LOCUS       NM_198007               7477 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus activating signal cointegrator 1 complex subunit 3
            (Ascc3), mRNA.
ACCESSION   NM_198007 NM_001146089 XM_909518
VERSION     NM_198007.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7477)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7477)
  AUTHORS   Ye,A., Kim,H. and Kim,J.
  TITLE     PEG3 control on the mammalian MSL complex
  JOURNAL   PLoS One 12 (6), e0178363 (2017)
   PUBMED   28609438
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7477)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137877.6, AC153529.7 and AC159114.7.
            
            On or before Aug 20, 2011 this sequence version replaced
            NM_001146089.1, XM_909518.2, NM_198007.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.9831.1,
                                           SRR10223970.12367.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               AC137877.6         94014-94242
            230-361             AC137877.6         106096-106227
            362-512             AC137877.6         109265-109415
            513-1072            AC137877.6         119057-119616
            1073-1193           AC137877.6         139253-139373
            1194-1401           AC137877.6         143868-144075
            1402-1543           AC137877.6         146288-146429
            1544-1669           AC137877.6         147008-147133
            1670-1870           AC137877.6         150454-150654
            1871-2011           AC137877.6         151138-151278
            2012-2176           AC137877.6         151892-152056
            2177-2353           AC137877.6         160263-160439
            2354-2425           AC137877.6         162000-162071
            2426-2560           AC153529.7         32151-32285
            2561-2752           AC153529.7         41976-42167
            2753-2977           AC153529.7         42468-42692
            2978-3097           AC153529.7         49699-49818
            3098-3262           AC153529.7         52916-53080
            3263-3349           AC153529.7         55212-55298
            3350-3526           AC153529.7         56302-56478
            3527-3752           AC153529.7         58521-58746
            3753-3907           AC153529.7         60328-60482
            3908-4006           AC153529.7         62648-62746
            4007-4175           AC153529.7         63809-63977
            4176-4396           AC153529.7         70126-70346
            4397-4482           AC153529.7         71948-72033
            4483-4649           AC153529.7         73649-73815
            4650-4795           AC153529.7         74458-74603
            4796-4916           AC153529.7         74723-74843
            4917-5059           AC153529.7         77246-77388
            5060-5197           AC153529.7         90842-90979
            5198-5318           AC153529.7         91071-91191
            5319-5451           AC153529.7         92489-92621
            5452-5577           AC153529.7         96033-96158
            5578-5689           AC153529.7         109127-109238
            5690-5824           AC153529.7         109409-109543
            5825-6049           AC159114.7         49166-49390         c
            6050-6201           AC159114.7         32577-32728         c
            6202-6349           AC159114.7         30736-30883         c
            6350-6559           AC159114.7         27286-27495         c
            6560-6735           AC159114.7         23380-23555         c
            6736-7477           AC159114.7         21824-22565         c
FEATURES             Location/Qualifiers
     source          1..7477
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 24.87 cM"
     gene            1..7477
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /note="activating signal cointegrator 1 complex subunit 3"
                     /db_xref="GeneID:77987"
                     /db_xref="MGI:MGI:1925237"
