LOCUS       NM_007494               1631 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus argininosuccinate synthetase 1 (Ass1), mRNA.
ACCESSION   NM_007494
VERSION     NM_007494.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1631)
  AUTHORS   Mao,Y., Shi,D., Li,G. and Jiang,P.
  TITLE     Citrulline depletion by ASS1 is required for proinflammatory
            macrophage activation and immune responses
  JOURNAL   Mol Cell 82 (3), 527-541 (2022)
   PUBMED   35016033
  REMARK    GeneRIF: Citrulline depletion by ASS1 is required for
            proinflammatory macrophage activation and immune responses.
REFERENCE   2  (bases 1 to 1631)
  AUTHORS   van der Meer,J.H.M., de Boer,R.J., Meijer,B.J., Smit,W.L.,
            Vermeulen,J.L.M., Meisner,S., van Roest,M., Koelink,P.J.,
            Dekker,E., Hakvoort,T.B.M., Koster,J., Hawinkels,L.J.A.C.,
            Heijmans,J., Struijs,E.A., Boermeester,M.A., van den Brink,G.R. and
            Muncan,V.
  TITLE     Epithelial argininosuccinate synthetase is dispensable for
            intestinal regeneration and tumorigenesis
  JOURNAL   Cell Death Dis 12 (10), 897 (2021)
   PUBMED   34599156
  REMARK    GeneRIF: Epithelial argininosuccinate synthetase is dispensable for
            intestinal regeneration and tumorigenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1631)
  AUTHORS   McKell,M.C., Crowther,R.R., Schmidt,S.M., Robillard,M.C.,
            Cantrell,R., Lehn,M.A., Janssen,E.M. and Qualls,J.E.
  TITLE     Promotion of Anti-Tuberculosis Macrophage Activity by L-Arginine in
            the Absence of Nitric Oxide
  JOURNAL   Front Immunol 12, 653571 (2021)
   PUBMED   34054815
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1631)
  AUTHORS   Rogers,L.C., Zhou,J., Baker,A., Schutt,C.R., Panda,P.K. and Van
            Tine,B.A.
  TITLE     Intracellular arginine-dependent translation sensor reveals the
            dynamics of arginine starvation response and resistance in
            ASS1-negative cells
  JOURNAL   Cancer Metab 9 (1), 4 (2021)
   PUBMED   33478587
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1631)
  AUTHORS   Lange,S.M., McKell,M.C., Schmidt,S.M., Zhao,J., Crowther,R.R.,
            Green,L.C., Bricker,R.L., Arnett,E., Kohler,S.E., Schlesinger,L.S.,
            Setchell,K.D.R. and Qualls,J.E.
  TITLE     l-Arginine Synthesis from l-Citrulline in Myeloid Cells Drives Host
            Defense against Mycobacteria In Vivo
  JOURNAL   J Immunol 202 (6), 1747-1754 (2019)
   PUBMED   30710047
REFERENCE   6  (bases 1 to 1631)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   7  (bases 1 to 1631)
  AUTHORS   Reaume,A.G., Conlon,R.A., Zirngibl,R., Yamaguchi,T.P. and
            Rossant,J.
  TITLE     Expression analysis of a Notch homologue in the mouse embryo
  JOURNAL   Dev Biol 154 (2), 377-387 (1992)
   PUBMED   1426644
REFERENCE   8  (bases 1 to 1631)
  AUTHORS   Surh,L.C., Beaudet,A.L. and O'Brien,W.E.
  TITLE     Molecular characterization of the murine argininosuccinate
            synthetase locus
  JOURNAL   Gene 99 (2), 181-189 (1991)
   PUBMED   1708740
REFERENCE   9  (bases 1 to 1631)
  AUTHORS   Jackson,M.J., Surh,L.C., O'Brien,W.E. and Beaudet,A.L.
  TITLE     Assignment of the structural gene for argininosuccinate synthetase
            to proximal mouse chromosome 2
  JOURNAL   Genomics 6 (3), 545-547 (1990)
   PUBMED   1970331
REFERENCE   10 (bases 1 to 1631)
  AUTHORS   Siracusa,L.D., Silan,C.M., Justice,M.J., Mercer,J.A., Bauskin,A.R.,
            Ben-Neriah,Y., Duboule,D., Hastie,N.D., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     A molecular genetic linkage map of mouse chromosome 2
  JOURNAL   Genomics 6 (3), 491-504 (1990)
   PUBMED   1970329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732564.12.
