LOCUS       NM_025610               2274 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus asparaginase like 1 (Asrgl1), mRNA.
ACCESSION   NM_025610
VERSION     NM_025610.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2274)
  AUTHORS   Biswas,P., Berry,A.M., Zawaydeh,Q., Bartsch,D.G., Raghavendra,P.B.,
            Hejtmancik,J.F., Khan,N.W., Riazuddin,S.A. and Ayyagari,R.
  TITLE     A Mouse Model with Ablated Asparaginase and Isoaspartyl Peptidase 1
            (Asrgl1) Develops Early Onset Retinal Degeneration (RD)
            Recapitulating the Human Phenotype
  JOURNAL   Genes (Basel) 13 (8), 1461 (2022)
   PUBMED   36011372
  REMARK    GeneRIF: A Mouse Model with Ablated Asparaginase and Isoaspartyl
            Peptidase 1 (Asrgl1) Develops Early Onset Retinal Degeneration (RD)
            Recapitulating the Human Phenotype.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2274)
  AUTHORS   Zhou,Y., Tian,W., Jiang,X., Yang,H., Jiang,Z., Li,X., Jiang,D.,
            Sun,K., Yang,Y., Liu,W. and Zhu,X.
  TITLE     Deletion of Asrgl1 Leads to Photoreceptor Degeneration in Mice
  JOURNAL   Front Cell Dev Biol 9, 783547 (2022)
   PUBMED   35118070
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2274)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2274)
  AUTHORS   Biswas,P., Chavali,V.R., Agnello,G., Stone,E., Chakarova,C.,
            Duncan,J.L., Kannabiran,C., Homsher,M., Bhattacharya,S.S.,
            Naeem,M.A., Kimchi,A., Sharon,D., Iwata,T., Riazuddin,S.,
            Reddy,G.B., Hejtmancik,J.F., Georgiou,G., Riazuddin,S.A. and
            Ayyagari,R.
  TITLE     A missense mutation in ASRGL1 is involved in causing autosomal
            recessive retinal degeneration
  JOURNAL   Hum Mol Genet 25 (12), 2483-2497 (2016)
   PUBMED   27106100
REFERENCE   5  (bases 1 to 2274)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   6  (bases 1 to 2274)
  AUTHORS   Kadlec,L. and Pendergast,A.M.
  TITLE     The amphiphysin-like protein 1 (ALP1) interacts functionally with
            the cABL tyrosine kinase and may play a role in cytoskeletal
            regulation
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12390-12395 (1997)
   PUBMED   9356459
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK030209.1.
            
            On Apr 5, 2007 this sequence version replaced NM_025610.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030209.1, SRR1660815.55890.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2274              AK030209.1         2-2275
FEATURES             Location/Qualifiers
     source          1..2274
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 6.06 cM"
     gene            1..2274
                     /gene="Asrgl1"
                     /gene_synonym="2410004D18Rik; ALP; ALP1"
                     /note="asparaginase like 1"
                     /db_xref="GeneID:66514"
                     /db_xref="MGI:MGI:1913764"
     exon            1..52
                     /gene="Asrgl1"
                     /gene_synonym="2410004D18Rik; ALP; ALP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..993
                     /gene="Asrgl1"
                     /gene_synonym="2410004D18Rik; ALP; ALP1"
                     /EC_number="3.5.1.1"
                     /EC_number="3.4.19.5"
                     /note="L-asparaginase; L-asparagine amidohydrolase;
                     asparaginase-like protein 1; beta-aspartyl-peptidase;
                     isoaspartyl dipeptidase"
                     /codon_start=1
                     /product="isoaspartyl peptidase/L-asparaginase"
                     /protein_id="NP_079886.2"
                     /db_xref="CCDS:CCDS29566.1"
                     /db_xref="GeneID:66514"
                     /db_xref="MGI:MGI:1913764"
                     /translation="MACARGTVAPPVRASIDVSLVVVVHGGGASNISANRKELVREGI
                     ARAATEGYKILKAGGSAVDAVEGAVTVLENDPEFNAGYGSVLNVNGDIEMDASIMDGK
                     DLSAGAVSAVRCIANPVKLARLVMEKTPHCFLTGHGAEKFAEDMGIPQVPVEKLITER
                     TKKHLEKEKLEKGAQNADCPKNSGTVGAVALDCRGNLAYATSTGGIVNKMVGRVGDSP
                     CIGAGGYADNNLGAVSTTGHGESILKVNLARLALFHVEQGKTVEEAAQLALDYMKSKL
                     KGLGGLILVNKTGDWVAKWTSASMPWAAVKNGKLQAGIDLCETRTRDLPC"
     exon            53..253
