LOCUS       NM_080443               4893 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ankyrin repeat and SOCS box-containing 7 (Asb7),
            transcript variant 1, mRNA.
ACCESSION   NM_080443
VERSION     NM_080443.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4893)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4893)
  AUTHORS   Liu,Y., Li,X., He,Y., Wang,H., Gao,M., Han,L., Qiu,D., Ling,L.,
            Liu,H. and Gu,L.
  TITLE     ASB7 Is a Novel Regulator of Cytoskeletal Organization During
            Oocyte Maturation
  JOURNAL   Front Cell Dev Biol 8, 595917 (2020)
   PUBMED   33251222
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4893)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120791.13 and AC115761.12.
            
            On Nov 2, 2007 this sequence version replaced NM_080443.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.15126.1,
                                           SRR9219382.59802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-462               AC120791.13        59320-59781         c
            463-560             AC120791.13        59043-59140         c
            561-664             AC120791.13        51925-52028         c
            665-926             AC120791.13        49300-49561         c
            927-1532            AC115761.12        7638-8243
            1533-4893           AC115761.12        19968-23328
FEATURES             Location/Qualifiers
     source          1..4893
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 36.03 cM"
     gene            1..4893
                     /gene="Asb7"
                     /gene_synonym="Asb-7; D030055C23Rik"
                     /note="ankyrin repeat and SOCS box-containing 7"
                     /db_xref="GeneID:117589"
                     /db_xref="MGI:MGI:2152835"
     exon            1..462
                     /gene="Asb7"
                     /gene_synonym="Asb-7; D030055C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            463..560
                     /gene="Asb7"
                     /gene_synonym="Asb-7; D030055C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            561..664
                     /gene="Asb7"
                     /gene_synonym="Asb-7; D030055C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            665..926
                     /gene="Asb7"
                     /gene_synonym="Asb-7; D030055C23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             716..1672
                     /gene="Asb7"
                     /gene_synonym="Asb-7; D030055C23Rik"
                     /note="ankyrin repeat and SOCS box-containing protein 7"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 7"
                     /protein_id="NP_536691.2"
                     /db_xref="CCDS:CCDS21346.1"
                     /db_xref="GeneID:117589"
                     /db_xref="MGI:MGI:2152835"
                     /translation="MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRD
                     ANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLE
                     SEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIR
                     ERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPL
                     HLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQDVTRQPR
                     TLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI"
     exon            927..1532
                     /gene="Asb7"
