LOCUS       NM_001205204            7176 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus astrotactin 1 (Astn1), transcript variant 1, mRNA.
ACCESSION   NM_001205204
VERSION     NM_001205204.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7176)
  AUTHORS   Lara,P., Tellgren-Roth,A., Behesti,H., Horn,Z., Schiller,N.,
            Enquist,K., Cammenberg,M., Liljenstrom,A., Hatten,M.E., von
            Heijne,G. and Nilsson,I.
  TITLE     Murine astrotactins 1 and 2 have a similar membrane topology and
            mature via endoproteolytic cleavage catalyzed by a signal peptidase
  JOURNAL   J Biol Chem 294 (12), 4538-4545 (2019)
   PUBMED   30696770
  REMARK    GeneRIF: Differences in the degree of Astn1 and Astn2 maturation
            possibly contribute to the higher levels of the C-terminal domain
            of Astn1 detected on neuronal membranes of the central nervous
            system
REFERENCE   2  (bases 1 to 7176)
  AUTHORS   Liu,W., Han,F., Qu,S., Yao,Y., Zhao,J., Akhtar,M.L., Ci,Y.,
            Zhang,H., Li,H., Zhao,Y., Yue,L., Zhang,Y., Wang,C. and Li,Y.
  TITLE     MARVELD1 depletion leads to dysfunction of motor and cognition via
            regulating glia-dependent neuronal migration during brain
            development
  JOURNAL   Cell Death Dis 9 (10), 999 (2018)
   PUBMED   30250269
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7176)
  AUTHORS   Divya,T.S., Lalitha,S., Parvathy,S., Subashini,C., Sanalkumar,R.,
            Dhanesh,S.B., Rasheed,V.A., Divya,M.S., Tole,S. and James,J.
  TITLE     Regulation of Tlx3 by Pax6 is required for the restricted
            expression of Chrnalpha3 in Cerebellar Granule Neuron progenitors
            during development
  JOURNAL   Sci Rep 6, 30337 (2016)
   PUBMED   27452274
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7176)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 7176)
  AUTHORS   Piper,M., Harris,L., Barry,G., Heng,Y.H., Plachez,C.,
            Gronostajski,R.M. and Richards,L.J.
  TITLE     Nuclear factor one X regulates the development of multiple cellular
            populations in the postnatal cerebellum
  JOURNAL   J Comp Neurol 519 (17), 3532-3548 (2011)
   PUBMED   21800304
REFERENCE   6  (bases 1 to 7176)
  AUTHORS   Adams,N.C., Tomoda,T., Cooper,M., Dietz,G. and Hatten,M.E.
  TITLE     Mice that lack astrotactin have slowed neuronal migration
  JOURNAL   Development 129 (4), 965-972 (2002)
   PUBMED   11861479
  REMARK    GeneRIF: astrotactin is required for appropriate and timely
            migration of cerebellar granule cells.
REFERENCE   7  (bases 1 to 7176)
  AUTHORS   Bergstrom,D.E., Gagnon,L.H. and Eicher,E.M.
  TITLE     Genetic and physical mapping of the dreher locus on mouse
            chromosome 1
  JOURNAL   Genomics 59 (3), 291-299 (1999)
   PUBMED   10444330
REFERENCE   8  (bases 1 to 7176)
  AUTHORS   Fink,J.M., Hirsch,B.A., Zheng,C., Dietz,G., Hatten,M.E. and
            Ross,M.E.
  TITLE     Astrotactin (ASTN), a gene for glial-guided neuronal migration,
            maps to human chromosome 1q25.2
  JOURNAL   Genomics 40 (1), 202-205 (1997)
   PUBMED   9070947
REFERENCE   9  (bases 1 to 7176)
  AUTHORS   Zheng,C., Heintz,N. and Hatten,M.E.
  TITLE     CNS gene encoding astrotactin, which supports neuronal migration
            along glial fibers
  JOURNAL   Science 272 (5260), 417-419 (1996)
   PUBMED   8602532
REFERENCE   10 (bases 1 to 7176)
  AUTHORS   Fishell,G. and Hatten,M.E.
  TITLE     Astrotactin provides a receptor system for CNS neuronal migration
  JOURNAL   Development 113 (3), 755-765 (1991)
   PUBMED   1821847
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118728.12, AC091266.8, AC119867.11 and AC158910.3.
