LOCUS       NM_023066               6688 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus aspartate-beta-hydroxylase (Asph), transcript variant
            1, mRNA.
ACCESSION   NM_023066
VERSION     NM_023066.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6688)
  AUTHORS   Zhou,Q., Lin,J., Yan,Y., Meng,S., Liao,H., Chen,R., He,G., Zhu,Y.,
            He,C., Mao,K., Wang,J., Zhang,J., Zhou,Z. and Xiao,Z.
  TITLE     INPP5F translocates into cytoplasm and interacts with ASPH to
            promote tumor growth in hepatocellular carcinoma
  JOURNAL   J Exp Clin Cancer Res 41 (1), 13 (2022)
   PUBMED   34996491
  REMARK    GeneRIF: INPP5F translocates into cytoplasm and interacts with ASPH
            to promote tumor growth in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6688)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   3  (bases 1 to 6688)
  AUTHORS   Choo,H.J., Cutler,A., Rother,F., Bader,M. and Pavlath,G.K.
  TITLE     Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and
            Survival by Modulating Nuclear Import
  JOURNAL   Stem Cells 34 (11), 2784-2797 (2016)
   PUBMED   27434733
REFERENCE   4  (bases 1 to 6688)
  AUTHORS   Ye,J., Beetz,N., O'Keeffe,S., Tapia,J.C., Macpherson,L., Chen,W.V.,
            Bassel-Duby,R., Olson,E.N. and Maniatis,T.
  TITLE     hnRNP U protein is required for normal pre-mRNA splicing and
            postnatal heart development and function
  JOURNAL   Proc Natl Acad Sci U S A 112 (23), E3020-E3029 (2015)
   PUBMED   26039991
REFERENCE   5  (bases 1 to 6688)
  AUTHORS   Patel,N., Khan,A.O., Mansour,A., Mohamed,J.Y., Al-Assiri,A.,
            Haddad,R., Jia,X., Xiong,Y., Megarbane,A., Traboulsi,E.I. and
            Alkuraya,F.S.
  TITLE     Mutations in ASPH cause facial dysmorphism, lens dislocation,
            anterior-segment abnormalities, and spontaneous filtering blebs, or
            Traboulsi syndrome
  JOURNAL   Am J Hum Genet 94 (5), 755-759 (2014)
   PUBMED   24768550
REFERENCE   6  (bases 1 to 6688)
  AUTHORS   Hong,C.S., Kwak,Y.G., Ji,J.H., Chae,S.W. and Kim,D.H.
  TITLE     Molecular cloning and characterization of mouse cardiac junctate
            isoforms
  JOURNAL   Biochem Biophys Res Commun 289 (4), 882-887 (2001)
   PUBMED   11735129
REFERENCE   7  (bases 1 to 6688)
  AUTHORS   Alavizadeh,A., Kiernan,A.E., Nolan,P., Lo,C., Steel,K.P. and
            Bucan,M.
  TITLE     The Wheels mutation in the mouse causes vascular, hindbrain, and
            inner ear defects
  JOURNAL   Dev Biol 234 (1), 244-260 (2001)
   PUBMED   11356033
REFERENCE   8  (bases 1 to 6688)
  AUTHORS   Dinchuk,J.E., Henderson,N.L., Burn,T.C., Huber,R., Ho,S.P.,
            Link,J., O'Neil,K.T., Focht,R.J., Scully,M.S., Hollis,J.M.,
            Hollis,G.F. and Friedman,P.A.
  TITLE     Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved
            isoform of Asph missing the catalytic domain share exons with
            junctin
  JOURNAL   J Biol Chem 275 (50), 39543-39554 (2000)
   PUBMED   10956665
REFERENCE   9  (bases 1 to 6688)
  AUTHORS   Takahashi,Y., Miyata,M., Zheng,P., Imazato,T., Horwitz,A. and
            Smith,J.D.
  TITLE     Identification of cAMP analogue inducible genes in RAW264
            macrophages
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 385-394 (2000)
   PUBMED   11004510
REFERENCE   10 (bases 1 to 6688)
  AUTHORS   Jones,L.R., Zhang,L., Sanborn,K., Jorgensen,A.O. and Kelley,J.
