Aortic Valve
  JOURNAL   Circulation 147 (1), 47-65 (2023)
   PUBMED   36325906
  REMARK    Erratum:[Circulation. 2023 Jan 17;147(3):e63. doi:
            10.1161/CIR.0000000000001129.. PMID: 36649398]
REFERENCE   6  (bases 1 to 11697)
  AUTHORS   Fu,F., Li,R., Lei,T.Y., Wang,D., Yang,X., Han,J., Pan,M., Zhen,L.,
            Li,J., Li,F.T., Jing,X.Y., Li,D.Z. and Liao,C.
  TITLE     Compound heterozygous mutation of the ASXL3 gene causes autosomal
            recessive congenital heart disease
  JOURNAL   Hum Genet 140 (2), 333-348 (2021)
   PUBMED   32696347
REFERENCE   7  (bases 1 to 11697)
  AUTHORS   Jia,G., Preussner,J., Chen,X., Guenther,S., Yuan,X., Yekelchyk,M.,
            Kuenne,C., Looso,M., Zhou,Y., Teichmann,S. and Braun,T.
  TITLE     Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor
            cell transition states and lineage settlement
  JOURNAL   Nat Commun 9 (1), 4877 (2018)
   PUBMED   30451828
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 11697)
  AUTHORS   McGinley,A.L., Li,Y., Deliu,Z. and Wang,Q.T.
  TITLE     Additional sex combs-like family genes are required for normal
            cardiovascular development
  JOURNAL   Genesis 52 (7), 671-686 (2014)
   PUBMED   24860998
REFERENCE   9  (bases 1 to 11697)
  AUTHORS   Fisher,C.L., Randazzo,F., Humphries,R.K. and Brock,H.W.
  TITLE     Characterization of Asxl1, a murine homolog of Additional sex
            combs, and analysis of the Asx-like gene family
  JOURNAL   Gene 369, 109-118 (2006)
   PUBMED   16412590
REFERENCE   10 (bases 1 to 11697)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK082659.1, CK637390.1 and AC163208.2.
            
            On or before Nov 19, 2009 this sequence version replaced
            XM_140204.7, XM_001474902.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3121              AK082659.1         1-3121
            3122-3552           CK637390.1         97-527
            3553-11697          AC163208.2         19598-27742         c
FEATURES             Location/Qualifiers
     source          1..11697
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 11.96 cM"
     gene            1..11697
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /note="ASXL transcriptional regulator 3"
                     /db_xref="GeneID:211961"
                     /db_xref="MGI:MGI:2685175"
     exon            1..78
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /inference="alignment:Splign:2.1.0"
     exon            79..161
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /inference="alignment:Splign:2.1.0"
     exon            162..370
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /inference="alignment:Splign:2.1.0"
     exon            371..373
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /inference="alignment:Splign:2.1.0"
