LOCUS       NM_001163614            2248 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Mus musculus achaete-scute family bHLH transcription factor 4
            (Ascl4), mRNA.
ACCESSION   NM_001163614 XM_986783 XM_988322
VERSION     NM_001163614.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2248)
  AUTHORS   Papagno,V., Sulic,A.M., Satta,J.P., Hoshiar,A.K., Kumar,V.,
            Jernvall,J. and Mikkola,M.L.
  TITLE     Wnt target gene Ascl4 is dispensable for skin appendage development
  JOURNAL   Int J Dev Biol (2024) In press
   PUBMED   38770834
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2248)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2248)
  AUTHORS   Sulic,A.M., Das Roy,R., Papagno,V., Lan,Q., Saikkonen,R.,
            Jernvall,J., Thesleff,I. and Mikkola,M.L.
  TITLE     Transcriptomic landscape of early hair follicle and epidermal
            development
  JOURNAL   Cell Rep 42 (6), 112643 (2023)
   PUBMED   37318953
REFERENCE   4  (bases 1 to 2248)
  AUTHORS   Wang,W., Hao,X., Han,L., Yan,Z., Shen,W.J., Dong,D., Hasbargen,K.,
            Bittner,S., Cortez,Y., Greenberg,A.S., Azhar,S. and Kraemer,F.B.
  TITLE     Tissue-Specific Ablation of ACSL4 Results in Disturbed
            Steroidogenesis
  JOURNAL   Endocrinology 160 (11), 2517-2528 (2019)
   PUBMED   31504388
REFERENCE   5  (bases 1 to 2248)
  AUTHORS   Miyai,M., Hamada,M., Moriguchi,T., Hiruma,J., Kamitani-Kawamoto,A.,
            Watanabe,H., Hara-Chikuma,M., Takahashi,K., Takahashi,S. and
            Kataoka,K.
  TITLE     Transcription Factor MafB Coordinates Epidermal Keratinocyte
            Differentiation
  JOURNAL   J Invest Dermatol 136 (9), 1848-1857 (2016)
   PUBMED   27208706
  REMARK    Review article
REFERENCE   6  (bases 1 to 2248)
  AUTHORS   Tomann,P., Paus,R., Millar,S.E., Scheidereit,C. and
            Schmidt-Ullrich,R.
  TITLE     Lhx2 is a direct NF-kappaB target gene that promotes primary hair
            follicle placode down-growth
  JOURNAL   Development 143 (9), 1512-1522 (2016)
   PUBMED   26952977
REFERENCE   7  (bases 1 to 2248)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   8  (bases 1 to 2248)
  AUTHORS   Smith,M.E., Saraceno,G.E., Capani,F. and Castilla,R.
  TITLE     Long-chain acyl-CoA synthetase 4 is regulated by phosphorylation
  JOURNAL   Biochem Biophys Res Commun 430 (1), 272-277 (2013)
   PUBMED   23159612
REFERENCE   9  (bases 1 to 2248)
  AUTHORS   Stevens,J.D., Roalson,E.H. and Skinner,M.K.
  TITLE     Phylogenetic and expression analysis of the basic helix-loop-helix
            transcription factor gene family: genomic approach to cellular
            differentiation
  JOURNAL   Differentiation 76 (9), 1006-1022 (2008)
   PUBMED   18557763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151901.3.
            
            On Jun 20, 2019 this sequence version replaced NM_001163614.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7652917.292253.1,
                                        SRR7345562.4723679.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2248              AC151901.3         25769-28016         c
FEATURES             Location/Qualifiers
     source          1..2248
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 41.8 cM"
     gene            1..2248
                     /gene="Ascl4"
                     /gene_synonym="1700054F16Rik; bHLHa44"
                     /note="achaete-scute family bHLH transcription factor 4"
                     /db_xref="GeneID:67341"
                     /db_xref="MGI:MGI:1914591"
     exon            1..2248
                     /gene="Ascl4"
                     /gene_synonym="1700054F16Rik; bHLHa44"
                     /inference="alignment:Splign:2.1.0"
     CDS             1090..1524
                     /gene="Ascl4"
