LOCUS       NM_001039939            7002 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus ASXL transcriptional regulator 1 (Asxl1), mRNA.
ACCESSION   NM_001039939 XM_149245 XM_902501
VERSION     NM_001039939.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7002)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7002)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7002)
  AUTHORS   Shi,Z., Liu,J., Zhao,Y., Yang,L., Cai,Y., Zhang,P., Xu,Z., Qin,T.,
            Qu,S., Pan,L., Wu,J., Yan,X., Li,Z., Zhang,W., Yan,Y., Huang,H.,
            Huang,G., Li,B., Wu,X. and Xiao,Z.
  TITLE     ASXL1 mutations accelerate bone marrow fibrosis via EGR1-TNFA
            axis-mediated neoplastic fibrocyte generation in myeloproliferative
            neoplasms
  JOURNAL   Haematologica 108 (5), 1359-1373 (2023)
   PUBMED   36005555
  REMARK    GeneRIF: ASXL1 mutations accelerate bone marrow fibrosis via
            EGR1-TNFA axis-mediated neoplastic fibrocyte generation in
            myeloproliferative neoplasms.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7002)
  AUTHORS   Braun,T.P., Estabrook,J., Schonrock,Z., Curtiss,B.M., Darmusey,L.,
            Macaraeg,J., Enright,T., Coblentz,C., Callahan,R., Yashar,W.,
            Taherinasab,A., Mohammed,H., Coleman,D.J., Druker,B.J., Demir,E.,
            Lusardi,T.A. and Maxson,J.E.
  TITLE     Asxl1 deletion disrupts MYC and RNA polymerase II function in
            granulocyte progenitors
  JOURNAL   Leukemia 37 (2), 478-487 (2023)
   PUBMED   36526735
  REMARK    GeneRIF: Asxl1 deletion disrupts MYC and RNA polymerase II function
            in granulocyte progenitors.
REFERENCE   5  (bases 1 to 7002)
  AUTHORS   Medina,E.A., Delma,C.R. and Yang,F.C.
  TITLE     ASXL1/2 mutations and myeloid malignancies
  JOURNAL   J Hematol Oncol 15 (1), 127 (2022)
   PUBMED   36068610
  REMARK    GeneRIF: ASXL1/2 mutations and myeloid malignancies.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7002)
  AUTHORS   Fisher,C.L., Pineault,N., Brookes,C., Helgason,C.D., Ohta,H.,
            Bodner,C., Hess,J.L., Humphries,R.K. and Brock,H.W.
  TITLE     Loss-of-function Additional sex combs like 1 mutations disrupt
            hematopoiesis but do not cause severe myelodysplasia or leukemia
  JOURNAL   Blood 115 (1), 38-46 (2010)
   PUBMED   19861679
  REMARK    GeneRIF: Asxl1 is needed for normal hematopoiesis.
REFERENCE   7  (bases 1 to 7002)
  AUTHORS   Fisher,C.L., Lee,I., Bloyer,S., Bozza,S., Chevalier,J., Dahl,A.,
            Bodner,C., Helgason,C.D., Hess,J.L., Humphries,R.K. and Brock,H.W.
  TITLE     Additional sex combs-like 1 belongs to the enhancer of trithorax
            and polycomb group and genetically interacts with Cbx2 in mice
  JOURNAL   Dev Biol 337 (1), 9-15 (2010)
   PUBMED   19833123
  REMARK    GeneRIF: Asxl1 function is determined by its interacting partners
            or chromatin environment to bring about changes in gene regulation.
REFERENCE   8  (bases 1 to 7002)
  AUTHORS   Millien,G., Spira,A., Hinds,A., Wang,J., Williams,M.C. and
            Ramirez,M.I.
  TITLE     Alterations in gene expression in T1 alpha null lung: a model of
            deficient alveolar sac development
  JOURNAL   BMC Dev Biol 6, 35 (2006)
   PUBMED   16869965
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 7002)
  AUTHORS   Cho,Y.S., Kim,E.J., Park,U.H., Sin,H.S. and Um,S.J.
