LOCUS       NM_007384               3024 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus acid-sensing ion channel 2 (Asic2), transcript variant
            MDEG2, mRNA.
ACCESSION   NM_007384 XM_906637 XM_919950
VERSION     NM_007384.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3024)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   2  (bases 1 to 3024)
  AUTHORS   Lin,B., Jin,Z., Park,G., Ge,Q., Singh,K., Ryan,V. WG, Imami,A.S.,
            Naghavi,F., Miller,O.A., Khan,S., Lu,H., McCullumsmith,R.E. and
            Du,J.
  TITLE     Mice lacking acid-sensing ion channel 2 in the medial prefrontal
            cortex exhibit social dominance
  JOURNAL   Sci Adv 10 (43), eadn7573 (2024)
   PUBMED   39453995
  REMARK    GeneRIF: Mice lacking acid-sensing ion channel 2 in the medial
            prefrontal cortex exhibit social dominance.
REFERENCE   3  (bases 1 to 3024)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   4  (bases 1 to 3024)
  AUTHORS   Hamby,M., Stec,D.E., Hildebrandt,E., Stec,D.F. and Drummond,H.A.
  TITLE     Mice lacking ASIC2 and betaENaC are protected from
            high-fat-diet-induced metabolic syndrome
  JOURNAL   Front Endocrinol (Lausanne) 15, 1449344 (2024)
   PUBMED   39224121
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3024)
  AUTHORS   Wasson,R., Fleming,A.B., McLin,J., Hildebrandt,E. and Drummond,H.A.
  TITLE     Bone marrow monocytes and macrophages from mice lacking betaENaC
            and ASIC2 have a reduced chemotactic migration response and
            polarization
  JOURNAL   Physiol Rep 12 (14), e16139 (2024)
   PUBMED   39016176
  REMARK    GeneRIF: Bone marrow monocytes and macrophages from mice lacking
            betaENaC and ASIC2 have a reduced chemotactic migration response
            and polarization.
REFERENCE   6  (bases 1 to 3024)
  AUTHORS   Garcia-Anoveros,J., Samad,T.A., Zuvela-Jelaska,L., Woolf,C.J. and
            Corey,D.P.
  TITLE     Transport and localization of the DEG/ENaC ion channel BNaC1alpha
            to peripheral mechanosensory terminals of dorsal root ganglia
            neurons
  JOURNAL   J Neurosci 21 (8), 2678-2686 (2001)
   PUBMED   11306621
REFERENCE   7  (bases 1 to 3024)
  AUTHORS   Price,M.P., Lewin,G.R., McIlwrath,S.L., Cheng,C., Xie,J.,
            Heppenstall,P.A., Stucky,C.L., Mannsfeldt,A.G., Brennan,T.J.,
            Drummond,H.A., Qiao,J., Benson,C.J., Tarr,D.E., Hrstka,R.F.,
            Yang,B., Williamson,R.A. and Welsh,M.J.
  TITLE     The mammalian sodium channel BNC1 is required for normal touch
            sensation
  JOURNAL   Nature 407 (6807), 1007-1011 (2000)
   PUBMED   11069180
  REMARK    Erratum:[Nature 2002 Jul 18;418(6895):352]
REFERENCE   8  (bases 1 to 3024)
  AUTHORS   Cohen-Tannoudji,M., Vandormael-Pournin,S., Le Bras,S.,
            Coumailleau,F., Babinet,C. and Baldacci,P.
  TITLE     A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus
            region on mouse chromosome 11
  JOURNAL   Genomics 68 (3), 273-282 (2000)
   PUBMED   10995569
REFERENCE   9  (bases 1 to 3024)
  AUTHORS   Lingueglia,E., de Weille,J.R., Bassilana,F., Heurteaux,C.,
            Sakai,H., Waldmann,R. and Lazdunski,M.
  TITLE     A modulatory subunit of acid sensing ion channels in brain and
            dorsal root ganglion cells
  JOURNAL   J Biol Chem 272 (47), 29778-29783 (1997)
   PUBMED   9368048
REFERENCE   10 (bases 1 to 3024)
  AUTHORS   Garcia-Anoveros,J., Derfler,B., Neville-Golden,J., Hyman,B.T. and
            Corey,D.P.
