LOCUS       NM_183000               1978 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus acid-sensing ion channel 3 (Asic3), transcript variant
            1, mRNA.
ACCESSION   NM_183000
VERSION     NM_183000.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1978)
  AUTHORS   Huang,C., Sun,P.Y., Jiang,Y., Liu,Y., Liu,Z., Han,S.L., Wang,B.S.,
            Huang,Y.X., Ren,A.R., Lu,J.F., Jiang,Q., Li,Y., Zhu,M.X., Yao,Z.,
            Tian,Y., Qi,X., Li,W.G. and Xu,T.L.
  TITLE     Sensory ASIC3 channel exacerbates psoriatic inflammation via a
            neurogenic pathway in female mice
  JOURNAL   Nat Commun 15 (1), 5288 (2024)
   PUBMED   38902277
  REMARK    GeneRIF: Sensory ASIC3 channel exacerbates psoriatic inflammation
            via a neurogenic pathway in female mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1978)
  AUTHORS   Yamada,A., Ling,J., Yamada,A.I., Furue,H. and Gu,J.G.
  TITLE     ASICs mediate fast excitatory synaptic transmission for tactile
            discrimination
  JOURNAL   Neuron 112 (8), 1286-1301 (2024)
   PUBMED   38359825
REFERENCE   3  (bases 1 to 1978)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1978)
  AUTHORS   Negm,A., Stobbe,K., Ben Fradj,S., Sanchez,C., Landra-Willm,A.,
            Richter,M., Fleuriot,L., Debayle,D., Deval,E., Lingueglia,E.,
            Rovere,C. and Noel,J.
  TITLE     Acid-sensing ion channel 3 mediates pain hypersensitivity
            associated with high-fat diet consumption in mice
  JOURNAL   Pain 165 (2), 470-486 (2024)
   PUBMED   37733484
  REMARK    GeneRIF: Acid-sensing ion channel 3 mediates pain hypersensitivity
            associated with high-fat diet consumption in mice.
REFERENCE   5  (bases 1 to 1978)
  AUTHORS   Han,D.S., Lee,C.H., Shieh,Y.D., Chang,K.V., Lin,S.H., Chu,Y.C.,
            Wang,J.L. and Chen,C.C.
  TITLE     Involvement of ASIC3 and Substance P in Therapeutic
            Ultrasound-Mediated Analgesia in Mouse Models of Fibromyalgia
  JOURNAL   J Pain 24 (8), 1493-1505 (2023)
   PUBMED   37054767
  REMARK    GeneRIF: Involvement of ASIC3 and Substance P in Therapeutic
            Ultrasound-Mediated Analgesia in Mouse Models of Fibromyalgia.
REFERENCE   6  (bases 1 to 1978)
  AUTHORS   Chen,C.C., Zimmer,A., Sun,W.H., Hall,J., Brownstein,M.J. and
            Zimmer,A.
  TITLE     A role for ASIC3 in the modulation of high-intensity pain stimuli
  JOURNAL   Proc Natl Acad Sci U S A 99 (13), 8992-8997 (2002)
   PUBMED   12060708
REFERENCE   7  (bases 1 to 1978)
  AUTHORS   Xie,J., Price,M.P., Berger,A.L. and Welsh,M.J.
  TITLE     DRASIC contributes to pH-gated currents in large dorsal root
            ganglion sensory neurons by forming heteromultimeric channels
  JOURNAL   J Neurophysiol 87 (6), 2835-2843 (2002)
   PUBMED   12037186
  REMARK    GeneRIF: DRASIC contributes to pH-gated currents in large dorsal
            root ganglion sensory neurons by forming heteromultimeric channels.
REFERENCE   8  (bases 1 to 1978)
  AUTHORS   Benson,C.J., Xie,J., Wemmie,J.A., Price,M.P., Henss,J.M.,
            Welsh,M.J. and Snyder,P.M.
  TITLE     Heteromultimers of DEG/ENaC subunits form H+-gated channels in
            mouse sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2338-2343 (2002)
   PUBMED   11854527
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Apr 2;99(7):4752]
REFERENCE   9  (bases 1 to 1978)
  AUTHORS   Price,M.P., McIlwrath,S.L., Xie,J., Cheng,C., Qiao,J., Tarr,D.E.,
            Sluka,K.A., Brennan,T.J., Lewin,G.R. and Welsh,M.J.
  TITLE     The DRASIC cation channel contributes to the detection of cutaneous
            touch and acid stimuli in mice
  JOURNAL   Neuron 32 (6), 1071-1083 (2001)
   PUBMED   11754838
  REMARK    Erratum:[Neuron 2002 Jul 18;35(2):407]
REFERENCE   10 (bases 1 to 1978)
  AUTHORS   Askwith,C.C., Cheng,C., Ikuma,M., Benson,C., Price,M.P. and
            Welsh,M.J.
  TITLE     Neuropeptide FF and FMRFamide potentiate acid-evoked currents from
            sensory neurons and proton-gated DEG/ENaC channels
  JOURNAL   Neuron 26 (1), 133-141 (2000)
   PUBMED   10798398
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC054460.1.
