LOCUS       NM_009597               4124 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus acid-sensing ion channel 1 (Asic1), transcript variant
            1, mRNA.
ACCESSION   NM_009597 XM_128133
VERSION     NM_009597.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4124)
  AUTHORS   Wang,Y.M., Tang,H., Tang,Y.J., Liu,J., Yin,Y.F., Tang,Y.L.,
            Feng,Y.G. and Gu,H.F.
  TITLE     ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy
  JOURNAL   J Adv Res 63, 195-206 (2024)
   PUBMED   37931656
  REMARK    GeneRIF: ASIC1/RIP1 accelerates atherosclerosis via disrupting
            lipophagy.
REFERENCE   2  (bases 1 to 4124)
  AUTHORS   Lai,K., Pritisanac,I., Liu,Z.Q., Liu,H.W., Gong,L.N., Li,M.X.,
            Lu,J.F., Qi,X., Xu,T.L., Forman-Kay,J., Shi,H.B., Wang,L.Y. and
            Yin,S.K.
  TITLE     Glutamate acts on acid-sensing ion channels to worsen ischaemic
            brain injury
  JOURNAL   Nature 631 (8022), 826-834 (2024)
   PUBMED   38987597
  REMARK    GeneRIF: Glutamate acts on acid-sensing ion channels to worsen
            ischaemic brain injury.
REFERENCE   3  (bases 1 to 4124)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4124)
  AUTHORS   Armstrong,A., Yang,T., Leng,T. and Xiong,Z.G.
  TITLE     Inhibition of ASIC1a Improves Behavioral Recovery after Stroke
  JOURNAL   eNeuro 11 (2) (2024)
   PUBMED   38233146
  REMARK    GeneRIF: Inhibition of ASIC1a Improves Behavioral Recovery after
            Stroke.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4124)
  AUTHORS   Peng,Z., Ziros,P.G., Martini,T., Liao,X.H., Stoop,R., Refetoff,S.,
            Albrecht,U., Sykiotis,G.P. and Kellenberger,S.
  TITLE     ASIC1a affects hypothalamic signaling and regulates the daily
            rhythm of body temperature in mice
  JOURNAL   Commun Biol 6 (1), 857 (2023)
   PUBMED   37591947
  REMARK    GeneRIF: ASIC1a affects hypothalamic signaling and regulates the
            daily rhythm of body temperature in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4124)
  AUTHORS   Alvarez de la Rosa,D., Krueger,S.R., Kolar,A., Shao,D.,
            Fitzsimonds,R.M. and Canessa,C.M.
  TITLE     Distribution, subcellular localization and ontogeny of ASIC1 in the
            mammalian central nervous system
  JOURNAL   J Physiol 546 (Pt 1), 77-87 (2003)
   PUBMED   12509480
  REMARK    GeneRIF: Ontogeny of ASIC1 in mouse brain revealed constant levels
            of expression of ASIC1 protein from embryonic day 12 to postnatal
            period, indicating early and almost constant level of expression of
            ASIC1 during brain development.
REFERENCE   7  (bases 1 to 4124)
  AUTHORS   Wemmie,J.A., Chen,J., Askwith,C.C., Hruska-Hageman,A.M.,
            Price,M.P., Nolan,B.C., Yoder,P.G., Lamani,E., Hoshi,T.,
            Freeman,J.H. Jr. and Welsh,M.J.
  TITLE     The acid-activated ion channel ASIC contributes to synaptic
            plasticity, learning, and memory
  JOURNAL   Neuron 34 (3), 463-477 (2002)
   PUBMED   11988176
  REMARK    GeneRIF: These results identify ASIC as a key component of
            acid-activated currents and implicate these currents in processes
            underlying synaptic plasticity, learning, and memory (ASIC
            channel).
REFERENCE   8  (bases 1 to 4124)
  AUTHORS   Benson,C.J., Xie,J., Wemmie,J.A., Price,M.P., Henss,J.M.,
            Welsh,M.J. and Snyder,P.M.
  TITLE     Heteromultimers of DEG/ENaC subunits form H+-gated channels in
            mouse sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 99 (4), 2338-2343 (2002)
   PUBMED   11854527
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Apr 2;99(7):4752]
REFERENCE   9  (bases 1 to 4124)
  AUTHORS   Bassler,E.L., Ngo-Anh,T.J., Geisler,H.S., Ruppersberg,J.P. and
            Grunder,S.
  TITLE     Molecular and functional characterization of acid-sensing ion
            channel (ASIC) 1b
  JOURNAL   J Biol Chem 276 (36), 33782-33787 (2001)
   PUBMED   11448963
REFERENCE   10 (bases 1 to 4124)
  AUTHORS   Garcia-Anoveros,J., Derfler,B., Neville-Golden,J., Hyman,B.T. and
            Corey,D.P.
  TITLE     BNaC1 and BNaC2 constitute a new family of human neuronal sodium
            channels related to degenerins and epithelial sodium channels
  JOURNAL   Proc Natl Acad Sci U S A 94 (4), 1459-1464 (1997)
   PUBMED   9037075
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB527867.1, BC067025.1 and AI850572.1.
