LOCUS       NM_207109               4831 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus astrotactin 2 (Astn2), transcript variant 2, mRNA.
ACCESSION   NM_207109
VERSION     NM_207109.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4831)
  AUTHORS   Hanzel,M., Fernando,K., Maloney,S.E., Horn,Z., Gong,S., Matlik,K.,
            Zhao,J., Pasolli,H.A., Heissel,S., Dougherty,J.D., Hull,C. and
            Hatten,M.E.
  TITLE     Mice lacking Astn2 have ASD-like behaviors and altered cerebellar
            circuit properties
  JOURNAL   Proc Natl Acad Sci U S A 121 (34), e2405901121 (2024)
   PUBMED   39150780
REFERENCE   2  (bases 1 to 4831)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4831)
  AUTHORS   Ito,T., Yoshida,M., Aida,T., Kushima,I., Hiramatsu,Y., Ono,M.,
            Yoshimi,A., Tanaka,K., Ozaki,N. and Noda,Y.
  TITLE     Astrotactin 2 (ASTN2) regulates emotional and cognitive functions
            by affecting neuronal morphogenesis and monoaminergic systems
  JOURNAL   J Neurochem 165 (2), 211-229 (2023)
   PUBMED   36807153
  REMARK    GeneRIF: Astrotactin 2 (ASTN2) regulates emotional and cognitive
            functions by affecting neuronal morphogenesis and monoaminergic
            systems.
REFERENCE   4  (bases 1 to 4831)
  AUTHORS   Govek,K.W., Chen,S., Sgourdou,P., Yao,Y., Woodhouse,S., Chen,T.,
            Fuccillo,M.V., Epstein,D.J. and Camara,P.G.
  TITLE     Developmental trajectories of thalamic progenitors revealed by
            single-cell transcriptome profiling and Shh perturbation
  JOURNAL   Cell Rep 41 (10), 111768 (2022)
   PUBMED   36476860
REFERENCE   5  (bases 1 to 4831)
  AUTHORS   Chen,S.Y., Lu,K.M., Ko,H.A., Huang,T.H., Hao,J.H., Yan,Y.T.,
            Chang,S.L., Evans,S.M. and Liu,F.C.
  TITLE     Parcellation of the striatal complex into dorsal and ventral
            districts
  JOURNAL   Proc Natl Acad Sci U S A 117 (13), 7418-7429 (2020)
   PUBMED   32170006
REFERENCE   6  (bases 1 to 4831)
  AUTHORS   Boyle,M.P., Bernard,A., Thompson,C.L., Ng,L., Boe,A., Mortrud,M.,
            Hawrylycz,M.J., Jones,A.R., Hevner,R.F. and Lein,E.S.
  TITLE     Cell-type-specific consequences of Reelin deficiency in the mouse
            neocortex, hippocampus, and amygdala
  JOURNAL   J Comp Neurol 519 (11), 2061-2089 (2011)
   PUBMED   21491433
REFERENCE   7  (bases 1 to 4831)
  AUTHORS   Wilson,P.M., Fryer,R.H., Fang,Y. and Hatten,M.E.
  TITLE     Astn2, a novel member of the astrotactin gene family, regulates the
            trafficking of ASTN1 during glial-guided neuronal migration
  JOURNAL   J Neurosci 30 (25), 8529-8540 (2010)
   PUBMED   20573900
  REMARK    GeneRIF: ASTN2 regulates the levels of ASTN1 in the plasma membrane
            and that the release of neuronal adhesions to the glial fiber
            during neuronal locomotion involves the intracellular trafficking
            of ASTN1.
REFERENCE   8  (bases 1 to 4831)
  AUTHORS   Zagoraiou,L., Akay,T., Martin,J.F., Brownstone,R.M., Jessell,T.M.
            and Miles,G.B.