            
            On Jan 14, 2022 this sequence version replaced NM_001205204.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-519               AC118728.12        137896-138414
            520-707             AC091266.8         159299-159486
            708-1101            AC119867.11        58075-58468
            1102-1248           AC119867.11        60230-60376
            1249-1356           AC119867.11        61389-61496
            1357-1506           AC119867.11        65873-66022
            1507-1698           AC119867.11        66982-67173
            1699-1783           AC119867.11        76471-76555
            1784-1858           AC119867.11        128979-129053
            1859-1996           AC119867.11        135608-135745
            1997-2147           AC119867.11        136238-136388
            2148-2314           AC119867.11        153184-153350
            2315-2509           AC119867.11        156342-156536
            2510-2637           AC119867.11        157964-158091
            2638-2742           AC119867.11        165278-165382
            2743-2931           AC119867.11        168373-168561
            2932-3200           AC119867.11        213067-213335
            3201-3334           AC158910.3         110144-110277
            3335-3486           AC158910.3         113631-113782
            3487-3622           AC158910.3         114777-114912
            3623-3723           AC158910.3         120729-120829
            3724-3907           AC158910.3         130226-130409
            3908-7176           AC158910.3         134662-137930
FEATURES             Location/Qualifiers
     source          1..7176
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 68.35 cM"
     gene            1..7176
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /note="astrotactin 1"
                     /db_xref="GeneID:11899"
                     /db_xref="MGI:MGI:1098567"
     exon            1..519
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..4145
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; neuronal migration protein GC14"
                     /codon_start=1
                     /product="astrotactin-1 isoform 1 precursor"
                     /protein_id="NP_001192133.1"
                     /db_xref="CCDS:CCDS56648.1"
                     /db_xref="GeneID:11899"
                     /db_xref="MGI:MGI:1098567"
                     /translation="MALAGLCALFACCWGPAAVLATAAGDVDPSKELECKLKSITVSA
                     LPFLRENDLSIMHSPSASEPKLLFSVRNDFPGEMVVVDDLENTELPYFVLEISGNTED
                     IPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGM
                     IALLLSILCLVMILYTRRRWCKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLR
                     NARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQRECMNGGEDFASQVTRTLDSLQ
                     GCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINN
                     KARAGSAFLNPEGDSSTEAENDPQLTFYTDPSRSRRRSRVGSPRSPVNKTTLTLISVT
                     SCVIGLVCSSHVSCPLVVKITLHVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFS
                     QQNSSGPWAMDLCARRLLDPCEHQCDPETGRREHRAAGECLCYEGYMKDPVHKHLCIR
                     NEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGEGMWLPLSKSFVIPPAELA
                     INPSAKCKTDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFR
                     CISDRKLDSTGCVCPSGLSPMKDSSGCYDRHIGVDCSDGFNGGCEQLCLQQMAPFPED
                     PTLYNILMFCGCIEDYKLGVDGRSCQLVTETCPEGGDCGESREVPMNQTLFGEMFFGY
                     NNQSKEVATGQVLKGTFRQNNFARGLDQQLPDGLVVASVPLENQCLEEISEPTPDPDF
                     LTGMVNFSEVSGYPVLQHWKVRSVMYHIKLNQAAISQAFSNALHSLDGATSRADFVAL
                     LDQFGNHYIQEAVYGFEESCSIWYPNKQVQRRLWLEYEDISKGNSPSDESEERERDPK
