LOCUS       NM_001355662            3455 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus ankyrin repeat and SOCS box-containing 4 (Asb4),
            transcript variant 2, mRNA.
ACCESSION   NM_001355662 XM_017321708
VERSION     NM_001355662.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3455)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3455)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3455)
  AUTHORS   Iskusnykh,I.Y., Fattakhov,N., Li,Y., Bihannic,L., Kirchner,M.K.,
            Steshina,E.Y., Northcott,P.A. and Chizhikov,V.V.
  TITLE     Lmx1a is a master regulator of the cortical hem
  JOURNAL   Elife 12, e84095 (2023)
   PUBMED   37725078
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3455)
  AUTHORS   Gu,R., Zhang,S., Saha,S.K., Ji,Y., Reynolds,K., McMahon,M., Sun,B.,
            Islam,M., Trainor,P.A., Chen,Y., Xu,Y., Chai,Y., Burkart-Waco,D.
            and Zhou,C.J.
  TITLE     Single-cell transcriptomic signatures and gene regulatory networks
            modulated by Wls in mammalian midline facial formation and clefts
  JOURNAL   Development 149 (14) (2022)
   PUBMED   35781558
REFERENCE   5  (bases 1 to 3455)
  AUTHORS   Vagena,E., Crneta,J., Engstrom,P., He,L., Yulyaningsih,E.,
            Korpel,N.L., Cheang,R.T., Bachor,T.P., Huang,A., Michel,G.,
            Attal,K., Berrios,D.I., Valdearcos,M., Koliwad,S.K., Olson,D.P.,
            Yi,C.X. and Xu,A.W.
  TITLE     ASB4 modulates central melanocortinergic neurons and calcitonin
            signaling to control satiety and glucose homeostasis
  JOURNAL   Sci Signal 15 (733), eabj8204 (2022)
   PUBMED   35536884
REFERENCE   6  (bases 1 to 3455)
  AUTHORS   Ono,R., Shiura,H., Aburatani,H., Kohda,T., Kaneko-Ishino,T. and
            Ishino,F.
  TITLE     Identification of a large novel imprinted gene cluster on mouse
            proximal chromosome 6
  JOURNAL   Genome Res 13 (7), 1696-1705 (2003)
   PUBMED   12840045
REFERENCE   7  (bases 1 to 3455)
  AUTHORS   Mizuno,Y., Sotomaru,Y., Katsuzawa,Y., Kono,T., Meguro,M.,
            Oshimura,M., Kawai,J., Tomaru,Y., Kiyosawa,H., Nikaido,I.,
            Amanuma,H., Hayashizaki,Y. and Okazaki,Y.
  TITLE     Asb4, Ata3, and Dcn are novel imprinted genes identified by
            high-throughput screening using RIKEN cDNA microarray
  JOURNAL   Biochem Biophys Res Commun 290 (5), 1499-1505 (2002)
   PUBMED   11820791
  REMARK    GeneRIF: Asb4 has been identified as an imprinted gene by
            high-throughput screening using RIKEN cDNA microarray.
REFERENCE   8  (bases 1 to 3455)
  AUTHORS   Kile,B.T., Metcalf,D., Mifsud,S., DiRago,L., Nicola,N.A.,
            Hilton,D.J. and Alexander,W.S.
  TITLE     Functional analysis of Asb-1 using genetic modification in mice
  JOURNAL   Mol Cell Biol 21 (18), 6189-6197 (2001)
   PUBMED   11509662
REFERENCE   9  (bases 1 to 3455)
  AUTHORS   Kile,B.T., Viney,E.M., Willson,T.A., Brodnicki,T.C., Cancilla,M.R.,
            Herlihy,A.S., Croker,B.A., Baca,M., Nicola,N.A., Hilton,D.J. and
            Alexander,W.S.
  TITLE     Cloning and characterization of the genes encoding the ankyrin
            repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and
            Asb-4
  JOURNAL   Gene 258 (1-2), 31-41 (2000)
   PUBMED   11111040
REFERENCE   10 (bases 1 to 3455)
  AUTHORS   Palmer,R., Gallagher,P.M., Boyko,W.L. and Ganschow,R.E.
  TITLE     Genetic control of levels of murine kidney glucuronidase mRNA in
            response to androgen
  JOURNAL   Proc Natl Acad Sci U S A 80 (24), 7596-7600 (1983)
   PUBMED   6584873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023285.5 and AC119865.12.