     exon            374..482
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..7019
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /note="polycomb group protein; additional sex combs-like
                     protein 3; additional sex combs like 3, transcriptional
                     regulator"
                     /codon_start=1
                     /product="putative Polycomb group protein ASXL3"
                     /protein_id="NP_001161249.1"
                     /db_xref="CCDS:CCDS50234.1"
                     /db_xref="GeneID:211961"
                     /db_xref="MGI:MGI:2685175"
                     /translation="MLHTNTRVGDGTFFKIPGKSGLYALRKEESSCPVDGTLDLVVDP
                     DLDGAEMAEASANGEENRVCTKQVTDEVSSTRDCSLTNTAVQSKLVSSFQQHTKKALK
                     QALRQQQKRRNGVSMMVNKTVPRVVLTPLKVSDEQSDSPSGSESKNGEADSSDKEMKH
                     GQKSPTGKQTSQHLKRLKKSGLGHLKWTKAEDIDIETPGSILVNTNLRALINKHTFAS
                     FPQHFQQYLLLLLPEVDRQMGSDGILRLSTSALNNEFFAYAAQGWKQRLAEGEFTPEM
                     QLRIRQEIEKEKKTEPWKEKFFERFYGERSGMSREESIKLTSGPNHEGAEGSSSHGDS
                     GIPGPSAQNALEEQQPKILKSSASLEPDFCTTVCPMLEVPVKDVMTESETEDIFIPEE
                     SVIQEEVAEEVETSIYECQDEHLKTIPAFSEESESPATPCEEPQVAAPEDSLESCVVM
                     NDILHTLPHIEVKIVEKLECPQEEMSVVIDQLEICDSLLPCPSSVTHILDVEQKEQET
                     TIETSAMALREGPSSLESQLPNEGIAVDMELQSDPEEQLSENACISETSFSSESPEGA
                     CASLPSPGGETQSTSEESCTPASLETTFCSEVSSTENTDKYNQRNPTGESLHASLVSE
                     VSPLATSPEISEASLMSNLPLTSEASPVSNLPLTSEASPMSDLPPTSETSSESSMPLT
                     SETPFVSSLPIPAETSPISNSSVNERMVHQQRKSPSGSEEANSPQKEEPSIPTKPLGE
                     SLVSHPKPLSTIPEPINMSSAMVPEALPPEGLHSQTLSQEPCNAHVEMEKLYASSIPE
                     LPSSEMTKVKNHSVLQRPEKKGLSAPLEVPVFSEETETKGIELPPAKLQDKQYAPSVD
                     KATFLEGSRNKIHKQSSTLNRLETSHTSKVSEPSKSPDGIRNDNRESEISKRKTVEHS
                     FGICKEKRARIEDDQSARSLASSSPPEKEQPPREEPRVPPLKIQLSKIGPPFIIKSQP
                     VSKAESRASTSTSVSSGRNTGARTLADIKARAQQARAQREAAAAAAVAAAASIVSGAM
                     GSPGEGGKARTLAHIKEQTKAKLFAKHQSRAHLFQTSKETRLPSVSTKEDSLNMEASP
                     TPETKMEGSTGVIIINPNCRSPSSKPTHIREITTVLQQPLNPPQIPETATDLSVHSSD
                     DNIPVSHLTEKIVSSTSSENSSVPILHNKSPINPIPMSVCSTAMSGAIKEHPFVSPVD
                     KSSVLMSVDSANSTISACNISMLKSIQGSDAPCIALVPKCINRTPIPAAPEGTGQSNS
                     MDGKALLVPSSKAANVISNQYTSVPAPTIASNLPNHLCTSSVLIPPTGINNRFVSEKI
                     AMPGSEEQAAVSIGATMRTALSCGDSVAVTDSLVPRSPIAMFAGNMLTANSYNCPPKL
                     SGENLDNNSGPLNRTDNSEKPQQPAGGFVPATINRSIPCKVIVDHSTTLTSNLSLTVS
                     IESGDSSLDSQTRSVRTDVSIQPVACPQVSVISRPEQATSEGLDHGSVFIAAPTAKQD
                     CKTLQATCTSLRELPLTLPDKLNEVTVPTHGFAEQARNSSTFKKETDTACSNQYNPGN