                     /gene="Asrgl1"
                     /gene_synonym="2410004D18Rik; ALP; ALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            254..396
                     /gene="Asrgl1"
                     /gene_synonym="2410004D18Rik; ALP; ALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            397..554
                     /gene="Asrgl1"
                     /gene_synonym="2410004D18Rik; ALP; ALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..673
                     /gene="Asrgl1"
                     /gene_synonym="2410004D18Rik; ALP; ALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..784
                     /gene="Asrgl1"
                     /gene_synonym="2410004D18Rik; ALP; ALP1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..2274
                     /gene="Asrgl1"
                     /gene_synonym="2410004D18Rik; ALP; ALP1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1065
                     /gene="Asrgl1"
                     /gene_synonym="2410004D18Rik; ALP; ALP1"
                     /note="major polyA site"
     regulatory      1931..1936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asrgl1"
                     /gene_synonym="2410004D18Rik; ALP; ALP1"
                     /note="hexamer: AATAAA"
     polyA_site      1956
                     /gene="Asrgl1"
                     /gene_synonym="2410004D18Rik; ALP; ALP1"
ORIGIN      
        1 cagtttgaca tcatggcgtg cgcccgcggc accgtggcgc cgccagtccg agcctccatc
       61 gatgtgagtc tcgtggtggt agtccatggt ggcggagcaa gcaacatctc agccaaccgg
      121 aaagagctgg tgcgcgaggg catcgccaga gcggcaaccg agggctacaa aatcctcaag
      181 gcgggaggga gcgcggtaga tgctgtggaa ggagccgtga ctgtcctgga aaacgaccca
      241 gagttcaacg caggttatgg gtctgtcctg aatgtaaacg gtgatattga gatggatgct
      301 agtatcatgg atgggaagga cctgtctgca ggtgcagtgt ctgccgtgcg ctgtatcgca
      361 aatcccgtta aacttgcacg gcttgttatg gaaaagacac ctcattgctt tctgactggc
      421 catggtgcag agaaatttgc agaagacatg gggattccac aggtccctgt agaaaaactg
      481 ataactgaga gaaccaagaa gcacctggag aaagagaagc ttgagaaggg agcacagaat
      541 gctgactgcc ctaaaaactc aggaactgtg ggtgctgttg ccttggactg cagaggaaac
      601 ttggcttacg caacctctac tggggggatt gtcaataaaa tggttggccg agttggagac
      661 tcgccttgca taggagctgg aggttacgca gataataacc ttggagccgt ttcaaccaca
      721 ggacatgggg aaagtatcct gaaggtgaat ctggccagac ttgccctctt ccatgtagag
      781 caaggaaaga ccgtagagga ggctgctcag ttggcattgg attacatgaa gtcaaaactc
      841 aaaggtctag gtggcctcat cttggtcaac aaaacaggag actgggtggc aaagtggacc
      901 tctgcctcca tgccctgggc agcggtgaag aatggcaagc tgcaggccgg cattgacctc
      961 tgtgagacca ggacaaggga cctaccttgc tagcctggac gtgaagctga gctacctggt
     1021 gtgaagacct aacttaatca attagatgta gacatggaaa acttacgcag tctgtccctc
     1081 cttttgttgc cttgatcagt aaatcaatga atgcttggtt gagggtcggg ttctgaagcg
     1141 atgagagatg cctgcctgta ttaagaccag ggaaaatgga agccttgagg agcctacatc
     1201 tccatcatgt aaggctagaa aggaggtgtt agattttgac ccacggaact gcctctgagc
     1261 tatagaagtg ccatttggat tgggagaatg gcactttgca gaggctaggc taggggagtg
     1321 tgggaagaag gactgaaaaa aaaaagtgta agaaagaccc aggtccaggt gaagctcaaa
     1381 atgttacaga gttcattctt agtcacagga acactggaca agatgttcaa gaaggttctc
     1441 tttgtctgtg aggggggagt ggatctttat ccaaaaagct caaacttctc caacacatat
     1501 ctgggcactt gaagagtctc ccttgctgcc cgagctgtag actattggag tttcttaatg
     1561 tctgggattt ttcttggctc ccaaaagcca gccccacctg aaccagcccc agttgtcctc
     1621 attggggctt gatagggcac atgacatttc cagcctctcc aacagcgggg gtggcagatg
     1681 gctggagaga tgacaccgtg agtcactaag gagtagctgc cagcgcttta ggacagtccc
     1741 aagcgcagtg aatcaaatgt tcagggtggt gagcatgacg cagaaagcag tctcctcggt
     1801 ggagagcact ctgtgcacct gtcagcactc aggaaatggc atgtctgccg tgatgtgtct
     1861 gctcagcttc ttagtctagc agggatcccc ttctctctgg gaagaaactg attaccttta
     1921 acgtgccact aataaaattt attttttgaa agaaaagagt gtggttaggt gtcactttga
     1981 ccaagaccag aacagataca agctcccttc ttggtccttt agcgcaggca gatataatag
     2041 ttgagaggac cttttgcaga aatgtaagtg tggcagtata tcctgcctcg tggagtttag
     2101 tagggagtgt tttagagcat tgaactttct ctgagtgtgt taaggcattt ccaagtctca
     2161 gccagactca tggctgtctc ccaacacgtt gctcaagttc atagtgtgtc ctgaccccag
     2221 accctcttgt gagcctgtat ctgccctgca ttaaagagag tgctgaggag tctg
//