  TITLE     Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts
            as a ligand-dependent coactivator for retinoic acid receptor
  JOURNAL   J Biol Chem 281 (26), 17588-17598 (2006)
   PUBMED   16606617
  REMARK    GeneRIF: ASXL1 is a novel coactivator of RAR that cooperates with
            SRC-1
REFERENCE   10 (bases 1 to 7002)
  AUTHORS   Fisher,C.L., Randazzo,F., Humphries,R.K. and Brock,H.W.
  TITLE     Characterization of Asxl1, a murine homolog of Additional sex
            combs, and analysis of the Asx-like gene family
  JOURNAL   Gene 369, 109-118 (2006)
   PUBMED   16412590
  REMARK    GeneRIF: Asxl1and Asxl2 are expressed as multiple transcripts, at
            varying levels, in adult tissues and in embryonic stem cells
            analyzed by Northern blot, and exhibit similar expression patterns
            suggesting they may be co-regulated
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807380.6, AK122413.1, AK141208.1 and BC076565.1.
            
            On Apr 26, 2018 this sequence version replaced NM_001039939.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK005683.1, AK122413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               AL807380.6         200626-200934
            310-5075            AK122413.1         1-4766
            5076-6982           AK141208.1         1147-3053
            6983-7002           BC076565.1         428-447
FEATURES             Location/Qualifiers
     source          1..7002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..7002
                     /gene="Asxl1"
                     /note="ASXL transcriptional regulator 1"
                     /db_xref="GeneID:228790"
                     /db_xref="MGI:MGI:2684063"
     exon            1..561
                     /gene="Asxl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             505..5049
                     /gene="Asxl1"
                     /note="putative Polycomb group protein ASXL1; additional
                     sex combs-like protein 1; additional sex combs like 1"
                     /codon_start=1
                     /product="polycomb group protein ASXL1"
                     /protein_id="NP_001035028.1"
                     /db_xref="CCDS:CCDS38285.1"
                     /db_xref="GeneID:228790"
                     /db_xref="MGI:MGI:2684063"
                     /translation="MKDKQKRKKERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLK
                     EMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKKDAVQWSRNAATVDGDEP
                     EDSADVESCGSNEASTVSGENDVSLDETSSNASCSTESQSRPLSNPRDSHRASSQANK
                     QKKRTGVMLPRVVLTPLKVNGAHVEPASGFSGRHADGESGSPSSSSSGSLALGNSAIR
                     GQAEVTRDPAPLLRGFRKPATGQMKRNRGEEVDFETPGSILVNTNLRALINSRTFHAL
                     PLHFQQQLLLLLPEVDRQVGTDGLLRLSGSALNNEFFTHAAQSWRERLADGEFTHEMQ
                     VRLRQEMEKEKKVEQWKEKFFEDYYGQKLGLTKEESLQQKEVQEEAKVKSGLCVSGES
                     VRPQRGPNTRQRDGHFKKRSRPDLRTRSRRNIYKKQEPEQAGVAKDASAAPDVSLSKD