            
            On Sep 22, 2017 this sequence version replaced XM_017321708.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133894.1, BC054745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-386               AC023285.5         173440-173825
            387-686             AC023285.5         181254-181553
            687-1177            AC119865.12        50030-50520         c
            1178-1291           AC119865.12        44009-44122         c
            1292-3455           AC119865.12        40840-43003         c
FEATURES             Location/Qualifiers
     source          1..3455
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 1.99 cM"
     gene            1..3455
                     /gene="Asb4"
                     /gene_synonym="8430401O13Rik"
                     /note="ankyrin repeat and SOCS box-containing 4"
                     /db_xref="GeneID:65255"
                     /db_xref="MGI:MGI:1929751"
     exon            1..386
                     /gene="Asb4"
                     /gene_synonym="8430401O13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1480
                     /gene="Asb4"
                     /gene_synonym="8430401O13Rik"
                     /note="ASB-4; ankyrin repeat and SOCS box-containing
                     protein 4"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 4"
                     /protein_id="NP_001342591.1"
                     /db_xref="CCDS:CCDS19901.1"
                     /db_xref="GeneID:65255"
                     /db_xref="MGI:MGI:1929751"
                     /translation="MDGITAPISKAGAAKLVKKDFLEALKTNDFGKLKAILIERQIDV
                     DTVFEVEDENMILASYKQGYWLPSYKLKSSWATGLHLSVLLGHVECLMVLLDHNATIN
                     CRPNGKTPLHVACEIANLECVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLV
                     LRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVENGAIVDSMNAHMETPLAIATYW
                     ALRFKEQEYSREHHLICRTLLDNNAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGA
                     EANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSC
                     PKAIEVVVNAYEHIRWNIKWRRAIPDDDLEKHWDFYHSLFKVCCNTPRTLMHLSRCAI
                     RKALHNRCHKAIPMLSLPLPLKKYLLLEPEGIIY"
     exon            387..686
                     /gene="Asb4"
                     /gene_synonym="8430401O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            687..1177
                     /gene="Asb4"
                     /gene_synonym="8430401O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1291
                     /gene="Asb4"
                     /gene_synonym="8430401O13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..3455
                     /gene="Asb4"
                     /gene_synonym="8430401O13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3426..3431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asb4"
                     /gene_synonym="8430401O13Rik"
                     /note="hexamer: AATAAA"
     regulatory      3437..3442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asb4"
                     /gene_synonym="8430401O13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3451
                     /gene="Asb4"
                     /gene_synonym="8430401O13Rik"
     polyA_site      3455
                     /gene="Asb4"
                     /gene_synonym="8430401O13Rik"
                     /note="major polyA site"
ORIGIN      
        1 tccagtttaa aggacctgag aactcaggga gagtctggga ggatattttg aagtttgaaa
       61 tgatccctat ataaatagaa cgggtcagca taactttggg ataaaattag ccggcagttt
      121 gtggactctc cagccttgcc tgtgtgctgg gtgctgctct cctgataaat cattgctccg
      181 cttccacagg gctccgagga tggacggcat cactgcccct atcagcaaag ctggagctgc
      241 caaattagtt aagaaagatt tcctggaggc tctaaaaaca aatgacttcg gaaaactgaa
      301 ggctatttta atcgagaggc aaatagatgt ggacacagtg tttgaagttg aagatgagaa
