LOCUS       NM_009714               1260 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus asialoglycoprotein receptor 1 (Asgr1), transcript
            variant 1, mRNA.
ACCESSION   NM_009714
VERSION     NM_009714.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1260)
  AUTHORS   Zhang,Z., Leng,X.K., Zhai,Y.Y., Zhang,X., Sun,Z.W., Xiao,J.Y.,
            Lu,J.F., Liu,K., Xia,B., Gao,Q., Jia,M., Xu,C.Q., Jiang,Y.N.,
            Zhang,X.G., Tao,K.S. and Wu,J.W.
  TITLE     Deficiency of ASGR1 promotes liver injury by increasing
            GP73-mediated hepatic endoplasmic reticulum stress
  JOURNAL   Nat Commun 15 (1), 1908 (2024)
   PUBMED   38459023
  REMARK    GeneRIF: Deficiency of ASGR1 promotes liver injury by increasing
            GP73-mediated hepatic endoplasmic reticulum stress.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1260)
  AUTHORS   Svecla,M., Da Dalt,L., Moregola,A., Nour,J., Baragetti,A.,
            Uboldi,P., Donetti,E., Arnaboldi,L., Beretta,G., Bonacina,F. and
            Norata,G.D.
  TITLE     ASGR1 deficiency diverts lipids toward adipose tissue but results
            in liver damage during obesity
  JOURNAL   Cardiovasc Diabetol 23 (1), 42 (2024)
   PUBMED   38281933
  REMARK    GeneRIF: ASGR1 deficiency diverts lipids toward adipose tissue but
            results in liver damage during obesity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1260)
  AUTHORS   Shi,R., Wang,J., Zhang,Z., Leng,Y. and Chen,A.F.
  TITLE     ASGR1 promotes liver injury in sepsis by modulating
            monocyte-to-macrophage differentiation via NF-kappaB/ATF5 pathway
  JOURNAL   Life Sci 315, 121339 (2023)
   PUBMED   36621538
  REMARK    GeneRIF: ASGR1 promotes liver injury in sepsis by modulating
            monocyte-to-macrophage differentiation via NF-kappaB/ATF5 pathway.
REFERENCE   4  (bases 1 to 1260)
  AUTHORS   Zhu,X., Song,G., Zhang,S., Chen,J., Hu,X., Zhu,H., Jia,X., Li,Z.,
            Song,W., Chen,J., Jin,C., Zhou,M., Zhao,Y., Xie,H., Zheng,S. and
            Song,P.
  TITLE     Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in
            Liver Cancer via Inhibition of STAT3
  JOURNAL   Cancer Res 82 (21), 3987-4000 (2022)
   PUBMED   36043912
REFERENCE   5  (bases 1 to 1260)
  AUTHORS   An,H., Qian,C., Huang,Y., Li,J., Tian,X., Feng,J., Hu,J., Fang,Y.,
            Jiao,F., Zeng,Y., Huang,X., Meng,X., Liu,X., Lin,X., Zeng,Z.,
            Guilliams,M., Beschin,A., Chen,Y., Wu,Y., Wang,J., Oggioni,M.R.,
            Leong,J., Veening,J.W., Deng,H., Zhang,R., Wang,H., Wu,J., Cui,Y.
            and Zhang,J.R.
  TITLE     Functional vulnerability of liver macrophages to capsules defines
            virulence of blood-borne bacteria
  JOURNAL   J Exp Med 219 (4) (2022)
   PUBMED   35258552
REFERENCE   6  (bases 1 to 1260)
  AUTHORS   Remmers,E.F., Goldmuntz,E.A., Cash,J.M., Crofford,L.J.,
            Misiewicz-Poltorak,B., Zha,H. and Wilder,R.L.
  TITLE     Genetic map of nine polymorphic loci comprising a single linkage
            group on rat chromosome 10: evidence for linkage conservation with
            human chromosome 17 and mouse chromosome 11
  JOURNAL   Genomics 14 (3), 618-623 (1992)
   PUBMED   1358809
REFERENCE   7  (bases 1 to 1260)
  AUTHORS   Baron,B., Poirier,C., Simon-Chazottes,D., Barnier,C. and
            Guenet,J.L.
  TITLE     A new strategy useful for rapid identification of microsatellites
            from DNA libraries with large size inserts
  JOURNAL   Nucleic Acids Res 20 (14), 3665-3669 (1992)
   PUBMED   1386425
REFERENCE   8  (bases 1 to 1260)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   9  (bases 1 to 1260)
  AUTHORS   Buckwalter,M.S., Katz,R.W. and Camper,S.A.
  TITLE     Localization of the panhypopituitary dwarf mutation (df) on mouse
            chromosome 11 in an intersubspecific backcross
  JOURNAL   Genomics 10 (3), 515-526 (1991)
   PUBMED   1889803
REFERENCE   10 (bases 1 to 1260)
  AUTHORS   Hsieh,C.L., Cheng-Deutsch,A., Gloor,S., Schachner,M. and Francke,U.
  TITLE     Assignment of Amog (adhesion molecule on glia) gene to mouse
            chromosome 11 near Zfp-3 and Asgr-1,2 and to human chromosome 17
  JOURNAL   Somat Cell Mol Genet 16 (4), 401-405 (1990)
   PUBMED   1699290
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596185.12 and AK132959.1.