  TITLE     Purification, primary structure, and immunological characterization
            of the 26-kDa calsequestrin binding protein (junctin) from cardiac
            junctional sarcoplasmic reticulum
  JOURNAL   J Biol Chem 270 (51), 30787-30796 (1995)
   PUBMED   8530521
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY268464.1, AK030293.1 and AL671970.9.
            
            On Apr 29, 2010 this sequence version replaced NM_023066.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF289487.1, AK030293.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                BY268464.1         2-79
            79-3979             AK030293.1         3-3903
            3980-6688           AL671970.9         69222-71930         c
FEATURES             Location/Qualifiers
     source          1..6688
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 4.17 cM"
     gene            1..6688
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /note="aspartate-beta-hydroxylase"
                     /db_xref="GeneID:65973"
                     /db_xref="MGI:MGI:1914186"
     exon            1..382
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..2478
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /EC_number="1.14.11.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calsequestrin-binding protein; aspartyl/asparaginyl
                     beta-hydroxylase; jumbug; junctin; junctate; ASP
                     beta-hydroxylase; peptide-aspartate beta-dioxygenase;
                     aspartly beta-hydroxylase; aspartyl beta-hydroxylase
                     Humbug"
                     /codon_start=1
                     /product="aspartyl/asparaginyl beta-hydroxylase isoform 1"
                     /protein_id="NP_075553.2"
                     /db_xref="CCDS:CCDS38690.1"
                     /db_xref="GeneID:65973"
                     /db_xref="MGI:MGI:1914186"
                     /translation="MAPRKNAKGGGGNSSSSGSGSGSGSGSPSTGSSGSSSSPGARRE
                     AKHGGHKNGRRGGISGGSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGVYDAD
                     GDGDFDVDDAKVLLGLKERSPSERTFPPEEEAETHAELEEQAPEGADIQNVEDEVKEQ
                     IQSLLQESVHTDHDLEADGLAGEPQPEVEDFLTVTDSDDRFEDLEPGTVHEEIEDTYH
                     VEDTASQNHPNDMEEMTNEQENSDPSEAVTDAGVLLPHAEEVRHQDYDEPVYEPSEHE
                     GVAISDNTIDDSSIISEEINVASVEEQQDTPPVKKKKPKLLNKFDKTIKAELDAAEKL
                     RKRGKIEEAVNAFEELVRKYPQSPRARYGKAQCEDDLAEKQRSNEVLRRAIETYQEAA
                     DLPDAPTDLVKLSLKRRSERQQFLGHMRGSLLTLQRLVQLFPSDTTLKNDLGVGYLLL
                     GDNDSAKKVYEEVLNVTPNDGFAKVHYGFILKAQNKISESIPYLKEGIESGDPGTDDG
                     RFYFHLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPRETGY
                     TELVKSLERNWKLIRDEGLMVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRKNENAC
                     KGAPKTCALLEKFSETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEG
                     CKIRCANETRTWEEGKVLIFDDSFEHEVWQDASSFRLIFIVDVWHPELTPQQRRSLPA
                     I"
     exon            383..532
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            533..601
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            602..697
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            698..772
