LOCUS       NM_025541               2192 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus anti-silencing function 1A histone chaperone (Asf1a),
            mRNA.
ACCESSION   NM_025541
VERSION     NM_025541.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2192)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2192)
  AUTHORS   Wang,X., Wang,L., Dou,J., Yu,T., Cao,P., Fan,N., Borjigin,U. and
            Nashun,B.
  TITLE     Distinct role of histone chaperone Asf1a and Asf1b during
            fertilization and pre-implantation embryonic development in mice
  JOURNAL   Epigenetics Chromatin 14 (1), 55 (2021)
   PUBMED   34906203
  REMARK    GeneRIF: Distinct role of histone chaperone Asf1a and Asf1b during
            fertilization and pre-implantation embryonic development in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2192)
  AUTHORS   Deng,K., Feng,W., Liu,X., Su,X., Zuo,E., Du,S., Huang,Y., Shi,D.
            and Lu,F.
  TITLE     Anti-silencing factor 1A is associated with genome stability
            maintenance of mouse preimplantation embryosdagger
  JOURNAL   Biol Reprod 102 (4), 817-827 (2020)
   PUBMED   31916576
  REMARK    GeneRIF: Anti-silencing factor 1A is associated with genome
            stability maintenance of mouse preimplantation embryosdagger.
REFERENCE   4  (bases 1 to 2192)
  AUTHORS   Li,F., Huang,Q., Luster,T.A., Hu,H., Zhang,H., Ng,W.L.,
            Khodadadi-Jamayran,A., Wang,W., Chen,T., Deng,J., Ranieri,M.,
            Fang,Z., Pyon,V., Dowling,C.M., Bagdatlioglu,E., Almonte,C.,
            Labbe,K., Silver,H., Rabin,A.R., Jani,K., Tsirigos,A.,
            Papagiannakopoulos,T., Hammerman,P.S., Velcheti,V., Freeman,G.J.,
            Qi,J., Miller,G. and Wong,K.K.
  TITLE     In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an
            Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma
  JOURNAL   Cancer Discov 10 (2), 270-287 (2020)
   PUBMED   31744829
  REMARK    GeneRIF: In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an
            Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma.
REFERENCE   5  (bases 1 to 2192)
  AUTHORS   Gao,Y., Gan,H., Lou,Z. and Zhang,Z.
  TITLE     Asf1a resolves bivalent chromatin domains for the induction of
            lineage-specific genes during mouse embryonic stem cell
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 115 (27), E6162-E6171 (2018)
   PUBMED   29915027
  REMARK    GeneRIF: Asf1a-mediated nucleosome disassembly provides a means for
            resolution of bivalent domain barriers for induction of
            lineage-specific genes during differentiation.
REFERENCE   6  (bases 1 to 2192)
  AUTHORS   Hartford,S.A., Luo,Y., Southard,T.L., Min,I.M., Lis,J.T. and
            Schimenti,J.C.
  TITLE     Minichromosome maintenance helicase paralog MCM9 is dispensible for
            DNA replication but functions in germ-line stem cells and tumor
            suppression
  JOURNAL   Proc Natl Acad Sci U S A 108 (43), 17702-17707 (2011)
   PUBMED   21987787
REFERENCE   7  (bases 1 to 2192)
  AUTHORS   Fernandez-Tenorio,M., Porras-Gonzalez,C., Castellano,A., Del
            Valle-Rodriguez,A., Lopez-Barneo,J. and Urena,J.
  TITLE     Metabotropic regulation of RhoA/Rho-associated kinase by L-type
            Ca2+ channels: new mechanism for depolarization-evoked mammalian
            arterial contraction
  JOURNAL   Circ Res 108 (11), 1348-1357 (2011)
   PUBMED   21493898
REFERENCE   8  (bases 1 to 2192)
  AUTHORS   Canfield,C., Rains,J. and De Benedetti,A.
  TITLE     TLK1B promotes repair of DSBs via its interaction with Rad9 and
            Asf1
  JOURNAL   BMC Mol Biol 10, 110 (2009)
   PUBMED   20021694
  REMARK    GeneRIF: tousled-like kinases play important roles in DNA repair,
            not only by modulation of chromatin assembly via Asf1, but also by
            a more direct function in processing the ends of a tousled-like
            kinase via interaction with Rad9.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2192)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   10 (bases 1 to 2192)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK010210.1 and AC153949.3.