                     RICWSEDPMRNTAPPVVSHSSSSKQKEHPEQTGLKAVKTEHVSYAHVSDLHPRNLITN
                     VSLPVKPEPHEVDKGFRMDTEDFPGPERPPPVTEVTSSASVQPTQTMKPSTTSPVEEA
                     ISLAPDTLKRIPSASSSSCRLSSVEANNPLVTQLLQGNLPLEKVLPQPRLGAKLEINR
                     LPLPLQTTSVGKTGLERNMVEMPSSSPNPDGKGYLAGTLAPVQMRKRENHPKKRAART
                     VGDHAQVKCEPGKMVMEPDVKAVPCVISPSMSQLGHNQPFKQERLNKPSMANRIMPSP
                     EVKQQKRLLPACSFQPSLFHVNKNEGFHADTGTSHRQQFYQMPMAARGPLPTPALLQN
                     SPKTPVGCNAFAFNRHLEQKALGDVNLPTAPHQLRLANMLSPNMPIKEGEDGGGTTHT
                     MPSKAVVHAPLPPPPPPPPPPPPPLALPPPPPPPPPLPPPLPTVEVPSDQKQPPVNME
                     TTKRLSWPQSTGICSNIKSEPLSFEESLSSSCELGMKQVPYDQNEVKEQLKAFALKNA
                     DFSSYLLSEPQKPFTQLAAQKLPVPQQQPLCGSYPTIHFGSTNFKRAASAIEKSIGIL
                     GSGSNPATSTGLTGQNTQMPVQNFADNSNADELELKCSCRLKAMIVCKGCGAFCHDDC
                     IGPSKLCVACLVVR"
     exon            483..591
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /inference="alignment:Splign:2.1.0"
     exon            592..713
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /inference="alignment:Splign:2.1.0"
     exon            714..831
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /inference="alignment:Splign:2.1.0"
     exon            832..951
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1115
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1212
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1318
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..3272
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..11697
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11467..11472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /note="hexamer: AAGAAA"
     polyA_site      11485
                     /gene="Asxl3"
                     /gene_synonym="C230079D11Rik; D430002O22Rik;
                     D930044O18Rik; Gm329; Gm945"
                     /note="major polyA site"
ORIGIN      
        1 gacatttgtc ctgggagatt agaagtctgc agctacgtgt gtttcaccgc tggcttgctg
       61 ggcagcttta ctggcctggc actagaaaaa caccccaact ccccaatgac agcaaagcag
      121 attctggagg tcattcagaa agaaggctta aaagagacaa gtctggtttc agaccccggc
      181 atggcttgga gacagcgttg gtgtgtatga aggctcttcc tggaatgaag gatttgggac
      241 acctttccat gatgattgta ttagagcctc agctgctttc gtggtggtca tgaggtgatg
      301 ctgaaccgaa tgcttgaact agcaggagtg gctgggattg cagtggagtg gttccgttca
      361 ttccttccgg aaatggaacc tctcccttag cctgtctgaa tgccatgctt cacactaaca
      421 ctcgagtcgg ggatgggacg ttcttcaaaa tccctggaaa gtcgggcctc tatgctctca
      481 gaaaagagga gtcatcatgc ccagtggatg gaacattgga tctagtcgtt gacccagacc
      541 tggatggcgc tgagatggca gaggccagtg ccaacggaga agagaacagg gtgtgtacga
      601 agcaggtaac ggatgaagta tcttccactc gagattgcag ccttacgaac acggcagtgc
