LOCUS       NM_011791               3303 bp    mRNA    linear   ROD 26-OCT-2024
DEFINITION  Mus musculus ASH2 like histone lysine methyltransferase complex
            subunit (Ash2l), transcript variant 1, mRNA.
ACCESSION   NM_011791
VERSION     NM_011791.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3303)
  AUTHORS   Wang,Q., Zeng,S., Liang,Y., Zhou,R. and Wang,D.
  TITLE     ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification
  JOURNAL   J Invest Dermatol 144 (11), 2406-2416 (2024)
   PUBMED   38582368
  REMARK    GeneRIF: ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification.
REFERENCE   2  (bases 1 to 3303)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3303)
  AUTHORS   Zhong,W., Dong,Y.J., Hong,C., Li,Y.H., Xiao,C.X., Liu,X.H. and
            Chang,J.
  TITLE     ASH2L upregulation contributes to diabetic endothelial dysfunction
            in mice through STEAP4-mediated copper uptake
  JOURNAL   Acta Pharmacol Sin 45 (3), 558-569 (2024)
   PUBMED   37903897
  REMARK    GeneRIF: ASH2L upregulation contributes to diabetic endothelial
            dysfunction in mice through STEAP4-mediated copper uptake.
REFERENCE   4  (bases 1 to 3303)
  AUTHORS   Su,Z., Wang,J., Xiao,C., Zhong,W., Liu,J., Liu,X. and Zhu,Y.Z.
  TITLE     Functional role of Ash2l in oxLDL induced endothelial dysfunction
            and atherosclerosis
  JOURNAL   Cell Mol Life Sci 81 (1), 62 (2024)
   PUBMED   38280036
  REMARK    GeneRIF: Functional role of Ash2l in oxLDL induced endothelial
            dysfunction and atherosclerosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3303)
  AUTHORS   Zhu,X., Ma,Z., Xie,F. and Wang,J.
  TITLE     ASH2L, Core Subunit of H3K4 Methylation Complex, Regulates
            Amelogenesis
  JOURNAL   J Dent Res 103 (1), 81-90 (2024)
   PUBMED   37990471
  REMARK    GeneRIF: ASH2L, Core Subunit of H3K4 Methylation Complex, Regulates
            Amelogenesis.
REFERENCE   6  (bases 1 to 3303)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3303)
  AUTHORS   Hughes,C.M., Rozenblatt-Rosen,O., Milne,T.A., Copeland,T.D.,
            Levine,S.S., Lee,J.C., Hayes,D.N., Shanmugam,K.S.,
            Bhattacharjee,A., Biondi,C.A., Kay,G.F., Hayward,N.K., Hess,J.L.
            and Meyerson,M.
  TITLE     Menin associates with a trithorax family histone methyltransferase
            complex and with the hoxc8 locus
  JOURNAL   Mol Cell 13 (4), 587-597 (2004)
   PUBMED   14992727
REFERENCE   8  (bases 1 to 3303)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 3303)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 3303)
  AUTHORS   Ikegawa,S., Isomura,M., Koshizuka,Y. and Nakamura,Y.
  TITLE     Cloning and characterization of ASH2L and Ash2l, human and mouse
            homologs of the Drosophila ash2 gene
  JOURNAL   Cytogenet Cell Genet 84 (3-4), 167-172 (1999)
   PUBMED   10393421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122752.10, AK146938.1, CV556779.1 and BQ769493.1.
            
            On Oct 31, 2013 this sequence version replaced NM_011791.2.