  TITLE     A cluster of cholinergic premotor interneurons modulates mouse
            locomotor activity
  JOURNAL   Neuron 64 (5), 645-662 (2009)
   PUBMED   20005822
REFERENCE   9  (bases 1 to 4831)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 4831)
  AUTHORS   Qureshi,S.T., Lariviere,L., Leveque,G., Clermont,S., Moore,K.J.,
            Gros,P. and Malo,D.
  TITLE     Endotoxin-tolerant mice have mutations in Toll-like receptor 4
            (Tlr4)
  JOURNAL   J Exp Med 189 (4), 615-625 (1999)
   PUBMED   9989976
  REMARK    Erratum:[J Exp Med 1999 May 3;189(9):following 1518]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL713878.15, AL731829.10, AL691475.18, AL691438.16, AL691474.29,
            AL691456.7 and AL691454.15.
            
            On Nov 17, 2006 this sequence version replaced NM_207109.1.
            
            Transcript Variant: This variant (2) represents the longer
            transcript and it encodes the longer isoform (b). Isoform b is most
            similar to the protein encoded by transcript variant 3 of the human
            gene.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-601               AL713878.15        16011-16611         c
            602-789             AL731829.10        75773-75960         c
            790-1174            AL691475.18        167271-167655       c
            1175-1330           AL691475.18        101204-101359       c
            1331-1438           AL691475.18        41277-41384         c
            1439-1585           AL691438.16        169735-169881       c
            1586-1753           AL691438.16        127574-127741       c
            1754-1838           AL691438.16        91160-91244         c
            1839-1913           AL691438.16        90008-90082         c
            1914-2051           AL691438.16        89107-89244         c
            2052-2202           AL691474.29        148572-148722       c
            2203-2369           AL691474.29        100392-100558       c
            2370-2558           AL691474.29        83414-83602         c
            2559-2683           AL691474.29        5956-6080           c
            2684-2788           AL691474.29        2348-2452           c
            2789-2968           AL691456.7         155749-155928       c
            2969-3234           AL691456.7         92591-92856         c
            3235-3368           AL691456.7         53702-53835         c
            3369-3517           AL691456.7         51990-52138         c
            3518-3659           AL691454.15        148669-148810       c
            3660-3760           AL691454.15        110475-110575       c
            3761-3944           AL691454.15        108588-108771       c
            3945-4831           AL691454.15        94320-95206         c
FEATURES             Location/Qualifiers
     source          1..4831
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 34.31 cM"
     gene            1..4831
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /note="astrotactin 2"
                     /db_xref="GeneID:56079"
                     /db_xref="MGI:MGI:1889277"
     exon            1..601
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..4182
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; bM423P8.1 (astrotactin 2); bM468K2.1