                     TKTDLAGVNSTPGPDVSSATSGQEGPKCPSEPVASQIQAERDNLACASASPDRIPTLP
                     QDTVDQETKDQKRKSFEQEASASFPEKKPRLEDRQSFRNTIESVHTEKPQPTKEEPKV
                     PPIRIQLSRIKPPWVAKGRPTYQICPRIVPITESSCRGWTGARTLADIKARALQARGA
                     RGYHCNRETATTAIGGGGGPGGGGSGAIDEGGGRDSSSGDGSEACGHPEPRGAPSTSG
                     ESASDLQRTQLLPPCPLNGEHTPAEAAMPRARREDSASLRKEESCLLKRVPGVLTSGL
                     EDASQPPIAPTGDQPCQALPPLSSQTPVAEMLTEQPKLLLDDRTECESSREDQGPTIP
                     SESSSGRFPLGDLLGGGSDQAFDNMKEPVSMTPTFISELSLANYLQDRPDDDGLGLGA
                     TGLLIRESSRQEALTEAFASGSPTSWVPILSNYEVIKTSDPESRENIPCPEPQDEKEW
                     ERAVPLIAATESVPQPESCISHWTPPPAAVGSTGSDSEQVDLERLEMNGISEAPSPHS
                     ESTDTASDSEGHLSEDSSEVDASEVTVVKGSLGGDEKQDWDPSASLSKVNNDLSVLTR
                     TGGVAASQSWVSRVCSVPHKIPDSLLLSSTECQPRSVCPLRPGSSVEVTNPLVMHLLH
                     GNLPLEKVLPPGHRSSRLESSQLPLREQSQDRGTLQGTGENNRLAARINPGSAQTLKE
                     SILAQSYGASAGLVRAMASKAPAMSQKIAKMVTSLDSQHPETELTPSSGNLEEIDSKE
                     HLSSFLCEEQKEGHSLSQGSDPGAAPGQCLGDHTTSKVPCFSSTNVSLSFGSEQTDGT
                     LSDQNNAGGHEKKLFGPGNTVTTLQCPRSEEQTPLPAEVPPVFPSRKIEPSKNSVSGG
                     VQTTRENRMPKPPPVSADSIKTEQTFLRDPIKADAENRKAAGYSSLELVGHLQGMPFV
                     VDLPFWKLPREPGKGFSQPLEPSSIPSQLNIKQALYGKLSKLQLSPTSFNYSSSSATF
                     PKGLAGGVVQLSHKASFGTGHTASLSLQMFADSSAVESISLQCACSLKAMIMCQGCGA
                     FCHDDCIGPSKLCVLCLVVR"
     exon            562..644
                     /gene="Asxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..647
                     /gene="Asxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..756
                     /gene="Asxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..877
                     /gene="Asxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..975
                     /gene="Asxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1069
                     /gene="Asxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1222
                     /gene="Asxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1386
                     /gene="Asxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1483
                     /gene="Asxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1589
                     /gene="Asxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..2214
                     /gene="Asxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..6983
                     /gene="Asxl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5048..5053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asxl1"
                     /note="hexamer: AATAAA"
     polyA_site      5076
                     /gene="Asxl1"
                     /note="major polyA site"
     regulatory      6963..6968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asxl1"
                     /note="hexamer: AATAAA"