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon in the central coding region compared to variant 4 and encodes
            a shorter protein (isoform a) compared to isoform d.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012957.1, AK146938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC122752.10        53334-53357         c
            25-2426             AK146938.1         2-2403
            2427-2823           CV556779.1         241-637
            2824-3280           BQ769493.1         274-730
            3281-3303           AC122752.10        28570-28592         c
FEATURES             Location/Qualifiers
     source          1..3303
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 14.17 cM"
     gene            1..3303
                     /gene="Ash2l"
                     /note="ASH2 like histone lysine methyltransferase complex
                     subunit"
                     /db_xref="GeneID:23808"
                     /db_xref="MGI:MGI:1344416"
     exon            1..206
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1902
                     /gene="Ash2l"
                     /note="isoform a is encoded by transcript variant 1;
                     set1/Ash2 histone methyltransferase complex subunit ASH2;
                     ASH2-like protein; ash2 (absent, small, or homeotic)-like"
                     /codon_start=1
                     /product="set1/Ash2 histone methyltransferase complex
                     subunit ASH2 isoform a"
                     /protein_id="NP_035921.2"
                     /db_xref="CCDS:CCDS40307.1"
                     /db_xref="GeneID:23808"
                     /db_xref="MGI:MGI:1344416"
                     /translation="MAAAGAGPGPGVSAGPGPGAAASATTAEDRETEPVAAGAGEGPS
                     AAPGAEPSSGEAESGDANLVDVSGLETESSNGKDTLEGTGDTSEVMDTQAGSVDEENG
                     RQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANL
                     KEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNI
                     VKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSASG
                     NLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKD
                     GYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDD
                     RLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDK
                     FSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIK
                     FKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYRDIFEGVYFPAISLYKS
                     CTVSINFGPSFKYPPKDLTYHPMSDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP"
     exon            207..270
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            271..416
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            417..505
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            506..600
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            601..696
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            697..792
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            793..868
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            869..962
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1180
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1348
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1542
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1635
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1734
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1794
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..3303
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1960..1965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ash2l"
                     /note="hexamer: TATAAA"
     polyA_site      1985
                     /gene="Ash2l"
     regulatory      2404..2409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ash2l"
                     /note="hexamer: AATAAA"
     polyA_site      2433
                     /gene="Ash2l"
                     /note="major polyA site"
     regulatory      2751..2756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ash2l"
                     /note="hexamer: AATACA"
     polyA_site      2783
                     /gene="Ash2l"
     regulatory      3281..3286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ash2l"