                     (astrotactin 2); bM243L4.1 (astrotactin 2); bM264P11.1
                     (astrotactin 2); bM383P24.1 (astrotactin 2)"
                     /codon_start=1
                     /product="astrotactin-2 isoform b precursor"
                     /protein_id="NP_996992.1"
                     /db_xref="CCDS:CCDS18269.1"
                     /db_xref="GeneID:56079"
                     /db_xref="MGI:MGI:1889277"
                     /translation="MAAAGARRSPGRGLGLRGRPRLGFHPGPPPPPPPPLLLLFLLLL
                     PPPPLLAGATAAAASREPDSPCRLKTVTVSTLPALRESDIGWSGARTGAAAGAGAGTG
                     AGAGAAAAAASAASPGSAGSAGTAAESRLLLFVRNELPGRIAVQDDLDNTELPFFTLE
                     MSGTAADISLVHWRQQWLENGTLYFHVSMSSSGQLAQATAPTLQEPSEIVEEQMHILH
                     ISVMGGLIALLLLLLVFTVALYAQRRWQKRRRIPQKSASTEATHEIHYIPSVLLGPQA
                     RESFRSSRLQTHNSVIGVPIRETPILDDYDYEEEEEPPRRANHVSREDEFGSQMTHAL
                     DSLGRPGEEKVEFEKKAAAEATQETVESLMQKFKESFRANTPVEIGQLQPASRSSTSA
                     GKRKRRNKSRGGISFGRTKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTAL
                     TLIAVSSCILAMVCGNQMSCPLTVKVTLHVPEHFIADGSSFVVSEGSYLDISDWLNPA
                     KLSLYYQINATSPWVRDLCGQRTTDACEQLCDPDTGECSCHEGYAPDPVHRHLCVRSD
                     WGQSEGPWPYTTLERGYDLVTGEQAPEKILRSTFSLGQGLWLPVSKSFVVPPVELSIN
                     PLASCKTDVLVTEDPADVREEAMLSTYFETINDLLSSFGPVRDCSRNNGGCTRNFKCV
                     SDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTLPLPYDTT
                     SSTIFMFCGCVEEYKLAPDGKSCLMLSDVCEGPKCLKPDSKFNDTLFGEMLHGYNNRT
                     QHVNQGQVFQMTFRENNFIKDFPQLADGLLVIPLPVEEQCRGVLSEPLPDLQLLTGDI
                     RYDEAMGYPMVQQWRVRSNLYRVKLSTITLSAGFTNVLKILTKESSRDELLSFIQHYG
                     SHYIAEALYGSELTCIIHFPSKKVQQQLWLQYQKETTELGSKKELKSMPFITYLSGLL
                     TAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTLI
                     QDNGTKEAFKNALMSSYWCSGKGDVIDDWCRCDLSAFDASGLPNCSPLPQPVLRLSPT
                     VEPSSTVVSLEWVDVQPAIGTKVSDYILQHKKVDEYTDTDLYTGEFLSFADDLLSGLG
                     TSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVDTRGRHSELSTVTLRTACP
                     LVDDNKAEEIADKIYNLYNGYTSGKEQQTAYNTLMEVSASMLFRVQHHYNSHYEKFGD
                     FVWRSEDELGPRKAHLILRRLERVSSHCSSLLRSAYIQSRVDTIPYLFCRSEEVRPAG
                     MVWYSILKDTKITCEEKMVSMARNTYGETKGR"
     exon            602..789
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1174
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1330
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1438
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1585
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1753
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1838
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1913
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2051
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2202
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2369
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2558
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2683
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2788
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2968
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3234
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3368
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3517
