LOCUS       NM_001270609            1490 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus achaete-scute family bHLH transcription factor 5
            (Ascl5), mRNA.
ACCESSION   NM_001270609
VERSION     NM_001270609.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1490)
  AUTHORS   Zhu,S., Huo,S., Wang,Z., Huang,C., Li,C., Song,H., Yang,X., He,R.,
            Ding,C., Qiu,M. and Zhu,X.J.
  TITLE     Follistatin controls the number of murine teeth by limiting
            TGF-beta signaling
  JOURNAL   iScience 27 (9), 110785 (2024)
   PUBMED   39286503
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1490)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1490)
  AUTHORS   Jia,L., Chiba,Y., Saito,K., Yoshizaki,K., Tian,T., Han,X.,
            Mizuta,K., Chiba,M., Wang,X., Al Thamin,S., Yamada,A. and
            Fukumoto,S.
  TITLE     The tooth-specific basic helix-loop-helix factor AmeloD promotes
            differentiation of ameloblasts
  JOURNAL   J Cell Physiol 237 (2), 1597-1606 (2022)
   PUBMED   34812512
  REMARK    GeneRIF: The tooth-specific basic helix-loop-helix factor AmeloD
            promotes differentiation of ameloblasts.
REFERENCE   4  (bases 1 to 1490)
  AUTHORS   Al Thamin,S., Chiba,Y., Yoshizaki,K., Tian,T., Jia,L., Wang,X.,
            Saito,K., Li,J., Yamada,A. and Fukumoto,S.
  TITLE     Transcriptional regulation of the basic helix-loop-helix factor
            AmeloD during tooth development
  JOURNAL   J Cell Physiol 236 (11), 7533-7543 (2021)
   PUBMED   33844290
  REMARK    GeneRIF: Transcriptional regulation of the basic helix-loop-helix
            factor AmeloD during tooth development.
REFERENCE   5  (bases 1 to 1490)
  AUTHORS   Chiba,Y., He,B., Yoshizaki,K., Rhodes,C., Ishijima,M.,
            Bleck,C.K.E., Stempinski,E., Chu,E.Y., Nakamura,T., Iwamoto,T., de
            Vega,S., Saito,K., Fukumoto,S. and Yamada,Y.
  TITLE     The transcription factor AmeloD stimulates epithelial cell motility
            essential for tooth morphology
  JOURNAL   J Biol Chem 294 (10), 3406-3418 (2019)
   PUBMED   30504223
  REMARK    GeneRIF: AmeloD stimulates epithelial cell motility essential for
            tooth morphology
REFERENCE   6  (bases 1 to 1490)
  AUTHORS   He,B., Chiba,Y., Li,H., de Vega,S., Tanaka,K., Yoshizaki,K.,
            Ishijima,M., Yuasa,K., Ishikawa,M., Rhodes,C., Sakai,K., Zhang,P.,
            Fukumoto,S., Zhou,X. and Yamada,Y.
  TITLE     Identification of the Novel Tooth-Specific Transcription Factor
            AmeloD
  JOURNAL   J Dent Res 98 (2), 234-241 (2019)
   PUBMED   30426815
REFERENCE   7  (bases 1 to 1490)
  AUTHORS   Stevens,J.D., Roalson,E.H. and Skinner,M.K.
  TITLE     Phylogenetic and expression analysis of the basic helix-loop-helix
            transcription factor gene family: genomic approach to cellular
            differentiation
  JOURNAL   Differentiation 76 (9), 1006-1022 (2008)
   PUBMED   18557763
REFERENCE   8  (bases 1 to 1490)
  AUTHORS   Sugimori,M., Nagao,M., Parras,C.M., Nakatani,H., Lebel,M.,
            Guillemot,F. and Nakafuku,M.
  TITLE     Ascl1 is required for oligodendrocyte development in the spinal
            cord
  JOURNAL   Development 135 (7), 1271-1281 (2008)
   PUBMED   18287202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124375.5.