            
            On May 22, 2007 this sequence version replaced NM_183000.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849383,
                              SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-949               BC054460.1         1-949
            950-1978            BC054460.1         1219-2247
FEATURES             Location/Qualifiers
     source          1..1978
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 11.72 cM"
     gene            1..1978
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /note="acid-sensing ion channel 3"
                     /db_xref="GeneID:171209"
                     /db_xref="MGI:MGI:2159339"
     exon            1..798
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1854
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dorsal root ASIC; acid-sensing (proton-gated) ion channel
                     3; amiloride-sensitive cation channel 3"
                     /codon_start=1
                     /product="acid-sensing ion channel 3 isoform 1"
                     /protein_id="NP_892045.2"
                     /db_xref="CCDS:CCDS51433.1"
                     /db_xref="GeneID:171209"
                     /db_xref="MGI:MGI:2159339"
                     /translation="MKPPSGLEEAQRRQASDIRVFANSCTMHGLGHIFGPGGLTLRRG
                     LWATAVLLSLAAFLYQVAERVRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSR
                     LTPNDLHWAGTALLGLDPAEHAAYLRALGQPPAPPGFMPSPTFDMAQLYARAGHSLED
                     MLLDCRYRGQPCGPENFTVIFTRMGQCYTFNSGAQGAELLTTPKGGAGNGLEIMLDVQ
                     QEEYLPIWKDMEETPFEVGIRVQIHGQEEPPAIDQLGFGAAPGHQTFVSCQQQQLSFL
                     PPPWGDCNTASVDPDFDPEPSDPLGSPSSSPPYSLIGCRLACESRYVARKCGCRMMHM
                     PGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMVRIPSRASARYL
                     ARKYNRSETYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFIGASLL
                     TILEILDYLCEVFQDRVLGYFWNRRSSQRRSGNTLLQEELNGHRTHVPHLSLGPRPPT
                     APSAVTKTLAASHRTCYLVTRL"
     exon            799..949
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1077
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1267
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1324
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1472
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1564
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1644
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1716
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1775
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1942
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1921..1926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /note="hexamer: AATAAA"
     polyA_site      1942
                     /gene="Asic3"
                     /gene_synonym="Accn3; DRASIC; SLNAC1; TNAC1"
                     /note="major polyA site"
ORIGIN      
        1 cagagaccca gccccacgga gtcaacgcct gttctgggga aggcagagct gaccgaagtt
       61 caactcatcc agtcctatca ggccagtact ttcacctgtc ttggctcctc ccgtctctac
      121 cttctccttc tctctccgta ttccttgctg agctacttga gtcccatttc aatccccacc
      181 actatcctgc tagccctaca aaacagcttc cgtgctcctt agaaatccca tccccagtca
      241 ggaaacctcc ctgctccagc catgaaacct ccctcaggac tggaggaggc ccagcggcga
      301 caggcctcag acatccgggt gttcgccaac agctgcacga tgcatggttt gggccacatc
      361 tttggccctg gaggcctgac cctgcgccgt gggctgtggg ccacagctgt actcctgtcg
      421 ctggcggcct tcctctacca ggtggctgag cgggttcgct actatgggga gttccaccat
      481 aagaccaccc tggatgagcg tgagagccac cagcttacct tcccagctgt cactttgtgt
      541 aacatcaatc ccctgcgccg ctcacgcctc acacccaatg acttgcactg ggccggaacg
      601 gcactgctgg gtctggaccc tgctgaacat gctgcctacc ttcgtgccct gggccagccc
      661 cctgcaccac ctggcttcat gcccagtccg acttttgaca tggcacaact ctacgccaga
      721 gccggccact cccttgagga catgttgctg gactgccgat accgtggcca gccctgtgga
      781 cctgagaact tcacagtgat tttcactcga atggggcaat gctacacctt caactctggt
      841 gcccaggggg cagagctgct caccactcct aagggcggtg ctggcaatgg actggagatt
      901 atgctggatg tacagcagga ggagtatctg cccatctgga aggacatgga agagacccca
      961 tttgaggtgg ggatccgagt gcagatccac ggccaggagg aaccccctgc cattgaccag
     1021 ctgggcttcg gtgctgcccc aggccaccag acttttgtgt cctgccagca acagcaactg
     1081 agtttcctgc caccaccctg gggtgactgc aataccgcat ctgtggatcc cgactttgat
     1141 ccagagccct ctgatcccct gggttcccct agctccagcc ctccttatag cttaataggg
     1201 tgtcgcctgg cctgtgagtc acgctatgtg gctcggaagt gcggatgtcg aatgatgcat
     1261 atgcctggaa actccccagt gtgcagcccc cagcagtaca aggactgtgc cagcccagct
     1321 ctggacgcta tgctgcgaaa ggacacttgt gtctgtccca acccgtgcgc cactacacgc
     1381 tatgccaagg agctctccat ggtgcggatt cccagccgcg cttcagctcg ctacctggcc
     1441 cggaaataca accgtagcga gacttacatc acggagaatg tactggttct ggatatcttc
     1501 tttgaagccc tcaactatga ggccgtggaa caaaaggcag cttatgaagt gtcggagttg
     1561 ctgggagaca ttgggggaca gatgggactg tttatcggag ccagcctgct taccatcctc
     1621 gagatcctcg actacctctg tgaggttttt caagacagag tcctggggta cttctggaac
     1681 agaaggagct ctcaaaggcg ctctggcaac actctgctcc aggaagagtt gaatgggcat
     1741 cgaacacatg ttccccatct cagcctaggc cccaggcctc ctaccgctcc cagtgctgtc
     1801 accaagacac tcgctgcctc ccaccgtacc tgttacctcg tgacaaggct ctagacctgc
     1861 ttggctgcgc cgtgacatct tggacatgcc caggctgtac atctttgcct tctttaccct
     1921 aataaagctc tagtacacgt gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