            
            On Oct 5, 2005 this sequence version replaced NM_025541.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088618.1, AK031513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-967               AK010210.1         11-977
            968-2192            AC153949.3         76106-77330
FEATURES             Location/Qualifiers
     source          1..2192
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 27.24 cM"
     gene            1..2192
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
                     /note="anti-silencing function 1A histone chaperone"
                     /db_xref="GeneID:66403"
                     /db_xref="MGI:MGI:1913653"
     exon            1..338
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..844
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
                     /note="anti-silencing function protein 1 homolog A; ASF1
                     anti-silencing function 1 homolog A"
                     /codon_start=1
                     /product="histone chaperone ASF1A"
                     /protein_id="NP_079817.1"
                     /db_xref="CCDS:CCDS23847.1"
                     /db_xref="GeneID:66403"
                     /db_xref="MGI:MGI:1913653"
                     /translation="MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIY
                     VGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNAGLIPDADAVGVTVVLITCTYR
                     GQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKL
                     EDAESSNPNLQSLLSTDALPSASKGWSTSENSLNVMLESHMDCM"
     exon            339..454
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            455..631
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            632..2192
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1007..1012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
                     /note="hexamer: AATACA"
     polyA_site      1026
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
                     /note="major polyA site"
     regulatory      1073..1078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1090
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
     regulatory      1112..1117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1137
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
     regulatory      1296..1301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1318
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
     regulatory      1545..1550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1565
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
     regulatory      2153..2158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2176
                     /gene="Asf1a"
                     /gene_synonym="2310079C17Rik"
ORIGIN      
        1 tgctagttat cagggcagaa tgggctgtag tttagtgaaa taggaaagct gcaaaacacc
       61 gtggagtgcc gccgtgtaaa taaaaaggaa aaaaaagttt ctcaagtcgc agctgcacga
      121 cgtcgggccg cgccgcgccg gggcgggggt ctgcgctctc ggagcggccg cgcgcgggac
      181 tcggtggtgc cgccagcccc ggccccattg tttgtgtttt cttcaaaata tggcaaaggt
      241 tcaggtgaac aatgtagtgg tgctggataa cccgtcgcct ttctacaacc cgttccagtt
      301 cgagatcacc ttcgagtgca tcgaggacct gtctgaagac ttggagtgga aaataatcta
      361 tgtgggctct gcagaaagtg aagaatacga tcaagtttta gactctgttt tagtgggtcc
      421 cgttcctgca ggaaggcata tgtttgtgtt tcaggctgat gcaccgaatg caggactcat
      481 cccagatgca gatgcagtgg gggtaacagt tgttctgatt acttgcacct accgaggtca
      541 agaatttatt agagttggct actatgtaaa taatgaatac actgaaacag aattaaggga
      601 aaacccacca gtaaaaccag acttttctaa gcttcaaagg aatattttgg catctaatcc
      661 cagagtcaca agattccaca ttaactggga agataataca gaaaaactgg aagatgcaga
      721 gagcagtaac ccaaatctac agtcccttct ttcaacagat gcattaccgt cagcgtcaaa
      781 gggatggtcc acgtcagaaa actcactcaa tgttatgtta gaatcccaca tggactgcat
      841 gtgaccacgt gccatcccat tagtacagat taagctatta aaaacagaac tatttccctg
      901 aagttccgta agtacatagt caacgtgaaa tgtgaagaat ttgtttaaaa acatcctgta
      961 gaaagtttat aagaaaaacc agtatttgag caaattgtgg attataaata caactatttt
     1021 taagtacttt tttctctaat gtgttatttt atttgttcat gaaactaatc tgattaaagc
     1081 atatatatta ttttcttctc ttttatatgt aattaaagca cttatatcaa attattagac
     1141 caggttgtaa aggtgttgtt ttagcctctt ggacaataag atttactagc ttttaaaaaa
     1201 acaaagttta cttcaactaa aatgatttat tcctgtgaag atagtgtcct tttaatttga
     1261 ggagaaaact tccattctgt agtaaaaaag atcacattaa aatgggattt gaagtcaatt
     1321 atatgccacc agggtttttc taggccaccc cagtgcatct taccacaact tgtgttacac
     1381 cagacttcta gtttttatat aacaaatgca gctgcctttg aagtccctct gactatggtg
     1441 tatgcttcct tacatctaaa actgggaaac cacgaccata aatcattgtc cagagatttc
     1501 aacatggcaa gagcaaatac aagttctcta aagtgtaaga ttacattaaa atggttcaga
     1561 tctgctcttt ctttcagttt acagaaatgc cgaacttaca agggtaattt agaaaggcct
     1621 ggttagcttt attctggcta gctactttac gaagcatgtc ttaccatttg cagttgtatt
     1681 accccatatc ctctggctct cattaacgtg taagatcagg gtattttctg tagttgacat
     1741 aatctacata acttttccag acttcttttt ttctttctga agagcagttt tagaaaggat
     1801 aaatgggcca aaagtgtatt ttctttaatg agaagtaaat acttcctcaa agttctgatc
     1861 cattacattt acagtacagt attttcattt gattatggtg atgatgcaca ggagagccat
     1921 gggatgcagg ttatgcggtg ccttcacatc taagctttta tactgcactt ttcaaaacag
     1981 tctgaggaaa aggaaagggc atttgtctaa acagactctt ttaagttgta tatatttctt
     2041 gctattttaa aaggtaaatt tgtgcaacca agtcttgtta aatgttaaac tttgaaattt
     2101 aagactccag gttattacag tattgaccat tacccagttc atagatttta aaaataaaac
     2161 ctgactacta aaacgatttg aaaaaaaaaa aa
//