     polyA_site      6983
                     /gene="Asxl1"
                     /note="major polyA site"
ORIGIN      
        1 actcttctct ctcacacaca cgcgggcaca cacatacaca cacataccca cggcagacac
       61 gcacgcatcc gagcgtcgaa aggaaagccg cgtctcgcca tccgggcccg cccgccacta
      121 gttcgctctt gggtttccca gcagcgcggg aacgcggagg ccggagccgt gacctctgac
      181 cccgtggtta tgcggagccg ccgcattcct tagccatcgc ggggctgccg ctgccgctgc
      241 caccgtgggc gactgacgca gcgcgggcgc gtggagccgc cgccgcccct ccccccagcg
      301 ccaccctcgc gccggggtct cgctctagcc agtcccggtg cgcccgccct ctccggccgc
      361 acccgagccc tcgcacgcgc cgccgccgcc acgcgccccc cgccgctgcc gccgcctccg
      421 ccccagcccc gcgccgccac cgccccagtc cgccccgccc gaaggacccg cgtggagccg
      481 ccaccgccgc cgcggaggag gaggatgaag gacaaacaga agaggaagaa ggagcgcacg
      541 tgggccgagg ccgcgcgcct ggtgttagaa aactactcag atgctccaat gacaccaaaa
      601 cagattctgc aggtcataga ggcagaagga ctgaaggaaa tgagaagtgg gacatcccct
      661 cttgcgtgcc tcaatgccat gctacattcc aactcaagag gaggagaagg gctgttttat
      721 aaattacctg gccgcattag tcttttcaca ctcaagaaag atgcagtgca gtggtctaga
      781 aatgcagcta cagtggatgg agacgagcca gaggactccg ctgatgtgga aagctgtggg
      841 tctaatgaag ccagcactgt gagtggtgaa aatgatgtat ctctggatga aacatcttca
      901 aatgcatcct gctctacaga gtctcagagc cgacccctct ccaatcccag ggacagccac
      961 agggcttcct cacaggcaaa caaacagaag aaaaggactg gggttatgct acctcgtgtt
     1021 gtcctgactc ctctgaaggt aaacggggcc cacgtggaac ctgcgtcagg attctcaggc
     1081 cgccacgcag atggcgagag tggcagtcca tcgagcagca gcagcggttc tctggccttg
     1141 ggcaacagtg ccattcgagg ccaggccgag gtcactcggg accctgcccc cctcttaaga
     1201 ggcttccgga agccagccac agggcaaatg aagcgcaaca gaggggaaga ggtagatttt
     1261 gagacgcctg ggtccattct tgttaacacc aacctccgtg ctctgataaa ctctcggacc
     1321 ttccatgccc tgccactaca cttccagcag caactcctcc tcctcctgcc tgaagtggac
     1381 agacaggtgg ggacagatgg cctgctgcgc ctcagcggca gtgcactcaa taatgagttt
     1441 ttcacccatg cagctcagag ctggcgagaa cgccttgctg atggtgaatt cactcatgag
     1501 atgcaagtca ggctaagaca ggaaatggaa aaggagaaga aggtggaaca atggaaggaa
     1561 aagttctttg aagattacta cggacagaaa ttgggtttga ccaaagaaga atcactgcag
     1621 cagaaagagg tccaggagga ggccaaagtc aagagtggtt tatgtgtctc tggagagtct
     1681 gtgcggccgc agcgtgggcc caacacccgt caacgggacg gacattttaa gaaacgttct
     1741 cggccagatc tccgaaccag atccagaagg aatatataca aaaaacagga gccagaacaa
     1801 gcaggggttg ctaaagatgc aagtgctgca ccagacgtct cactctctaa agatactaaa
     1861 accgacttag caggggtgaa cagtacccct gggccagatg tgtcctcagc aacatctgga
     1921 caggagggtc ccaagtgtcc cagtgaacct gtggcttccc agatccaagc agaaagggac
     1981 aacttggcat gtgcctctgc atctccagac agaatcccta ccttacctca ggacactgtg
     2041 gatcaagaga caaaggatca gaagagaaaa tcctttgagc aggaagcctc tgcatccttt
     2101 cccgaaaaga aaccccggct tgaagatcgt cagtcctttc gtaacacaat tgaaagtgtt
     2161 cacaccgaaa agccacagcc cactaaagag gagcccaaag tcccgcccat ccggattcaa
     2221 ctttcacgta tcaaaccacc ctgggtggct aaaggtcggc ccacttacca gatatgcccc