  TITLE     BNaC1 and BNaC2 constitute a new family of human neuronal sodium
            channels related to degenerins and epithelial sodium channels
  JOURNAL   Proc Natl Acad Sci U S A 94 (4), 1459-1464 (1997)
   PUBMED   9037075
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645626.10, BC138530.1, CJ282964.1 and BB342826.1.
            
            On Oct 1, 2013 this sequence version replaced NM_007384.2.
            
            Transcript Variant: This variant (MDEG2) is the longer transcript
            and encodes the longer isoform (MDEG2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y14634.1, BC138530.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AL645626.10        105430-105580       c
            152-2650            BC138530.1         1-2499
            2651-3018           CJ282964.1         129-496
            3019-3024           BB342826.1         306-311
FEATURES             Location/Qualifiers
     source          1..3024
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 48.43 cM"
     gene            1..3024
                     /gene="Asic2"
                     /gene_synonym="Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg"
                     /note="acid-sensing ion channel 2"
                     /db_xref="GeneID:11418"
                     /db_xref="MGI:MGI:1100867"
     exon            1..1146
                     /gene="Asic2"
                     /gene_synonym="Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1297
                     /gene="Asic2"
                     /gene_synonym="Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1425
                     /gene="Asic2"
                     /gene_synonym="Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1576
                     /gene="Asic2"
                     /gene_synonym="Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1633
                     /gene="Asic2"
                     /gene_synonym="Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1787
                     /gene="Asic2"
                     /gene_synonym="Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1879
                     /gene="Asic2"
                     /gene_synonym="Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1959
                     /gene="Asic2"
                     /gene_synonym="Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2028
                     /gene="Asic2"
                     /gene_synonym="Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..3024
                     /gene="Asic2"
                     /gene_synonym="Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2986..2991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asic2"
                     /gene_synonym="Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg"
                     /note="hexamer: ATTAAA"
     polyA_site      3007
                     /gene="Asic2"
                     /gene_synonym="Accn1; ACIC2; BNaC1; BNaC1a; BNC1; Mdeg"
                     /note="major polyA site"
ORIGIN      
        1 gtaaaaactg gggttagtcc gtgcaggggg gactcatctc agggtccccc gaggtccagg
       61 accaggatag gtcggcgggc acagagccca gggattggag aggcggctcc caatggggcc
      121 cctccggagg tagtgcccag tgactctcgt ccttctggaa gactcggggc cagcagagcc
      181 tgggggtggg gggtagttag gagaggccag agctaggggc ggcgggccga ggcggcactc
      241 agtcccgggc gagcgcccgc ggaggcggcg gcggcgacgc cgggagggca tgccgcgcca
