LOCUS       NM_026937               1505 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus activating signal cointegrator 1 complex subunit 1
            (Ascc1), transcript variant 2, mRNA.
ACCESSION   NM_026937 XM_483908
VERSION     NM_026937.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1505)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1505)
  AUTHORS   Knierim,E., Hirata,H., Wolf,N.I., Morales-Gonzalez,S.,
            Schottmann,G., Tanaka,Y., Rudnik-Schoneborn,S., Orgeur,M.,
            Zerres,K., Vogt,S., van Riesen,A., Gill,E., Seifert,F., Zwirner,A.,
            Kirschner,J., Goebel,H.H., Hubner,C., Stricker,S., Meierhofer,D.,
            Stenzel,W. and Schuelke,M.
  TITLE     Mutations in Subunits of the Activating Signal Cointegrator 1
            Complex Are Associated with Prenatal Spinal Muscular Atrophy and
            Congenital Bone Fractures
  JOURNAL   Am J Hum Genet 98 (3), 473-489 (2016)
   PUBMED   26924529
  REMARK    GeneRIF: homozygous and compound-heterozygous nonsense and
            frameshift TRIP4 and ASCC1 mutations that cosegregated with the
            Prenatal Spinal Muscular Atrophy and Congenital Bone Fracture
            phenotype
REFERENCE   3  (bases 1 to 1505)
  AUTHORS   Yoo,H.M., Kang,S.H., Kim,J.Y., Lee,J.E., Seong,M.W., Lee,S.W.,
            Ka,S.H., Sou,Y.S., Komatsu,M., Tanaka,K., Lee,S.T., Noh,D.Y.,
            Baek,S.H., Jeon,Y.J. and Chung,C.H.
  TITLE     Modification of ASC1 by UFM1 is crucial for ERalpha transactivation
            and breast cancer development
  JOURNAL   Mol Cell 56 (2), 261-274 (2014)
   PUBMED   25219498
REFERENCE   4  (bases 1 to 1505)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1505)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053811.1, BC030905.1 and AW457357.1.
            
            On Dec 1, 2010 this sequence version replaced NM_026937.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030905.1, AK171958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AK053811.1         2-35
            35-1484             BC030905.1         1-1450
            1485-1505           AW457357.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..1505
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 29.67 cM"
     gene            1..1505
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /note="activating signal cointegrator 1 complex subunit 1"
                     /db_xref="GeneID:69090"
                     /db_xref="MGI:MGI:1916340"
     exon            1..103
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            104..236
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1198
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /note="ASC-1 complex subunit p50; trip4 complex subunit
                     p50"
                     /codon_start=1
                     /product="activating signal cointegrator 1 complex subunit
                     1"
                     /protein_id="NP_081213.1"
                     /db_xref="CCDS:CCDS23870.1"
                     /db_xref="GeneID:69090"
                     /db_xref="MGI:MGI:1916340"
                     /translation="MDVLRPQIVTFDGRNYRKNPIQEKQYQHEEDEDFYPDSMEYSDE
                     PCGAYEVAQTPHGFRATVSAPSLLYKHIVGKRGDTKKKIEVETKTSINIPKHGHEGEI
                     VITGQHRNGVVSARTRIDVLLDTFRRRQPFTHFLSFFLNEVEVQERFLMFQEEVLRKC
                     SKDRGVDSTIFQNPKKLHLTIGMLVLLSEQEIQQTCEILQRCKEEFINDISGGRPLEV
                     EMAGIEYMNDDPAMVDVLYAKVHMKDGSNRLQELVDRVLERFQSLGLIVKEWTSVKLH
                     ATVMNTLLRKDPNAEGRYNLYTADGKYIFKERESFDGRNILKTFENFYFGSLRLNSIH
                     ISQRFTVDSFGNYASCGHVDFS"
     exon            237..336
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            337..434
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            435..613
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            614..750
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            751..870
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            871..995
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1081
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1203
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1488
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1464..1469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /note="hexamer: AATAAA"
     polyA_site      1484
                     /gene="Ascc1"
                     /gene_synonym="1810015P09Rik; ASC1p50; CGI-18"
                     /note="major polyA site"
ORIGIN      
        1 aacccgcccc acgcatgctc agtcggatga cgctgccttt gcatacggcc ggcgcgggcg
       61 agcctccagg gtctcttcct acgctcccag ttagtcctgg caggactttc ctggaacgtc
      121 atttgtcatg gatgttctac gcccacagat tgtaacgttc gatggacgga attatagaaa
      181 gaatcccatc caggagaaac agtaccaaca tgaagaagac gaggatttct atcctgactc
      241 catggaatac tctgatgagc cctgcggtgc ctacgaggtg gcacagaccc ctcacggatt
      301 ccgggccacc gtcagtgccc ctagcctgct ctacaagcac atagttggaa agagagggga
      361 taccaagaaa aagatagaag tggagactaa aacatctatt aacattccga agcatgggca
      421 tgaaggggaa atcgtgatca ctggtcagca tcgaaatggc gtggtctcag cgcgaacacg
      481 gatcgacgtg ctcctggaca cgttcaggag gaggcagcct tttacccact tcctttcctt
      541 cttcctcaat gaagttgagg ttcaggaacg gtttctgatg ttccaggagg aggtgctgag
      601 gaagtgctcc aaggatcgtg gagttgatag caccattttt cagaacccca aaaagcttca
      661 cctaactatt gggatgttgg tacttctaag tgagcaggag atccagcaga cgtgtgagat
      721 cctgcagcgc tgtaaagagg aattcattaa tgacatttct ggaggcagac ccctggaagt
      781 cgagatggca ggcatcgaat acatgaatga cgatcctgct atggtggatg ttctttatgc
      841 caaagtccac atgaaagatg gctccaacag gctgcaggag ctggttgatc gagtgctgga
      901 gcgttttcag tccctgggac tcatcgtgaa agagtggacc agtgtgaaac tgcacgccac
      961 ggtcatgaac acactgctca ggaaagaccc caacgcggaa ggcaggtaca atctctacac
     1021 agcagatggc aaatatatct tcaaggagag agagtctttt gatggccgga acattttaaa
     1081 gacatttgag aacttctact ttggttccct gaggctcaat tctattcaca tctcccagag
     1141 gttcacggtg gacagctttg gaaactatgc ctcctgcgga catgttgact tctcctgacg
     1201 cgggagagca gcagagaacc atgactgact ggatgtcggg agcctggcag tgtggcagca
     1261 gcaggccctt tggctccagt tgaccggcag agaagggtgc tccagcccat gctcctccct
     1321 cctggctctc attctccccc tcctccttgg cttctgtcct tcattcctta ccctccaccc
     1381 tcctttctgt gactctgctc ctgagctctg tggtgtggcc gaccactgtg ctgtgcgctg
     1441 tgagatggca cagaccgtct gcaaataaat gagcttccca ggtggctgaa aaaaaaaaaa
     1501 aaaaa
//