                     /gene_synonym="Asb-7; D030055C23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..4893
                     /gene="Asb7"
                     /gene_synonym="Asb-7; D030055C23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3851..3856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asb7"
                     /gene_synonym="Asb-7; D030055C23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3875
                     /gene="Asb7"
                     /gene_synonym="Asb-7; D030055C23Rik"
                     /note="major polyA site"
     regulatory      3976..3981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asb7"
                     /gene_synonym="Asb-7; D030055C23Rik"
                     /note="hexamer: AATGAA"
     polyA_site      3997
                     /gene="Asb7"
                     /gene_synonym="Asb-7; D030055C23Rik"
ORIGIN      
        1 atcccagtga ccccaaagtg ctggaaggag ggggcggggg tggcccagtg caaagtgcat
       61 cccgaaagcc ccctgtcggg acaccctgct gctgacactt cggacctggt atgacttagg
      121 gtctctctgt ccccagacct cttgagtccc tcggtagctg aaagcctccg gcccggcgcg
      181 cggcagaccc ttggtctgag cccctggacc gggactgccc cccccccccc ccacccagcc
      241 ggcacttcct cccagcgccc cttcccggag gctgctccga ggccaagacc gccaccccca
      301 gcctgatcga ctatctggat gctctctggg ttggggccgt gaagcaccca ggaggatcag
      361 gaacacggtg tccggccctg cctggggtgt ttcttcaatg gagaagttgg tgaatgtgca
      421 ggaggctgaa aggagagaga ggagctgcaa ctgaggacac aggtttgagc ttgctggagg
      481 acactcgcga gtagaagggg tctggccacc caccagagga gcaataaaca gagtgctttg
      541 gaccagcatc ctcttgaaag gtgaagaagg ccggcgcaca ctgggagccc ttcccgccat
      601 gctgcatgca cgccatggtt attagacaag ctgtctaccg agagaagaga cattcttctg
      661 taaggctgcc tcccgtgacc taatgtctgg ttggtgaaaa gcagactcca ctaggatgtt
      721 acaccaccac tgccggagga accctgagct tcaggaagag ttgcagattc aggctgcagt
      781 ggcagccggg gatgttcaca cagtacgaaa gatgttggaa caaggctatt ccccaaatgg
      841 ccgagatgcc aatggctgga ccttgctcca tttctctgca gcaagaggaa aggagaggtg
      901 tgttcgagtg tttctggaac acggagctga tcccacggtt aaggatttaa tcggaggctt
      961 cactgctctg cattacgctg ccatgcacgg ccgggcccgg attgcacgcc tgatgttaga
     1021 gtctgagtac aggagtgaca ttattaatgc aaaaagcaat gatggctgga ctcccctcca
     1081 tgtggctgcc cactacggta gggactcatt tgtccggctc ctcctggagt tcaaggctga
     1141 agttgacccg ctcagtgata aaggtacaac gccacttcag cttgccatca tccgagagcg
     1201 gtcaagctgt gtgaagatcc ttctggacca caacgccaac atcgacatcc agaacggatt
     1261 cctgctgcgc tatgctgtga tcaaaagcaa tcactcttac tgccgcatgt ttcttcagag
     1321 aggagcagac acaaacttag ggcgtctaga agacggacag actcctttgc acttgtctgc
     1381 cctccgtgat gacgtgctct gcgcacggat gctgtataac tatggagcgg acacgaacac
     1441 aaggaactat gaaggtcaga ctccactggc cgtttccata agtatttcag gaagtagtcg
     1501 gccgtgtttg gatttcttac aagacgtcac aagacagccc agaaccctgc aggacctgtg
     1561 ccgaattaaa attcgacagt gtataggcct tcaaaacctg aagctgcttg atgagctacc
     1621 aattgccaag gtcatgaaag actacttaaa acacaaattt gatgatatct gatacacctg
     1681 gactgtggac aagattacga gttattccag atacttaaaa ggcttcaggc cttgcacaaa
     1741 gtatatccta tgcaatttct gatttgcggt caagtcagaa agcaggtata cacttttagg
     1801 tttatgtttg tttggatttc atttggggga gggatctgtg tgtgtgtgtg tgtgtgtgtg
     1861 tgtgtgtgtg tgtgtgtcta cactcacaca tacacacccc acgcttgaag gtcttaattt
     1921 ggtttcttgg tccaagtcga tgaggtccaa gcctttctat acaatactgc atttagaaaa
     1981 tttgtttttc ctaagtgcac aatatagaca ggtttgaagc agagaatttt cccttttgat
     2041 gctctggttt cattggtgaa cacggtacta ggaaccagta gacggaatac ttcttaaagt
