LOCUS       NM_020051                706 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus achaete-scute family bHLH transcription factor 3
            (Ascl3), mRNA.
ACCESSION   NM_020051
VERSION     NM_020051.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 706)
  AUTHORS   Montoro,D.T., Haber,A.L., Biton,M., Vinarsky,V., Lin,B.,
            Birket,S.E., Yuan,F., Chen,S., Leung,H.M., Villoria,J., Rogel,N.,
            Burgin,G., Tsankov,A.M., Waghray,A., Slyper,M., Waldman,J.,
            Nguyen,L., Dionne,D., Rozenblatt-Rosen,O., Tata,P.R., Mou,H.,
            Shivaraju,M., Bihler,H., Mense,M., Tearney,G.J., Rowe,S.M.,
            Engelhardt,J.F., Regev,A. and Rajagopal,J.
  TITLE     A revised airway epithelial hierarchy includes CFTR-expressing
            ionocytes
  JOURNAL   Nature 560 (7718), 319-324 (2018)
   PUBMED   30069044
REFERENCE   2  (bases 1 to 706)
  AUTHORS   Weng,P.L., Vinjamuri,M. and Ovitt,C.E.
  TITLE     Ascl3 transcription factor marks a distinct progenitor lineage for
            non-neuronal support cells in the olfactory epithelium
  JOURNAL   Sci Rep 6, 38199 (2016)
   PUBMED   27910949
  REMARK    GeneRIF: These results demonstrate that Ascl3 marks progenitors
            that are lineage-committed strictly to microvillar cells and
            Bowman's glands, and highlight the requirement for these cell types
            to support OE homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 706)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 706)
  AUTHORS   Arany,S., Catalan,M.A., Roztocil,E. and Ovitt,C.E.
  TITLE     Ascl3 knockout and cell ablation models reveal complexity of
            salivary gland maintenance and regeneration
  JOURNAL   Dev Biol 353 (2), 186-193 (2011)
   PUBMED   21377457
  REMARK    GeneRIF: Ascl3 knockouts develop smaller salivary glands than wild
            types, but secrete saliva normally. They display a lower level of
            cell proliferation, consistent with their smaller size. In the
            absence of Ascl3, the cells maintain their progenitor function.
REFERENCE   5  (bases 1 to 706)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 706)
  AUTHORS   Sugimori,M., Nagao,M., Parras,C.M., Nakatani,H., Lebel,M.,
            Guillemot,F. and Nakafuku,M.
  TITLE     Ascl1 is required for oligodendrocyte development in the spinal
            cord
  JOURNAL   Development 135 (7), 1271-1281 (2008)
   PUBMED   18287202
REFERENCE   7  (bases 1 to 706)
  AUTHORS   Yamaguchi,Y., Yonemura,S. and Takada,S.
  TITLE     Grainyhead-related transcription factor is required for duct
            maturation in the salivary gland and the kidney of the mouse
  JOURNAL   Development 133 (23), 4737-4748 (2006)
   PUBMED   17079272
REFERENCE   8  (bases 1 to 706)
  AUTHORS   Yoshida,S., Ohbo,K., Takakura,A., Takebayashi,H., Okada,T., Abe,K.
            and Nabeshima,Y.
  TITLE     Sgn1, a basic helix-loop-helix transcription factor delineates the
            salivary gland duct cell lineage in mice
  JOURNAL   Dev Biol 240 (2), 517-530 (2001)
   PUBMED   11784080
REFERENCE   9  (bases 1 to 706)
  AUTHORS   Amid,C., Bahr,A., Mujica,A., Sampson,N., Bikar,S.E.,
            Winterpacht,A., Zabel,B., Hankeln,T. and Schmidt,E.R.
  TITLE     Comparative genomic sequencing reveals a strikingly similar
            architecture of a conserved syntenic region on human chromosome
            11p15.3 (including gene ST5) and mouse chromosome 7
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 284-290 (2001)
   PUBMED   11528127
REFERENCE   10 (bases 1 to 706)
  AUTHORS   Cichutek,A., Brueckmann,T., Seipel,B., Hauser,H., Schlaubitz,S.,
            Prawitt,D., Hankeln,T., Schmidt,E.R., Winterpacht,A. and Zabel,B.U.
  TITLE     Comparative architectural aspects of regions of conserved synteny
            on human chromosome 11p15.3 and mouse chromosome 7 (including genes
            WEE1 and LMO1)
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 277-283 (2001)
   PUBMED   11528126
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ400878.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB046448.1, BC104346.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..706
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.46 cM"
     gene            1..706
                     /gene="Ascl3"
                     /gene_synonym="bHLHa42; Sgn1"
                     /note="achaete-scute family bHLH transcription factor 3"
                     /db_xref="GeneID:56787"
                     /db_xref="MGI:MGI:1928820"
     exon            1..47
                     /gene="Ascl3"
                     /gene_synonym="bHLHa42; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     exon            48..706
                     /gene="Ascl3"
                     /gene_synonym="bHLHa42; Sgn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..585
                     /gene="Ascl3"
                     /gene_synonym="bHLHa42; Sgn1"
                     /note="ASH-3; mASH3; mASH-3; bHLH transcriptional
                     regulator Sgn-1; ICRFP703B1614Q5.4; ICRFP703N2430Q5.4;
                     achaete-scute complex homolog-like 3; achaete-scute
                     complex homolog 3"
                     /codon_start=1
                     /product="achaete-scute homolog 3"
                     /protein_id="NP_064435.1"
                     /db_xref="CCDS:CCDS21737.1"
                     /db_xref="GeneID:56787"
                     /db_xref="MGI:MGI:1928820"
                     /translation="MDTRSYPSPPDRLSVFAESAHLPLSRPFYLDPMVTVHLCPETPV
                     PASYTDELPLLPFSSDTLIMNNYGDPYPFPFPMPYTNYRRCDYTYGPAFIRKRNERER
                     QRVKCVNEGYARLRRHLPEDYLEKRLSKVETLRAAIKYISYLQSLLYPDESETKKNPR
                     TASCGSLDPALRVI"
ORIGIN      
        1 ttcagtcaga ctcagcccca aatacagcat cttgaactac aaaacaggtg aaaggaaacg
       61 atggacacca gaagctaccc cagccctcca gacaggctct cggtcttcgc tgagtcggcc
      121 cacttaccac tgtccaggcc cttctacctg gaccccatgg tcactgtcca cctatgcccc
      181 gagaccccgg taccggcctc ttacacagat gagctgcctc tgctgccctt ctccagcgac
      241 accctgatca tgaacaatta cggggatcca tacccttttc ccttccccat gccttacacc
      301 aactacaggc gctgtgacta cacctacggg ccggccttca tccgcaagag gaacgagcga
      361 gagaggcaac gagtcaagtg tgtgaacgaa ggctacgccc ggctgcggcg gcacctgccg
      421 gaggactacc tggagaaacg gctcagcaaa gtggagaccc tcagagctgc catcaaatat
      481 atcagctacc tgcagtctct cttgtacccg gatgaatctg agaccaagaa gaaccctcga
      541 acagccagct gcggctccct ggacccggct ctgagagtca tttgaatcag ttcttcctcg
      601 aatgggagtc ttctgctgcc gcagccagta cattctcata cacatggttt cgaggacaca
      661 acagtacctc ccaataccaa ccttcattaa atgttgcttg cctggg
//