                     VLTFPEYIASLSDSGTKRMAAGVRMECQSKGRCPSSCPLCHVTSSPETPAEPVLLEVT
                     RASPIYELVTNNQTQRLLQEATMSSLWCSGTGDVIEDWCRCDSTAFGADGLPTCAPLP
                     QPVLRLSTVHEPSSNLVVLEWEHSEPPIGVQIVDYLIRQEKVTDRMDHSKVETETVLS
                     FVDDIISGAKAPCAMPSQVPDKQLTTISLIIRCLEPDTIYMFTLWGVDNTGRRSRPSD
                     VIVKTPCPVVDDVKAQEIADKIYNLFNGYTSGKEQQTAYNTLLDLGSPTLHRVLYHYN
                     QHYESFGEFTWRCEDELGPRKAGLILSQLGDLSSWCNGLLQEPKISLRRGSLKYLGCR
                     YSEIKPYGLDWSELSRDLRKTCEEQTLSVPYNDYGDSKDI"
     exon            520..707
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            708..1101
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1248
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1356
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1506
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1698
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1783
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1858
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1996
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2147
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2314
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2509
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2637
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2742
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2931
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3200
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3334
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..3486
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3622
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            3623..3723
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            3724..3907
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     exon            3908..7176
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7160..7165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /note="hexamer: AACAAA"
     polyA_site      7176
                     /gene="Astn1"
                     /gene_synonym="Astn; GC14; mKIAA0289"
                     /note="major polyA site"
ORIGIN      
        1 cctttcccca gataagcagc tccgggaaac aaagagctgg gctctccaga cctcagcgct
       61 ggaacctaag gctctctgag tagcatctca tttcggggac cagggctctc gagctccgtg
      121 tcccctcccc aactcccccc cccccccccc gcctcccttg cttgctcgct gctccctccc
      181 tgctggctgc ctcccccacc atcgcagcgc tgggaggaag gcggccaggg ctcaagatgg
      241 ctttagccgg gctctgcgcc ctgttcgcct gctgctgggg gccggctgcg gtgctggcca
      301 cagctgccgg cgacgtggat ccatccaagg agctggagtg caagctcaag agcatcactg
      361 tgtcggcact gcccttcctg cgcgagaacg acctgagcat catgcacagt ccctcggcct
      421 ccgaacccaa gcttctcttc tccgtgcgca atgacttccc gggagaaatg gtcgtggtgg
      481 acgacctaga gaacacggag ctaccctatt tcgtgctgga gatctcaggg aatacagaag
      541 acatccccct ggtgcgctgg aggcagcaat ggctggagaa tggcacttta ctctttcata
      601 ttcaccacca agatggtgct ccaagtctcc ctggacaaga cccaactgaa gaaccccaac
      661 atgaatcagc agaggaagag ctgaggatcc tgcacatctc agtcatgggt ggcatgatcg
      721 ctctgttgct atccatcttg tgcctggtga tgatcctgta cactcgcagg cgctggtgca
      781 aacgtcgccg ggttccccag ccccagaaga gtgccagtgc agaggcagca aatgagattc
      841 actacatccc atctgtgctg attggaggcc atgggcggga aagcttgcgc aatgcccgtg
      901 tgcagggcca caactccagt ggcactctga gcattcggga gacacccatc ctggatggct
      961 atgagtatga catcacagac ctgcgtcacc acctgcaaag ggagtgtatg aatggagggg
     1021 aggactttgc cagtcaggtc acacgcactt tggactccct acagggatgc aatgagaagt
     1081 ctgggatgga tctaacacca gggagtgaca atgccaagct ttccctgatg aacaagtata
     1141 aagacaatat catagccaca agccccgtgg attctaacca ccagcaagcc actctgctct
     1201 cccacacctc cagcagccag agaaagagga tcaacaataa agccagagct ggttctgcct
