LOCUS       NM_008554               1612 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus achaete-scute family bHLH transcription factor 2
            (Ascl2), mRNA.
ACCESSION   NM_008554
VERSION     NM_008554.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1612)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   2  (bases 1 to 1612)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1612)
  AUTHORS   Wang,F., Chander,A., Yoon,Y., Welton,J.M., Wallingford,M.C.,
            Espejo-Serrano,C., Bustos,F., Findlay,G.M., Mager,J. and Bach,I.
  TITLE     Roles of the Rlim-Rex1 axis during X chromosome inactivation in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (52), e2313200120 (2023)
   PUBMED   38113263
REFERENCE   4  (bases 1 to 1612)
  AUTHORS   Zhang,D., Ni,Q.Q., Liang,Q.Y., He,L.L., Qiu,B.W., Zhang,L.J.,
            Mou,T.Y., Le,C.C., Huang,Y., Li,T.T., Wang,S.Y., Ding,Y.Q.,
            Jiao,H.L. and Ye,Y.P.
  TITLE     ASCL2 induces an immune excluded microenvironment by activating
            cancer-associated fibroblasts in microsatellite stable colorectal
            cancer
  JOURNAL   Oncogene 42 (38), 2841-2853 (2023)
   PUBMED   37591954
  REMARK    GeneRIF: ASCL2 induces an immune excluded microenvironment by
            activating cancer-associated fibroblasts in microsatellite stable
            colorectal cancer.
REFERENCE   5  (bases 1 to 1612)
  AUTHORS   Iida,K., Suga,K., Suzuki,K., Kurihara,S., Yabe,Y., Kageyama,T.,
            Meguro,K., Tanaka,S., Iwata,A., Suto,A. and Nakajima,H.
  TITLE     A role of Achaete-scute complex homolog 2 in T follicular
            regulatory cell development
  JOURNAL   Biochem Biophys Res Commun 664, 9-19 (2023)
   PUBMED   37130460
  REMARK    GeneRIF: A role of Achaete-scute complex homolog 2 in T follicular
            regulatory cell development.
REFERENCE   6  (bases 1 to 1612)
  AUTHORS   Leighton,P.A., Saam,J.R., Ingram,R.S., Stewart,C.L. and
            Tilghman,S.M.
  TITLE     An enhancer deletion affects both H19 and Igf2 expression
  JOURNAL   Genes Dev 9 (17), 2079-2089 (1995)
   PUBMED   7544754
REFERENCE   7  (bases 1 to 1612)
  AUTHORS   Guillemot,F., Caspary,T., Tilghman,S.M., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Anderson,D.J., Joyner,A.L., Rossant,J.
            and Nagy,A.
  TITLE     Genomic imprinting of Mash2, a mouse gene required for trophoblast
            development
  JOURNAL   Nat Genet 9 (3), 235-242 (1995)
   PUBMED   7773285
  REMARK    GeneRIF: Mash2 gene is preferentially expressed from the paternal
            allele.
REFERENCE   8  (bases 1 to 1612)
  AUTHORS   Guillemot,F., Nagy,A., Auerbach,A., Rossant,J. and Joyner,A.L.
  TITLE     Essential role of Mash-2 in extraembryonic development
  JOURNAL   Nature 371 (6495), 333-336 (1994)
   PUBMED   8090202
REFERENCE   9  (bases 1 to 1612)
  AUTHORS   Johnson,J.E., Zimmerman,K., Saito,T. and Anderson,D.J.
  TITLE     Induction and repression of mammalian achaete-scute homologue
            (MASH) gene expression during neuronal differentiation of P19
            embryonal carcinoma cells
  JOURNAL   Development 114 (1), 75-87 (1992)
   PUBMED   1576967
REFERENCE   10 (bases 1 to 1612)
  AUTHORS   Bastian,H. and Gruss,P.
  TITLE     A murine even-skipped homologue, Evx 1, is expressed during early
            embryogenesis and neurogenesis in a biphasic manner
  JOURNAL   EMBO J 9 (6), 1839-1852 (1990)
   PUBMED   1971786
  REMARK    Erratum:[EMBO J 1991 Dec;10(12):3978]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ074389.1, AK167324.1, CJ215499.1 and BB079730.1.