                     /gene_synonym="1700054F16Rik; bHLHa44"
                     /note="achaete-scute complex homolog 4"
                     /codon_start=1
                     /product="achaete-scute homolog 4"
                     /protein_id="NP_001157086.1"
                     /db_xref="CCDS:CCDS59549.1"
                     /db_xref="GeneID:67341"
                     /db_xref="MGI:MGI:1914591"
                     /translation="MEKRRSAGLLALPSALRTAPLGALPGREPCRVSVRQDAADCARR
                     RPYSSLPLGGVAEPAFLRQRNERERQRVRCVNEGYARLRQHLPRELAGQRLSKVETLR
                     AAISYIKQLQELLERHRPDCNSDGESKASSGASPCSESEERS"
     regulatory      2227..2232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ascl4"
                     /gene_synonym="1700054F16Rik; bHLHa44"
                     /note="hexamer: AATAAA"
     polyA_site      2248
                     /gene="Ascl4"
                     /gene_synonym="1700054F16Rik; bHLHa44"
                     /note="major polyA site"
ORIGIN      
        1 ctttctcctt gggattgggg ctctcttctt ttcaaatgtt gttttccagt cctctgggga
       61 ggaaataaac ttaatgatga gtacaatagg aaaatacttc gtgctatggg aagatattgt
      121 tatatcctga gtgggattag aagaggttgg gaggcaggac taaaggtgtg tttacagtaa
      181 gcactccgag aaataactgg ctaaaagtgt ttgttactgt tcgggctttt gatgtgtttt
      241 tacagagcag cagaagcaca aagggccccg cgttaaacat accttagaac acaatgtgcg
      301 gatccttaca ttcgatgcta aagtacatat attttgttct tgattccttt gaaaagtgtc
      361 taatttggtt tttaaagatt ctatttcgca gaagaaaacc tcgggcttcc ccggaggtcc
      421 aaggaggact tgacacatcg tctaaccaca agagagcagt cttccctttg atgagcgctt
      481 cttctccacc tccccagaaa tgaaagagca gagaggtatg tttgcaaaca ctctgaaagc
      541 tctttccatc agacctgaac gccggaaacc acaaagggca gtcaagtttg gattttcaag
      601 gagaacgccg gagtaaactt tcgctctgtt ggccagccga tcagccagtg cctggggagg
      661 ctctctgctc aattcctgaa caagttcggg ctcccggata gccacacttg ctgacccaag
      721 gagtgaatta caacaattgg gcagctttga aagatcaatc tgcttagagt gcgaccgtct
      781 atccaggctg ggaaccctat gttaactctt aaactaagat cagaggaagc acatggatac
      841 aagcgttgat gaggcgagcc ctctatcttt gccccttctt ctctgaagct ttataaagac
      901 ccaagaagag caacctgctt cggaaatcat gcaaagttca ctccaagtgt gctcaggtac
      961 ctaacttctg gacctagaaa cttctccaga gacagaccgg gaagtctgga tggaccagaa
     1021 tctccgctac gacagcttcc agtctcgtct tcaaggtgag agagtcatct gcgtgctttt
     1081 tcgcagagaa tggaaaaacg cagatcggcc ggactgcttg ccctgccgtc cgcgctacgt
     1141 acagcgccgc tgggcgcgct gcccgggagg gagccctgca gggtctcggt gcgccaggat
     1201 gccgcggact gcgcgcggag acggccgtac tcgtccctgc cgcttggggg cgtcgccgag
     1261 cccgcctttt tgcgccaacg caacgagcgc gagcggcagc gcgtgcgctg tgtgaacgag
     1321 ggctacgcgc gcctccgcca gcacctgccg cgcgagctgg cgggccagcg gctcagcaag
     1381 gtggagacgc tgcgcgccgc catcagctac atcaagcaac tgcaggagct gctggagcgc
     1441 caccggccgg actgcaacag cgatggcgag tccaaagcat cctccggagc ctcgccctgc
     1501 agcgagtctg aggagcgtag ctagcagcat cctagcccac tgggctttca tggttgcttc
     1561 tccgggccta gatctttaaa acaaaaccaa aaaccagaaa acaactaagt gcttctggat
     1621 ctaggaaaga aaggtaattg aatgtttaga gagtttggtt tttttttttt tttttttttt
     1681 ttgtcccctt tcaccttcat tggttccgag tttgcagctt aaaaatgctt aaggaaactc
     1741 aattctcgta tttttgaagc acagaagggc catctcaaat ctatgcggtg attttaaaaa
     1801 cacaaaggac tttaagaaac cttagccaga gaagaaacac acacacacac acacacacac
     1861 acacacacac acgagacagt ccttcacgcg agaggaacat tctcactcat tccttccaat
     1921 tgggaaatgc actggaaatc tcaacacctc actgagggta ggacactcca taagacattt
     1981 gtggagcatc tgctggacct gaacgtcgct gtgctaaaaa ggacaatgct tgacctatct
     2041 tgcttcgtcc gcaagaggta gatcggaaac tttagcagct aataaagtgc cgcgaagtta
     2101 atgatctttt tggaggagct ctgaatggcc atcttctctc ccggtttctg cccactgttt
     2161 ctcttgccct tttgtctatg tgttcccctg tacagttctc atcccgtcta acctttgctt
     2221 ggaaaaaata aaaaagcaag tatgctta
//