            
            On Feb 17, 2018 this sequence version replaced NM_009597.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067025.1, SRR7345562.2509562.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               CB527867.1         10-350
            342-4105            BC067025.1         1-3764
            4106-4124           AI850572.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..4124
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.13 cM"
     gene            1..4124
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /note="acid-sensing ion channel 1"
                     /db_xref="GeneID:11419"
                     /db_xref="MGI:MGI:1194915"
     exon            1..518
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..896
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             535..2115
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     degenerin 2; brain sodium channel 2; amiloride-sensitive
                     cation channel 2, neuronal; acid-sensing (proton-gated)
                     ion channel 1"
                     /codon_start=1
                     /product="acid-sensing ion channel 1 isoform 1"
                     /protein_id="NP_033727.1"
                     /db_xref="CCDS:CCDS27826.1"
                     /db_xref="GeneID:11419"
                     /db_xref="MGI:MGI:1194915"
                     /translation="MELKTEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRA
                     LWALCFLGSLAVLLCVCTERVQYYFCYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQ
                     VSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDR
                     AGHDIRDMLLSCHFRGEACSAEDFKVVFTRYGKCYTFNSGQDGRPRLKTMKGGTGNGL
                     EIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQ
                     EQRLIYLPSPWGTCNAVTMDSDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY
                     CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKF
                     NKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLE
                     LFDYAYEVIKHRLCRRGKCQKEAKRNSADKGVALSLDDVKRHNPCESLRGHPAGMTYA
                     ANILPHHPARGTFEDFTC"
     exon            897..1092
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1243
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1371
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1522
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1579
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1733
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1825
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1905
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2010
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..4107
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3297..3302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /note="hexamer: CATAAA"
     polyA_site      3320
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /note="major polyA site"
     regulatory      4086..4091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /note="hexamer: AATAAA"
     polyA_site      4107
                     /gene="Asic1"
                     /gene_synonym="Accn2; ASIC; ASIC1a; ASIC1b; B530003N02Rik;
                     BNaC2"
                     /note="major polyA site"
ORIGIN      
        1 acacacacac aagccacagg gcctcgcaag cagagagcgg agccggctcc gggatccgaa
       61 cgaggcagct ctgctgagag cggcgggagg aggcgagcca gcggggggag ccctcggttc
      121 cgctcccggg ccgggggccc cccgcgcaca ccggcccaga gacaccctcg cagacactcg
      181 taggcgcgca cgcgcaccct ttcccctcct cctcccctcc cgccgcctcc cggccggacg
      241 atggatccct gcagatcccg gggctgagag caccgcgcag cgccagcgcg ccgagccccg
      301 ggcggaccaa gccgagcgag caagcgcgcg cgggcggcgg accgagctga gccgagctgg
      361 ccgagcgggc cgctccctgc agggctctac gcgggtgccg cggcagccgg cggctcgggc
      421 tccgggccat gagcccctcc gccgcgcggc gctgagccca cggaccgcct cgcgccccag
      481 gacctgcagc ggcggccggc tttccccagc cccctcagga tccccttggc aagcatggaa
      541 ctgaagaccg aggaggagga ggtgggtggt gtccagccgg tgagcatcca ggcttttgcc
      601 agcagctcca cgctgcacgg tcttgcccac atcttctcct atgagcggct gtctctgaag
      661 cgggcactgt gggccctgtg tttcctgggt tcgctggccg tcctgctgtg tgtgtgcact
      721 gagcgtgtgc agtactactt ctgctaccac cacgtcacca agctcgacga ggtggctgcc