            
            On Mar 26, 2014 this sequence version replaced NM_009714.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Both variants 1 and
            2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022106.1, U09362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AL596185.12        166000-166133
            135-1259            AK132959.1         26-1150
            1260-1260           AL596185.12        169540-169540
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.98 cM"
     gene            1..1260
                     /gene="Asgr1"
                     /gene_synonym="ASGPR1; Asgr; Asgr-1; HL-1"
                     /note="asialoglycoprotein receptor 1"
                     /db_xref="GeneID:11889"
                     /db_xref="MGI:MGI:88081"
     exon            1..134
                     /gene="Asgr1"
                     /gene_synonym="ASGPR1; Asgr; Asgr-1; HL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            135..220
                     /gene="Asgr1"
                     /gene_synonym="ASGPR1; Asgr; Asgr-1; HL-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1008
                     /gene="Asgr1"
                     /gene_synonym="ASGPR1; Asgr; Asgr-1; HL-1"
                     /note="isoform a is encoded by transcript variant 1;
                     hepatic lectin 1"
                     /codon_start=1
                     /product="asialoglycoprotein receptor 1 isoform a"
                     /protein_id="NP_033844.1"
                     /db_xref="CCDS:CCDS24933.1"
                     /db_xref="GeneID:11889"
                     /db_xref="MGI:MGI:88081"
                     /translation="MTKDYQDFQHLDNDNDHHQLRRGPPPTPRLLQRLCSGSRLLLLS
                     SSLSILLLVVVCVITSQNSQLREDLLALRQNFSNLTVSTEDQVKALSTQGSSVGRKMK
                     LVESKLEKQQKDLTEDHSSLLLHVKQLVSDVRSLSCQMAAFRGNGSERTCCPINWVEY
                     EGSCYWFSSSVRPWTEADKYCQLENAHLVVVTSRDEQNFLQRHMGPLNTWIGLTDQNG
                     PWKWVDGTDYETGFQNWRPEQPDNWYGHGLGGGEDCAHFTTDGRWNDDVCRRPYRWVC
                     ETKLDKAN"
     exon            221..337
                     /gene="Asgr1"
                     /gene_synonym="ASGPR1; Asgr; Asgr-1; HL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            338..433
                     /gene="Asgr1"
                     /gene_synonym="ASGPR1; Asgr; Asgr-1; HL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..505
                     /gene="Asgr1"
                     /gene_synonym="ASGPR1; Asgr; Asgr-1; HL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..592
                     /gene="Asgr1"
                     /gene_synonym="ASGPR1; Asgr; Asgr-1; HL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..744
                     /gene="Asgr1"
                     /gene_synonym="ASGPR1; Asgr; Asgr-1; HL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..851
                     /gene="Asgr1"
                     /gene_synonym="ASGPR1; Asgr; Asgr-1; HL-1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1260
                     /gene="Asgr1"
                     /gene_synonym="ASGPR1; Asgr; Asgr-1; HL-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1234..1239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asgr1"
                     /gene_synonym="ASGPR1; Asgr; Asgr-1; HL-1"
                     /note="hexamer: AGTAAA"
     polyA_site      1255
                     /gene="Asgr1"
                     /gene_synonym="ASGPR1; Asgr; Asgr-1; HL-1"
                     /note="major polyA site"
ORIGIN      
        1 agcgtgctcg gacacacatg ggccctggat ggaccctgtc ccctcccctc ccattgccca
       61 gggctcttca cctggttctt caggcttcag ccccctcctt agcctgggct cttcgtggtg
      121 ctgagggacc ttcagtccgg atccagtgcc atcatgacaa aggattatca agatttccag
      181 cacctggaca atgataatga ccatcatcaa ctccggagag ggccgcctcc cactccacgg
      241 ctcttgcagc gactctgctc tggatcccgc ctcctcctgc tctcctcgag cctcagcatt
      301 ctgttgctgg tggttgtctg tgtgatcaca tcccaaaatt cccaactccg ggaagatctg
      361 ctggctctaa ggcagaattt cagcaacctc actgtgagca ctgaggacca ggtcaaggcc
      421 ctgagcaccc agggaagtag tgtgggaaga aagatgaagt tagtggagtc gaagctggaa
      481 aaacagcaga aggatctgac tgaagatcac tccagtttgc tactgcacgt gaagcagtta
      541 gtgtctgacg tgcgaagctt gagctgccag atggctgcat ttcggggcaa tggctctgaa
      601 aggacctgct gccccatcaa ctgggtggag tatgaaggca gctgctactg gttctccagc
      661 tctgtgaggc cttggactga agctgacaag tactgccagc tggaaaatgc ccatctggtg
      721 gtggtgacct ccagggatga gcagaacttc ctccagcgcc acatgggccc cttaaacact
      781 tggattggcc taactgacca gaacgggccc tggaaatggg tggatggaac agactacgag
      841 acaggcttcc agaattggag accagagcag ccagataact ggtacggaca tgggcttgga
      901 ggaggcgagg actgtgccca cttcacgacg gatggccgct ggaatgacga cgtctgcagg
      961 aggccctacc gctgggtctg tgagacaaag ttggataagg ctaattagga accttccttc
     1021 ccctcattta tatccttaat tccttgagct gctgaggttt agaactggta gagcctacct
     1081 aagggtctcc ccatctccag gaactctcat gtaggatttt taaaggaccg gtaaagaatg
     1141 gtgtttgaga aatggtgtat gatgcctggt ggtggtaggg gtgcgtattg aaacccagcg
     1201 cgcagttctc ttctgtcagc ttgttttttt tagagtaaaa ggaagagaaa taaaagttca
//