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            773..886
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            887..919
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            920..976
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1024
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1057
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1096
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1132
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1177
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1263
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1350
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1501
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1638
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1737
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1827
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1965
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2101
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2193
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2327
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..6688
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4463..4468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /note="hexamer: AATAAA"
     polyA_site      4489
                     /gene="Asph"
                     /gene_synonym="2310005F16Rik; 3110001L23Rik; BAH; cI-37"
                     /note="major polyA site"
ORIGIN      
        1 agatctggtg ggtgggcaga ggctggcgtg ggcggggccg aggccggggg gagctgagcg
       61 ctcttggcag cctaaggagt cgcaggctgg gcgcacgcga ggctaaccgc gcggctgcac
      121 gctggtgcaa gtcgtccgag gcgcagcgag cgcagtggac gctaaggcgc tgctacagga
      181 gtctcgaagc cccggtgtcc ctagtgcact cagcaaggcc ccggttctct gcagtccccg
      241 gagcagctcg cgatggcccc gcgcaagaac gccaagggcg gcggcggcaa cagcagcagc
      301 agcggcagcg gcagcggctc gggcagcggt agcccgagca cgggtagcag cggtagcagc
      361 agtagccccg gggctcggag agaggcaaag cacggaggac acaagaatgg gagaagagga
      421 gggatttcag gagggtcctt tttcacatgg ttcatggtca ttgcattgct cggcgtctgg
      481 acatctgtgg ctgtcgtgtg gtttgacttg gtcgattatg aagaagttct aggaaaacta
      541 ggagtctatg atgcggatgg cgatggagac tttgatgtgg atgatgccaa agttttatta
      601 ggccttaaag aaagatctcc ttctgagagg acatttccac cggaggagga ggcagagact
      661 cacgctgagc tggaggagca ggcccctgag ggggcagaca tccagaatgt tgaagatgaa
      721 gtaaaggaac aaattcagtc ccttcttcag gaatcagtac acacagacca tgaccttgaa
      781 gcagatgggc tggcaggaga accacagccg gaggttgagg acttcctcac agtgaccgac
      841 agtgatgaca gatttgagga cctggaaccc gggacagttc atgaagaaat cgaggatact
      901 taccatgtgg aagacacagc atcgcagaac catccaaatg acatggaaga gatgacgaat
      961 gagcaggaaa attcagatcc cagtgaagca gtgacagatg caggtgtgct gctgccccat
     1021 gcagaggaag taagacacca agactatgat gaaccagtat atgaaccctc agagcatgaa
     1081 ggggtcgcga tttcagataa caccatagat gattccagca taatctcaga agaaataaat
     1141 gtcgcctctg ttgaagaaca gcaagacaca ccaccagtta agaagaagaa gcctaaactt
     1201 ctgaacaaat ttgataagac aattaaggct gagctggatg ctgcagaaaa gctccggaaa
     1261 aggggtaaaa ttgaggaagc agtgaacgca tttgaagaac tggttcgaaa gtaccctcag
     1321 agcccacgag caagatatgg caaagcgcag tgtgaagatg acttggcaga gaagcagaga
     1381 agcaatgagg ttctgcgcag ggccatcgag acctaccagg aggcagccga cctgcctgat
