LOCUS       NM_007493               1373 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus asialoglycoprotein receptor 2 (Asgr2), transcript
            variant 2, mRNA.
ACCESSION   NM_007493
VERSION     NM_007493.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1373)
  AUTHORS   Kim,H., Zaheer,J., Choi,E.J. and Kim,J.S.
  TITLE     Enhanced ASGR2 by microplastic exposure leads to resistance to
            therapy in gastric cancer
  JOURNAL   Theranostics 12 (7), 3217-3236 (2022)
   PUBMED   35547772
  REMARK    GeneRIF: Enhanced ASGR2 by microplastic exposure leads to
            resistance to therapy in gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1373)
  AUTHORS   Susan-Resiga,D., Girard,E., Essalmani,R., Roubtsova,A.,
            Marcinkiewicz,J., Derbali,R.M., Evagelidis,A., Byun,J.H.,
            Lebeau,P.F., Austin,R.C. and Seidah,N.G.
  TITLE     Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand
            of liver LDLR cleaved by furin
  JOURNAL   J Biol Chem 297 (4), 101177 (2021)
   PUBMED   34508778
REFERENCE   3  (bases 1 to 1373)
  AUTHORS   Yang,W.H., Heithoff,D.M., Aziz,P.V., Haslund-Gourley,B.,
            Westman,J.S., Narisawa,S., Pinkerton,A.B., Millan,J.L., Nizet,V.,
            Mahan,M.J. and Marth,J.D.
  TITLE     Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes
            by Discrete Pathogens Fuels Sepsis
  JOURNAL   Cell Host Microbe 24 (4), 500-513 (2018)
   PUBMED   30308156
REFERENCE   4  (bases 1 to 1373)
  AUTHORS   Mi,Y., Coonce,M., Fiete,D., Steirer,L., Dveksler,G., Townsend,R.R.
            and Baenziger,J.U.
  TITLE     Functional Consequences of Mannose and Asialoglycoprotein Receptor
            Ablation
  JOURNAL   J Biol Chem 291 (36), 18700-18717 (2016)
   PUBMED   27405760
  REMARK    GeneRIF: the key roles of the ManR and ASGR in controlling
            circulating levels of numerous glycoproteins critical for
            regulating reproductive hormones and blood coagulation.
REFERENCE   5  (bases 1 to 1373)
  AUTHORS   Yang,W.H., Aziz,P.V., Heithoff,D.M., Mahan,M.J., Smith,J.W. and
            Marth,J.D.
  TITLE     An intrinsic mechanism of secreted protein aging and turnover
  JOURNAL   Proc Natl Acad Sci U S A 112 (44), 13657-13662 (2015)
   PUBMED   26489654
REFERENCE   6  (bases 1 to 1373)
  AUTHORS   Dalton,S.R., Wiegert,R.L., Baldwin,C.R., Kassel,K.M. and Casey,C.A.
  TITLE     Impaired receptor-mediated endocytosis by the asialoglycoprotein
            receptor in ethanol-fed mice: implications for studying the role of
            this receptor in alcoholic apoptosis
  JOURNAL   Biochem Pharmacol 65 (4), 535-543 (2003)
   PUBMED   12566080
REFERENCE   7  (bases 1 to 1373)
  AUTHORS   Braun,J.R., Willnow,T.E., Ishibashi,S., Ashwell,G. and Herz,J.
  TITLE     The major subunit of the asialoglycoprotein receptor is expressed
            on the hepatocellular surface in mice lacking the minor receptor
            subunit
  JOURNAL   J Biol Chem 271 (35), 21160-21166 (1996)
   PUBMED   8702886
REFERENCE   8  (bases 1 to 1373)
  AUTHORS   Ishibashi,S., Hammer,R.E. and Herz,J.
  TITLE     Asialoglycoprotein receptor deficiency in mice lacking the minor
            receptor subunit
  JOURNAL   J Biol Chem 269 (45), 27803-27806 (1994)
   PUBMED   7961705
REFERENCE   9  (bases 1 to 1373)
  AUTHORS   Sanford,J.P. and Doyle,D.
  TITLE     Mouse asialoglycoprotein receptor cDNA sequence: conservation of
            receptor genes during mammalian evolution
  JOURNAL   Biochim Biophys Acta 1087 (2), 259-261 (1990)
   PUBMED   2223888
REFERENCE   10 (bases 1 to 1373)
  AUTHORS   Sanford,J.P., Elliott,R.W. and Doyle,D.
  TITLE     Asialoglycoprotein receptor genes are linked on chromosome 11 in
            the mouse
  JOURNAL   DNA 7 (10), 721-728 (1988)
   PUBMED   3234178
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL596185.12.
            
            On Nov 17, 2006 this sequence version replaced NM_007493.2.
            
            Summary: This gene encodes a subunit of the asialoglycoprotein
            receptor. This receptor is a transmembrane protein that plays a
            critical role in serum glycoprotein homeostasis by mediating the
            endocytosis and lysosomal degradation of glycoproteins with exposed
            terminal galactose or N-acetylgalactosamine residues. The
            asialoglycoprotein receptor is a hetero-oligomeric protein composed
            of major and minor subunits, which are encoded by different genes.