     1261 tcttgaaccc tgaaggggac tccagcacag aggccgaaaa tgacccacag ctgaccttct
     1321 acacagaccc ctctcggagc cggaggcgca gtcgagtggg ctctccccga agtcctgtga
     1381 ataagaccac cttgaccctg atcagtgtca ccagctgcgt gattggcctc gtgtgctctt
     1441 ctcatgtcag ctgccctctt gttgtcaaga tcaccctaca cgtccctgag cacttgatcg
     1501 ctgatgggag ccgcttcatc ctgctggagg ggagccagct ggatgccagt gactggctga
     1561 accctgccca agtggttctc ttctctcagc agaactccag cgggccctgg gccatggacc
     1621 tctgtgcccg gcggctcctg gacccttgtg aacaccaatg tgaccccgaa actggtaggc
     1681 gggagcaccg ggcagcgggg gaatgcctgt gctatgaagg ctacatgaag gatcctgtcc
     1741 acaagcacct ttgcattcgg aatgaatggg ggaccaacca ggggccttgg ccttacacga
     1801 tatttcagcg aggctttgac ctggttttgg gagagcaacc ctctgataag atattcagat
     1861 tcacctatac cctcggggaa ggcatgtggt tacccctcag taagagcttt gtgattccac
     1921 cagccgaact agccatcaat ccatcagcaa agtgtaagac ggatatgact gtgatggaag
     1981 atgctgtaga ggtcagagag gagctgatga catcatcatc ctttgacagc ctggaggtcc
     2041 tattagactc ctttgggcca gtgcgtgatt gcagcaaaga taacggaggc tgcagtaaga
     2101 attttcgctg catttcagat cgcaagttgg actctactgg ttgtgtgtgt ccttcaggac
     2161 tcagccctat gaaggacagc tcaggctgct atgatcgcca tatcggagtg gactgctcag
     2221 atggtttcaa cggcggctgc gaacagctgt gtctccagca gatggcgccg ttcccagagg
     2281 accccacctt gtacaacatc cttatgttct gcgggtgtat cgaagactac aagcttggtg
     2341 tggatggacg ctcttgccaa cttgtcactg agacctgccc agagggaggt gactgtgggg
     2401 aaagcagaga ggttcccatg aaccagactc tctttggaga aatgttcttt ggctacaaca
     2461 accagtccaa ggaagtagcc actggacagg tgctaaaagg aacattcaga cagaacaact
     2521 ttgctcgtgg tttagaccag caactgccgg atggtcttgt ggttgcctct gtcccactgg
     2581 agaatcagtg cctagaggaa atctcagagc ccaccccaga ccctgacttc ttgactggga
     2641 tggtgaactt cagtgaagtg tctggatacc cggtgctgca gcactggaag gttcggtctg
     2701 tgatgtacca catcaaactc aaccaagcag ccatctcgca ggccttcagc aatgctcttc
     2761 actccttgga tggggctaca tctcgtgcag attttgtggc tttgttggat cagtttggaa
     2821 accattacat ccaggaagct gtctacggct ttgaggaatc ctgttctata tggtacccaa
     2881 acaagcaagt ccagcggaga ctctggctgg aatatgaaga catcagtaaa ggcaactctc
     2941 catctgatga gtcggaggag cgggaaaggg atcccaaggt gctgacattc ccagaataca
     3001 tcgctagcct gtcagactct ggcaccaagc gaatggcagc tggagtccgg atggagtgcc
     3061 agagcaaggg acggtgtccc tcatcctgtc ctttatgtca tgtgacatcc agccctgaaa
     3121 cccctgctga gccagttcta ctggaagtga ccagagcatc ccccatctat gaactggtga
     3181 ccaataacca gacccagagg ctcttacagg aagccaccat gagctctctc tggtgttcag
     3241 ggaccggaga tgtcattgag gactggtgcc gatgcgactc gactgctttt ggagcagatg
     3301 gacttcctac ctgtgcaccc ctcccacagc ctgtgctgag actttccaca gtacacgagc
     3361 ccagcagtaa cctcgtggtc ctggagtggg aacattcaga gccgccaatt ggggtgcaga
     3421 ttgtagacta cctgatccgg caagagaaag tcactgaccg gatggaccac tccaaagtag
     3481 agacggaaac agtgctgagc tttgtagacg acatcatctc tggagcaaag gctccatgtg
     3541 ccatgccgtc tcaggtgcca gacaaacagc tcaccacgat ttctctcatc atccgatgcc
     3601 tggaacctga caccatttac atgttcaccc tctggggagt agataacaca gggcgacgtt
     3661 ccaggccaag tgatgtgatt gtgaagaccc catgtcctgt ggtggatgat gtcaaagccc
     3721 aagaaatagc agacaagatc tacaatctct tcaatggcta caccagtgga aaggagcaac
     3781 agactgccta caacaccctt ctggatctgg gttctcccac tttgcaccga gtcctctacc
     3841 actataacca gcactatgag agttttgggg aattcacctg gcggtgtgaa gatgagttag
     3901 gacccaggaa agcaggcctc atcctttccc agcttggaga tctgagcagc tggtgcaatg
     3961 gactccttca ggagcccaag ataagcttga ggcgtggttc actcaagtac ctgggctgcc
     4021 gctacagtga gatcaaaccc tatggactgg actggtcaga gctcagtcgg gacctcagga
     4081 agacatgtga agaacagacc ctgagtgtcc cctacaatga ctacggggac agcaaagaca
     4141 tctagcatca tgggaccagg aaataactgc agaaataaag caggggagaa gagggcaaca
