LOCUS       NM_026414               1477 bp    mRNA    linear   ROD 10-JUN-2024
DEFINITION  Mus musculus aspartic peptidase, retroviral-like 1 (Asprv1), mRNA.
ACCESSION   NM_026414 XM_888129 XM_915089 XM_980566
VERSION     NM_026414.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1477)
  AUTHORS   Matsui,T., Kadono-Maekubo,N., Suzuki,Y., Furuichi,Y., Shiraga,K.,
            Sasaki,H., Ishida,A., Takahashi,S., Okada,T., Toyooka,K.,
            Sharif,J., Abe,T., Kiyonari,H., Tominaga,M., Miyawaki,A. and
            Amagai,M.
  TITLE     A unique mode of keratinocyte death requires intracellular
            acidification
  JOURNAL   Proc Natl Acad Sci U S A 118 (17) (2021)
   PUBMED   33893234
REFERENCE   2  (bases 1 to 1477)
  AUTHORS   Thyssen,J.P., Jakasa,I., Riethmuller,C., Schon,M.P., Braun,A.,
            Haftek,M., Fallon,P.G., Wroblewski,J., Jakubowski,H., Eckhart,L.,
            Declercq,W., Koppes,S., Engebretsen,K.A., Bonefeld,C., Irvine,A.D.,
            Keita-Alassane,S., Simon,M., Kawasaki,H., Kubo,A., Amagai,M.,
            Matsui,T. and Kezic,S.
  TITLE     Filaggrin Expression and Processing Deficiencies Impair Corneocyte
            Surface Texture and Stiffness in Mice
  JOURNAL   J Invest Dermatol 140 (3), 615-623 (2020)
   PUBMED   31479664
REFERENCE   3  (bases 1 to 1477)
  AUTHORS   Wang,J., Sekai,M., Matsui,T., Fujii,Y., Matsumoto,M., Takeuchi,O.,
            Minato,N. and Hamazaki,Y.
  TITLE     Hassall's corpuscles with cellular-senescence features maintain
            IFNalpha production through neutrophils and pDC activation in the
            thymus
  JOURNAL   Int Immunol 31 (3), 127-139 (2019)
   PUBMED   30534943
REFERENCE   4  (bases 1 to 1477)
  AUTHORS   Whittaker Hawkins,R.F., Patenaude,A., Dumas,A., Jain,R.,
            Tesfagiorgis,Y., Kerfoot,S., Matsui,T., Gunzer,M., Poubelle,P.E.,
            Larochelle,C., Pelletier,M. and Vallieres,L.
  TITLE     ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B
            cell-dependent autoimmune encephalomyelitis
  JOURNAL   JCI Insight 2 (23), 96882 (2017)
   PUBMED   29212956
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1477)
  AUTHORS   Hildenbrand,M., Rhiemeier,V., Hartenstein,B., Lahrmann,B.,
            Grabe,N., Angel,P. and Hess,J.
  TITLE     Impaired skin regeneration and remodeling after cutaneous injury
            and chemically induced hyperplasia in taps-transgenic mice
  JOURNAL   J Invest Dermatol 130 (7), 1922-1930 (2010)
   PUBMED   20237492
  REMARK    GeneRIF: aberrant Taps expression causes impaired skin regeneration
            and skin remodeling after cutaneous injury and chemically induced
            hyperplasia
REFERENCE   6  (bases 1 to 1477)
  AUTHORS   Matsui,T., Kinoshita-Ida,Y., Hayashi-Kisumi,F., Hata,M.,
            Matsubara,K., Chiba,M., Katahira-Tayama,S., Morita,K., Miyachi,Y.
            and Tsukita,S.
  TITLE     Mouse homologue of skin-specific retroviral-like aspartic protease
            involved in wrinkle formation
  JOURNAL   J Biol Chem 281 (37), 27512-27525 (2006)
   PUBMED   16837463
  REMARK    GeneRIF: the retroviral-like aspartic protease, SASPase, is
            involved in prevention of fine wrinkle formation via activation in
            a weakly acidic stratum corneum environment
REFERENCE   7  (bases 1 to 1477)
  AUTHORS   Rhiemeier,V., Breitenbach,U., Richter,K.H., Gebhardt,C., Vogt,I.,
            Hartenstein,B., Furstenberger,G., Mauch,C., Hess,J. and Angel,P.
  TITLE     A novel aspartic proteinase-like gene expressed in stratified
            epithelia and squamous cell carcinoma of the skin
  JOURNAL   Am J Pathol 168 (4), 1354-1364 (2006)
   PUBMED   16565508
  REMARK    GeneRIF: Detection of Taps levels represents a novel strategy to
            discriminate the progression state of squamous skin cancers.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ841260.1.
