LOCUS       NM_001286207            3186 bp    mRNA    linear   ROD 26-OCT-2024
DEFINITION  Mus musculus ASH2 like histone lysine methyltransferase complex
            subunit (Ash2l), transcript variant 3, mRNA.
ACCESSION   NM_001286207
VERSION     NM_001286207.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3186)
  AUTHORS   Wang,Q., Zeng,S., Liang,Y., Zhou,R. and Wang,D.
  TITLE     ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification
  JOURNAL   J Invest Dermatol 144 (11), 2406-2416 (2024)
   PUBMED   38582368
  REMARK    GeneRIF: ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification.
REFERENCE   2  (bases 1 to 3186)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3186)
  AUTHORS   Zhong,W., Dong,Y.J., Hong,C., Li,Y.H., Xiao,C.X., Liu,X.H. and
            Chang,J.
  TITLE     ASH2L upregulation contributes to diabetic endothelial dysfunction
            in mice through STEAP4-mediated copper uptake
  JOURNAL   Acta Pharmacol Sin 45 (3), 558-569 (2024)
   PUBMED   37903897
  REMARK    GeneRIF: ASH2L upregulation contributes to diabetic endothelial
            dysfunction in mice through STEAP4-mediated copper uptake.
REFERENCE   4  (bases 1 to 3186)
  AUTHORS   Su,Z., Wang,J., Xiao,C., Zhong,W., Liu,J., Liu,X. and Zhu,Y.Z.
  TITLE     Functional role of Ash2l in oxLDL induced endothelial dysfunction
            and atherosclerosis
  JOURNAL   Cell Mol Life Sci 81 (1), 62 (2024)
   PUBMED   38280036
  REMARK    GeneRIF: Functional role of Ash2l in oxLDL induced endothelial
            dysfunction and atherosclerosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3186)
  AUTHORS   Zhu,X., Ma,Z., Xie,F. and Wang,J.
  TITLE     ASH2L, Core Subunit of H3K4 Methylation Complex, Regulates
            Amelogenesis
  JOURNAL   J Dent Res 103 (1), 81-90 (2024)
   PUBMED   37990471
  REMARK    GeneRIF: ASH2L, Core Subunit of H3K4 Methylation Complex, Regulates
            Amelogenesis.
REFERENCE   6  (bases 1 to 3186)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3186)
  AUTHORS   Hughes,C.M., Rozenblatt-Rosen,O., Milne,T.A., Copeland,T.D.,
            Levine,S.S., Lee,J.C., Hayes,D.N., Shanmugam,K.S.,
            Bhattacharjee,A., Biondi,C.A., Kay,G.F., Hayward,N.K., Hess,J.L.
            and Meyerson,M.
  TITLE     Menin associates with a trithorax family histone methyltransferase
            complex and with the hoxc8 locus
  JOURNAL   Mol Cell 13 (4), 587-597 (2004)
   PUBMED   14992727
REFERENCE   8  (bases 1 to 3186)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 3186)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 3186)
  AUTHORS   Ikegawa,S., Isomura,M., Koshizuka,Y. and Nakamura,Y.