      661 aaagcaagct ggtatcttcc ttccagcagc acaccaaaaa ggccctgaag caggctttga
      721 ggcagcagca gaaaagaaga aatggagtct caatgatggt gaacaagact gtccctcgtg
      781 ttgttttgac accattaaag gtgtctgatg agcagtcgga ttcgccttca ggatccgagt
      841 ctaaaaatgg ggaagcagac agttcagata aagaaatgaa acacgggcaa aaatctccca
      901 ctggaaaaca aacaagtcag cacttaaaac gcttaaaaaa gtctggttta ggacacttga
      961 aatggaccaa agctgaggac attgacatag aaacccctgg ctctattctt gtcaacacta
     1021 acctgagggc actaatcaac aagcacacct ttgcctcctt ccctcagcat ttccagcagt
     1081 atctcctgct tctgctccca gaagtggaca ggcagatggg aagtgatgga attttacgcc
     1141 tcagtacttc agctctaaat aatgaattct ttgcatacgc agcacaaggg tggaaacagc
     1201 gactggcaga aggagagttt accccagaaa tgcaattacg aataaggcaa gaaattgaga
     1261 aggaaaagaa aacagaacct tggaaagaaa aattctttga gaggttttat ggagagagat
     1321 cgggcatgtc cagagaagaa tctattaagc ttacttctgg accaaaccat gaaggagctg
     1381 aagggagttc ctcacatggg gactctggca ttcctggtcc ttctgctcag aatgcattag
     1441 aagaacagca accaaaaatc ctgaaaagtt cagcttcctt ggagcctgac ttctgcacta
     1501 ccgtttgccc tatgttagag gtcccggtga aggatgtaat gacagaatca gaaacagaag
     1561 acatatttat cccggaggaa tctgtgattc aggaggaagt ggcagaggag gtagagacga
     1621 gtatctacga atgccaagat gaacatctta agacaattcc tgcgttttct gaggagtcgg
     1681 aaagtcctgc caccccttgt gaggaacccc aggtagcagc ccctgaagat agcttggagt
     1741 cctgtgttgt aatgaatgat attttacaca ctttacctca catcgaagtg aagatagtgg
     1801 agaaattaga atgtccacag gaagaaatgt cagttgttat tgaccaacta gaaatctgtg
     1861 actctcttct tccctgccct tcatctgtca cccatatcct ggatgtggaa cagaaggagc
     1921 aagaaaccac catagaaacc agtgccatgg ccctgagaga agggccatct tctctagaaa
     1981 gccaacttcc aaatgagggg attgctgtag atatggagct gcagagtgac cccgaagaac
     2041 agctctcaga aaacgcttgc atctctgaga cttctttctc ctctgaaagt ccagagggag
     2101 catgtgccag ccttccatcc ccaggcgggg aaacacagtc cacatctgaa gagtcatgca
     2161 ctccagcctc tctggaaaca acattctgtt ctgaggtatc cagcactgag aatacagata
     2221 agtacaacca gagaaacccc actggtgaga gccttcatgc atctctcgtg tcagaagtat
     2281 ctccactggc cacctcacct gaaatctcag aagcatctct tatgtccaac ttgcctctga
     2341 cgtctgaggc atcaccagta tccaacttac ctctaacatc tgaagcatct ccaatgtctg
     2401 atttaccacc gacatcagaa acttcctcag agtcttccat gcctctgacc tctgagacac
     2461 cttttgtatc cagtttgcca attcctgcag agacttctcc aatttctaat tcttccgtga
     2521 atgaaagaat ggtgcatcaa cagagaaagt caccttcagg atctgaagaa gctaactctc
     2581 cacagaaaga ggaaccttcc atccccacca agcccctggg agagagcctt gtctcccacc
     2641 caaagccttt gtccaccatt ccagaaccca tcaacatgag ttctgccatg gtgcctgaag
     2701 cacttccacc tgaaggattg catagtcaga ctctgagtca ggagccttgt aacgctcatg
     2761 ttgaaatgga aaagctctat gcctcttcca tcccagaact tccttcctca gagatgacaa
     2821 aagttaaaaa ccatagtgtt ctgcaaagac ctgaaaagaa agggttgtct gcaccattgg