            
            On Aug 11, 2009 this sequence version replaced NM_008554.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167324.1, BC019520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 7773285
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-410               CJ074389.1         2-411
            411-1380            AK167324.1         394-1363
            1381-1607           CJ215499.1         183-409
            1608-1612           BB079730.1         290-294
FEATURES             Location/Qualifiers
     source          1..1612
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.08 cM"
     gene            1..1612
                     /gene="Ascl2"
                     /gene_synonym="2410083I15Rik; bHLHa45; Mash2"
                     /note="achaete-scute family bHLH transcription factor 2"
                     /db_xref="GeneID:17173"
                     /db_xref="MGI:MGI:96920"
     exon            1..294
                     /gene="Ascl2"
                     /gene_synonym="2410083I15Rik; bHLHa45; Mash2"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..1076
                     /gene="Ascl2"
                     /gene_synonym="2410083I15Rik; bHLHa45; Mash2"
                     /note="ASH-2; mASH-2; mammalian achaete scute homolog 2;
                     achaete-scute complex homolog-like 2; long transient
                     receptor potential-related channel 5; achaete-scute
                     complex homolog 2"
                     /codon_start=1
                     /product="achaete-scute homolog 2"
                     /protein_id="NP_032580.2"
                     /db_xref="CCDS:CCDS40194.1"
                     /db_xref="GeneID:17173"
                     /db_xref="MGI:MGI:96920"
                     /translation="MEAHLDWYGVPGLQEASDACPRESCSSALPEAREGANVHFPPHP
                     VPREHFSCAAPELVAGAQGLNASLMDGGALPRLMPTSSGVAGACAARRRQASPELLRC
                     SRRRRSGATEASSSSAAVARRNERERNRVKLVNLGFQALRQHVPHGGANKKLSKVETL
                     RSAVEYIRALQRLLAEHDAVRAALAGGLLTPATPPSDECAQPSASPASASLSCASTSP
                     SPDRLGCSEPTSPRSAYSSEESSCEGELSPMEQELLDFSSWLGGY"
     exon            295..1094
                     /gene="Ascl2"
                     /gene_synonym="2410083I15Rik; bHLHa45; Mash2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1612
                     /gene="Ascl2"
                     /gene_synonym="2410083I15Rik; bHLHa45; Mash2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1586..1591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ascl2"
                     /gene_synonym="2410083I15Rik; bHLHa45; Mash2"
                     /note="hexamer: TATAAA"
     polyA_site      1608
                     /gene="Ascl2"
                     /gene_synonym="2410083I15Rik; bHLHa45; Mash2"
                     /note="major polyA site"
ORIGIN      
        1 gtgctaccct agggggtcgc gctcttctgc ctcctacctc ttggtcaccg caaagcttgg
       61 tccggttctt catccggctg caagcgctag gtgtgcggag acctggcagc tcttggggct
      121 taagggctga gcaccaggac gggtggaggt gcctgtagag tacattcgga ccctctctcg
      181 gaccctctct cagcccctga gtgtgcggga cctgcggagc gcagttcggg atctgcactc
      241 gaggattttt cgaggacgca ataagctaag catctgcccg gagcatggaa gcacaccttg
      301 actggtacgg ggtcccagga ctgcaggagg ccagcgacgc gtgccctagg gagtcctgca
      361 gcagtgccct gcctgaggcc cgtgaaggtg caaacgtcca cttcccaccg cacccggttc
      421 ctcgcgagca cttttcctgt gccgcaccag aactcgtagc aggggcccag gggctgaatg
      481 caagcttgat ggacggcggc gcgctgccca gactcatgcc cacctcgtct ggagtcgctg
      541 gagcctgcgc tgctcggcgg agacaagcgt ctccggaatt gctgcgctgc agccggcggc
      601 ggcgatctgg agcaaccgag gccagcagca gctcggctgc cgtggcacgc cgcaatgagc
      661 gcgagcgcaa ccgcgtaaag ctggtaaact tgggcttcca ggcgctgcgg cagcacgtgc
      721 cgcacggcgg cgccaacaag aagctgagta aggtggagac gctgcgctcc gcggtagagt
      781 acattcgtgc gctgcagcgg ctgctcgcag agcacgacgc ggtgcgtgcc gcgctcgctg
      841 gggggctgtt aacacccgct actccgccgt ccgatgagtg cgcgcagccc tctgcctccc
      901 ctgccagcgc gtctctgtcc tgcgcctcta cgtctccgtc cccggaccgc ctgggctgct
      961 ctgagcctac ctccccgcgc tccgcctact cgtcggagga aagcagctgc gagggagagc
     1021 taagcccgat ggagcaggag ctgcttgact tttccagttg gttagggggc tactgagcat
     1081 cccacccccc taagctgcat ccctgggtga ctcctggtgg acctacctgc ttctagccca
     1141 agaaacctgg gcctatgcct tacccatgct gtctagtgca gcctgaccaa atgccaagtg
     1201 ctgactgacc tctgctcggc ctccacgccg cggaatgaca tcttccatct tccggacctt
     1261 gcagcatcag gacttggaaa tttctcagga taaagatttt tacaatgaca atctactttt
     1321 tatcaattaa cttgaactgt tgtaggactc tactgaaaat atgaagaatt atttttatac
     1381 aaaggatcct taagcttgga gcacaataaa gatgacctct gtccctcacc cccactgtct
     1441 agaactttcc aacctggcca aagtgtggac cggttgggcc ctgagggcaa gatgcctggc
     1501 tgcacccttc ttcctcttct gaagcctata ctgacgctga tgtttggcca gtgtgggaac
     1561 cctgctgttg caaagtgtac tattctataa aagttgtttt tcattggtgt tt
//