     exon            1..229
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            230..361
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..6868
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /EC_number="3.6.4.12"
                     /note="helicase, ATP binding 1"
                     /codon_start=1
                     /product="activating signal cointegrator 1 complex subunit
                     3"
                     /protein_id="NP_932124.2"
                     /db_xref="CCDS:CCDS48555.1"
                     /db_xref="GeneID:77987"
                     /db_xref="MGI:MGI:1925237"
                     /translation="MALPRLTGALRSFSNVTKQDNYNEEVADLKLKRSKLHEQVLDFG
                     LTWKKIVKFLNEKLEKNKMQNINEDLKDILQAAKQIVGTDNGREAIESGAAFLFMTFH
                     MTDSVGYMETKAIRQTFGPFPSSSATSACNATNRIISHFSQDDLTAFVQMAENPCNDR
                     VVFGKNLAFSFDMYDLDHFDELPINGESQKTISLDYKKFLNEQFQEPYTPELKPVEKT
                     NGSLLWCEVEKYLNATLKEMTEAARVEDLCCTLYDMLASAKSGDELQDELFELLGPEG
                     LDLIEKLLQNRITIVDRFLNSSSDHKFQVLQDSCKKILGENSKPNYGCQVTIQSEQEK
                     QLMKQYRREEKRIARREKKAGEDGEVSGEGVLPFDPKELRIQREHALLNARNAPILGR
                     QRDVEFEKIRYPHVYDSQAQARETSAFIAGAKMILPEGIQRENTKLYEEVRIPYGEPM
                     PVGFEEKPVYIKDLDEVGQLAFKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTN
                     IAMLTILHEIRQHFHQGVIKKNEFKIVYVAPMKALAAEMTNYFSKRLEPLGIVVKELT
                     GDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVKLLILDEVHLLHEDRGPV
                     LESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFYFDGRFRPVPL
                     GQTFLGIKSTNKMQQLNNMDEVCYESVLKQVKAGHQVMVFVHARNATVRTAMSLIERA
                     KNSGQISCFLPTEGPEYGHALKQVQKSRNKQVRELFSDGFSIHHAGMLRQDRNLVENL
                     FSNGHIKVLVCTATLAWGVNLPAHAVVIKGTQIYAAKRGSFVDLGILDVMQIFGRAGR
                     PQFDKFGEGIIITTHDKLSHYLSLLTQQNPIESQFLESLADNLNAEIALGTVTNVEEA
                     VRWMSYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLLIEVGQKLDKAKMIRFEE
                     RTGYFSSTDLGRTASHFYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREE
                     EIEELDALLNNFCELSAPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAA
                     RIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSVLPPHILTRLEEKN
                     LTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVTMEASIQPITRTVLRVSLNIH
                     PDFSWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVINKEAQLLVFTIPIFE
                     PLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYE
                     ALYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVY
                     IAPLKALVRERMDDWKIRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVS
                     RSWQNRSYVQQVNILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTAL
                     ANARDLADWLNIKQMGLFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRS
                     HSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEQEMDNIIGTVRDSNLK
                     LTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEY
                     YDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVES
                     SLLGVLSDHLNAEIAGGTITSKQDAMDYITWTYFFRRLIMNPSYYSLGDVSQDSINKF
                     LSHLIGQSLVELELSHCIEVGEDNRTIEPLTCGRIASYYYLKHKTVKMFKDRLKPECS
                     TEELLSILSDAEEYTDLPVRHNEDHTNNELAKCLPIELNPHSFDSPHTKAHLLLQAHL
                     SRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAASQGWLVTVLNITHLIQMVIQGRWLK
                     DSSLLTIPNIEQHHLHLFRKWKPPVKSSHAKCRTSIECLPELIHACEGKDHVFSSMVE
                     KELQPAKTKQAWNFLSRLPVINVGISVKGSWDDLVEGHNELSISTLTADKRDENKWIK
                     LHADQEYVLQVSLQRVHFGLPKGKHENHAVTPRFPKLKDEGWFLILGEVDKRELMAVK
                     RVGFVRTHHDASISFFTPETPGRYIFTLYLMSDCYLGLDQQYDIYLNVIKANISTKDS
                     DVFTDLSV"
     exon            362..512
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            513..1072
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1193
