LOCUS       NM_029291               4961 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus activating signal cointegrator 1 complex subunit 2
            (Ascc2), transcript variant 1, mRNA.
ACCESSION   NM_029291 XM_903353
VERSION     NM_029291.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4961)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4961)
  AUTHORS   Cao,Y., Pan,C., Wang,Y.C., Zhou,Z., Jedian,V., Meng,Y.,
            Campbell,G., Guardino,K., Li,C., Wang,J. and Lusis,A.J.
  TITLE     Identification of DNA Damage Repair Enzyme Ascc2 as Causal for
            Heart Failure With Preserved Ejection Fraction
  JOURNAL   Circulation 145 (14), 1102-1104 (2022)
   PUBMED   35377742
REFERENCE   3  (bases 1 to 4961)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 4961)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 4961)
  AUTHORS   Lee,J., Saha,P.K., Yang,Q.H., Lee,S., Park,J.Y., Suh,Y., Lee,S.K.,
            Chan,L., Roeder,R.G. and Lee,J.W.
  TITLE     Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase
            activity in the mouse reveals vital roles for MLL3 in adipogenesis
  JOURNAL   Proc Natl Acad Sci U S A 105 (49), 19229-19234 (2008)
   PUBMED   19047629
  REMARK    GeneRIF: ASC-2, MLL3, and MLL4 are recruited to the
            PPARgamma-activated aP2 gene during adipogenesis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606521.24.
            
            On Dec 6, 2019 this sequence version replaced NM_029291.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.10679.1,
                                           SRR9219382.165020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AL606521.24        55514-55586
            74-171              AL606521.24        58147-58244
            172-330             AL606521.24        64326-64484
            331-501             AL606521.24        64827-64997
            502-631             AL606521.24        67504-67633
            632-699             AL606521.24        74033-74100
            700-810             AL606521.24        75979-76089
            811-923             AL606521.24        77036-77148
            924-998             AL606521.24        81993-82067
            999-1106            AL606521.24        86079-86186
            1107-1175           AL606521.24        86344-86412
            1176-1250           AL606521.24        86626-86700
            1251-1437           AL606521.24        88040-88226
            1438-1652           AL606521.24        90047-90261
            1653-1772           AL606521.24        91092-91211
            1773-1866           AL606521.24        97016-97109
            1867-1988           AL606521.24        97195-97316
            1989-2088           AL606521.24        97847-97946
            2089-2168           AL606521.24        99203-99282
            2169-4961           AL606521.24        100671-103463
FEATURES             Location/Qualifiers
     source          1..4961
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.94 cM"
     gene            1..4961
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /note="activating signal cointegrator 1 complex subunit 2"
                     /db_xref="GeneID:75452"
                     /db_xref="MGI:MGI:1922702"
     exon            1..73
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            74..171
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            172..330
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            331..501
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            502..631
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            632..699
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            700..810
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            811..923
