LOCUS       NM_025651               2785 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Mus musculus asteroid homolog 1 (Aste1), transcript variant 1,
            mRNA.
ACCESSION   NM_025651
VERSION     NM_025651.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2785)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2785)
  AUTHORS   Zhao,F., Kim,W., Gao,H., Liu,C., Zhang,Y., Chen,Y., Deng,M.,
            Zhou,Q., Huang,J., Hu,Q., Chen,S.H., Nowsheen,S., Kloeber,J.A.,
            Qin,B., Yin,P., Tu,X., Guo,G., Qin,S., Zhang,C., Gao,M., Luo,K.,
            Liu,Y., Lou,Z. and Yuan,J.
  TITLE     ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating
            end resection
  JOURNAL   Nat Cell Biol 23 (8), 894-904 (2021)
   PUBMED   34354233
REFERENCE   3  (bases 1 to 2785)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2785)
  AUTHORS   van der Zwaag,B., Burbach,J.P., Scharfe,C., Oefner,P.J.,
            Brunner,H.G., Padberg,G.W. and van Bokhoven,H.
  TITLE     Identifying new candidate genes for hereditary facial paresis on
            chromosome 3q21-q22 by RNA in situ hybridization in mouse
  JOURNAL   Genomics 86 (1), 55-67 (2005)
   PUBMED   15953540
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113016.7 and AK030661.1.
            
            On Nov 10, 2017 this sequence version replaced NM_025651.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058377.1, AK030661.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC113016.7         41661-41820         c
            161-2422            AK030661.1         2-2263
            2423-2785           AC113016.7         31424-31786         c
FEATURES             Location/Qualifiers
     source          1..2785
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 56.61 cM"
     gene            1..2785
                     /gene="Aste1"
                     /gene_synonym="1100001A21Rik"
                     /note="asteroid homolog 1"
                     /db_xref="GeneID:66595"
                     /db_xref="MGI:MGI:1913845"
     exon            1..304
                     /gene="Aste1"
                     /gene_synonym="1100001A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            305..1618
                     /gene="Aste1"
                     /gene_synonym="1100001A21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..2341
                     /gene="Aste1"
                     /gene_synonym="1100001A21Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein asteroid homolog 1; single-strand DNA endonuclease
                     ASTE1"
                     /codon_start=1
                     /product="single-strand DNA endonuclease ASTE1 isoform 1"
                     /protein_id="NP_079927.2"
                     /db_xref="CCDS:CCDS23465.1"
                     /db_xref="GeneID:66595"
                     /db_xref="MGI:MGI:1913845"
                     /translation="MGIRGLMSFVEDYSNEFFVDLKLRNTKLIIDGYSLFHRLCFNSD
                     LELRYGGDYDLFADVVQKFFESLFVCHICPYVVLDGGCDISDKKLTTLKDRAKEKIQA
                     ARSLSLGGGGNVCPLLIREVFIQVLIRLEVCFVQSFSEADRDIMTLANHWNCPVLSSD
                     SDFCIFDLRSGFCSLNSFQWRNLNTIKDTQDYYIPARSFSLNAFCHYFNNMNKALLPL
                     FAVLCGNDHVNLPIMDTFISKVRLPLSSKGRRYHRVLGLLNWLSHFDDPTEALDNVLK
                     SLPKKSRENVKELLCCSMEEYQQSPVKLQDFFQYGSYVCTDASDLGLPEWVLGALAKG
                     QLPPFISDALVLRRTFLHTQVENMQRPNAHRISQPIRQIIYGLLLNGPSHAEDIAQNT
                     LPSQLLAFNEVERIDTNIKTSTVYAKQLLKDQCDLSKLAELPLARRQMLLLEALKVKQ
                     VVLESIPTFLKLPIAVTCYWLQSTEAKAKLHHLQALLLGMLREPLHAIVNSPGTEDPQ
                     RGGAKMLYEELCQVKAPMRPGPRVDLDTAHVFCQWQSCLQMGLYLNQLLSTPLPEPNL
                     TWLYNGSLVHRLCQQLPASSSVESLLSLCPEAKQLYEHLFNATKSYAPAELFLPKTKS
                     KSKKKRQKKKVASLGTTADAKHWYDRSNRFGPLMPESLEEHVENSELE"
     exon            1619..1829
                     /gene="Aste1"
                     /gene_synonym="1100001A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2025
                     /gene="Aste1"
                     /gene_synonym="1100001A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2785
                     /gene="Aste1"
                     /gene_synonym="1100001A21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2337..2342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aste1"
