LOCUS       NM_133768               1824 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus argininosuccinate lyase (Asl), mRNA.
ACCESSION   NM_133768
VERSION     NM_133768.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1824)
  AUTHORS   Jin,Z., Jiang,M.M. and Lee,B.
  TITLE     Nitric oxide is required for lung alveolarization revealed by
            deficiency of argininosuccinate lyase
  JOURNAL   Hum Mol Genet 33 (1), 33-37 (2023)
   PUBMED   37738569
  REMARK    GeneRIF: Nitric oxide is required for lung alveolarization revealed
            by deficiency of argininosuccinate lyase.
REFERENCE   2  (bases 1 to 1824)
  AUTHORS   Kho,J., Polak,U., Jiang,M.M., Odom,J.D., Hunter,J.V., Ali,S.M.,
            Burrage,L.C., Nagamani,S.C., Pautler,R.G., Thompson,H.P.,
            Urayama,A., Jin,Z. and Lee,B.
  TITLE     Argininosuccinate lyase deficiency causes blood-brain barrier
            disruption via nitric oxide-mediated dysregulation of claudin
            expression
  JOURNAL   JCI Insight 8 (17), e168475 (2023)
   PUBMED   37490345
  REMARK    GeneRIF: Argininosuccinate lyase deficiency causes blood-brain
            barrier disruption via nitric oxide-mediated dysregulation of
            claudin expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1824)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   4  (bases 1 to 1824)
  AUTHORS   Zhao,K., Huang,X., Zhao,W., Lu,B. and Yang,Z.
  TITLE     LONP1-mediated mitochondrial quality control safeguards metabolic
            shifts in heart development
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35237793
REFERENCE   5  (bases 1 to 1824)
  AUTHORS   Crowther,R.R., Schmidt,S.M., Lange,S.M., McKell,M.C.,
            Robillard,M.C., Zhao,J., Haffey,W.D., Wyder,M.A., Greis,K.D.,
            Setchell,K.D.R. and Qualls,J.E.
  TITLE     Cutting Edge: l-Arginine Transfer from Antigen-Presenting Cells
            Sustains CD4+ T Cell Viability and Proliferation
  JOURNAL   J Immunol 208 (4), 793-798 (2022)
   PUBMED   35101895
REFERENCE   6  (bases 1 to 1824)
  AUTHORS   Wang,Y.K., Sporle,R., Paperna,T., Schughart,K. and Francke,U.
  TITLE     Characterization and expression pattern of the frizzled gene Fzd9,
            the mouse homolog of FZD9 which is deleted in Williams-Beuren
            syndrome
  JOURNAL   Genomics 57 (2), 235-248 (1999)
   PUBMED   10198163
REFERENCE   7  (bases 1 to 1824)
  AUTHORS   Paperna,T., Peoples,R., Wang,Y.K., Kaplan,P. and Francke,U.
  TITLE     Genes for the CPE receptor (CPETR1) and the human homolog of RVP1
            (CPETR2) are localized within the Williams-Beuren syndrome deletion
  JOURNAL   Genomics 54 (3), 453-459 (1998)
   PUBMED   9878248
REFERENCE   8  (bases 1 to 1824)
  AUTHORS   Sutton,V.R., Pan,Y. and Craigen,W.J.
  TITLE     Regional localization of the mouse argininosuccinate lyase gene to
            chromosome 5
  JOURNAL   Mamm Genome 8 (11), 871 (1997)
   PUBMED   9337408
REFERENCE   9  (bases 1 to 1824)
  AUTHORS   Salier,J.P., Chan,P., Raguenez,G., Zwingman,T. and Erickson,R.P.
  TITLE     Developmentally regulated transcription of the four liver-specific
            genes for inter-alpha-inhibitor family in mouse
  JOURNAL   Biochem J 296 (Pt 1) (Pt 1), 85-91 (1993)
   PUBMED   7504460
REFERENCE   10 (bases 1 to 1824)
  AUTHORS   Todd,S., McGill,J.R., McCombs,J.L., Moore,C.M., Weider,I. and
            Naylor,S.L.
  TITLE     cDNA sequence, interspecies comparison, and gene mapping analysis
            of argininosuccinate lyase
  JOURNAL   Genomics 4 (1), 53-59 (1989)
   PUBMED   2644168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY770404.1, AK140160.1 and AI325988.1.