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1401
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1543
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1669
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1870
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2011
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2176
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2353
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2425
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2560
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2752
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2977
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3097
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3262
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3349
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3526
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3752
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3753..3907
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3908..4006
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            4007..4175
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            4176..4396
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            4397..4482
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            4483..4649
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            4650..4795
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            4796..4916
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            4917..5059
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            5060..5197
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            5198..5318
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            5319..5451
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            5452..5577
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            5578..5689
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            5690..5824
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            5825..6049
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            6050..6201
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            6202..6349
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            6350..6559
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            6560..6735
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            6736..7477
                     /gene="Ascc3"
                     /gene_synonym="ASC1p200; B630009I04Rik; D430001L07Rik;
                     D630041L21; Helic1; RNAH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccggcg cccgccccgc ccctccgtcg ctcggcgcgg gtgtgtgggt ttgtgggtca
       61 gtgccagctg ggcagccctc gcgcgctaag gcgtgacagc gagcgacccc cgccggcccg
      121 cgtgtgctgc ggaggaggtc ggggcgcagc cctccgctcc gctccgccgg agtgagaaga
      181 ggaagcaaac ctccaggagg ccggaggcgc gcgtggcggc ggggctgagt ttcgagtttc
      241 ttatttctat ggatcactga ctgagttata aatggctcta cctcggctca caggagcctt
      301 gcgctccttt tcaaatgtca ccaagcaaga taattacaat gaagaagtag ctgacttgaa
      361 gttgaagcga tctaaacttc atgaacaagt tttagatttt ggccttacat ggaagaagat
      421 agtgaaattt ttgaatgaaa agctagagaa gaataaaatg caaaatataa atgaagactt
      481 aaaagacata ctacaagctg caaaacaaat cgttggaacg gataatggga gagaagcaat
      541 tgagagtggg gctgcatttc tctttatgac atttcacatg acggactctg ttggttacat
      601 ggagacaaag gctatcagac agacgtttgg tccctttcca tcgtcatctg ctacttcagc
      661 ttgtaatgcc actaatcgaa ttatttctca ttttagtcaa gatgatctca ctgcttttgt
      721 ccagatggca gaaaacccat gtaacgatag agtggttttt ggcaaaaact tagcattttc
      781 ttttgacatg tatgatctgg accactttga tgaattacca ataaatggtg aatcccagaa
      841 aactataagc ttagactaca agaagttcct gaatgaacag ttccaggaac cctacactcc
      901 tgagctcaag cctgtggaga aaacaaatgg ctccctattg tggtgtgaag ttgagaagta
      961 cttaaacgca acgttaaagg aaatgactga agcagcaaga gttgaagatc tttgctgtac
     1021 tctatatgac atgcttgctt ctgctaaaag cggcgatgaa cttcaggacg agctgtttga