     2281 cggatcgtcc ccatcacgga gtcctcctgc cggggttgga ctggtgccag gaccctcgca
     2341 gacattaaag cccgtgcttt gcaggcccga ggggcgagag gttaccactg caatcgagag
     2401 acggccacca ctgccatcgg aggggggggt ggcccgggtg gaggtggcag tggggccatc
     2461 gatgagggag gtggcagaga cagcagcagt ggtgatggta gtgaggcctg tggccaccct
     2521 gagcccaggg gagccccaag cacctctgga gagagtgcgt cagatctaca gcgaacacaa
     2581 ctactgccgc cttgtcctct gaatggagag cacactccag ctgaagctgc catgcccaga
     2641 gccagaagag aagactcagc ttctctcaga aaggaagaga gctgcctgtt gaagagggtc
     2701 ccaggtgtgc ttacaagtgg gctggaagat gcctctcaac cccctattgc tcccactgga
     2761 gaccagccgt gtcaggcttt gccccctctg tcctcccaaa ctccagtggc cgagatgtta
     2821 acagagcagc ctaagttgct tctagatgat agaactgagt gtgaatctag tagagaagat
     2881 caaggaccca ccattccctc agagagtagt tctggacggt ttccattggg agatctatta
     2941 ggaggaggaa gtgaccaggc ctttgataat atgaaggagc ctgtaagtat gacacctact
     3001 tttatatctg aattgtcatt agctaactac ctacaggata ggcctgatga tgatggatta
     3061 gggcttggtg ccacaggcct actcataagg gaaagtagta gacaagaagc tttgactgag
     3121 gcttttgcat ctggcagtcc tacctcctgg gtacccattc tgtcaaatta tgaggtaata
     3181 aaaacatctg atccagaatc cagagaaaac ataccatgtc cggagcccca ggatgaaaaa
     3241 gagtgggaga gagctgttcc tctcattgca gcaacagaaa gtgtgcccca acctgagagc
     3301 tgcatttcac attggacacc tcctccagca gctgtgggca gcactggcag tgacagtgag
     3361 caagtggacc ttgaaagact ggaaatgaat ggcatctctg aagcaccaag tcctcacagt
     3421 gaatccacag atacagcctc tgactccgaa ggccatctct ctgaggacag cagtgaggtt
     3481 gatgcaagtg aagtcacagt ggtaaaaggg tcattaggtg gggatgaaaa gcaagactgg
     3541 gacccatctg cctcactgtc caaggtgaac aatgacctaa gtgtgcttac aaggacagga
     3601 ggggtggctg cttctcagag ctgggtgtct agagtatgtt cagtcccaca caagatccca
     3661 gactctctgt tgctgtccag tactgagtgc cagccgaggt ctgtgtgccc actgaggcct
     3721 ggctcttcag tggaggttac caacccactt gtgatgcacc tgctgcatgg taatttgccc
     3781 ttggagaagg ttcttcctcc aggtcacaga agcagccgac tagagtcatc acagctgcca
     3841 cttagagaac agagccagga tagaggcact ctacaaggta caggggaaaa caatcgccta
     3901 gctgccagaa tcaaccctgg ttctgcacaa acattgaaag agtctattct ggcccagagc
     3961 tatggagcaa gtgctggtct tgtcagggca atggcctcca aggctcctgc aatgtcccag
     4021 aagattgcga agatggttac aagtttagac tcacagcatc cagagacaga actgacacct
     4081 tcctctggca atctggaaga aatagattcc aaagagcatc tctcttcctt cctttgtgaa
     4141 gagcagaaag aaggccattc cctgtctcaa ggcagtgatc caggtgcggc cccaggccaa
     4201 tgtctaggag atcacactac ctccaaagtg ccatgtttct cctccacaaa tgtgagcctc
     4261 tcctttggat ctgagcagac agatgggacc ctgagtgatc agaacaatgc tggtggtcat
     4321 gaaaagaaac tatttggtcc cgggaataca gttaccaccc ttcagtgccc caggtctgaa
     4381 gagcagacac cactacctgc tgaggtccct ccagtgtttc ccagtaggaa gatagaacca
     4441 agcaaaaact ctgtgtctgg tggtgtgcaa actacaaggg aaaacaggat gcccaaacca
     4501 cctcctgtct ctgctgacag catcaagaca gagcagacat ttttgaggga tcctattaag
     4561 gcagatgcag agaacagaaa agctgcaggg tacagttctc tggaactagt gggtcacttg
