LOCUS       NM_001308488            1191 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus acetylserotonin O-methyltransferase (Asmt), transcript
            variant 2, mRNA.
ACCESSION   NM_001308488
VERSION     NM_001308488.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1191)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1191)
  AUTHORS   Liu,W., Huang,Z., Zhang,Y., Zhang,S., Cui,Z., Liu,W., Li,L.,
            Xia,J., Zou,Y. and Qi,Z.
  TITLE     ASMT determines gut microbiota and increases neurobehavioral
            adaptability to exercise in female mice
  JOURNAL   Commun Biol 6 (1), 1126 (2023)
   PUBMED   37935873
  REMARK    GeneRIF: ASMT determines gut microbiota and increases
            neurobehavioral adaptability to exercise in female mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1191)
  AUTHORS   Zhang,C., Clough,S.J., Adamah-Biassi,E.B., Sveinsson,M.H.,
            Hutchinson,A.J., Miura,I., Furuse,T., Wakana,S., Matsumoto,Y.K.,
            Okanoya,K., Hudson,R.L., Kato,T., Dubocovich,M.L. and Kasahara,T.
  TITLE     Impact of endogenous melatonin on rhythmic behaviors, reproduction,
            and survival revealed in melatonin-proficient C57BL/6J congenic
            mice
  JOURNAL   J Pineal Res 71 (2), e12748 (2021)
   PUBMED   34085306
REFERENCE   4  (bases 1 to 1191)
  AUTHORS   Zhang,Z., Silveyra,E., Jin,N. and Ribelayga,C.P.
  TITLE     A congenic line of the C57BL/6J mouse strain that is proficient in
            melatonin synthesis
  JOURNAL   J Pineal Res 65 (3), e12509 (2018)
   PUBMED   29768727
REFERENCE   5  (bases 1 to 1191)
  AUTHORS   Trent,S., Fry,J.P., Ojarikre,O.A. and Davies,W.
  TITLE     Altered brain gene expression but not steroid biochemistry in a
            genetic mouse model of neurodevelopmental disorder
  JOURNAL   Mol Autism 5 (1), 21 (2014)
   PUBMED   24602487
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1191)
  AUTHORS   Kasahara,T., Abe,K., Mekada,K., Yoshiki,A. and Kato,T.
  TITLE     Genetic variation of melatonin productivity in laboratory mice
            under domestication
  JOURNAL   Proc Natl Acad Sci U S A 107 (14), 6412-6417 (2010)
   PUBMED   20308563
REFERENCE   7  (bases 1 to 1191)
  AUTHORS   Vollrath,L., Huesgen,A., Manz,B. and Pollow,K.
  TITLE     Day/night serotonin levels in the pineal gland of male BALB/c mice
            with melatonin deficiency
  JOURNAL   Acta Endocrinol (Copenh) 117 (1), 93-98 (1988)
   PUBMED   3381630
REFERENCE   8  (bases 1 to 1191)
  AUTHORS   Ebihara,S., Hudson,D.J., Marks,T. and Menaker,M.
  TITLE     Pineal indole metabolism in the mouse
  JOURNAL   Brain Res 416 (1), 136-140 (1987)
   PUBMED   3620949
REFERENCE   9  (bases 1 to 1191)
  AUTHORS   Ebihara,S., Marks,T., Hudson,D.J. and Menaker,M.
  TITLE     Genetic control of melatonin synthesis in the pineal gland of the
            mouse
  JOURNAL   Science 231 (4737), 491-493 (1986)
   PUBMED   3941912
REFERENCE   10 (bases 1 to 1191)
  AUTHORS   Balemans,M.G., Pevet,P., Legerstee,W.C. and Nevo,E.
  TITLE     Preliminary investigations of melatonin and 5-methoxy-tryptophol
            synthesis in the pineal, retina, and harderian gland of the mole
            rat and in the pineal of the mouse 'eyeless'
  JOURNAL   J Neural Transm 49 (4), 247-255 (1980)
   PUBMED   7463037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from MG954260.1 and AEKQ02189142.1.
            
            On Jul 30, 2020 this sequence version replaced NM_001308488.1.
            
            Summary: This gene belongs to the methyltransferase superfamily and
            is located in the pseudoautosomal region (PAR) of the X and Y
            chromosomes. The encoded enzyme catalyzes the final reaction in the
            synthesis of melatonin and is abundant in the pineal gland. Two
            amino acid substitutions (R78G and R242C) are present in the
            encoded protein derived from the reference strain, C57BL/6J, and
            this protein shows low enzyme activity relative to the protein
            derived from other strains. [provided by RefSeq, May 2015].
            