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            924..998
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1106
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1175
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1250
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1437
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1652
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1772
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1866
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1988
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2088
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2168
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..4961
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2623..2628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /note="hexamer: AATAAA"
     polyA_site      2647
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /note="major polyA site"
     regulatory      4934..4939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /note="hexamer: AATAAA"
     polyA_site      4961
                     /gene="Ascc2"
                     /gene_synonym="1700011I11Rik; 2610034L15Rik; ASC1p100"
                     /note="major polyA site"
ORIGIN      
        1 gaccccggaa gtgctggatc tgtggaagct gtggtgtttt gcagctgaac atctcgggtg
       61 tggagccggg gaggagggtc acacagcaca atgccagctc tgcccctgga ccaactccag
      121 atcacccaca aagacccgaa gacaggacag ccgaagactt cagcagcgct gaaccctgag
      181 cagaaggcag accggtattt tgtgttgtac aaaccgcccc ctaaagacaa cattcccgcc
      241 ctagtggagg agtacctgga acgtgccaac ttcgtagcta atgacctcga ctggctcctg
      301 gccttgcctc acgataaatt ctggtgccag gttatttttg atgagaccct gcagaagtgc
      361 ctggactcct acctgcacta tgtaccccga aagtttgatg agtgggtggc cccgacccct
      421 gaggtggctg acatgcagaa tcacctgcac cggagtgttt tcctcacctt cctccgaatg
      481 tccacgcaca aggaatccaa agaccacttc atttctccat ctgcatttgg agaaatcctc
      541 tacaacaact tcctctttga catcccgaag atcctggacc tctgtgtgct ctttggaaaa
      601 ggcaactcac cactgctcca gaaaatgata ggaaacatat ttacccagca gccaagttac
      661 tatactgacc tggatgaaac cattcccacc atacttcagg tcttcagcaa tatcctccag
      721 cactgtggtt tgcaagggga tgggaccagc accacacccc agaaactcgg ggagaggagt
      781 ccgttgaccc ccagtgacat gcctctcttg gaattaaagg acattgttct ctacctgtgt
      841 gacacctcca ccacactctg ggcctttctg gacatctttc ctttggcctg ccaaaccttc
      901 cagaaacatg acttttgtta cagactagct tccttttatg agatggcaat tccggaattg
      961 gagtctgcaa ttaagaagag gaggcttgaa gacagcaagc tcctgggtga catgtggcag
     1021 aggctctccc attccaagaa gaagctaatg gaggtgtttc acatcatcct gaaccagatc
     1081 tgcctgcttc ccattctaga gagcagctgt gacaacattc aaggcttcat tgaagaattc
     1141 cttcaaatct tcagctcttt actgcaggaa aaaagattcc tccgtgacta cgacacattc
     1201 tcccctgtag ctgaagatat cagcttgctg cagcaagctt catcagcctt ggatgagacc
     1261 cggactgcct acatcctcca ggctgtggaa agtgcctggg aaggggttga cagacagaaa
     1321 atcaaggaca ttaaagaccc accaagggcc aagggttcta ataatgaagt cacagtgaca
     1381 gcagagccgg tcagtgagat gccatcccag ctggagaact tagaagagga tgaggagtgc
     1441 atgggtgcag cagctgcgct gggccctgcc gtgagtggtg tggaactaga ctcactcatc
     1501 tcccaagtga aggacctgct gccagacctc ggcgagggct ttattctggc ctgcctggag
     1561 cactacagct atgactcaga gcaggtgatc aacaacatcc tggaggatcg gctggcccct
     1621 gagctcagtc agctggaccg aggcctagaa agacaagtga agccggaccc tacacccctg
     1681 ttgtcatctc gtcacaacat cttccagaac gatgagtttg atgtgttcag cagggactcg
     1741 gtggacctga gccgagtgca caagggcagg aggaaggagg agaacgtgag gagcctggtg
     1801 aatgacaagc aggctgtggt ggcacagtgg cagcgctacc agaagtacag cgtggtggta
     1861 gaggaggtcc ccctgcagcc aggagaatac caggctgatg actatgagga cgagtatgac
     1921 gacacatacg atggcaacca ggtgggcgcc aacgatgcag actctgatga cgagctcatc
