LOCUS       NM_008553               2490 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus achaete-scute family bHLH transcription factor 1
            (Ascl1), mRNA.
ACCESSION   NM_008553
VERSION     NM_008553.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2490)
  AUTHORS   Myers,B.L., Brayer,K.J., Paez-Beltran,L.E., Villicana,E.,
            Keith,M.S., Suzuki,H., Newville,J., Anderson,R.H., Lo,Y.,
            Mertz,C.M., Kollipara,R.K., Borromeo,M.D., Lu,Q.R., Bachoo,R.M.,
            Johnson,J.E. and Vue,T.Y.
  TITLE     Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation
            and co-regulate tumor cell types and migration
  JOURNAL   Nat Commun 15 (1), 10363 (2024)
   PUBMED   39609428
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2490)
  AUTHORS   Alvarez,S., Gupta,S., Mercado-Ayon,Y., Honeychurch,K.,
            Rodriguez,C., Kawaguchi,R. and Butler,S.J.
  TITLE     Netrin1 patterns the dorsal spinal cord through modulation of Bmp
            signaling
  JOURNAL   Cell Rep 43 (11), 114954 (2024)
   PUBMED   39547237
REFERENCE   3  (bases 1 to 2490)
  AUTHORS   Rodarte,K.E., Nir Heyman,S., Guo,L., Flores,L., Savage,T.K.,
            Villarreal,J., Deng,S., Xu,L., Shah,R.B., Oliver,T.G. and
            Johnson,J.E.
  TITLE     Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1
  JOURNAL   Cancer Res 84 (21), 3522-3537 (2024)
   PUBMED   39264686
REFERENCE   4  (bases 1 to 2490)
  AUTHORS   He,H., Bell,S.M., Davis,A.K., Zhao,S., Sridharan,A., Na,C.L.,
            Guo,M., Xu,Y., Snowball,J., Swarr,D.T., Zacharias,W.J. and
            Whitsett,J.A.
  TITLE     PRDM3/16 regulate chromatin accessibility required for NKX2-1
            mediated alveolar epithelial differentiation and function
  JOURNAL   Nat Commun 15 (1), 8112 (2024)
   PUBMED   39284798
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2490)
  AUTHORS   Rasetto,N.B., Giacomini,D., Berardino,A.A., Waichman,T.V.,
            Beckel,M.S., Di Bella,D.J., Brown,J., Davies-Sala,M.G.,
            Gerhardinger,C., Lie,D.C., Arlotta,P., Chernomoretz,A. and
            Schinder,A.F.
  TITLE     Transcriptional dynamics orchestrating the development and
            integration of neurons born in the adult hippocampus
  JOURNAL   Sci Adv 10 (29), eadp6039 (2024)
   PUBMED   39028813
REFERENCE   6  (bases 1 to 2490)
  AUTHORS   Lee,J.E., Hollenberg,S.M., Snider,L., Turner,D.L., Lipnick,N. and
            Weintraub,H.
  TITLE     Conversion of Xenopus ectoderm into neurons by NeuroD, a basic
            helix-loop-helix protein
  JOURNAL   Science 268 (5212), 836-844 (1995)
   PUBMED   7754368
REFERENCE   7  (bases 1 to 2490)
  AUTHORS   Conlon,R.A., Reaume,A.G. and Rossant,J.
  TITLE     Notch1 is required for the coordinate segmentation of somites
  JOURNAL   Development 121 (5), 1533-1545 (1995)
   PUBMED   7789282
REFERENCE   8  (bases 1 to 2490)
  AUTHORS   Guillemot,F., Caspary,T., Tilghman,S.M., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Anderson,D.J., Joyner,A.L., Rossant,J.
            and Nagy,A.
  TITLE     Genomic imprinting of Mash2, a mouse gene required for trophoblast
            development
  JOURNAL   Nat Genet 9 (3), 235-242 (1995)
   PUBMED   7773285
REFERENCE   9  (bases 1 to 2490)
  AUTHORS   Johnson,J.E., Zimmerman,K., Saito,T. and Anderson,D.J.
  TITLE     Induction and repression of mammalian achaete-scute homologue
            (MASH) gene expression during neuronal differentiation of P19
            embryonal carcinoma cells
  JOURNAL   Development 114 (1), 75-87 (1992)
   PUBMED   1576967
REFERENCE   10 (bases 1 to 2490)
  AUTHORS   Lo,L.C., Johnson,J.E., Wuenschell,C.W., Saito,T. and Anderson,D.J.
  TITLE     Mammalian achaete-scute homolog 1 is transiently expressed by
            spatially restricted subsets of early neuroepithelial and neural
            crest cells
  JOURNAL   Genes Dev 5 (9), 1524-1537 (1991)
   PUBMED   1909283
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143210.1 and BX512680.1.