     2881 aagtccctgt cttttctgag gaaacggaga ccaagggaat cgagcttcct ccagctaaac
     2941 tacaggacaa gcaatatgca ccatcagtag ataaggctac atttctagaa ggctcaagaa
     3001 acaaaattca taaacagagc agtacactaa atcgattgga gacctcacat acttccaaag
     3061 tatcagagcc ctccaagtcc cccgatggga taagaaatga caatagagag tcagagatat
     3121 caaaaaggaa aaccgtggaa cacagctttg gaatatgtaa agaaaaaaga gctaggatag
     3181 aagatgatca gtcagcccgc agcctagcat ccagcagtcc tcctgagaaa gagcagccac
     3241 cacgggagga gcccagggtt ccccctctaa agatacagct ttctaaaatt gggccacctt
     3301 ttatcattaa gagccagcca gtctccaaag cagagtccag ggcatccact agtacatcag
     3361 tcagcagtgg gaggaacacg ggagccagga cccttgcaga catcaaggcc cgtgctcaac
     3421 aagcccgggc ccagcgtgag gctgctgcag ctgctgcagt tgcagctgca gcgagcattg
     3481 tctcaggagc catgggaagc ccaggagaag gtgggaaggc aagaacccta gcccacatca
     3541 aggagcagac caaagctaag ctctttgcaa aacatcagtc cagagcccac ctcttccaga
     3601 cctccaagga gacccggtta ccttctgtca gcacgaagga agactctctc aatatggaag
     3661 cctctcctac ccctgagaca aaaatggaag gctctacagg agtcatcatc atcaatccaa
     3721 actgcagatc tcctagcagc aagcccacac acatccggga gatcaccact gtactacagc
     3781 agcctctgaa cccacctcag attccagaaa ctgccactga cttgtctgtg catagttctg
     3841 atgacaacat acctgtgtca catttaactg agaaaattgt ttcatctacc tcttcagaaa
     3901 atagcagtgt acccatactt cataataaaa gtcccatcaa ccccatcccg atgtctgtct
     3961 gcagcactgc tatgtcagga gcaattaaag agcatccctt tgtgagtcct gttgacaaat
     4021 cttctgtcct catgtctgtt gacagtgcaa acagtacaat ttctgcttgt aatataagca
     4081 tgttgaaatc catccaggga tctgatgctc catgcatagc ccttgtacca aaatgtatca
     4141 acaggactcc tataccagct gctccagaag gtactggaca gtcaaactcc atggatggga
     4201 aggccctgct tgtacccagc agcaaggctg ctaacgtaat atctaatcag tacacttctg
     4261 tgccagctcc caccattgca agtaatttgc caaaccatct ctgcactagc tctgtcttga
     4321 ttccccccac agggattaat aacagatttg tttctgagaa gatagccatg cctgggagtg
     4381 aagagcaggc cgccgtgtcc ataggtgcca ccatgagaac agccctcagc tgtggtgatt
     4441 cagtggctgt cactgattca ctggttccac gctcgcccat cgcaatgttt gcaggaaaca
     4501 tgctcactgc aaactcttac aactgtcctc ccaaattaag tggggagaac ttggacaaca
     4561 attcagggcc tctaaacaga acagacaatt ctgagaaacc tcagcagcca gcagggggct
     4621 ttgtcccagc aaccataaac agatcaattc cctgtaaagt catagtggac cacagcacaa
     4681 cgctgacctc caatttgtct ctgactgtct ccattgaaag tggagactca agtttggatt
     4741 cccagactag gtcggtgagg acagacgtat ccatccagcc cgtggcatgt cctcaggtgt
     4801 ctgtcatcag tagacctgag caggccacaa gtgaagggct tgaccatggt tctgttttca
     4861 ttgctgctcc tacggccaaa caggactgta agacactgca ggccacttgc accagtctcc
     4921 gagaattgcc ccttactctt ccagataaac taaatgaagt gaccgtacct actcatggct
     4981 ttgctgagca agcacgaaac tcaagtactt tcaagaaaga aacagacaca gcctgtagca
     5041 atcagtataa cccaggaaac cgcatttgct ggagtgaaga cccaatgaga aacacagcac