                     /gene_synonym="1100001A21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2361
                     /gene="Aste1"
                     /gene_synonym="1100001A21Rik"
                     /note="major polyA site"
     regulatory      2474..2479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aste1"
                     /gene_synonym="1100001A21Rik"
                     /note="hexamer: AATACA"
     polyA_site      2494
                     /gene="Aste1"
                     /gene_synonym="1100001A21Rik"
                     /note="major polyA site"
     regulatory      2752..2757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aste1"
                     /gene_synonym="1100001A21Rik"
                     /note="hexamer: CATAAA"
     polyA_site      2785
                     /gene="Aste1"
                     /gene_synonym="1100001A21Rik"
ORIGIN      
        1 gaggcgtggc gaagcgagca gggtgaggag gcggccgcaa gtgtgagagg aatggctcaa
       61 cctctcacac caagttccca ccacccggcc cgaaagcatt ttctcctcca gggagagccc
      121 tcagcttctc ggagccaggc ttcccagtga cgtcgttcgc agcacttcct gtttccgctc
      181 gcggtcttcc acgcacccgc gggtctgccg tttctccccg ggatcctacc tgctgctgct
      241 ggtgaagtga gccggcggtc gggcggaagc agccggcgga tccggagggc aggagcaggt
      301 tgagggattt ctgtcgatca tcatgggtat tcggggacta atgagctttg tggaagatta
      361 tagtaatgaa ttcttcgttg atttgaaatt gcggaacaca aaacttatca ttgatggcta
      421 ttctctcttc caccgacttt gcttcaattc tgacttggag ctcaggtatg gaggagacta
      481 tgatttattc gcagatgttg tacagaaatt ctttgaatca ctgtttgtgt gtcatatttg
      541 tccgtatgtt gtattagatg gaggatgtga catttcagat aaaaagctga caactttgaa
      601 ggatcgagca aaagagaaga tccaagcagc ccgttccctt tctcttggtg ggggtgggaa
      661 tgtgtgcccc ttactcatcc gagaagtgtt catacaggtt ttgatcaggc ttgaggtatg
      721 tttcgtacag agcttttcag aagcagatcg ggacattatg acacttgcca atcactggaa
      781 ttgtcctgtg ctatcatcgg atagtgactt ttgcattttt gacttgagaa gtgggttttg
      841 ctcactgaat agcttccagt ggagaaatct gaacactatt aaagatacac aagattacta
      901 cattcccgcc agaagctttt ccctcaatgc attctgccat tacttcaaca acatgaacaa
      961 agctctacta cctctctttg cggtgctgtg tggaaatgac catgttaacc tgcccatcat
     1021 ggacacattc ataagtaaag tacgtctacc ccttagttct aaggggagga gatatcaccg
     1081 agtcctggga cttctgaact ggttgtctca tttcgatgac cccactgaag cactagataa
     1141 cgttctgaag tctctcccca agaagagtcg agaaaatgtt aaggaacttc tctgctgctc
     1201 catggaggag taccagcagt ccccggtgaa gctgcaggac ttcttccagt atggtagtta
     1261 tgtctgtacg gacgcttcgg atctgggtct accagagtgg gtgctaggag ctctggccaa
     1321 aggccagcta ccacctttca tcagtgatgc tttggtgctc cgaaggacct ttcttcacac
     1381 acaggtagaa aacatgcagc ggccaaatgc tcacagaata tctcagccca tccgccaaat
     1441 catctatgga ctccttttga atggcccatc acacgcagaa gatatagccc agaatacatt
     1501 gccttcccag cttctggctt tcaatgaagt ggaaagaatt gatacaaata tcaaaacatc
     1561 aactgtttat gcaaagcaac tgctcaagga tcaatgtgac ttgagcaaat tggctgagct
     1621 ccccttggct aggcggcaga tgcttctctt agaagccctg aaggtcaaac aggttgtcct
     1681 ggagtccatc cctacttttc tgaagttgcc cattgctgtg acttgttact ggttgcagtc
     1741 cacagaagcc aaggcaaagc tccatcatct gcaggcccta ctgctgggga tgctgaggga
     1801 acccttgcat gccatcgtca acagccctgg cactgaagat ccacagagag gtggtgccaa
     1861 gatgttgtat gaagaattat gccaggtgaa ggcacccatg cggccgggtc caagagtgga
     1921 tttagacaca gcgcacgtct tctgtcagtg gcagtcctgt ctccagatgg ggttatatct
     1981 caaccagctg ctgtccactc ctctgccaga gccaaaccta acttggttgt acaacggaag
     2041 cctggtccac agactctgcc agcaactgcc agcatctagt tctgtagaaa gcctcctgag
     2101 tctatgtcct gaggcaaagc aactttatga acatctgttc aatgccacaa aatcatatgc
     2161 cccagctgaa ttgttcttac caaaaactaa atcaaaatcc aaaaaaaaga ggcagaagaa
     2221 aaaggttgcc agcctgggaa ccactgcaga tgccaagcac tggtatgaca gaagcaaccg
     2281 gtttggaccg ttaatgcctg aaagcttgga ggagcatgta gagaactcag agcttgaata
     2341 aacagtctgt agtacacaag atttacagtt ctagcttgta aaatgtctct tacctcactt
     2401 gaagctaatt tttctttagg actaaagttt ataagagatc atcttaatac taagatattt
     2461 gtactatact tttaatacag cctaatttaa gaaatgtctg tatttattta tatgtgtgtt
     2521 ggggatggag aaccattgta cttgtgtgga agtcagagag caccttgtga gagttggttc
     2581 tgattccatc atgtgagctc cagggatcac cctcaggttg tcaggcttag aagcgtctca
     2641 caggctctga gtcatctgta gttcttcagt gtgctttctt tcactcctca tggtcctttt
     2701 cagcaaatag taatacctta taatcttaat gctgcatata ctcataattt tcataaaatc
     2761 cagtagtaat cattttattt taaaa
//