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..3659
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3660..3760
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3761..3944
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3945..4831
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4806..4811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /note="hexamer: ATTAAA"
     polyA_site      4827
                     /gene="Astn2"
                     /gene_synonym="1d8; Astnl; bM452J22.1"
                     /note="major polyA site"
ORIGIN      
        1 ggctctctag gctccttagc tcgggcgtcc tggttcgctt cagtgtccgc tgtctccacc
       61 gctgcttctt cttccttctt cttcacggtc gccaccgccc gcagcaccgc agcccctcct
      121 gccatggccg ccgccggcgc ccggcgcagc ccgggccgcg gcttggggct tcgggggcgg
      181 ccgaggctcg gcttccaccc ggggccgccg ccgccaccgc cgccgccgct gctgttgctg
      241 tttctgctcc tgctgccgcc gccgccgttg ctggccggcg ccacggccgc cgccgcctcg
      301 cgggagcccg acagcccatg ccggctcaag accgtcaccg tatccacgct gcccgctctg
      361 cgggaaagcg acatcggctg gagcggtgcc cgcaccgggg ccgcggccgg ggctggggcc
      421 gggaccggag ccggggccgg agctgctgct gctgccgcct ccgccgcgtc cccgggctcc
      481 gcgggttcag ccggcacagc cgcggagtct cgtctccttc tctttgtgcg taatgagctc
      541 cccgggcgca tcgcggtaca agatgacctg gacaacactg agctgccctt cttcaccctg
      601 gagatgtctg gcacagcagc ggacatttct ttggttcact ggaggcagca gtggctggag
      661 aatggcacat tgtacttcca cgtttccatg agcagctctg ggcaactggc tcaggccact
      721 gctcccacac tccaggagcc ctcggagatc gttgaggaac agatgcatat cctccacatt
      781 tctgtgatgg gtggactcat tgcacttctc ctcctgctgt tggtgttcac agtggcactg
      841 tatgcccagc gacgctggca gaagcgccgg cgcatcccac agaagagcgc aagtacagaa
      901 gctactcatg agattcacta catcccatca gtgctgctgg gtcctcaggc cagggaaagc
      961 ttccgatcct ccagacttca gacacacaac tcagtcattg gtgtgcctat ccgggaaacc
     1021 cccatcctgg atgactatga ctatgaagag gaggaggaac cacccaggcg agccaaccac
     1081 gtctcccgtg aggatgagtt tggtagccag atgacccatg ccctggacag cttgggaagg
     1141 ccaggagaag agaaagtgga atttgagaag aaagcagcag ctgaggcgac acaggaaaca
     1201 gtggagtccc tgatgcagaa gttcaaggag agtttccgtg ctaacacacc agtggagatc
     1261 ggtcagttgc agccagcctc gcgcagcagc acctctgcag ggaagaggaa gcggaggaac
     1321 aaatctcgag ggggaatcag ctttgggaga accaagggga catcaggctc agaagcagat
     1381 gacgaaacac agctgacctt ctacacagag cagtaccgca gtcgccgccg cagcaaaggt
     1441 ttactgaaaa gccctgtgaa taagacagcc ttaacactga ttgctgtgag ctcctgcatc
     1501 ttggccatgg tgtgtggcaa ccagatgtcc tgtccactta ctgtgaaggt gactttgcat
     1561 gtgcctgaac acttcattgc agatgggagc agctttgtgg tgagtgaagg aagctacctg
     1621 gatatctccg attggctaaa ccctgccaag ctgtctctgt attaccagat caatgccacc
     1681 tcgccatggg tgagagacct ctgtggacag aggacgacag atgcctgtga acagctctgt
     1741 gacccagata ctggggagtg cagttgtcat gaaggttacg cccctgaccc agtccacaga
     1801 catctatgtg ttcgcagtga ctggggtcaa agtgaaggac cttggcctta cacaacactg
     1861 gagaggggct atgatctggt gacaggagag caagcccctg aaaagattct caggtctact
     1921 ttcagcttgg gccaaggcct ctggcttccg gtcagcaaaa gctttgtggt gccaccggtg
     1981 gagctgtcca tcaaccccct ggccagctgc aagacggatg tgctcgtcac agaagaccct
     2041 gcggatgtca gggaagaagc aatgttgtcc acgtactttg aaaccatcaa cgacctgctg
     2101 tcctcctttg gtccagtccg tgactgctca aggaacaacg ggggctgtac ccgtaacttc
     2161 aagtgtgtgt ctgaccgcca ggtggactcc tcgggatgtg tgtgtcctga ggaactgaag