     4201 tctgggttgg tttgtggatt cttagacatt ttttaatgga acacccaaag ctctacaagt
     4261 cccttctaaa ccaggaagag ggtagacctt tgctccctgc aagatttgtc cagtgtgata
     4321 ttctccacct gcatgaccag tcaacccgcc agccagtagc ttcatgcagc actgttcgtt
     4381 tttgtttttg tttttgtttt tgtttttgtt tttttcttag aagattacct tgaaactcac
     4441 tttggtatcc attggttttg ttcacttttt cgccttcagt caacccatca ggattctcaa
     4501 gagcactatc ctgcatccta cagcaggtct aatgtggagg ctcttctgcc taatgggttc
     4561 ccaagtctat gacacctggg gacagaagtg agggcataaa gcttctgctg cctcatgccc
     4621 ttgctcaggc atttcttagg aagcatcaga atgttgggag ccaaggcatg tactgaagaa
     4681 gataataaat gacccatgcc cttttctcat gggttttccc ccagactctc tcctgttact
     4741 gtttccacac ctcagaggta aacctaagct ctgttacagg actgttggac ataacagaga
     4801 tttaggtctc tcttccccca ttttaaacca ggactccaag ttctcgttga tttctgtcct
     4861 ttcttctaaa caacctgatc tttgagaggc agtgagataa tacctgttaa atatggctcc
     4921 agagagggct acctgcaaga ttatttagta gccttcactg taggaaataa gtggagttta
     4981 tttaaaaaaa aaaacagttg tacatgtcta gagtatcatc agagtcctaa gagccttgat
     5041 tctgcttggt cccaggcctt tttccctgga cagaaaggac ttggctgttg tttgctttag
     5101 tccaggaatg agattatttc ttgtcagtgt tttagtgaac taaagctctt atcaatctga
     5161 aaagtacttc tgtccgcact gccctcacta aattttctta attatattgt aaattttgac
     5221 agcctattct ctgatgaaaa tcatcagtac tctgtcattg tcactgcctg cccacccaac
     5281 tctgccagtt actgaagagc aacagagcct ctggagagac ctgaacatct gatgattgca
     5341 cataaggact gaggctccat ttgcacacac tgcccaagga tgatgatacg gtgaactagc
     5401 tactaggaag cctagcctgt tagaaacaac ctcatgggac cagaatgact aacaatgacc
     5461 caatgtacat tcagccagct tgccttgact ggaattcttc atgtggaaac acagccttca
     5521 tgtggaaggc tctataattc agccactgag ccttattcat actttccaat taggaataat
     5581 gacagatgac atctgaggtg tgatgtgtgc tactataaat aacaggaatc tcacagaacc
     5641 cctaaagaaa gttctattcc tattcactat tcttttagta atgaggaaaa caaggaagtg
     5701 aggtgacttg ccattcccca ggtccctcat acactatata ccctgagctg cagtgcctct
     5761 agaacacagg agtttaacta ctctgtgttg cctaaagcat atgactgttg aagctctaag
     5821 ctctactggg aacatgccca gagaacttca ccttcctaag ggaccgtgta caaatataca
     5881 atgagtcaaa gtacacccat agcctttgga gtcagggcac ctttggtatg ctcaacactg
     5941 tggcacacta gcttccccac tgatgaatag gaaggaaatt cagttgcagg ctggtcttat
     6001 ttctctcttt gcttctttgc agagaaatat tggaaaactt gccttgtact ttttggcctc
     6061 agagatacca tcacttttag aacaaaacac agcagaaaac ttagctggct ttcctctggc
     6121 cagcataggg atttcagtaa aagtgcatcc gaaggaagct tgttcactat tgccagagaa
     6181 gaggatgcta tgggacagtg tggcagtgtg gacagcatcc ctttactgcc gttctttttc
     6241 cactcttctg ttcaatccta tgaagaaaag agtgtcttct tttgaacaga atgatagtga
     6301 gactgtggat gccttccagc cctgttggag ataggaactt atgggctcag gagggaggac
     6361 aggagtgata taatgatcac tactgttacc caccccatct tttattccag acatactctc
     6421 ctcctctctt ttacctttat gccccatttt ccaaagattt ttcacctctc acacacatat
     6481 ctcctttatc ctccatcttt cccccctctt cccatcgact gccttattct ttcagtgtgc
     6541 tcttgtgttt tctcttcaga tgtgtgtgtg tctatacaca cactcactcc caagcaccac
     6601 gtacatagct cctattattg gagcaatgta cttttgagtt aaaaactcca acatgaatgg
     6661 attgggggtc gtctggagat ggttctacat gttgctggag gacttttacc ctcagagaga
     6721 tcatatcaca ccctgccaat gattctcagt ttttgcctgg aggaactgtc tagaaaggct
     6781 aatgtaatga agccagtatt aaacctcatt tctaagctgc caaacaggtc ttaagggagc
     6841 cacttctgtc cacctaacca cctccagctc tgtgtccagc tgagatctct attgtttcct
     6901 cttgaatgtc cacgaaccac tgtatagcat cagaccctta aatgagtgtg caattgtttc
     6961 tcttgaagtt tggtccattc gttattttta attaactgca cttcttgata ttcaaatgtt
     7021 ctattaaaaa taattgtgaa aaacactcca ctactgtaga agaaagaggt ggtacaatgt
     7081 gaccaacttc aactacaaca gtgttgttta agagatttat tgtacgatta tgaaaaatga
     7141 agtaatcgac taaataataa acaaagctgt cagtaa
//