            The protein encoded by this gene is the less abundant minor
            subunit. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene [provided by
            RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011197.1, X53042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL596185.12        204289-204435
            148-285             AL596185.12        204701-204838
            286-402             AL596185.12        208447-208563
            403-498             AL596185.12        208824-208919
            499-570             AL596185.12        209465-209536
            571-657             AL596185.12        209698-209784
            658-803             AL596185.12        209873-210018
            804-910             AL596185.12        217021-217127
            911-1373            AL596185.12        217370-217832
FEATURES             Location/Qualifiers
     source          1..1373
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.99 cM"
     gene            1..1373
                     /gene="Asgr2"
                     /gene_synonym="ASGPR2; Asgr; Asgr-2; HL-2"
                     /note="asialoglycoprotein receptor 2"
                     /db_xref="GeneID:11890"
                     /db_xref="MGI:MGI:88082"
     exon            1..147
                     /gene="Asgr2"
                     /gene_synonym="ASGPR2; Asgr; Asgr-2; HL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            148..285
                     /gene="Asgr2"
                     /gene_synonym="ASGPR2; Asgr; Asgr-2; HL-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1067
                     /gene="Asgr2"
                     /gene_synonym="ASGPR2; Asgr; Asgr-2; HL-2"
                     /note="isoform a is encoded by transcript variant 2;
                     hepatic lectin 2"
                     /codon_start=1
                     /product="asialoglycoprotein receptor 2 isoform a"
                     /protein_id="NP_031519.1"
                     /db_xref="CCDS:CCDS24934.1"
                     /db_xref="GeneID:11890"
                     /db_xref="MGI:MGI:88082"
                     /translation="MEKDCQDIQQLDSEENDHQLSGDDEHGSHVQDPRIENPHWKGQP
                     LSRPFPQRLCSTFRLSLLALAFNILLLVVICVVSSQSIQLQEEFRTLKETFSNFSSST
                     LMEFGALDTLGGSTNAILTSWLAQLEEKQQQLKADHSTLLFHLKHFPMDLRTLTCQLA
                     YFQSNGTECCPVNWVEFGGSCYWFSRDGLTWAEADQYCQLENAHLLVINSREEQDFVV
                     KHRSQFHIWIGLTDRDGSWKWVDGTDYRSNYRNWAFTQPDNWQGHEQGGGEDCAEILS
                     DGHWNDNFCQQVNRWVCEKRRNITH"
     exon            286..402
                     /gene="Asgr2"
                     /gene_synonym="ASGPR2; Asgr; Asgr-2; HL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            403..498
                     /gene="Asgr2"
                     /gene_synonym="ASGPR2; Asgr; Asgr-2; HL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            499..570
                     /gene="Asgr2"
                     /gene_synonym="ASGPR2; Asgr; Asgr-2; HL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            571..657
                     /gene="Asgr2"
                     /gene_synonym="ASGPR2; Asgr; Asgr-2; HL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            658..803
                     /gene="Asgr2"
                     /gene_synonym="ASGPR2; Asgr; Asgr-2; HL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            804..910
                     /gene="Asgr2"
                     /gene_synonym="ASGPR2; Asgr; Asgr-2; HL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1373
                     /gene="Asgr2"
                     /gene_synonym="ASGPR2; Asgr; Asgr-2; HL-2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1373
                     /gene="Asgr2"
                     /gene_synonym="ASGPR2; Asgr; Asgr-2; HL-2"
                     /note="major polyA site"
ORIGIN      
        1 gacccagctc ttgcctagat tggcccctcc tccctctcac ctagctccac tagcaccacc
       61 tgtcccgtct cccaggttta gcccctcttt ctctttgggc tcaggctgtc tccgaaagcc
      121 agagtcagct ctctatacct ttaacagccc ttagggccat catggagaag gactgtcaag
      181 acatccagca gctggactct gaggagaatg accatcagct cagtggcgat gatgaacatg
      241 gctctcatgt gcaggatcct aggatagaaa atccacactg gaaagggcag cctctttcca
      301 ggccctttcc tcagcgcctc tgctccacgt tccgcctcag tctgctcgcc ctggccttca
      361 acatcctcct gttggtggtc atctgtgtgg tttcatctca aagcatacag ctgcaagaag
      421 agtttcggac cctgaaagaa accttcagca acttttcctc cagcaccctg atggagttcg
      481 gggctctgga caccctcgga ggtagcacaa acgccatact gacttcctgg ttagcccaac
      541 tggaggagaa gcagcaacag ctaaaggcag accattccac attgctcttt cacctgaagc
      601 acttcccaat ggatctgcga accctgacct gtcagctggc gtacttccag agcaatggca
      661 cggaatgctg ccctgttaac tgggtggagt tcgggggaag ctgctactgg ttttctcggg
      721 atgggctcac ctgggctgag gctgaccagt actgccagct ggagaacgcc cacctgctgg
      781 tcatcaactc cagggaggag caggactttg ttgtaaagca caggagccag tttcatattt
      841 ggataggtct taccgacagg gatggctcct ggaaatgggt ggatggaact gattatagaa
      901 gcaactacag gaattgggcc ttcactcagc cagataactg gcagggccat gaacagggtg
      961 gaggtgaaga ctgtgctgaa atcctgtcag atggccattg gaatgacaac ttctgccagc
     1021 aggtgaaccg ctgggtatgc gaaaagagac ggaacatcac ccactaggag tcggctcgac
     1081 caatccccca ccccgccccc acccccacat cccccactag gagtctgctc aatcatgcct
     1141 ctgccctacc tccagcccca caccacccca acatcctcac tggggatact ggagcaagga
     1201 agagagacag ggtcccaagc atgaggaggg gttatggaaa actggaaagg gcatggctct
     1261 atggtctcat accttaggaa gactgagaat ccccccttct gcacaattta ttgcaattgt
     1321 tataaatttc ggccttctga atggagtagg aaaaaaaaga gaaagacttg aaa
//