     1441 gcccctacag acctggtgaa gctgagcttg aagcgaaggt cggaacggca gcagtttcta
     1501 ggtcacatga gaggttctct acttaccctc cagagactag ttcaactgtt ccctagtgat
     1561 actaccttaa aaaacgacct tggcgtagga tacctcttgt tgggagacaa cgacagtgcc
     1621 aagaaggttt acgaagaggt gctaaatgtg acaccaaatg atggcttcgc taaagtgcat
     1681 tacggcttca tcctgaaggc acagaacaag atatctgaga gcattcccta cttaaaggaa
     1741 ggaatcgaat ctggggaccc tggcacggat gatggccggt tttacttcca cttgggggat
     1801 gccatgcaga gggtcgggaa caaagaggca tataagtggt atgaacttgg gcacaagaga
     1861 ggacattttg cctctgtctg gcagcgttcc ctctacaatg tgaatggtct gaaggctcag
     1921 ccgtggtgga cacccaggga gactggctac acagagctag tgaagtcttt agagagaaac
     1981 tggaagttaa tccgtgatga aggcctcatg gtgatggata aagccaaggg tctcttcctg
     2041 cctgaggacg aaaaccttcg ggagaagggc gactggagcc agttcacact gtggcagcaa
     2101 ggaaggaaga atgagaatgc ctgtaaagga gcgcctaaga cctgtgcttt actagaaaag
     2161 ttttccgaaa caacaggatg cagaagagga cagatcaaat actccatcat gcaccctgga
     2221 actcatgtgt ggccgcatac aggacccaca aactgcaggc tccgaatgca tctggggtta
     2281 gtgatcccca aggaaggctg caagatccgg tgtgccaatg agaccaggac gtgggaagaa
     2341 ggcaaggtgc tcatctttga tgactctttt gagcacgagg tttggcagga tgcctcgtct
     2401 ttccggctga tattcatcgt ggatgtgtgg caccccgagc tgacccctca gcagagacgc
     2461 agccttcccg caatttgaaa ggcactgacg cagacttggt tgctctccag ggaggctgcc
     2521 tttctggttc cttttgggtg tggagataga agtccaagta ccatgactct tcatccccgt
     2581 gccatgcagc tggagacctc taaggttcct tctggattag aactcactgg agggaacatt
     2641 tgccttcctg cgattcattt aggaggcctc ttgcttcatg tcacccatga cagcacagaa
     2701 ctagtgcctg catttaaggg gcagaaaact tggttgtgtt gtctacatgg ctggccaaag
     2761 atatttttct acatagaata gtgtctacat caatgcacat ggaggatata ctatatagag
     2821 aaactgtgaa tgaatcactt tagtttgtaa tttttctatg cagttatatt tttctaagta
     2881 gctaaactgt tctgtcacca tctaccccca tgttttcgtt gactttaatg acaagaagta
     2941 taaattcttt acgtctgtta aatagtaatt ttcctggtaa attcagacat ttcttttttt
     3001 agaaagaaaa aaatcacgtg tgaaagaaaa gaactttgtt ttcctaacat aaattggaag
     3061 tcatgctagg atgcatgaac tgtgccaaca cttgcccttg ggtctacctg tgtatcctca
     3121 tttagactca gtgtctcccc ctttctctgt gctaatagta caaagttgtt atttctaaga
     3181 gcaacatttc tttttaaatt acactgagca aagccataga aacattttat gtgataggaa
     3241 aataccacag ataatggagc ttggagagaa aatatcacat ggaagtgaaa tttcctgctc
     3301 agggtcaggg acccaggtag cctggcctct ttgccttcta tacccaaggc ctggagtctg
     3361 cagttcctgc ctgctgtaga tccacttacg tgtcaaaaag aaggcctctt agtctctgag
     3421 agtctcttca ctattttatc catgtaggaa tagcagcata gaaagtgccc agggatgcta
     3481 gcatcctagg tggtcaagca tccttgatta tgaatttgca gtgcttttcc atcttcctcc
     3541 cctcagaata atgtcagcca tctcatttta tactgaacca gcgttgacag gcatgtttga
     3601 tttgagtgct atccatggct gagaaagagc agtagaaagc catcttgctc ctcaagatga
     3661 tcattagtaa agcattgctg cattttattt tctattttaa aattaaagat aactcaagcc
     3721 ctagaatgta atgacattca tgcactgatc tctaagccag tcgaacaaca ttgctgcaga
     3781 aatggctggt attccagcca cacagagatg tgtgcctttc aagcagtgcc caaaaaaagc
     3841 agctttctgt acctcattta aagagcaatt cattgagctt gatcctttcc cttttagctt
     3901 aaggacatta gctcttcgta ggaaagttta caaaatatgt gtccattctt aaaataggta
     3961 cttgtccctt cctttgccag tgttcaaaaa ttcctctaaa acagatggca aaggcatgag
     4021 gggaaatatc aaatccttac caaattccag aaaagaaaac aaactctcag acaacagaaa