     2101 ttggaggtct caggctcacc tcctgtgatc ctgggtgatg ctggaaaatt ctctgtgaag
     2161 aaacttacag taatgctgtc gcctcattca tttttaatga gtacagatga gctgtttaaa
     2221 aatccttttt cccttctaat taatgtagct ttccgatgaa aaaaaccaac ccaggacctc
     2281 ggcttccttt ggtgtgcgct ttttttttaa attatttttt ttaacaactg taagacacta
     2341 ccctgaaaca ttgtgtttca actcccccac cccctctctt attgaattgt gcttttaaaa
     2401 caaaatcaat ggggaaagga attaactttt taaagccagt gtattctgtt ttttaaaaaa
     2461 caaaacaaaa acaaaaaatg gtgcctcttg tgcaactctc ttggtgtcgt ctctggatgg
     2521 tttgctcttc ctgttcttca gttggcttcc ttgtgcccct tggagccatc atcaccacct
     2581 ccatcccaca gcaggccacc aggatcacct cagtttccac cttaaacttt gtgttttatt
     2641 tcaccttaaa gaacaaattt catattctgg tgatgacaga ggtccctaga aatagcccac
     2701 attcttgcta aaccattcta ctttaatgac taaatatttc agggtggttt cttggtggat
     2761 ttttttgcct tcctggtaat atgtatacat atatatttta aggggaaagt ctctaatggg
     2821 cacccttttg taagcctggc aaattgctga tacgctaatt aagtatttcc tgtctatttt
     2881 gaaggtgagt acagtaaagc tcttcaagac aaatatttta attttctggg ttggttggac
     2941 aagtatgtgc aagaaagacc cggatgtagt aaagtgttag taacaagggg gagggcccag
     3001 aggccctagg catcatgggt gttcctgggg acacacactc actgcttcat ttgacgttat
     3061 gttagtttga agacaccccc ttttaagttc cccatgccat tcttagtgct gtgacaaatt
     3121 ttttaaatat ttataaactg ttaataaatt tgctatcaaa aggttgcagg ataagggctt
     3181 ctcctttctt gtcagaattg ccagtttgaa ggcatagagg gtaaagtctt cccctcctaa
     3241 cataattaag cagaattagg tttccctgag ttcaggctag cagtgttgtt cactcaagcc
     3301 caaagcttgc cgtcttggcc agagtagctg tgaccgcaga acattgggtt tgcgtgtgcc
     3361 taggtggcac agggattcct gaacaggcaa aaggatgctt cagggacttg ctgatgtggc
     3421 ccatagcctc cttcagggag agcatgaggc cagagtgata gctgggaccc aggaagatag
     3481 ggatggctgt ggtgaccctg gctgaaaggt tacctccatg gagagtcccc ttctaaggca
     3541 cctgcaaagc tgtgttctca gtctttattc aggccccagg tcagggctgg agacacacta
     3601 ccagccttag ggacacaaag tgaccagaaa ttagttgagt gtaacttgtg ttagagcccc
     3661 agcccagcat ggaaagtggt gggaggagag ctgagagtct ggactctgag ctgccatatt
     3721 agtgtccagt tgcacaggaa tcatacatga aaattaattt attttgtaag ttaaaagtga
     3781 cattcacttt ccagccattc agagggttct gaactaagcc actgaaatcg aattgaatca
     3841 ggggatccca aataaaaaga tcatattaag gcaaattctt tgtgctgttt actgctgtga
     3901 cttcagaaaa aaaaacaaaa aacaaaaaaa caaaaacaat tctgagtgct cttccaggaa
     3961 ttgaaaattc tatttaatga agaagtgtat aattccatta tttattgttt gtggtttgat
     4021 ttatctggaa gcttgagaga atgtcctttg tttatactag accccagtcc tgtgctgtat
     4081 tctatggtaa cggaagggct gtccagttgc tgatgtggtt gtggtgacca tgcaggtctg
     4141 cccctgaatt tgttatcaga gaagcagtct gtggccctag gagagaaaac agcccctcat
     4201 aacacagccc gttgactcaa aattcacact gagtcttttg cgcttctttt gaaatttatt
     4261 atttaagcct attactaaaa ctttataaaa tgcatttggc gaatacacca aagaaaccag
     4321 ctcataaaat atgatcatta acgaactgca aacctcatct tttgaaaaca agggtgtttc
     4381 tttgtaaata tttgtgttta taaatgtaca gcagagttaa gagtgttttt ttagattatt
     4441 taattcccat atttctaaac tatttactac agaataaccc ctgcttatta gtttgggtga
     4501 cttgattgtt tgtttttttt ttttttaatt cattaccagt catgcttgga gtgacgattc
     4561 tgctggagag gtcagcactc tggcagtggc tggagtcgct tgtaaagcat gggggagact
     4621 agcatgacct gtcagactcc tccctcgtaa gacaccagga aagcgtagct taatggccag
     4681 agtggaccat gagaaagagt ttctaacttc cctactgaat cacctgttag cccagggtgg
     4741 aattgggaca aggctgtttg cccacaaatt tagctttcat gtaactccca gtgtgttgta
     4801 tcataatata ttctgttctt tctttgtaac gtaagttttg ctttgggtcg atttgaatta
     4861 aaaaaaaaaa tcttaaatct ggtttaaaaa aaa
//