            
            On Sep 30, 2020 this sequence version replaced NM_026414.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DQ841260.1, BC057938.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1477              DQ841260.1         61-1537
FEATURES             Location/Qualifiers
     source          1..1477
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.75 cM"
     gene            1..1477
                     /gene="Asprv1"
                     /gene_synonym="2300003P22Rik; SASP; SASPase; Taps"
                     /note="aspartic peptidase, retroviral-like 1"
                     /db_xref="GeneID:67855"
                     /db_xref="MGI:MGI:1915105"
     exon            1..1477
                     /gene="Asprv1"
                     /gene_synonym="2300003P22Rik; SASP; SASPase; Taps"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..960
                     /gene="Asprv1"
                     /gene_synonym="2300003P22Rik; SASP; SASPase; Taps"
                     /note="skin-specific retroviral-like aspartic protease;
                     skin aspartic protease; TPA-inducible aspartic
                     proteinase-like protein"
                     /codon_start=1
                     /product="retroviral-like aspartic protease 1"
                     /protein_id="NP_080690.3"
                     /db_xref="CCDS:CCDS39542.1"
                     /db_xref="GeneID:67855"
                     /db_xref="MGI:MGI:1915105"
                     /translation="MATSGVRSKEGRREHAFVPEPFTGTNLAPSLWLHRFEVIDDLNH
                     WDHATKLRFLKESLKGDALDVYNGLSSQAQGDFSFVKQALLRAFGAPGEAFSEPEEIL
                     FANSMGKGYYLKGKVGHVPVRFLVDSGAQVSVVHPALWEEVTDGDLDTLRPFNNVVKV
                     ANGAEMKILGVWDTEISLGKTKLKAEFLVANASAEEAIIGTDVLQDHNAVLDFEHRTC
                     TLKGKKFRLLPVGSSLEDEFDLELIEEEEGSSAPEGSH"
ORIGIN      
        1 acagcctgcc tctgtgccca gcagccagcc agacactttg taccggctcc cttcaactcg
       61 tccaggcagg gcaagaacac ggcccagccg acagagccct cgctctccag cgtgattgcg
      121 cccacactct tctgtgcgtt tctttacttg gcttgtgtta ctgctgaact tccagaggtg
      181 agcagaagga tggccaccag cggagtcaga agcaaggaag gacgccggga gcatgccttc
      241 gtcccagaac ctttcactgg tactaactta gctcccagcc tttggctgca ccgctttgaa
      301 gtcattgatg acctcaacca ttgggatcat gccaccaaac tgaggttcct gaaagagtcg
      361 ctcaagggag atgccctgga tgtctacaat ggactcagtt cccaggccca gggcgatttc
      421 agttttgtga agcaagccct cctgagggcc tttggggccc ctggggaggc cttcagtgag
      481 cccgaagaga ttttgtttgc caacagcatg ggtaagggct actaccttaa agggaaggtt
      541 ggccatgtgc ctgtgagatt cctggtggac tctggggctc aggtgtctgt ggttcacccc
      601 gccttatggg aggaggtcac tgatggtgac ctggatactc ttcgtccttt taacaatgtg
      661 gtcaaagtgg ccaatggggc agagatgaag atcttgggtg tgtgggacac agaaattagc
      721 ctgggcaaga caaagctgaa ggccgagttt ctggtggcca acgccagcgc agaagaggct
      781 attattggca cagacgtctt gcaggaccac aatgccgtgc tggacttcga acaccgcacc
      841 tgcaccctga aggggaagaa gttccgcctg ctccctgtcg ggagctcctt ggaggatgag
      901 tttgacctgg agcttattga ggaagaggag gggtcttctg caccggaggg ctcccactaa
      961 gaaaccccat ttcttgttcc cagcattggt agggggactt tgtgttgggg ggagcagatg
     1021 tcctgggggg tatcatccgg cctagccagt ctttacaccg gttctcagtt tccctccttc
     1081 tacaggggcc ttgctttgcc tttgtttggg gagggaggcc agcttggtgg cctaaagcag
     1141 tgtccccaag gtctgcaaag acttccaagg ctggcaggag cttctgagga agccaggaat
     1201 gtcaatcttg agagaggacc cttttagatc ccctgaagta tggctcagtc actttcacgt
     1261 ccccaagcct gctgagctga gcctggtctt ggctaagacc ctcacaatcc agatgcttgg
     1321 aggagactgg cagctgctct gggagtcctc cctgagtcct cccacctgca caaggatgct
     1381 ccctcctgtc ctgtcacttg ccttgaatct catggagcct gtatcaataa ttcaattatt
     1441 tcaaaacacc aataaagatc tgttcatgga aaaaaaa
//