            
            On Jun 22, 2018 this sequence version replaced NM_008553.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143210.1, BC055748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2259              AK143210.1         2-2260
            2260-2490           BX512680.1         2-232               c
FEATURES             Location/Qualifiers
     source          1..2490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 43.64 cM"
     gene            1..2490
                     /gene="Ascl1"
                     /gene_synonym="ASH1; bHLHa46; Mash1"
                     /note="achaete-scute family bHLH transcription factor 1"
                     /db_xref="GeneID:17172"
                     /db_xref="MGI:MGI:96919"
     exon            1..1308
                     /gene="Ascl1"
                     /gene_synonym="ASH1; bHLHa46; Mash1"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..2481
                     /gene="Ascl1"
                     /gene_synonym="ASH1; bHLHa46; Mash1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2455..2460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ascl1"
                     /gene_synonym="ASH1; bHLHa46; Mash1"
                     /note="hexamer: TATAAA"
     polyA_site      2481
                     /gene="Ascl1"
                     /gene_synonym="ASH1; bHLHa46; Mash1"
                     /note="major polyA site"
ORIGIN      
        1 agcagtctct cacttctggc cagggaacgt ggaaggcgta ccggctggga gccggttagg
       61 gagggcgaat tggggggaac gagagagcaa ttagaaagaa agggggttca accaaataat
      121 cccagaagca ggctcaagcc caggctggag caagggagag cgggcgcaag aaagcgcagc
      181 cccggagcag ctccacctgg cagagtgcgc tcggcactga cttttgcggc tgctttcctt
      241 ttccctttcc tcttttaaaa ccgagaaggc gccggcggcg gccgcacacg cgagcgccac
      301 gcgaggctcc cgaagccaac cgcggcggga ggaggggagg gaggaggcgg cgcagaggga
      361 agacgatcgc ccaggcacct tcctccgctg cagcctgaca actctgcctc cttctgcgcg
      421 tttcttcccc tttaactttc ctccggggct cgtttctccc ctctcctttt tcttcgtccc
      481 cctttgatcg tgcttcgcag ccccgcttcc ttcaagggct ctgcgcaccc tgcgtcccca
      541 actcgttctc ccccgcgaca gtttggcccg gcatggagag ctctggcaag atggagagtg
      601 gagccggcca gcagccgcag cccccgcagc ccttcctgcc tcccgcagcc tgcttctttg
      661 cgaccgcggc ggcggcggca gcggcggcgg ccgcggcagc tcagagcgcg cagcagcaac
      721 agccgcaggc gccgccgcag caggcgccgc agctgagccc ggtggccgac agccagccct
      781 cagggggcgg tcacaagtca gcggccaagc aggtcaagcg ccagcgctcg tcctctccgg
      841 aactgatgcg ctgcaaacgc cggctcaact tcagcggctt cggctacagc ctgccacagc
      901 agcagccggc cgccgtggcg cgccgcaacg agcgcgagcg caaccgggtc aagttggtca
      961 acctgggttt tgccaccctc cgggagcatg tccccaacgg cgcggccaac aagaagatga
     1021 gcaaggtgga gacgctgcgc tcggcggtcg agtacatccg cgcgctgcag cagctgctgg
     1081 acgagcacga cgcggtgagc gctgcctttc aggcgggcgt cctgtcgccc accatctccc
     1141 ccaactactc caacgacttg aactctatgg cgggttctcc ggtctcgtcc tactcctccg
     1201 acgagggatc ctacgaccct cttagcccag aggaacaaga gctgctggac tttaccaact
     1261 ggttctgagg acctgccagg ctctcctggg aatggacttt ggaagcagga tggcagcaga
     1321 tcctgcatct ttagtgtttc tcgccaacga cgtcaaatgg ggaggcagaa aaacaagggg
     1381 aaaaaagaag aagaaatgaa acaaacaaac cagacagcca acctacaggg gcaccttcac
     1441 taagatgcaa tgttctcagc aaacaggggt gggctccaac agtgtctctg cattccaaca
     1501 tcatttccag acacgagaag agtgactggt gtctgaacct aagcccgaat cacagatggg
     1561 ttcctttcct ggagcaagag cgtcacacac acacacacac acacagacag acactatatt
     1621 aactcccaac cactaacagg cagggctgga agcgcgcatg tgcaagtgcc ttcacctccc
     1681 actctctgtc agagctgtct tagccccctg aaactgggtt gatgtctttc ctcagtcacc
     1741 cccattccag cgatctatgg acatttgcct ccattgaagc aacgtcagtt ctcggacagc
     1801 ctttccctct cctggtggcc tcctccccaa accccacatc gccctcccac ggtctttgct
     1861 tctgttttct tcatagaatg cttccaatct ttgtgaattt ttttattata agaaaaaaat
     1921 ctatttgtat ctatcctaac cagtttgggg atatattaag atatttttgt acataagaaa
     1981 aagagagaga aaaaatttat agaagttttg tacaaatggt ttaaaaatgt gtatatcttg
     2041 atactttaac atgtaatgag attacctctg cgtactttag atatgtagtt catcttacaa
     2101 ctgccatccc cacccccatc cccagtgtgg ttttggaaag aactctcctc ataggtgaga
     2161 tctaaatgcc accagaatga cttcagcacc aatgtgtctt acttcacaga aacgtggtta
     2221 atgtattaat gatgttatta aaaaaaactg ttcaagaaga acaaaagttt atgcagctac
     2281 tgtccaaacg caaagtggca gcccgttggt tcccataggt tgccttttgg aagtttctac
     2341 cattgccttc cccctcacac ccacccctta ctgttttatt acaaacttac aaaaaaaagt
     2401 gtataaccct gttttataca aactagtttt gtaataaaac tttttccttt tttatataaa
     2461 aagaagagag agagagaatg aaaaaaaaaa
//