      301 ccggagctcc tgtcgggagc aggcttccct ggcacaagct gcgcgcggct gctgctgctc
      361 ccactgctgc tgcggactcc catggcggct ccgcccggcc ggggccgccg ccgctgtcgc
      421 cagcctcggg ctgaatgaat gagccggagc ggcggagccc ggctgccggc gaccgcgctc
      481 agcggcccgg gacgcttccg tatggcccgc gagcagccgg cgcccgcggc ggtggcggca
      541 gctaggcagc ccgggggcga ccggagcggc gatcgggagc tgcaggggcc aggggtcgcc
      601 cgcagggggc ggccgtccct gagtcgcact aaattgcacg ggctgcggca catgtgcgcg
      661 gggcgcacgg cggcgggagg ctctttccag cggcgggcgc tgtgggtgct ggccttctgc
      721 acgtcccttg gcttgctgtt gtcctggtcc tcgaaccgcc tgctctactg gctcagtttc
      781 ccgtcacaca cgcgagtgca ccgcgagtgg agccgccagc tgccgttccc cgctgtcacc
      841 gtgtgcaaca acaaccccct gcgcttcccg cgcctctcca agggggacct ctactacgcg
      901 ggccactggc taggactgct gctgcccaac cgcaccgcgc gcccgctggt cagcgagctg
      961 ctgcggggcg acgagccgcg cagacagtgg ttccgcaagc tggccgactt ccgcctcttc
     1021 ctgccgccgc gccacttcga gggcatcagc gctgccttca tggaccgtct gggccaccag
     1081 ctggaggaca tgctgctctc ctgcaagtac cggggcgagc tctgtggccc gcacaacttc
     1141 tcctcagtgt ttacaaaata tgggaagtgt tacatgttta actcaggcga ggatggcaag
     1201 cctctgctca ccacggtcaa gggggggacg ggcaacgggc tggagatcat gctggacatt
     1261 cagcaagatg agtacctgcc catctgggga gagacagagg aaacaacgtt tgaagcagga
     1321 gtgaaggttc agatccacag ccagtctgag ccacctttca tccaagagct gggctttggg
     1381 gtggctccgg ggttccagac cttcgtggcc acacaagagc agaggctcac atatctgccc
     1441 ccgccgtggg gggagtgccg gtcctcagag atgggactcg acttctttcc tgtttacagc
     1501 atcacagcct gtcggatcga ctgtgagacc cgctacatcg tggagaactg taactgccgc
     1561 atggtccaca tgccagggga tgcccctttc tgcacccctg agcagcacaa ggagtgtgca
     1621 gagccagccc tcggcttact ggcagaaaag gacagcaatt actgtctctg caggacaccc
     1681 tgcaacctga cccgctacaa caaagagctc tccatggtaa agatccccag caagacgtca
     1741 gccaagtacc tggagaagaa atttaacaaa tcggaaaaat atatctccga gaacattctt
     1801 gttctggata tattttttga ggcgctcaat tacgagacaa ttgaacagaa gaaggcgtat
     1861 gaagttgctg ccttacttgg tgacattggt ggtcaaatgg gattgttcat tggtgctagt
     1921 atccttacaa tactagagct ctttgattac atttacgagc tgatcaaaga gaagctatta
     1981 gacctgcttg gcaaagaaga agaggaaggg agccatgatg agaacatgag cacctgcgac
     2041 acaatgccaa accactccga aaccatcagc cacactgtga acgtgcccct gcagacagct
     2101 ttgggcaccc tggaggagat tgcctgctga cacctctcag gcagcccagc acctccaaac
     2161 agaccttaaa ggcccaagac ccaggacagg ggacagcaag ctcaggtggc atagcccctg
     2221 aggacagaaa gaagcaagag cccccccata tgcacacatt gcgaacttct gccaaacctc
     2281 acctggccac atctgacacg aacggtcccg ggcccagcct cgtgtccctc ataggaccga
     2341 tgagtcgcgc tccggaactg tccaagaact aacctgccat cacatctcac tgccagatgt
     2401 acaaagcacc tgcatgctca gacttcttac agcgccgcct ccacttgcgt cttgtacatg
     2461 atattttctc cgtgcggttt ccggagggag cccactctgc tacccaggca gtgggaccag
     2521 gttgcagacc caaagtcacc ctgagcccag ctctggaatc aaaactgcac tgtcaagaag
     2581 gaaaccacag aactctctac aacgtttgat ccttgtgttg ttcgtgaagg ttcctagcct
     2641 tgtcccccaa actggcccac tgggctcctg cactaaaggt gaccagtacc aacctcctcc
     2701 ttcttttctc agcacctgtg gaggaagtac ggtggcctgg gtgaccccag tatttgtcca
     2761 tggagccact ttgttctctc cctgtgacac agatgtagag tctgattttt gtttggggcg
     2821 ggggctgttc ttgtttgtct atggaagatt tgttttgttt tgcttcgtct tacggtcttt
     2881 ggtttttgat gttctaaggt tcggtttggg ttttccattt cttttctttt cttttttctt
     2941 ttttcttttt ggagtttatt tattcgtgct tcgaaccaca gtcatattaa aagctggtct
     3001 tgtggaagtg gccacaccat cctg
//