     1981 agccgcaggc ccttcaccat ccctcaggtg ctgagaacca aaatgcctgg cgaagtgcag
     2041 gaggaggagt gggatgaaga ggatgaggtg gaagaggagg cccccaagcc agaccatttc
     2101 atccaggatc ctgcagtgct gagggaaaag gctgaagcca ggcgcatggc cttcctcgcc
     2161 aggaaggggt atcggcctga gaactccacg gcagtaacag gcggcccccg gggccatggg
     2221 caaagccggg aaacaaccca ggaacgcagg aagaaagaag ccaacaaggc agccagagcc
     2281 aaccacaacc gtagaaccat ggctgaccga aaaagaagca aaggcatgat tccatcctga
     2341 gaccacaagc tgcctggacg agggacgcct tcaaggcagc tctgccctca tgaccctcaa
     2401 gacctaccag ccagccgtga gcgccttctt gtcaaacaca cagtgcctta tcctttggtg
     2461 gaggaaccca gtgccatcaa gcaggctgtc tcccagctgt gctggcggga aaggatgggg
     2521 atgccgaacc aaagtgtctt tcatcttgtg cagcgaggca ccacctccgg aagtcctgga
     2581 tggcaggaga cctgtatatt cagaagcaac gaaaggccca tgaataaagt ttctgaccct
     2641 ccggcaatgc tctgtgacat gctccagcct tttcccctct tccttcctca gaaacaccaa
     2701 tacctgaaag aaaagaaggc atagtggtcc ccatactctg ttgacttcca tgcttgcccc
     2761 cttggtgtat ctcctagtgc tgttcttcct tgctgtgtga cctctgtgcc tgtggaagga
     2821 actggccagt gtgaggccca aggtcccttc tgtggttacc tcctgtgccg ccgcctcagg
     2881 aggtagctac tgttgtctgt tacaggacac atgaggagag tggggtgtga gggctgagag
     2941 tgtccctagg ccacaggaag gaagtggctg agcaggtctt gggaagctca gtctgacccc
     3001 tggcagtata ggctctcgac ccgtgtagat tatgtcaacc cctgtgtcac aactggcaca
     3061 aggacacttg gccagtttca gagtgtcata gttataaatg tactgttagc ctccaccctc
     3121 ccaatgtaga gatcggaaac ctctagaaag aagccctgtt gaagcgagaa ggactaggct
     3181 ggctctcaga gccctttccc catgtggccc actctgcagt gggaatcagc taacaggtct
     3241 cctgggttta actagtgtgc aggagacctg cagtggggtc tttgctgggc tgatcctgag
     3301 gcagcagggc ctggagtctt tccaacagat cttttagatg acagggacat tgatttgctt
     3361 gtagttggga ctagcaggca gacagatact tgatggattg ttttattagg ccagcctgca
     3421 cgagtgaacc taaatgccag ttcctctgtg ccttgttggc ctctgggagc atttgagata
     3481 cagagcaggt acagggtggg accctcccct agggctgccg aattagctga gatctgggag
     3541 agttagccat cctgacagac agcagggaaa ctgtttcctc ctagaagcgc ttagcagcgg
     3601 cccagctcag cggcacagtc atttcttttc tccctgacta aactcagacc aagctgctgt
     3661 gtcatgcaag gctgatgagc ttgggagctc ctgatcttca tccgccttgc ctgctgctct
     3721 tccctggagc agccctcatc tgctcttggc tctctcttct tacagccacc tagaggacac
     3781 ccaggtttcc tggtagcagt ctggctgaga ggacatcacc gtctcttgtg ttttctagca
     3841 ctttggtcaa ccgcaatgcc ccctgaggag ctgctgcttg tgtcttttag ctctccagga
     3901 caccctttga aaccagcctg ttaccccagc ccttcagcct cagtgagatg aatggtacta
     3961 cttggtggtg aagtccctaa agatgaatac tgaggctgtt gctcagtagg agaacacttg
     4021 agtaatctac acaggcttag gtttgtcggc taactatgta aaagaggtcc ccatggaatt
     4081 ccaaatttaa gattagtagc ccaagagtgt tgggtgggta aaccatttgg tccctagacc
     4141 caccctccct ccaccccatg ctgtcctaat gcgggtattt tccaagtgcc ttttctgtgc
     4201 cctacagaga atgtgaccac catagatgtt tctggagaaa cttttttttt tttatcgaga
     4261 cagggattct gtgtcctgtc ctggacttcg tagactaggc tggcctcaac tcacagagat
     4321 ctacctgctt ctgctgggat taaaggcgtg caccaccaca cctggccctg aggaaacttt
     4381 taaaaccttg tacctctaaa aggatacaag acccaaatgt cattattcca gtatctatga
     4441 ctggtcagcc acaagagctt ttgtgcccca gagatggatt atgagagacc cgagggcctg
     4501 cggagaggag cagagctggc agtctgccca tggtgtctta gtagtgggtg cgtgtgtcct
     4561 tgttaaactg ccccagctga ggctggagga ggaaacagtt ggctcaagcc tgcatgtcac
     4621 tcccctacca ggagctcaga ttcagtgaca gtgcagaaaa ataaaatcag aagtagacat
     4681 ggtggtggca tgcacttatt tcttgggagg tagacacagt tcagggatag cccaagctat
     4741 gtgagaccct gtccataaat aaataaaaac caaatatttc cgaagaacaa acttaagagg
     4801 cagaatacat aggtgaacat agtagtgtaa ggcattgttt gtgagaatgt tagtgctccg
     4861 tttgcacaca gaccaatgtg gaaggaactg catgcacaat ggtagtggcg gaactgtgat
     4921 ccctgctgtt ggcaataaac aggtttcctg agtctcactg a
//