  TITLE     Cloning and characterization of ASH2L and Ash2l, human and mouse
            homologs of the Drosophila ash2 gene
  JOURNAL   Cytogenet Cell Genet 84 (3-4), 167-172 (1999)
   PUBMED   10393421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122752.10, AK146599.1, CV556779.1 and BQ769493.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, has
            multiple differences in the coding region, and initiates
            translation at a downstream start codon, compared to variant 4. The
            resulting isoform (b) has, among multiple differences, a shorter
            N-terminus compared to isoform d. This variant (3), as well as
            variant 2, encodes isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146599.1, SRR7652917.143802.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC122752.10        53024-53027         c
            5-2300              AK146599.1         6-2301
            2301-2706           CV556779.1         232-637
            2707-3163           BQ769493.1         274-730
            3164-3186           AC122752.10        28570-28592         c
FEATURES             Location/Qualifiers
     source          1..3186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 14.17 cM"
     gene            1..3186
                     /gene="Ash2l"
                     /note="ASH2 like histone lysine methyltransferase complex
                     subunit"
                     /db_xref="GeneID:23808"
                     /db_xref="MGI:MGI:1344416"
     exon            1..89
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            90..153
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            154..299
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1785
                     /gene="Ash2l"
                     /note="isoform b is encoded by transcript variant 3;
                     set1/Ash2 histone methyltransferase complex subunit ASH2;
                     ASH2-like protein; ash2 (absent, small, or homeotic)-like"
                     /codon_start=1
                     /product="set1/Ash2 histone methyltransferase complex
                     subunit ASH2 isoform b"
                     /protein_id="NP_001273136.1"
                     /db_xref="CCDS:CCDS40308.1"
                     /db_xref="GeneID:23808"
                     /db_xref="MGI:MGI:1344416"
                     /translation="MDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLP
                     FMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKD
                     IIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKF
                     GLLDQDLSNIGPAYDNQKQSSAVSASGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTK
                     KARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPG
                     DLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVD
                     EMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVL
                     GFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFY
                     KNGVNQGVAYRDIFEGVYFPAISLYKSCTVSINFGPSFKYPPKDLTYHPMSDMGWGAV
                     VEHTLADVLYHVETEVDGRRSPPWEP"
     exon            300..388
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            389..483
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            484..579
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            580..675
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            676..751
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            752..845
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1063
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1231
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1425
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1518
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1617
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1677
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..3186
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1843..1848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ash2l"
                     /note="hexamer: TATAAA"
     polyA_site      1868
                     /gene="Ash2l"
     regulatory      2287..2292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ash2l"
                     /note="hexamer: AATAAA"
     polyA_site      2316
                     /gene="Ash2l"
                     /note="major polyA site"