            
            On Dec 20, 2021 this sequence version replaced NM_001270609.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on orthologous data and support for expression as shown
            in PubMed ID: 18287202.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1490              AC124375.5         107082-108571
FEATURES             Location/Qualifiers
     source          1..1490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 59.54 cM"
     gene            1..1490
                     /gene="Ascl5"
                     /gene_synonym="AmeloD; Ascl5-ps; bHLHa47; Gm197"
                     /note="achaete-scute family bHLH transcription factor 5"
                     /db_xref="GeneID:226439"
                     /db_xref="MGI:MGI:2685043"
     exon            1..1490
                     /gene="Ascl5"
                     /gene_synonym="AmeloD; Ascl5-ps; bHLHa47; Gm197"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..788
                     /gene="Ascl5"
                     /gene_synonym="AmeloD; Ascl5-ps; bHLHa47; Gm197"
                     /note="achaete-scute complex homolog 5, pseudogene"
                     /codon_start=1
                     /product="achaete-scute homolog 5"
                     /protein_id="NP_001257538.1"
                     /db_xref="CCDS:CCDS59541.1"
                     /db_xref="GeneID:226439"
                     /db_xref="MGI:MGI:2685043"
                     /translation="MNSNFCRALVDRGPPGGMQLGVVAPAGQTPLAATEPLSNVPFLL
                     YPGHSEPPYYDAYTGVFPYVPFPGAFGVYDYPFEPAFIQKRNERERQRVKCVNEGYAR
                     LRGHLPGALTEKRLSKVETLRAAIRYIKYLQELLSATPDGAPPPATSPPPAHTGHSNV
                     PQPSSLVAESSGSPFSSSPFLESEEPSL"
     regulatory      1471..1476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ascl5"
                     /gene_synonym="AmeloD; Ascl5-ps; bHLHa47; Gm197"
                     /note="hexamer: AATAAA"
     polyA_site      1490
                     /gene="Ascl5"
                     /gene_synonym="AmeloD; Ascl5-ps; bHLHa47; Gm197"
                     /note="major polyA site"
ORIGIN      
        1 cagcagatac ctgctgtgcc tctgctagct gctgcacttg tccagagcta tgactcacat
       61 taaggagtcc aagccaaccc aaaaaggcaa aatgaagcct tagcaactcg cagcacccca
      121 gagtgctagc aatgtgactt gtcccctttg tcaggaccac acagagcccg tgcagaggcc
      181 tttcagaggg cctcactctg ggtccagctc cacgaggcac aatgaacagt aacttctgcc
      241 gagctctggt ggaccgtggg cccccggggg gcatgcagct aggtgtcgtg gcccctgctg
      301 gacagacgcc gctggcagcc accgaaccct tgagcaacgt accctttcta ttgtaccccg
      361 gccactccga gccgccttac tacgacgcct acactggggt gttcccctac gtgccctttc
      421 ccggcgcctt cggggtttac gactacccgt tcgagcctgc cttcatccag aagcgcaacg
      481 agcgagagcg gcagcgcgtc aagtgcgtga atgagggcta cgcgcgcctc cgcggccacc
      541 tccccggcgc cctgactgag aagcggctca gcaaggtgga gacactgcgc gccgccatcc
      601 gctacatcaa gtacctgcag gagctgttga gcgccacccc cgacggcgcg ccacctcccg
      661 ccacctcccc gccgcccgcc cacacgggcc acagcaacgt gccgcagccc tcttccttgg
      721 tggccgagtc cagtggatcc cccttttcct cgtcgccttt tttggagtcg gaggaaccca
      781 gcctttgatc tggccagagg cctggacttg cccctctagg gaacagcttt gggggcttct
      841 gggtcatctg tgcgggacaa agaacagtgg tgttcgaggt ctgtgatccc acctccaccc
      901 acttgagcca gatgtgaggg cctggggtag agatggcgag atacggatcc caggagctga
      961 tgtctgcggt gaggagcaga gccctggaca gctcctggac cagcctcagc gaagctctgc
     1021 tgtccaccac accaagtccc ctggaagtca gccacacttt ctgttatgcc tgaaccttcc
     1081 acaagatggc ctcaaatact agcgaggagc ttgatggcct ctaaagagca ggaattctga
     1141 gggagggacg agggaagtga agacaggcag ctgcttgcat tcagcaccct ggagctgaca
     1201 gacttagggg aagtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgaga
     1261 gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga gagagggagg
     1321 gagaggtcgc tggtgcccat tggcttcctt gacagcgagt gatcacctcc cctctcccac
     1381 ccttcagtct cttctggact taacgcctcc cccaccccaa gacttgtaag cttctagggt
     1441 ccactgacat tgtgtttaca tcaaggacta aataaaaagg gattgttgaa
//