     4081 gttatttgtg ttcttcagta tttattaaac agaggaactt actgacaaag gcaatacaat
     4141 ccagtgttca tgtagtaacc ctcggttacc tgctgggttt agttctcctc tatactacat
     4201 atacatagcg aaatgcaaac catgtgttct cattgttaaa ctatcacctt acatccatgg
     4261 aataaaatgg aggaaatgag tgaaaattag ctgttaactt agtaaatata acatgttttt
     4321 taaaatatgg tcattacagt aggattctaa atcttgcctt gtgaaaagcc agcagtaccg
     4381 ttacttttgc aagtgttggc agtggtgcac tccaacagca ttttaagtac ttggatccca
     4441 cgttgatctt ataaacacaa gcaataaaag attttctaat tcactttaat ttttcctcgc
     4501 tcttacttgt gtcataagaa aagaatttcc atccatgtct tggtaaacat ttttcaaggt
     4561 tattatttta caattctaaa ggtctataca aaatgaattg gtagggtttt ttttttaata
     4621 tactatgatg caattgtttg ggaaatattt taaaattctg tttcaatttt gcttcttcaa
     4681 ggttggaaca taaaaatagc ttctgttact attctctgcc agtagaaaaa aataataaaa
     4741 cagtagatca actgaggagt atacatctag tttgtagctc agggctcagg ggttaggccc
     4801 tgggtttgat cttcagcatt ggagggagac agagaagaga gggtaacagg gagacagaga
     4861 aagaaagaca aaggaaaagg agaggagtgt aaggaggaga gaagtgggaa ggaacaggga
     4921 aagagagaga tggagagagg gaagtggcca tagtcagtaa tgttttgtgt ttatggcggg
     4981 aagtaagttg aattggtttc ctcttttctt taggctgttc agctagtaaa tcactctacc
     5041 aagtgcttaa aatgtaaagt attttaataa gtgttagcaa ttaaaaattt tgacattatc
     5101 actctggtca tattagtaag tgtctgtgtc gtacagatgc tagagaataa ggtatctaca
     5161 catactcagc tggtctcagg aaacatggca cagataaaat atcctcccct ttgctgttct
     5221 ctgtctgact tcctatgcat gggggctggg atccatttct aaggagaatg gataaggaag
     5281 taggctggtc tttggcattt catcttgcat tcttggtcct ctttagcttg gtacttacat
     5341 gctgatccat ccttaagggt ctttctgtga gatttgaatg cctgccccct cagggccttt
     5401 ctccacaggt aataggagca tggggacaaa gggacttatt tgatagcaag tttttgctgt
     5461 agtaacccaa gaattaactt aaaagggtaa tcagtcacca gtgtgtgtgt gtgtgtgtgt
     5521 gtggtgtgtg gtgtgtgttc caatgagttg ccccctctct gtaggcattc gcctacagga
     5581 aatcactttg ctacaatgaa gcagcctctt tttttttcaa actgcctctt tgtcttaaaa
     5641 agcaattcat gaaagtcagc tgatggtctg acaagcaaca cgatgtccaa atcattcttg
     5701 taggagagag atttaaatga aaaactttgc aaatagccag acgtgggaga tcacactctt
     5761 aggctgacta cttagatgct ggtgatgagg tcaggaaata agtcaatagg actggaaatt
     5821 attggagcta ctgctgctgg ggttcagcac tacattaaac ttgctgatgt gtctgcacat
     5881 tttaactctg ttttatttat ttcggaatgc atttcatctt aatttgcaaa acctggagag
     5941 ggttcctgtg tgagtcttta gagtgatgta tatgcaacta atttagggtt tttttcccct
     6001 tttgaagtat atttgctgcc aaaaatatga ggggagaatc ctttttacat aaatgccttt
     6061 cttcatcccc gtcaccattc ctcactaaaa cataaattaa ttcgttaaat ttttaaaagc
     6121 gtctctcaga tctttgtccg gtgtgggcta cccagaccaa tggttgctga cagtcatggc
     6181 tgggactggg atggaggacc tcatgtcaag cagagcacac agagtgtctg taggtcagtt
     6241 gcacaggctt gctggacggt tgctccactg gagatgtcac atgatgctgg ctggctcagt
     6301 ccagagccag cagtggctgg gtgttctcat tttctccttt ctcttcatgt ttcaaggtcc
     6361 cagcttctac cacagactga gatctaacaa gagaggaagg agacacacac agtcacagac
     6421 agtccatact ggtgatgctt gctactcacc tgaatcagag catgtgaaat agctacttag
     6481 tgcttccttt ctgccatctg ttttccacac accactttat ttcttttttt tttttttctt
     6541 tttgtttttc tgaagattga atctggtcat tctgagattc tttttttttt ctgctgaatt
     6601 tgatccatat ctttttgctg taataagtcc tatgagtgta acattttgtt catgttccaa
     6661 ataaaaataa aggtaattcg aaagatgc
//