     2221 cccatgaagg atggctctgg ctgctatgat cactccaagg gcatcgactg ctctgatggc
     2281 tttaatggag ggtgtgagca gctttgccta caacaaacac tgcctttgcc ctatgatacc
     2341 acctccagca ccatcttcat gttctgcggc tgtgtggaag agtacaagct ggctcctgat
     2401 gggaaatcct gtctaatgct ctcagatgtc tgtgagggcc ccaagtgcct caaacctgac
     2461 tccaaattca atgacaccct ctttggagag atgctacatg gttacaacaa ccggacacaa
     2521 catgtaaacc aaggccaagt cttccaaatg acattcaggg agaataactt catcaaggac
     2581 tttccacagc tggcagatgg gctgttggtg atcccgctgc cagtggaaga gcaatgccgg
     2641 ggggttctct ctgagcccct tccagacctt cagcttctca caggagacat caggtatgat
     2701 gaggccatgg ggtaccccat ggtgcaacag tggcgtgtcc ggagcaatct ctatcgtgtg
     2761 aagctgagta ctatcaccct ctcagcaggc ttcaccaatg tcctaaagat cctgaccaaa
     2821 gagagcagtc gggatgagct gctgtccttc atccagcact atggctccca ctacattgcc
     2881 gaggctttat acggttctga gctcacctgc atcatccatt ttcccagcaa gaaggtccag
     2941 cagcagctat ggctccaata tcagaaagag accacggagc tgggcagcaa gaaggagctc
     3001 aagtccatgc ccttcatcac ctacctctcc ggtctcctga cagcccagat gctatcagat
     3061 gaccagctca tctcaggtgt ggagattcga tgtgaggaga agggccgctg tccatctacc
     3121 tgtcaccttt gccgccggcc aggcaaagag cagctgagcc ccacaccagt gctgctggag
     3181 ataaaccgtg tggttccact ttataccctc atccaagaca atggcacaaa ggaggccttc
     3241 aagaatgcac tgatgagttc ttactggtgt tctggtaaag gagatgtgat tgatgactgg
     3301 tgcaggtgtg acctcagtgc ctttgatgcc agtgggcttc caaattgtag cccccttcca
     3361 cagccggtgt tacgactttc tccaacagtg gagccttcca gcactgtggt ttccctggag
     3421 tgggtagatg ttcagccagc cattggaacc aaagtctctg actatattct gcagcacaag
     3481 aaagtggatg aatacacaga cacggaccta tacacaggag aattcctgag ttttgccgat
     3541 gacttacttt ctggcctggg tacatcttgt gtagcagctg gtcgaagcca tggagaggtt
     3601 cctgaagtca gtatctactc ggtgatcttc aagtgcctgg agccagatgg tctttacaag
     3661 ttcactctgt atgctgtgga tactcgaggg aggcactcag agctcagcac agtgactcta
     3721 aggacagctt gtccactggt agatgacaac aaagcagaag agatagcgga caagatttac
     3781 aatctataca atggttacac aagtggcaag gagcagcaga ctgcttacaa cacactgatg
     3841 gaagtctccg cctccatgct cttccgtgtc cagcaccact acaactctca ctatgaaaag
     3901 tttggtgact tcgtctggag gagtgaggat gagctaggac caaggaaggc tcatctgatt
     3961 ctgcggcggc tggagcgggt cagcagccac tgttctagtc tcttgagaag cgcctacatc
     4021 cagagtcgtg tggacaccat accctatctc ttctgccgca gtgaggaggt ccggcctgca
     4081 ggaatggtgt ggtacagcat cctcaaagac accaaaatca catgtgagga gaagatggtg
     4141 tctatggccc gaaacacgta cggggaaacc aaaggccggt gagggagggc actaccctcc
     4201 gcgagcacag agacgctctt agggggagca cgactttcat ggatcctggg gcctgggtgg
     4261 gctgggggac agctgagggg cctggcacat gacacttgcc agcaaggcca aagcaaactg
     4321 tttctccgtg gacagacaac agagaacttt gtaaccaatg gaattattca tttttctctt
     4381 ttattttttc taagatatta tttgacccta tcaaatgtct ctccttttta aaccttttct
     4441 tatggatgga agtcaatgcg gcggcaggag ctttcgggcg gagaccaagg agccttgcat
     4501 tttcttcctc catcatgcca tggacccccc tgaaaagaga cctgtggaga gacaatttga
     4561 ctatttcagc attagcaaga atgccctaga attgttgcag caaggaagct tgggtcttta
     4621 agggtctctc tctctctctc tctctctctc tctctcgctc tctctccctc tccctctccc
     4681 tctctctctc tctccctccc tccctccctc cctccctccc tccctctttc tctttctcca
     4741 ttattgagtt tgcaggccca gtgcttcttt ctgctacctg tgggtctcta caggactttc
     4801 tgtgcattaa aattcctatt gtctctcttt t
//