     5101 cgcctgtggt tagtcattca agctcaagta aacagaaaga acatccagag cagactggcc
     5161 tgaaggctgt gaagacagag catgtcagct atgcacacgt gtcagatctc caccctagga
     5221 atctcatcac gaatgtcagt cttcctgtga agcctgaacc tcatgaagta gacaagggct
     5281 ttagaatgga cactgaggac tttcctggtc ccgagcgtcc tcctccagtc acagaggtga
     5341 caagcagtgc cagtgtgcaa ccaacacaga ccatgaagcc ttccaccaca agccctgtgg
     5401 aagaggctat ttccttggct ccagacaccc tgaaaagaat tccaagtgca agcagctcaa
     5461 gctgccgcct gtcttccgtg gaagctaata acccactggt gacacagcta ctgcagggca
     5521 acctgcctct ggagaaggtg ttgccacagc caagattggg agccaaactt gaaatcaaca
     5581 gactccctct gccccttcaa actacctcag tgggtaagac agggctggaa agaaacatgg
     5641 ttgaaatgcc atccagctct cctaatccag acgggaaggg ctatttggca gggactctag
     5701 caccagtcca aatgagaaag cgagaaaacc atcccaaaaa gagagcagcc aggacagtgg
     5761 gagaccatgc tcaagttaaa tgtgaaccag ggaagatggt gatggagccc gatgtcaaag
     5821 cggtaccctg cgtcatcagt cccagcatga gtcagctagg acacaaccag ccatttaagc
     5881 aggaacggct taataagccc tccatggcca acaggatcat gcccagccct gaggtcaaac
     5941 aacaaaagcg gctgttgcct gcatgtagct tccagccgag cctgttccat gtgaacaaaa
     6001 atgaaggctt ccacgctgac actggtacct cacatagaca gcagttctac caaatgccca
     6061 tggctgccag gggacccctt cccactcctg ctctgttaca gaactctccc aagaccccag
     6121 tgggctgtaa tgcatttgcc ttcaataggc atcttgaaca aaaagcattg ggagatgtga
     6181 atcttcccac agcacctcac cagctaagac tagccaatat gttgtccccc aacatgccta
     6241 taaaagaagg cgaggatgga ggaggcacca cacacacaat gccaagcaaa gcagtggtcc
     6301 atgctccact gccacctcca ccaccccctc caccaccacc ccctccaccc ttggccttgc
     6361 ccccgccacc ccctccaccc cctccactac ctccacctct tcccactgta gaagtcccat
     6421 ccgatcaaaa gcaaccacca gttaacatgg aaaccactaa gcgacttagt tggccccagt
     6481 ccacgggcat atgtagcaat atcaaatcag aacctctttc ttttgaggaa agtttaagca
     6541 gcagctgtga actgggcatg aagcaggttc cctatgacca gaacgaagtg aaagagcagc
     6601 tgaaggcatt tgcattaaaa aatgcagatt tttcttccta cttgctctct gagccccaaa
     6661 agccttttac ccaattagct gctcaaaaac taccagtacc ccagcaacaa ccgctctgtg
     6721 gaagttaccc gacgatacac tttgggagca caaatttcaa aagggcagca tctgccattg
     6781 aaaagtccat tgggattctg ggaagtggct ccaaccccgc caccagcacg ggtctgacag
     6841 gtcaaaacac tcagatgcca gttcagaact ttgcagacaa cagcaacgca gatgagttag
     6901 agctgaaatg ttcttgccgg ctcaaagcca tgattgtgtg caaaggctgt ggggccttct
     6961 gccacgatga ctgcataggt ccatccaaac tttgtgtagc ttgcctggtt gtccgataag
     7021 agctgggtga aggattcagt gcccccaccc tgcagcccaa attttaacat gaaaaagtct
     7081 aacaaaatta gcaaggagtc aattagagca ttggcttcca tgccaacata ttttcattga
     7141 aaagtaaatc atcttgggtt tttctaggtg attattttct tacgtttctc atacaggggt
     7201 tgatgcaaag cacggggatg aatggctttt gcctgttcag tcacgattca cagcttggtg