      781 tcccagctca ccttccctgc cgtcactctc tgcaacctca atgagtttcg ctttagccaa
      841 gtctccaaga atgacctgta ccatgctggg gaactgctgg ccctgctcaa caacaggtat
      901 gagataccgg acacacagat ggctgatgaa aagcagctgg agatattgca ggacaaggcc
      961 aacttccgta gcttcaagcc caagcccttc aacatgcgtg agttctacga cagagcaggg
     1021 catgacattc gagacatgct tctctcgtgc cacttccgag gggaggcctg cagcgctgaa
     1081 gacttcaaag tggtcttcac gcggtatggg aagtgctaca cattcaactc gggccaagat
     1141 gggcggccac ggctgaagac catgaaaggt gggactggca acggcctgga gatcatgctg
     1201 gacattcagc aagatgaata cttgcctgtg tggggagaga ctgatgagac atcgttcgaa
     1261 gcaggcatca aagtgcagat ccacagtcag gacgagcctc ctttcatcga ccagctgggc
     1321 tttggcgtgg ccccaggctt ccagacgttt gtgtcttgcc aggagcagag gctcatctac
     1381 ctgccctccc cctggggcac ctgcaatgct gttaccatgg actcggattt cttcgactcc
     1441 tacagcatca cggcctgccg gattgattgt gaaacccgtt acctggtgga aaactgcaac
     1501 tgccgtatgg tgcacatgcc aggggatgcc ccatactgta ctccggagca gtacaaggag
     1561 tgtgcagacc ctgccctgga cttcctagtg gagaaagacc aggaatactg tgtgtgtgag
     1621 atgccctgca acctgacccg ctacggcaag gagctgtcca tggtcaagat ccccagcaaa
     1681 gcctcagcca agtacctggc caagaagttc aacaaatctg aacagtacat aggggagaat
     1741 attctggtgc tggacatttt ctttgaagtc ctcaactatg agaccatcga gcagaagaag
     1801 gcctatgaga tcgcagggct tttgggtgac atcgggggcc agatgggatt gttcatcggg
     1861 gccagcatcc tcacagtgct ggaactcttt gactatgcct atgaggtcat taagcaccgg
     1921 ctgtgtagac gtgggaagtg ccagaaggag gctaagagga acagcgcaga taagggcgtg
     1981 gcgctcagcc tggatgacgt caaaagacac aatccctgcg agagcctccg aggacatcct
     2041 gccgggatga cgtacgctgc caacatccta cctcaccatc ccgctcgagg cacgtttgag
     2101 gactttacct gctaagccct cgccagccgc tgtaccaaag gcctaggtgg ggagggctgg
     2161 gggagcaagg ggtacctaac tgcccccagc taccctgggg acttaaactg catccctggg
     2221 cagtggttcc ctcttgtctg tggtgagaaa ggagtcttga ccagagtcct ctcccagcct
     2281 ctatctcatc tttttatttt aacaaaatta aactaatata aagagagaga gagagagaga
     2341 gagagagaga gagagagaga gatcagccgc gacctcaggc tgcccctctg ctccacgctg
     2401 ccgcccccag ctccaagcct gaattctgtc tgtctggctg tatgtcatct gagtgtccac
     2461 ctacattctg ctgcctccag tcaccaaagc cccctcctag tgaggggtgg aggggatctc
     2521 tagggtctga aatttggccc caaaccagag aatgtacctt aagggagagg gctggtgtgg
     2581 gggcttccct agccttaaga gatgctctca gccgggtgac tccccacgag cccaagtctc
     2641 caggtaagga ctccgtgccc agttactgct ccctcaagca tacggaatct ttacggggca
     2701 gaggatttcc tgaagaagta gagattggga ctccatgtgg ccctggtgct gtaggccaca
     2761 tcccaatatc tgtaagtcac ctccacccca aagctgctgg agagagatcc caagaggcaa
     2821 ccctctgtga catcccccag aagacctggc tggttagcgc ccggctcagg gagaggggca
     2881 cggccgcctg acctcactgg cttctctctc agaggccttt gcagaaggcc acatccataa
     2941 attttcttat ggaacaatcc caagtcctct tccccgacgt catccgcttc tctcggcaac
     3001 ctcatctgca ttttctattt ctatatgata cagactctat attactataa ccttgtatat
     3061 actcccctcc ggccctgttt gtctccccct ccattccctc ttgtctccaa gaaccgccct
     3121 cccgccccta gttctccctt ctgtctctcc cccattctcc tgtctctgaa tgcctttgcc
     3181 cgtataaaga gctggattct cccctggtgt ctgtactgta ctgtgtacac acatccctct
     3241 gagaagcaca aggagatgac acgcgcattg taaccttcgc actgtctcgg tggcgacata
     3301 aaggaagctg tgaattacaa gctctgcctc tttctggcct cgccctttgc ccccacgacc
     3361 ggggcaccct ctgccctccc cacagcctta acataccctc taccttgctc cacctatccc
     3421 agtgcccttt gcctggctga ctgtggcctc cctgagggaa gtgactgctg gagaggtagc
     3481 tcctacccag gaatggagga cactaagcgg agagagttac agacgggagg tggggaggga
     3541 ggctggggat tggtgactcc ctcttgcagc tgggcggtgg gtacccacag ccagaagccg
     3601 gagccctgac tcagtggcct ttctttcttc ggggtgccca gggcccagtc ctcaccttga
     3661 tgcccaggcc caccgcttgc attttctggt gagtcagggc gtggtcacat gaggaaagag
     3721 attggcctag agcagaagtt gaaagacgtg ctgttgtgtg tccctaccct aagggggcca
     3781 caaggtgagg tagagggcct cctcaaccag acacccttcc caggccagct ctccaatctc
     3841 attcctggcc ttctctgtcc ccactgtctc ttggtctcta atcccaaaac aggacttatg
     3901 ggcagatcac ctgtgtacgt tggcctggag ccagagagca aggctttggc atctttgaga
     3961 cctcttggtt ctcaagagtt gtttagagat cagaactccc cagaaagaaa cagggcaaag
     4021 ctgagaaatg tacactggct gggggggcag caggaggggc tctgggtgac gcatgcctct
     4081 ggtctaataa actgggtttc aaccatcaaa aaaaaaaaaa aaaa
//