            Transcript Variant: This variant (2) is based on a transcript from
            the reference strain and includes seven nucleotide substitutions in
            the coding sequence compared to variant 1. Two of these nucleotide
            substitutions result in amino acid substitutions (R78G and R242C)
            in the encoded isoform (2), which shows low enzyme activity.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB512670.1, AB512671.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               MG954260.1         1566-1675
            111-282             MG954260.1         2547-2718
            283-415             MG954260.1         3544-3676
            416-484             MG954260.1         3883-3951
            485-603             MG954260.1         4670-4788
            604-759             MG954260.1         5260-5415
            760-882             MG954260.1         5939-6061
            883-1191            AEKQ02189142.1     1343-1651
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X"
     gene            1..1191
                     /gene="Asmt"
                     /gene_synonym="Hiomt"
                     /note="acetylserotonin O-methyltransferase"
                     /db_xref="GeneID:107626"
                     /db_xref="MGI:MGI:96090"
     exon            1..110
                     /gene="Asmt"
                     /gene_synonym="Hiomt"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1187
                     /gene="Asmt"
                     /gene_synonym="Hiomt"
                     /EC_number="2.1.1.4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     hydroxyindole O-methyltransfease"
                     /codon_start=1
                     /product="acetylserotonin O-methyltransferase isoform 2"
                     /protein_id="NP_001295417.1"
                     /db_xref="CCDS:CCDS85832.1"
                     /db_xref="GeneID:107626"
                     /db_xref="MGI:MGI:96090"
                     /translation="MHRGRSASARQERDFRALMDLAHGFMASQVLFAGCALRVFDAAA
                     LGPVDAAALARSSGLSPRGTRLLLDACAGLGLLGRRRGAGPRGPAYTNSPLASTFLVA
                     GSPLSQRSLLLYLAGTTYLCWGHLADGVREGRSQYARAVGVDADDPFTAIYRSEAERL
                     LFMRGLQETWSLCGGRVLTAFDLSPFRVICDLGGGSGALARMAARLYPGSEVTVFETP
                     DVVAAARAHFPPPADEDGAEPRVCFLSGDFFRSPLPPADLYVLARVLHDWADAACVEL
                     LRRVRGALRPGGAVLLVESVLSPGGAGPTRTLLLSLTMLLQARGRERTEAEYRALTAR
                     AGFSRLRLRRPRGPYHAMMAARGGGAGARSDGGGGDATSQTGSGTGSEVGAQD"
     exon            111..282
                     /gene="Asmt"
                     /gene_synonym="Hiomt"
                     /inference="alignment:Splign:2.1.0"
     exon            283..415
                     /gene="Asmt"
                     /gene_synonym="Hiomt"
                     /inference="alignment:Splign:2.1.0"
     exon            416..484
                     /gene="Asmt"
                     /gene_synonym="Hiomt"
                     /inference="alignment:Splign:2.1.0"
     exon            485..603
                     /gene="Asmt"
                     /gene_synonym="Hiomt"
                     /inference="alignment:Splign:2.1.0"
     exon            604..759
                     /gene="Asmt"
                     /gene_synonym="Hiomt"
                     /inference="alignment:Splign:2.1.0"
     exon            760..882
                     /gene="Asmt"
                     /gene_synonym="Hiomt"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1191
                     /gene="Asmt"
                     /gene_synonym="Hiomt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcagcag ctcgcgtccc acgatgcaca ggggccgctc ggcctccgct cgccaggagc
       61 gcgacttccg ggccctcatg gacctggccc acggcttcat ggcctcccag gtgctgttcg
      121 cgggctgcgc gctccgcgtg ttcgacgccg cggccctggg ccccgtggac gccgcggcgc
      181 tggcgaggtc gtcgggcctg agcccccggg ggacgcggct gctgctcgac gcctgcgcgg
      241 ggctggggct gctggggaga cgcagggggg cggggccgcg cggccccgcc tacaccaact
      301 cccccctggc gtccaccttc ctggtcgcgg gcagccccct gtctcagcgc agcctcctgc
      361 tctacctggc gggcaccacc tacctgtgct gggggcacct ggcggacggc gtgagggaag
      421 ggcggagcca gtacgcgagg gccgtgggcg tcgacgcgga cgaccccttc accgccatct
      481 acaggtcgga ggccgagcgc ctgctgttca tgcggggcct gcaggagacc tggagcctgt
      541 gcggggggcg ggtcctcacg gccttcgacc tctcgccctt cagggtcatc tgcgacctcg
      601 gtggtgggtc cggggcgctg gcccgcatgg ccgcccggct ctacccgggc agcgaggtca
      661 ccgtgttcga gacgcccgac gtcgtcgctg ccgcccgcgc ccacttcccg cccccagcgg
      721 acgaggacgg ggcggagcct cgtgtgtgct tcctgtcagg cgacttcttc cgctcgccgc
      781 tgccgcccgc cgacctctac gtcctggccc gggtcctgca cgactgggcg gacgccgcct
      841 gcgtggagct gctgcggcgc gtgcggggtg ccctgcggcc aggcggcgcg gtgctgctgg
      901 tggagagcgt gctgtccccg ggaggggcgg ggccgacgcg gacgctgctg ctgtcgctca
      961 cgatgctgct gcaggcccgg ggccgcgagc gcacggaggc cgagtaccgg gcgctgaccg
     1021 cgcgtgccgg cttctcccgc ctgcggctgc ggcgcccgcg gggcccctac cacgccatga
     1081 tggccgcccg ggggggcggg gccggggcgc ggagcgacgg cggcggcggg gacgcgacgt
     1141 cacagacagg aagtgggaca ggaagtgagg tcggcgccca ggactgaggc a
//