            
            On Mar 21, 2007 this sequence version replaced NM_007494.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002074.1, AK146635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AL732564.12        18854-18923
            71-134              AL732564.12        23291-23354
            135-244             AL732564.12        25470-25579
            245-313             AL732564.12        27519-27587
            314-502             AL732564.12        29559-29747
            503-559             AL732564.12        35073-35129
            560-634             AL732564.12        37162-37236
            635-705             AL732564.12        40898-40968
            706-736             AL732564.12        41729-41759
            737-827             AL732564.12        46731-46821
            828-912             AL732564.12        49417-49501
            913-977             AL732564.12        50072-50136
            978-1109            AL732564.12        58694-58825
            1110-1266           AL732564.12        63263-63419
            1267-1332           AL732564.12        67310-67375
            1333-1631           AL732564.12        68956-69254
FEATURES             Location/Qualifiers
     source          1..1631
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.81 cM"
     gene            1..1631
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /note="argininosuccinate synthetase 1"
                     /db_xref="GeneID:11898"
                     /db_xref="MGI:MGI:88090"
     exon            1..70
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     exon            71..134
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     exon            135..244
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1378
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /EC_number="6.3.4.5"
                     /note="citrulline--aspartate ligase; arginosuccinate
                     synthetase 1"
                     /codon_start=1
                     /product="argininosuccinate synthase"
                     /protein_id="NP_031520.1"
                     /db_xref="CCDS:CCDS15898.1"
                     /db_xref="GeneID:11898"
                     /db_xref="MGI:MGI:88090"
                     /translation="MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDF
                     EEARKKALKLGAKKVFIEDVSKEFVEEFIWPAVQSSALYEDRYLLGTSLARPCIARRQ
                     VEIAQREGAKYVSHGATGKGNDQVRFELTCYSLAPQIKVIAPWRMPEFYNRFKGRNDL
                     MEYAKQHGIPIPVTPKSPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPN
                     SPDVLEIEFKKGVPVKVTNIKDGTTRTTSLELFMYLNEVAGKHGVGRIDIVENRFIGM
                     KSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFV
                     RHCIQKSQERVEGKVQVSVFKGQVYILGRESPLSLYNEELVSMNVQGDYEPIDATGFI
                     NINSLRLKEYHRLQSKVTAK"
     exon            245..313
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     exon            314..502
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     exon            503..559
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     exon            560..634
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     exon            635..705
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     exon            706..736
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     exon            737..827
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     exon            828..912
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     exon            913..977
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1109
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1266
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1332
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1631
                     /gene="Ass1"
                     /gene_synonym="ASS; Ass-1; fold"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttataacc ctggatgcgc gcctctctca gccctgctcc gccgtctgcc actgccgcct
       61 gggctcactg agtggttcat ctggccagga aagcagacta cacggactcc agggacctgt
      121 acctataatc caagacaaga tgtccagcaa gggctctgtg gttctggcct acagtggtgg
      181 cctggacacc tcctgcatcc tcgtgtggct gaaggaacaa ggctatgatg tcatcgccta
      241 cctggccaac attggccaga aggaagactt tgaggaagcc aggaagaagg cgctgaagct
      301 tggggccaaa aaggtgttca ttgaggatgt gagcaaggaa tttgtggaag agttcatctg
      361 gcctgctgtc cagtccagtg cactctacga ggaccgctat ctcctgggca cctctctcgc
      421 caggccttgc atagctcgca gacaggtgga gattgcccag cgtgaagggg ccaagtatgt
      481 gtctcacggc gccacgggaa aggggaatga ccaggtccgc tttgagctca cctgctattc
      541 actggcaccc cagattaagg tcatcgctcc ctggaggatg cctgagtttt acaaccggtt
      601 caagggccga aatgatctga tggagtatgc aaagcaacac ggaatcccca tccctgtcac
      661 ccccaagagc ccctggagta tggatgaaaa cctcatgcac atcagctatg aggctgggat
      721 cctggaaaac cccaagaatc aagcacctcc gggtctctac acaaaaactc aggaccctgc
      781 caaagcaccc aacagcccag atgtccttga gatagaattc aaaaaagggg tccctgtgaa
      841 ggtgaccaac atcaaagatg gcacaacccg caccacatcc ctggaactct tcatgtacct
      901 gaacgaagtt gcgggcaagc acggagtggg tcgcattgac atcgtggaga accgcttcat
      961 tggaatgaag tcccgaggta tctacgagac cccagcaggg accatccttt accacgctca
     1021 tttagacata gaggccttca cgatggatcg ggaagtacgc aaaatcaagc agggcctggg
     1081 cctcaaattc gcagagctcg tatacacagg tttctggcac agccctgaat gtgaatttgt
     1141 tcgccactgt atccagaagt cccaggagcg ggtagaaggg aaggtgcagg tgtctgtctt
     1201 caagggccaa gtgtacatcc tcggtcggga gtctccactt tcactctaca atgaagagct
     1261 ggtgagcatg aacgtgcagg gcgactatga gcccatcgac gccactggct tcatcaatat
     1321 caactcgctc aggctgaagg agtaccatcg ccttcagagc aaggtcactg ccaaatagac
     1381 cctgacaaag aggagcgggc ctccccactc tgcagctctc ccaggcttca gcattaattg
     1441 ttgtgataaa tttgtaattg tagcttgttc tccaccacct gactggggct gctgtgtccc
     1501 cccccgcccc cccacagcct ttgttccctg gtcccctata gcctacaaaa gtggtcatcc
     1561 aagggaaggg agggtggcgg gcagctgcag aaagcataaa atgacaatta aaagaagtta
     1621 cattagtctt t
//