     regulatory      2634..2639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ash2l"
                     /note="hexamer: AATACA"
     polyA_site      2666
                     /gene="Ash2l"
     regulatory      3164..3169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ash2l"
                     /note="hexamer: AATAAA"
     polyA_site      3182
                     /gene="Ash2l"
ORIGIN      
        1 gcccacccgg taccctccgc aaccccgctg gctgcttgct tgtggactcc aagccgctcc
       61 tcggctcctc ggctcccatc agcaccagtg gatgcaaact tggttgatgt aagtggtctg
      121 gagacagaat cttctaatgg aaaagatact ttggaaggta ccggagacac ttcagaagtg
      181 atggataccc aggcgggctc tgtggatgag gagaatgggc ggcagttggg agaagtggag
      241 ttgcagtgtg ggatatgtac aaaatggttc accgctgaca cctttggaat agacacgtcg
      301 tcatgtctgc cttttatgac caactacagc ttccattgca atgtgtgcca tcacagtggg
      361 aatacctact ttctccggaa gcaagcaaat ttaaaagaaa tgtgccttag tgccttggcg
      421 aatttgacgt ggcagtctcg aacacaggat gaacatccaa aaaccatgtt ctccaaagat
      481 aaggatatta taccatttat tgataaatac tgggaatgta tgacaaccag acagagacct
      541 ggaaaaatga cttggcccaa taacattgtc aaaacaatga gtaaggaaag agatgtgttc
      601 ttggtaaagg aacaccctga cccaggaagc aaagacccag aagaagatta ccccaagttt
      661 ggacttttgg atcaggatct tagtaatatt ggtcctgctt atgacaacca gaaacaaagc
      721 agtgctgtgt ctgctagtgg gaacctaaat ggggggatcg cagccggaag cagtgggaaa
      781 ggaagaggag ccaagcgtaa gcagcaagat ggagggacaa cagggaccac caagaaggcc
      841 agaagtgatc ctttattttc tgctcagcgt ctccctcctc atggctatcc tttggaacat
      901 ccatttaaca aagatggcta tcggtatatt cttgctgagc ccgatcctca tgcccccgac
      961 ccggagaagc ttgaacttga ctgctgggcg ggaaagccta ttcctggaga cctttacaga
     1021 gcctgcttat atgaacgagt cttgttagcc ctacatgatc gagctcccca gttaaagatc
     1081 tctgatgacc ggctgaccgt ggttggagag aagggctact ccatggtccg ggcctctcat
     1141 ggggtacgca aaggggcctg gtactttgaa atcactgtgg atgagatgcc cccagacact
     1201 gctgccaggc tgggctggtc ccagccctta ggtaacctcc aagctccctt aggctatgat
     1261 aagtttagct attcttggcg gagcaagaaa ggcaccaagt tccaccagtc cattggcaag
     1321 cactattcgt ctggctacgg acaaggggac gtcctagggt tctatatcaa ccttcccgaa
     1381 gacacagaga cagccaagtc actgccggac acctacaaag ataaggcttt gataaagttc
     1441 aagagttatt tgtattttga agaaaaagac tttgtggaca aagcagagaa gagcctaaaa
     1501 cagacccccc atagtgagat aatattttat aaaaatggtg tcaatcaggg tgtggcttac
     1561 agagatattt ttgaaggagt ttacttccca gccatctcac tgtacaagag ctgcacggtt
     1621 tccattaact ttggaccatc cttcaaatac cctccaaagg atctcacgta ccaccctatg
     1681 agtgacatgg gctggggcgc tgtggtagaa cacacactgg ctgatgtttt gtatcacgtg
     1741 gagacagaag tggacggaag acgtagtcca ccctgggaac cctaaccagt ccttgcttct
     1801 ggtgacactg taaaataatc ctgggggttt tgtttttgtt tttataaagt gtcaaatgtt
     1861 ttccaagaga tgctgcagta cactttgatc aaggtaaaag ggtgggtggg actgcagcag
     1921 tgcctgctct tcagcatccc tgccccacac aactacttac tctgagtgcc ataaatcagc
     1981 cgctccctgt aaggctgctg ctgtgcccag acctgccagg gaggacctgt tactttcctg
     2041 tgtctgtgtg ttccaaagag cgagtaatca tgctcagaca gcttgcttga ggatgttgga
     2101 tcccctggtt tctggggagg caagcttgtt tgagtggctg aaatcaatgg cattccattc
     2161 cagagcagtc taaaggcagt ctttttggtg tggagtttgg ggatcatctg ggaagctagt
     2221 gggttctata aactataatt gtgaaaggaa tatgcctaca gggtttaaaa gatagatctt
     2281 tcctccaata aaacttgttt tcaagcttgt atggtacttg gcttcactgg aagtgaagtt
     2341 cctgttgacc ctgttagcag tgtgagcagt gtgacgggga caacactggc agggtgggac
     2401 aggcgctttt attgctgtcc tccccgggtc accaggcgct ttcactgccc tgtgtacagt
     2461 ggactctcag ggagagcaag actgtagcag gcctccagtc cgtgtcttgg aacttggtgc
     2521 tgatatgtgc ggcttgtcct cttgcctgcc tttctagtag ccagccaggg gttaggatca
     2581 aagaatgatg aggagcctgc cttacgagga tgccttaatg acctccgatt ttaaatacat
     2641 aagtctgtgg caaatgcaaa atcctacact gacctaaaga cttccctttt ttgtgtagcc
     2701 ttttttgttt gtttgctttg ttttgtttta acttaagtac tagtgatata aagtgactaa
     2761 ccaggagcta ggtaggatgc agaattatat tctaagtatt ttgttttgct atttaagaaa
     2821 tttcccaagc cgggcgtggt ggcgcacgcc tttaatccca gcacttggga ggcagaggca
     2881 gatttctgag tttgaggcca gcctggtcta caaagtgagt tccaggacag ccagggctac
     2941 acagagaaac cctgtctcga aaaaaccaaa aaacaacaac aacaaaaaaa agaaatttcc
     3001 cgggctggcg agatggctca gtggttaaga gcaccaactg ctcttctgaa ggtcccgagt
     3061 tcaaatccca acaaccacat gatggctcac aaccatccat aacgagatct gatgccctct
     3121 tctggagtat ctgaggacag ctacagtgta cttacatata ataaataaat ctttaaaaga
     3181 aagaaa
//