     1081 attgctggga cctgaaggac tggatctgat tgagaagctg ctccagaaca gaattacaat
     1141 tgtagatcgg ttccttaatt cctcgagcga tcataagttt caagttctcc aagatagttg
     1201 taaaaagatt ttaggagaga attcaaagcc taattatgga tgtcaagtca ctattcaatc
     1261 tgaacaagaa aaacagttaa tgaaacaata tcgacgtgaa gaaaaaagaa ttgccaggcg
     1321 agaaaaaaag gctggagaag atggggaagt ttctggagaa ggagttttgc cctttgatcc
     1381 taaggaactc cggatacaga gagaacatgc acttctgaat gctagaaatg ctccaatttt
     1441 aggaagacag agagacgtgg agtttgaaaa aatccgttat cctcatgttt atgattccca
     1501 ggctcaggcc cgagaaacat cagcattcat agctggagcc aagatgattt taccagaagg
     1561 aatccagaga gagaatacca agctgtatga ggaagtcagg atcccctatg gtgaaccaat
     1621 gccagttggg tttgaggaaa aaccagttta tatcaaagat ttagatgagg ttggacagtt
     1681 ggcttttaaa ggaatgaaga gactcaatag aatccagtct atagtatttg aaacagccta
     1741 caacaccaac gaaaacatgc tgatctgtgc ccctacggga gctgggaaga ccaatattgc
     1801 aatgcttact atcttacatg aaatccgcca acactttcat caaggtgtta ttaaaaagaa
     1861 tgagtttaag attgtgtatg tcgctccaat gaaagccttg gcagctgaga tgacaaatta
     1921 cttcagcaaa cgtctagagc cactgggcat tgttgtgaaa gaattgactg gagatatgca
     1981 gttgtcaaaa agtgaaattt tacgaactca gatgctggtg accacaccag aaaaatggga
     2041 tgtagtaaca agaaagagtg ttggggatgt tgctctttcc caaatcgtaa aactcctgat
     2101 tcttgacgag gtgcacttgc tgcatgaaga cagaggccca gtgctagaaa gcatagtcgc
     2161 caggacctta cggcaggttg aatccacaca gagtatgata agaattcttg gattgtctgc
     2221 aaccttaccc aactacctcg atgttgctac atttttgcat gttaacccct acattggact
     2281 tttctacttt gatggccgtt ttcgacctgt acctcttgga cagacatttt tagggattaa
     2341 aagtacaaac aagatgcagc agttaaataa catggatgaa gtgtgctacg aaagtgttct
     2401 gaaacaagta aaggctggac accaggtgat ggtatttgta catgctcgca atgccactgt
     2461 aaggaccgct atgtctctaa tagagagagc aaaaaatagt ggccaaattt cttgctttct
     2521 acccaccgaa gggccagagt acggacatgc attaaaacag gtacaaaagt caagaaataa
     2581 gcaagtgcga gaattattct ccgatggctt tagcattcat catgccggga tgcttcggca
     2641 agacagaaat ttggttgaaa atttgttttc aaatgggcat atcaaagtcc tagtctgtac
     2701 agccacatta gcctggggtg tcaatcttcc tgcacatgcc gtggttatta agggaacaca
     2761 aatatacgct gccaaaagag gctcctttgt tgaccttgga attttagatg tcatgcagat
     2821 atttggccga gctggacgac cgcaatttga caaatttggg gaaggaatca ttataacaac
     2881 ccacgataaa ctcagccatt acctcagttt gctcactcaa caaaacccaa ttgagagtca
     2941 gtttctggaa agtcttgcag ataacctaaa tgcagagatt gcgctgggga cagtcaccaa
     3001 cgtggaagag gcagtgaggt ggatgagtta cacttacctc tatgtgcgca tgcgagcaaa
     3061 cccgctagca tacggcatca gtcacaaagc gtaccagatt gacccaacac taaggaagca
     3121 tcgagaacag ctccttattg aagttggaca aaagttggat aaagcaaaga tgattcgttt
     3181 tgaagaacga actggctatt tttcttctac tgatttgggt agaactgcca gccacttcta
     3241 tattaaatac aacaccattg agacatttaa tgaactcttt gatgcacaca aaacagaggg
     3301 tgatatcttt gctattgttt ccaaagctga agaatttgat caaattaagg tcagagaaga
     3361 agaaatagaa gaattagatg ccttgttaaa caatttctgt gaactctcag ctccaggagg
     3421 tgtggaaaat agttatggga aaataaatat cctacttcaa acctacatca gccgaggaga
     3481 gatggacagt ttctccctca tatcagattc tgcatatgtc gcccagaatg cagctagaat
     3541 tgtccgtgct ctctttgaaa ttgcactgag gaaacgttgg cctaccatga cctacaggct
     3601 tttgaatctt agtaaagtca ttgacaagag actctggggt tgggctagcc ctttgagaca
     3661 attttctgtg ttaccaccac acattctaac aagattagaa gaaaaaaacc ttactgtgga
     3721 taaactcaaa gacatgagaa aagatgaaat aggtcacatt ttgcatcatg tgaatattgg
     3781 actgaaggtc aaacagtgtg ttcatcaaat tccttctgtt acaatggaag cttccattca
     3841 gcccatcaca cggactgtcc tccgagtatc actgaacatc caccctgatt tctcttggaa
     3901 tgaccaggtt catggaacag tgggggaacc atggtggatt tgggtagaag atcctacaaa
     3961 tgaccatatt tatcactcgg agtactttct agctcttaaa aaacaggtta ttaataagga
     4021 agctcaactt ctggtattta caattcctat ttttgagcct ttgccctctc agtactacat
     4081 tcgagcagtg tctgatcgat ggctaggagc tgaagctgtt tgcattatca actttcaaca
     4141 tctgattcta ccagagagac atcctcccca tacagaatta ttggaccttc aacctttacc
     4201 aattacagct ttggggtgca aagcatatga agctctatat aacttcagcc actttaaccc