                     /note="hexamer: AATAAA"
     polyA_site      3299
                     /gene="Ash2l"
ORIGIN      
        1 attctcgcga gagcttggga aggagcagcg atggcggcgg ctggagcggg tcctggtccg
       61 ggagtcagcg ccggccctgg tcccggagcc gctgcaagtg ccacaacggc ggaggaccga
      121 gagacagagc cggtggccgc gggggctggc gaggggccgt cagccgcccc gggagcggag
      181 cccagctccg gagaggccga aagtggggat gcaaacttgg ttgatgtaag tggtctggag
      241 acagaatctt ctaatggaaa agatactttg gaaggtaccg gagacacttc agaagtgatg
      301 gatacccagg cgggctctgt ggatgaggag aatgggcggc agttgggaga agtggagttg
      361 cagtgtggga tatgtacaaa atggttcacc gctgacacct ttggaataga cacgtcgtca
      421 tgtctgcctt ttatgaccaa ctacagcttc cattgcaatg tgtgccatca cagtgggaat
      481 acctactttc tccggaagca agcaaattta aaagaaatgt gccttagtgc cttggcgaat
      541 ttgacgtggc agtctcgaac acaggatgaa catccaaaaa ccatgttctc caaagataag
      601 gatattatac catttattga taaatactgg gaatgtatga caaccagaca gagacctgga
      661 aaaatgactt ggcccaataa cattgtcaaa acaatgagta aggaaagaga tgtgttcttg
      721 gtaaaggaac accctgaccc aggaagcaaa gacccagaag aagattaccc caagtttgga
      781 cttttggatc aggatcttag taatattggt cctgcttatg acaaccagaa acaaagcagt
      841 gctgtgtctg ctagtgggaa cctaaatggg gggatcgcag ccggaagcag tgggaaagga
      901 agaggagcca agcgtaagca gcaagatgga gggacaacag ggaccaccaa gaaggccaga
      961 agtgatcctt tattttctgc tcagcgtctc cctcctcatg gctatccttt ggaacatcca
     1021 tttaacaaag atggctatcg gtatattctt gctgagcccg atcctcatgc ccccgacccg
     1081 gagaagcttg aacttgactg ctgggcggga aagcctattc ctggagacct ttacagagcc
     1141 tgcttatatg aacgagtctt gttagcccta catgatcgag ctccccagtt aaagatctct
     1201 gatgaccggc tgaccgtggt tggagagaag ggctactcca tggtccgggc ctctcatggg
     1261 gtacgcaaag gggcctggta ctttgaaatc actgtggatg agatgccccc agacactgct
     1321 gccaggctgg gctggtccca gcccttaggt aacctccaag ctcccttagg ctatgataag
     1381 tttagctatt cttggcggag caagaaaggc accaagttcc accagtccat tggcaagcac
     1441 tattcgtctg gctacggaca aggggacgtc ctagggttct atatcaacct tcccgaagac
     1501 acagagacag ccaagtcact gccggacacc tacaaagata aggctttgat aaagttcaag
     1561 agttatttgt attttgaaga aaaagacttt gtggacaaag cagagaagag cctaaaacag
     1621 accccccata gtgagataat attttataaa aatggtgtca atcagggtgt ggcttacaga
     1681 gatatttttg aaggagttta cttcccagcc atctcactgt acaagagctg cacggtttcc
     1741 attaactttg gaccatcctt caaataccct ccaaaggatc tcacgtacca ccctatgagt
     1801 gacatgggct ggggcgctgt ggtagaacac acactggctg atgttttgta tcacgtggag
     1861 acagaagtgg acggaagacg tagtccaccc tgggaaccct aaccagtcct tgcttctggt
     1921 gacactgtaa aataatcctg ggggttttgt ttttgttttt ataaagtgtc aaatgttttc
     1981 caagagatgc tgcagtacac tttgatcaag gtaaaagggt gggtgggact gcagcagtgc
     2041 ctgctcttca gcatccctgc cccacacaac tacttactct gagtgccata aatcagccgc
     2101 tccctgtaag gctgctgctg tgcccagacc tgccagggag gacctgttac tttcctgtgt
     2161 ctgtgtgttc caaagagcga gtaatcatgc tcagacagct tgcttgagga tgttggatcc
     2221 cctggtttct ggggaggcaa gcttgtttga gtggctgaaa tcaatggcat tccattccag
     2281 agcagtctaa aggcagtctt tttggtgtgg agtttgggga tcatctggga agctagtggg
     2341 ttctataaac tataattgtg aaaggaatat gcctacaggg tttaaaagat agatctttcc
     2401 tccaataaaa cttgttttca agcttgtatg gtacttggct tcactggaag tgaagttcct
     2461 gttgaccctg ttagcagtgt gagcagtgtg acggggacaa cactggcagg gtgggacagg
     2521 cgcttttatt gctgtcctcc ccgggtcacc aggcgctttc actgccctgt gtacagtgga
     2581 ctctcaggga gagcaagact gtagcaggcc tccagtccgt gtcttggaac ttggtgctga
     2641 tatgtgcggc ttgtcctctt gcctgccttt ctagtagcca gccaggggtt aggatcaaag
     2701 aatgatgagg agcctgcctt acgaggatgc cttaatgacc tccgatttta aatacataag
     2761 tctgtggcaa atgcaaaatc ctacactgac ctaaagactt cccttttttg tgtagccttt
     2821 tttgtttgtt tgctttgttt tgttttaact taagtactag tgatataaag tgactaacca
     2881 ggagctaggt aggatgcaga attatattct aagtattttg ttttgctatt taagaaattt
     2941 cccaagccgg gcgtggtggc gcacgccttt aatcccagca cttgggaggc agaggcagat
     3001 ttctgagttt gaggccagcc tggtctacaa agtgagttcc aggacagcca gggctacaca
     3061 gagaaaccct gtctcgaaaa aaccaaaaaa caacaacaac aaaaaaaaga aatttcccgg
     3121 gctggcgaga tggctcagtg gttaagagca ccaactgctc ttctgaaggt cccgagttca
     3181 aatcccaaca accacatgat ggctcacaac catccataac gagatctgat gccctcttct
     3241 ggagtatctg aggacagcta cagtgtactt acatataata aataaatctt taaaagaaag
     3301 aaa
//