     4621 caagggatgc cttttgttgt ggatctgcct ttctggaagt tacccagaga gccagggaaa
     4681 gggttcagtc aacccctgga gccttcttcc atcccttccc aactcaacat caagcaggcc
     4741 ttgtatggga agttgtctaa acttcagctc agtcccacca gctttaatta ctcctctagc
     4801 tctgctacct ttcccaaagg ccttgctggt ggtgtggtgc agctgagcca caaagccagc
     4861 tttggtacag gccacactgc atcactgtcc ttacaaatgt tcgctgacag cagtgcagta
     4921 gaaagcatct ctctccaatg tgcatgcagc ctgaaagcca tgatcatgtg ccaaggctgc
     4981 ggagcattct gccatgatga ctgcattgga ccttcaaagc tctgtgtatt gtgccttgtg
     5041 gtgagataat aaattatggc cattggaaac attgtacatt tagtgtgtgt attttaataa
     5101 tggttgatct taaatctgta tacaaaatat cactgatata atgaactctc tctctctaga
     5161 caagataaat tttgcctccc catgagattt atagtgctga agccctctgt cacttgacac
     5221 ccttctagcc ttgttggaag ggttttcagg gagatggggg cactatggtt gcccaagacc
     5281 ataaaccctc ttgtagtcag gcagtatagt gtagcagggc aatctgtctg acacctaaat
     5341 ggacttgaaa ttgaagcagg aaggttgggt tctccatgga tggaactcac ctgcctgaac
     5401 tgagcaggaa tgtcagtctt ccactgcccc tccctgccat cttctgctac ttagcttggg
     5461 agttgatggt tgcagaagcc acacagggtt aaagtaaatt ctgtctttgc ccaccagggg
     5521 atcaaacccc tgctgatctt gatatcatat ttctgtcatt tgccagttga tggagccaag
     5581 ttgacctttg gttctggtgc ttcacccagt ttggaacttt aatctgtaac ccatggatcc
     5641 acagattttc ttgggagctt gaatagccct tcttggacaa tggggtctgg aaatagggct
     5701 gtctgcttat ggaaatgcca tctgtagacc ttgagagtca actgtacaga tgtttgcagg
     5761 tgactcctgc ttgccaccca cccatcatat ttgattctgt gggagtgggc acccatacac
     5821 ctgtgtatgt gaaagtcatt ttacatttcc aagcagtctg tttcttattt ttatatttta
     5881 actctattct tggatgtata aagtgaactt tttcgcttct gtaagtatgc tctatgcacc
     5941 tctaacgttt tatcctgtat ttatatgttg tacacagtac tggccaattc tgtaaatgga
     6001 tgtattgtac agagaacacg aacgtctctt ccttatttta cgtcttcagc acccttgatt
     6061 aaaatggtgt cgtttactta tgtgcaccaa ttgtcaaaac cactgagtgc tgtgctgcct
     6121 atgtgagaag aaagttactg acttgtgacc tatgcttggc cctgtgccta gtcacctgtc
     6181 accagggatt ctactacagt ctgcgcgcca cagatagttg ctcacacacc attgagcaaa
     6241 cgtgtcttgt tccttgtatc tcttttcttc cagccctgag tggctgcgct gctgccatat
     6301 gtgacaagtg gtcctcacca gtgttaagtg cttctggatt catgggtgag ttccttggac
     6361 gaccccagac aggcttctgg atctggctcc agggtcatca catgtcaaag caatattggg
     6421 gattgctagg cttctttcaa cttacttttc acagtaggtt tcaggggaac aaagccatgc
     6481 ctgctgcctg cctctctcct aacatggttc catcaagtag acaccctttg tatttgacct
     6541 cttcccagtt cctgccctgt ttctgtatct ttacttgaaa gttgggagtc cttgtttaat
     6601 ttaggtctgt cttcttgtgt gactgtttct gtatgaagta taaaaatttg tgtgccttga
     6661 gcaagtctca ttttctttgt aagctgcctc ttccgccatt tcatctgagg ttgctgtctt
     6721 tttggtgggg aggggtttgg ggaacccatc aggtatgagt gaggagccgg tagtgaattc
     6781 agtattggcc aagtccatgt tgtgtgctca gaagtctctt taccaaagac caggagcagg
     6841 agccaagcat gtccagtcct cttctgagac ctctgaggtc tcagaagaga aacttgacag
     6901 tgtctggtcc atggggctgc tcagaaaagc gctgctcttg tatgtctcat tggtattgga
     6961 aaaataaacc tgtacaacct gcaaaaaaaa aaaaaaaaaa aa
//