     4261 tgtacagacg cagatattcc acacactgta tcacacagac tgtaatgttc tgcttggcgc
     4321 ccccaccgga tcaggaaaga cagttgcagc tgaactagcc attttcagag ttttcaacaa
     4381 atatcctact tcaaaggcag tatatattgc acccctcaaa gctctagtac gtgaaagaat
     4441 ggatgattgg aaaattagga tagaagaaaa acttggtaaa aaagttattg aactaactgg
     4501 ggatgtgact ccagacatga aatccattgc taaggctgac cttattgtca ccacaccaga
     4561 aaagtgggat ggagttagtc gaagctggca gaatagaagc tatgttcagc aggtcaacat
     4621 tctcatcata gatgagatcc atctgctagg ggaggagaga ggcccagttt tagaagtcat
     4681 tgtatctcga acaaacttta tctcatcaca cacagaaaaa ccagttagaa tagttggact
     4741 gtccactgca ttagctaatg ctagagatct tgctgactgg ctcaacatta agcagatggg
     4801 tttgtttaac ttccgaccat cagttcgccc agttccactg gaagttcaca ttcagggttt
     4861 cccaggacaa cattactgcc cacgcatggc tagtatgaac aagcctgcat ttcaggcaat
     4921 tagaagtcac tctccagcca agcctgtttt gatatttgtc tcatcaagac gtcaaacacg
     4981 acttacagcc ttagagttga tagcatttct ggccactgaa gaagacccaa agcagtggtt
     5041 gaatatggat gagcaagaga tggacaacat cattggaaca gtacgagatt ccaacctcaa
     5101 gctgactcta gcttttggaa taggaatgca tcatgctggc ctgcatgaaa gagaccgaaa
     5161 aactgtagaa gagctgtttg tgaactgtaa agttcaggtt ctcattgcta caagcacatt
     5221 agcatggggt gtaaactttc cagcacactt agtaattatt aagggaactg aatattatga
     5281 tggaaagaca agacgttatg tggattttcc catcacagat gtgctgcaga tgatgggacg
     5341 agctgggaga cctcagtttg atgaccaggg caaagctgta attctagttc atgatataaa
     5401 aaaagatttt tataaaaagt ttctttatga acctttccca gtagaatcaa gcttattagg
     5461 agtgttgtct gaccacttaa atgcagagat tgctggaggt acaataacat caaagcaaga
     5521 tgcaatggat tatatcacct ggacttactt tttccggcgt cttatcatga atcccagcta
     5581 ctacagcttg ggtgacgtca gccaggactc cataaacaag ttcctgtcac atctgattgg
     5641 gcagtctctg gttgaattgg agctttccca ctgcattgaa gttggagagg ataatcgcac
     5701 cattgaacca ctgacatgtg gtcgaattgc ctcctattac tatttgaagc acaaaactgt
     5761 caaaatgttc aaggaccgtt tgaaacctga gtgcagcact gaggaactgc tgtcaattct
     5821 gagtgatgca gaagaataca cagacttacc agtaagacac aatgaggacc atacgaataa
     5881 tgaattggcc aaatgtcttc ccattgaatt aaatcctcat tcatttgaca gccctcacac
     5941 caaagcccat ctcttgcttc aagcgcatct cagccgagcc atgctgccct gcccagatta
     6001 tgatactgat accaaaacag tcttagacca agctctcaga gtatgccagg caatgctgga
     6061 tgtggctgca agccagggat ggctagtgac cgtcctgaat atcacccacc tgattcagat
     6121 ggtgatccaa ggccgatggc tcaaggactc ttctcttctc acaataccaa acatagagca
     6181 gcaccacctt caccttttca ggaaatggaa gccacctgta aagagctcac atgctaagtg
     6241 ccgaacatcc attgagtgcc ttcctgagct gatccatgcc tgtgaaggga aggaccatgt
     6301 gttcagctcc atggtagaga aagagttaca gcctgcaaaa acaaagcagg catggaattt
     6361 cttatctcgc ttgccagtga taaatgttgg cataagtgtt aaaggctcat gggatgactt
     6421 agttgaagga cataatgaac tctccatctc aactctgaca gcagacaaac gggatgaaaa
     6481 caaatggatc aagttgcatg ctgatcagga gtatgtgctt caagtcagcc tacagagagt
     6541 ccattttggg cttccaaagg gaaaacatga gaatcacgca gttactcctc gatttccaaa
     6601 attaaaagat gaaggctggt ttttgatatt aggagaagtg gataagagag agctgatggc
     6661 tgtaaaacga gtaggatttg ttcgaacaca tcatgatgct tccatctcgt tctttactcc
     6721 tgaaacacct ggaagatata tctttaccct gtatctcatg agtgactgtt acctcggcct
     6781 agaccagcag tatgacattt atctcaatgt cataaaagca aacatttcta caaaggactc
     6841 tgatgtcttc actgacttgt cagtatagta tcctgaccca gacaggccat ttgaccagag
     6901 gctgagagtc ttgactgttc agtcatgtga acaagtcgaa ttacttggtg tctaccttga
     6961 cagaatcaac ttcaaacctc aaaccaacta ggaaattgac agcggctgca gtgatgattc
     7021 cagcaacgtt agccacagag gccttttaga aactgctgcc ttttgtaaca gatttatgag
     7081 tttctttaca tgtaagataa gtaagcatat agtatcattt ttaagttgtg tatgttggag
     7141 gtggtagtta tgggttatca aactttgcat ctctggatgt actgtttaca tgaataccag
     7201 ctactccttt ttctaaggaa aattacattg tggtgtgacg ggttaaatgt ttaagcaatt
     7261 taaaatatat aattctatga tgtgatacaa agttgatctt attagcaaaa ttcatacttt
     7321 ggtttgatca catgtagaaa tcttataaat gatagtaata tatgatatga atttatattg
     7381 cagagatcaa tgatgatttt tcaaagacca cacactgatc ttggaaaatg tgaacactgt
     7441 aactggtgga aataaagtat atagagtgct ccttcca
//