     7261 tgtttctgtg tatacaggtc actgcctctt tttttcattt tgtcattttt tttctttcaa
     7321 ctcaggccta gatagttagc gcatcatgag ttgtctaatc aacagatata cagctgttga
     7381 aaaactatga taagcatgat gtgacctagc catgtgtcct tccatagttt tgatatcaca
     7441 gcaagcaatt ctgcagtgat ttgggggagg ggggagcctt cccttaccca ctggttcaag
     7501 tcataatagg aatgggagcc tgctttaaaa atgtgattcc ttctggtgcc tctaatcaca
     7561 gaaggtgcac gaaggatgtg tctgtggagt ctactgtcct agctctcttt cctcccttct
     7621 tactctttct cagagactgg cagaaaccct aagttggctt tggattttgc ccacaaattg
     7681 tgattgaata tatattgcat ctgaattgac aactgggctt cgtgcgatag gtagtctgac
     7741 agtagccctt ggatagtcaa taatgtaaga tcctttgact gatcgtcatg ggccaagtgt
     7801 tgtggtgttc cacatgtggg ttttcagagc aaatctgaaa atctgtgccc tacctaatat
     7861 taaaagcaaa caataaaatg ctgtgcatgc attattgtga gctgatgaga tagaatatta
     7921 gccattctac tcactctgtt ccaaatacca catagaaatt gggtacacgt ggagtggatg
     7981 tagccctcag tcatgccagg gtgccctggc ctttccagag actggccacc tcttttcaca
     8041 ggtgtcatat atgacagtga ctgcagaagg cagtatgaat ggtgaccttt ttcagaacca
     8101 tttagtctct cttgattcac aatctataca gttgtctttg actctgaaat aactcttatt
     8161 aaaaaaaaaa aaaagtgctc cctcctgcat gtgttgctgt ttcatgcctc atacctaaga
     8221 gagtgggact ggaaagggga tattgcatct ctcacagttc cctctgaagt tcatccagta
     8281 aaagctgagg atttaagctc ctcccatatg ctgactcctt gcagtccaga gacagctgtg
     8341 cttgaggaga ggcttggttc ccaagagcaa gctcaaaagc acaggctcac tggaagatga
     8401 aaggaaggag aagtgcaccc atttaactcc agtttcagag cacaaaacac agtgccatta
     8461 gcctattggt tgtgcctata gaattaaaag aattcagagt ggaagaaaat tacatgacca
     8521 gggtaagagt gaaagatatt ttcacgtggg atcacctttt caatgtaaac ttttttgaca
     8581 ttccttgaaa atgcatctta aaagttaacc agaatgagta gaaaatacat tcctgaaaga
     8641 aacaaaagtc acgtttaaaa atcataaaca actatggtgg gttttttccc ccttctaaat
     8701 ttattattgt gatgttgcca aatttcttta ggtgacaaag acattgtttt aacaaatcac
     8761 tgaacgtgaa agatccttta tcttaagaca acaaagcaaa gaaaggcctg cctacagctg
     8821 atccgggcct ctggtcctgt tgctgccttt ccatattaaa taaagctaac agaattgaca
     8881 atggagaaag ccagtggtgg gcttagccag ctacacccca ggaccacagt cttaaggccg
     8941 ggatggtgag ctgcctgcct tgccagggtg tatatgcatg ctgtgcttat cagtgatgcc
     9001 cttatggtct gcttgggtat gatatcatct taattttgaa gactgtgctc ttagcctcac
     9061 agctgggcac cccaatacac aatgacactt gcatgccaac cccttcctat ttaatcgctg
     9121 ctattccagc gtcagatact gtctacacca gcagattctg aactacaact tcagtacctg
     9181 acacctatta aagaaaccca agtctacgaa gcctttgcac tctgtatgag aggaacagtt
     9241 gaggctgaag ggatactgag ctcactgtca gttgcacctt tgttgagtac tgcctgccaa
     9301 ttgcttcctg ggaataaaga aaagtgtcct tctgtatgtt tggatttttc acatagtaag
     9361 tttggaaatt caaatgttga tagtgcatgg attctgtcac ccaggtccaa agatcataat
     9421 ttttctacag cctcctctta tctgccccaa ttcaaattct cgatgttctc ttatagctta