            
            On Feb 8, 2017 this sequence version replaced NM_133768.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139,
                              SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BY770404.1         2-37
            37-1818             AK140160.1         2-1783
            1819-1824           AI325988.1         3-8                 c
FEATURES             Location/Qualifiers
     source          1..1824
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 68.37 cM"
     gene            1..1824
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /note="argininosuccinate lyase"
                     /db_xref="GeneID:109900"
                     /db_xref="MGI:MGI:88084"
     exon            1..88
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            89..143
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1526
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /EC_number="4.3.2.1"
                     /note="arginosuccinase"
                     /codon_start=1
                     /product="argininosuccinate lyase"
                     /protein_id="NP_598529.1"
                     /db_xref="CCDS:CCDS51655.1"
                     /db_xref="GeneID:109900"
                     /db_xref="MGI:MGI:88084"
                     /translation="MASESGKLWGGRFVGAVDPIMEKFNSSISYDRHLWNVDVQGSKA
                     YSRGLEKAGLLTKAEMQQILQGLDKVAEEWAQGTFKLHPNDEDIHTANERRLKELIGE
                     AAGKLHTGRSRNDQVVTDLRLWMRQTCSKLSALLRVLIGTMVDRAEAERDVLFPGYTH
                     LQRAQPIRWSHWILSHAVALTRDSERLLEVQKRINVLPLGSGAIAGNPLGVDRELLRA
                     ELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYGTKEFSFVQLSDA
                     YSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFE
                     VSDTMIAVLQVATGVISTLQIHRENMKQALSPDMLATDLAYYLVRKGMPFRQAHEASG
                     KAVFMAETKGVALNLLSLQELQTISPLFSGDVSHVWDYSHSVEQYSALGGTAKSSVEW
                     QIRQVRALLQAQEP"
     exon            144..338
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            339..422
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            423..479
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            480..577
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            578..655
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            656..733
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            734..786
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            787..849
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            850..964
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1049
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1109
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1193
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1274
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1381
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1824
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1553..1558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /note="hexamer: AATAAA"
     polyA_site      1579
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /note="major polyA site"
     regulatory      1799..1804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
                     /note="hexamer: CATAAA"
     polyA_site      1824
                     /gene="Asl"
                     /gene_synonym="2510006M18Rik; ASAL"
ORIGIN      
        1 aattggctct actcttccag gaggcgggga caagacagag gggcagcgga cgccatccgg
       61 accagaaaaa gccaggagag accagaagat tcgtaagaca gaagctccag gaggaggagg
      121 aaccgcccaa catggcatca gagagcggga agctatgggg tggccggttt gtgggtgctg
      181 tcgaccccat catggagaag ttcaactcat ctatctccta tgaccggcat ctgtggaatg
      241 tggatgtgca ggggagcaag gcctacagca ggggcctgga gaaggcgggg cttctcacca
      301 aagccgagat gcagcagata ctgcaagggt tggacaaggt tgctgaagag tgggcccaag
      361 gcaccttcaa attacatcct aatgatgaag acatccacac agccaacgag cggcgcctga
      421 aggaactcat cggtgaagct gcagggaagc tacacacagg acgaagtcgc aacgaccagg
      481 tggtcacgga cctcaggctg tggatgaggc agacctgctc aaaactctcc gccctcctcc
      541 gggtgctcat tggaaccatg gtcgaccggg cagaggcgga acgtgatgtc ctcttcccag
      601 ggtacacaca cttgcagaga gctcagccca ttcgctggag ccactggatc ctgagccacg
      661 ctgttgcgct gacacgagat tcagagagac tcttggaggt gcagaagcgg atcaatgtct
      721 tgccactggg gagtggggcc attgcaggca accctctggg tgtggaccgg gagctactcc
      781 gtgcagaact gaactttggg gccatcactc tcaacagcat ggatgccacc agtgagagag
      841 actttgtggc tgagttcctg ttttgggctt ctctgtgtat gacccacctc agcaggatgg
      901 cagaggacct aattctctat ggtaccaagg aattcagctt tgtgcaactc tcagatgcct
      961 acagcaccgg aagcagcttg atgccccaga agaaaaaccc agacagcctg gagctgatcc
     1021 ggagcaaggc gggccgagtg tttggacggt gtgccggact cctgatgacc ctcaagggac
     1081 ttccaagcac ctacaacaag gacttacagg aagacaagga ggctgtgttt gaagtgtctg
     1141 acaccatgat agctgtcctc caagtggcca ctggagtcat ctctacattg cagattcatc
     1201 gtgagaacat gaaacaggcg ctcagccctg acatgctggc cacggacctc gcctactacc
     1261 tggtccgcaa agggatgcca ttccgccagg cccacgaggc ctcagggaaa gctgtgttca
     1321 tggcagagac taaaggagtg gctctcaacc tgctgtcgct acaggagctg cagaccatca
     1381 gtcccctgtt ctcaggtgat gtgagtcacg tgtgggacta cagtcacagc gtggaacagt
     1441 acagtgcctt gggtggcaca gcgaaatcca gtgtcgaatg gcagatcagg caggtgcggg
     1501 ccctactgca agcccaggag ccctagatcc cgcccaccca aagctgctcc ccaataaagt
     1561 ggagccctga agaaaccgag acaagcatat gcttctgcct gtggtcctca tgagtgggct
     1621 gggggatttg ttgagctggc caatggggtc atgaaggaag tagaaaaaaa caaaacaaaa
     1681 cgaatgccaa tgcaaagaga gacaggaaca agggtttttc ctcctacacc ttaaatccca
     1741 gacccccacc ccccgccttg caggtagcat aactgtgaat gcaagattaa cacaaaatca
     1801 taaacttaaa acatcctgaa ggaa
//