      361 catgattttg gcatcttaca aacaaggcta ttggttgccc agttataagc tgaagtcttc
      421 ctgggccaca ggcctgcatc tgtcagtttt gcttggtcat gtggagtgcc tgatggtact
      481 gctggaccac aatgctacca tcaactgtcg tcccaacggg aagacccctc tgcacgtggc
      541 ttgtgaaatc gccaacctcg agtgcgtgaa gattctctgt gaccgtggcg caaagctcaa
      601 ctgctactcc ctgagtgggc acactgcttt gcacttctgc accacaccga gctccatcct
      661 ctgtgccaag cagttggtgt tgagaggtgc aaacgtaaac atgaaaacca acaaccagga
      721 tgaagagaca cccctgcaca cggcggccca cttcggcctc tctgagctgg ttgccttcta
      781 cgtggagaac ggggccatcg tggatagcat gaacgcccac atggagaccc cactggccat
      841 tgccacctac tgggccctgc gcttcaagga gcaggagtac agcagggaac accacctcat
      901 ctgccgcacc ctgctggaca acaacgccga ggtcaacgct cgtgatgatg atttcaagtc
      961 ccctctacac aaggctgcct ggaattgcga ccacgtgctc atgcacatga tgctggaggc
     1021 aggagctgag gccaacctca tggatatcaa tggctgtgcc gctatccagt acgtgctgaa
     1081 ggtcacctcc gtgcgtcctg ctgcacagcc tgagatctgc taccagctgc tgctgaacca
     1141 cggggctgcg cgcatctacc ccccacagtt ccacaaggtg atccaggctt gccactcttg
     1201 cccgaaagcc attgaagttg tggtcaatgc ctatgaacac attcgatgga acataaagtg
     1261 gagacgagcc attcctgatg atgacttgga gaaacactgg gatttttacc actctctctt
     1321 caaggtgtgc tgcaacaccc ccagaaccct catgcacctg tcaagatgtg ccattcgaaa
     1381 agcgctacac aacagatgcc acaaagcaat ccctatgctg tccctcccac tgccgttgaa
     1441 gaagtacctg cttttggagc cagagggaat catttactaa gtcttaggag acaacagttg
     1501 ccaatcctag atttctaagg ggactcactg ggtagacgca gtttgcatgg ataaaatggt
     1561 ccttgggttg gttatcacac tttagggatt ttaaaacact ttacaaacac caagccatta
     1621 atcctagagt agtatgctga gggaaaataa gcgagaaatg ttaaagaatt ttcagacaca
     1681 atggctacat ttagaaggca gatactatta tagtagctca tgtgacaaca tacagtgaca
     1741 acttttatta ggtgcctgat gtaatttgta aaatgttcac atatgatttc atctcaaaag
     1801 ggacccacat tttcttataa ccaatctcat tcactacatt atcagtaata cgtttacatg
     1861 attgtttcgt ttgcaatgta gcaggttttg tgagtgaccg cttaagcttg gtgtctccca
     1921 ccagtgacta ttgaggagac attactgtta ctagttttag aaacgccttc tccccaaatc
     1981 aaagtcatcc actccttttg gtgacaaatg cacaggagta cagtgggaac aagatctttg
     2041 agtctagata gaaaaagaag ggaagagcag tttactttat agcctaggaa tagacatttc
     2101 aacacactga gccagacact ggaggccgca gatggacctc cagggttgaa tgtttaaaag
     2161 gggatccaaa catacgagca gatgactgct gtatgaagtg atggggcagg agtacaggtg
     2221 caaactcata tgtactgctt aactttctga agtgtgctct gacttgaagt gcgtgattta
     2281 ttttatttta ttttttttta accatgaaga caaagcacgg agtactgttt agaggaacct
     2341 gctactattg gagtaaatgt ctttgaattt ttccagacta ttgagatagt gttttatttt
     2401 gtgtggtttc ctgattttag tacctttcca gagtctgaga aaaaatattc tacactccag
     2461 ctctcatgta gacgagaaag aaatttgagg aagtttttag gcaaaagcag ttgtaaagag
     2521 aacgtcttaa ttgattttct tggtgttttc atggaacagg tagacagttt agagtatttt
     2581 agctgataga aaaggaactt gcgttttaac agtggctccc ttcagttgga aaaagaaaga
     2641 aagaaaaaaa gaaaaaaaaa cctttgcata gaaggaaata tgctataaga cttatttagt
     2701 atttgctagt acaatcacac tggtatgcct cctggagaac tttgttttcc tcatttggtt
     2761 ctcagtgatc actgttggat tagcttgttg cctctgggca cagacttggt accagttaaa
     2821 attgtaagta gtgacgtgta gacactgtac cgctgtgggc agactccttt catttctctg
     2881 tggcgttgct tcttgcttcc tgtcggatgt tctcctgttg tggtgactag agatgttgtc
     2941 agacatccca gtagttcccg atgtagctgt gtttgtaaat cgagaccctc ttactcccag
     3001 ttttgtgtag gtggacacgt tcatgtattt gatgtatcaa tttaactcaa ctgatttcag
     3061 aaaaaaaaat tctgtattag aacaagatct ctagcctgaa acggaatgct gaatttgtac
     3121 agattacaca tagaaagtag tttgcttaac tgagtgttat ttagaacata tttcagaata
     3181 ttcaaagggt tgggggcttc tctccatcac caggaacatt ctggcagaaa agtctgtgct
     3241 ggactgattt atcacaggtg tagtgggact gagaacaagc agacaaggtt ttcctcatat
     3301 agggagctag ggatgtttgt catagtgttg caatgtttcc cttagtctag tgtggaatat
     3361 gtagccactt gttttgaatt gcttgcacat gtgtttaatg tgattatttc tgtaccttgt
     3421 cctttaataa aacttcaata aagatcataa ataaa
//