     9481 ttttcctgag tcattatctt tgggtgaata taataatgaa attcagaagc aaaatgtcgg
     9541 ctaggtattt tgtaggtatg catttcacct ttatatgaaa gccagcatat ctgaactaaa
     9601 cgagcagctt ctcagcttcc tcattctaca tgtttctccg tgtgtgcaac ttgacaatgt
     9661 tattgactat gcgattatgg tgatgtaatg tgcaaacttc atatgtgcag tttcttgatc
     9721 attggacatt attagtcccc tatcaggaac agaacttgca catgtaacat gtatttattt
     9781 ttaatcacaa aggatgtatt tctcaaaata gcacttttgg agcaggggag agggaaactg
     9841 ccgtgctcta ttcccctcca tgggatatgc atatgcctga ggtatataga acatttagct
     9901 agttaatggg catgttaata aaaagcattc tgatgcaaaa ttcattttca aaatgaaaat
     9961 atttatcctt ccccaaagta agattgcaaa atccagtgac tagagcacca cagttatgta
    10021 gaatatttcc atgtgaaggc ctaacaaact tgaaaaccta tgaggctgag ccaggttcct
    10081 agaaagactt catagcgatg tctctttccg aggtgagcta cagaggcata gcttacttct
    10141 ggttcctgga tattcctact cagttcaaaa taagcataca gaaatcgcct ggtacctgtg
    10201 gtgctttata atgtagtcag aaatgttgtt ttttaaagta cacaatgctg caagcctgtt
    10261 tcctttacaa acactcgcac aatttcaaaa gagggatttg ctgtggccag tctccctgct
    10321 tctccaggtg ggctgtgatg ctgaagccaa gcttagccct gtatggtcct agtctggtgt
    10381 agaagctcag cgtcctaata gctgcctggg gacacctacc ccaccgaaca cacacagctc
    10441 agactccagt ccatctgtgt tccccgagaa caatgtgaag agtcctggaa cagaactcat
    10501 caactgtcag gggcctatat agccaaaatg tcactgtaag aattgtgttg cctcctgctc
    10561 tcatgtttgt cacagttagg caagcaaacg gcatttctac tataatttaa aggagctgct
    10621 ttttttaaat agcatacagt atttagcttt gaactatatt ttatagttac aaaataatct
    10681 agactgtaga gagaatctgt tgtgtttata ctgttcacga atgttccagc aaagtgcttt
    10741 gcctggttcc tctcacttcc tggctctgct gtattccctc cttgctttgc agaaatccga
    10801 tctcatttat gttttcagta ccatttattt tttaaaacgt gttcgtgtgt attgttcctt
    10861 ctttgggtca gtattctaca tgtttacatc tgtttgacat tagccgtgta atgccttttt
    10921 tttttcaaag gcggaattta ctcctccagc atgacagcaa aatgtgaagt cgaccagagc
    10981 acaccacaca gggcacacac agactggggg ccaaggccct gattgtacac agacatttcc
    11041 tatcagcata gagaaaagtg aaaccctcct tcagtcctct accaaagaat atattattcc
    11101 cacaggaaaa actcagaaag gtgtgtaaaa ccctcaggag gaggtgcagt tgatccatga
    11161 gactgctaca acagaatagc ggtatgcttg ctttgatacc tgactaaatg tgactggctg
    11221 caacaagcat ttcaaaagaa agttttaggc agtgtttggt ttagaattca gggatcatgc
    11281 attctttaat ggtgctgttt gtttttttta tttcttcttt tctataaaga ataaaaagtg
    11341 ttgcctacaa aagtgactgc tcatgatgat gtaagtgaaa tggaacgtcc gtctctatgt
    11401 ttctatgttt ctccctttct ccaagtaaga atttggtttc agtatcaaaa tattctggag
    11461 aaaataaaga aatgaaaaca cgaaatactt gtcgttttca tttgtgaatg ttatttggga
    11521 aaacatgcat atagtgttga attatctact tattcttggt atgaggaact gtgaacatat
    11581 gattgtaacc attgttaaca ggaaaatcag caattgatgg tgtctgctga gcatacagtc
    11641 tacagcaata tttggccctt gtcacgagca tcttaatttc ttacatcaga agcattc
//
