LOCUS       NM_023906               3225 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus ankyrin repeat and SOCS box-containing 3 (Asb3), mRNA.
ACCESSION   NM_023906
VERSION     NM_023906.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3225)
  AUTHORS   Cheng,M., Xu,B., Sun,Y., Wang,J., Lu,Y., Shi,C., Pan,T., Zhao,W.,
            Li,X., Song,X., Wang,J., Wang,N., Yang,W., Jiang,Y., Huang,H.,
            Yang,G., Zeng,Y., Yang,D., Wang,C. and Cao,X.
  TITLE     ASB3 expression aggravates inflammatory bowel disease by targeting
            TRAF6 protein stability and affecting the intestinal microbiota
  JOURNAL   mBio 15 (9), e0204324 (2024)
   PUBMED   39162488
  REMARK    GeneRIF: ASB3 expression aggravates inflammatory bowel disease by
            targeting TRAF6 protein stability and affecting the intestinal
            microbiota.
REFERENCE   2  (bases 1 to 3225)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   3  (bases 1 to 3225)
  AUTHORS   Kile,B.T., Metcalf,D., Mifsud,S., DiRago,L., Nicola,N.A.,
            Hilton,D.J. and Alexander,W.S.
  TITLE     Functional analysis of Asb-1 using genetic modification in mice
  JOURNAL   Mol Cell Biol 21 (18), 6189-6197 (2001)
   PUBMED   11509662
REFERENCE   4  (bases 1 to 3225)
  AUTHORS   Kile,B.T., Viney,E.M., Willson,T.A., Brodnicki,T.C., Cancilla,M.R.,
            Herlihy,A.S., Croker,B.A., Baca,M., Nicola,N.A., Hilton,D.J. and
            Alexander,W.S.
  TITLE     Cloning and characterization of the genes encoding the ankyrin
            repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and
            Asb-4
  JOURNAL   Gene 258 (1-2), 31-41 (2000)
   PUBMED   11111040
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB618690.1, AK143580.1 and AK028489.1.
            
            On Sep 8, 2006 this sequence version replaced NM_023906.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143580.1, BC023086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-540               BB618690.1         3-542
            541-2404            AK143580.1         476-2339
            2405-3225           AK028489.1         2474-3294
FEATURES             Location/Qualifiers
     source          1..3225
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 18.19 cM"
     gene            1..3225
                     /gene="Asb3"
                     /gene_synonym="2400011J03Rik; Asb-3"
                     /note="ankyrin repeat and SOCS box-containing 3"
                     /db_xref="GeneID:65257"
                     /db_xref="MGI:MGI:1929749"
     exon            1..172
                     /gene="Asb3"
                     /gene_synonym="2400011J03Rik; Asb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            173..381
                     /gene="Asb3"
                     /gene_synonym="2400011J03Rik; Asb-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1763
                     /gene="Asb3"
                     /gene_synonym="2400011J03Rik; Asb-3"
                     /note="ankyrin repeat-containing SOCS box protein 3;
                     ankyrin repeat and SOCS box-containing protein 3"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 3"
                     /protein_id="NP_076395.2"
                     /db_xref="CCDS:CCDS24511.1"
                     /db_xref="GeneID:65257"
                     /db_xref="MGI:MGI:1929749"
                     /translation="MDFTEAYSDTCSTVGLAAREGNVKILRKLLKKGRSVDVADNRGW
                     MPIHEAAYHNAVECLQMLIHTDSSENYIKAKTFEGFCALHLAVSQGHWKITQILLEAG
                     ADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNGSHSMSGWNSLHQASFQGNAE
                     TIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFI
                     AAQEGHTKCVELLLSSGADPDLYCNEDNWQLPIHAAAQMGHTETLDLLIPRTNRACDT
                     GPDKVSPVYSAVFGGREECLEMLLQNGYSPDAQMCLVFGFSSPLCMAFQKDCDFSGIV
                     NILLKYGAQLNELHLAYCLKYEKFSMFCSFLKKGSLMVPWNHTSEFISYAVKAQTKYK
                     AWLPHLLLAGFDPLILLCSSSWVDSASDDILIFTLEFSNWKRLPSAVEKMLSVRANSS
                     WALQQHLASVPSLTHLCRLEIRASLKAEHLHSDIFIHQLPLPRSLQNYLLYEEVLRMN
                     EILEPAANQDGETSKAT"
     exon            382..540
                     /gene="Asb3"
                     /gene_synonym="2400011J03Rik; Asb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            541..653
                     /gene="Asb3"
                     /gene_synonym="2400011J03Rik; Asb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            654..789
                     /gene="Asb3"
                     /gene_synonym="2400011J03Rik; Asb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            790..967
                     /gene="Asb3"
                     /gene_synonym="2400011J03Rik; Asb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1165
                     /gene="Asb3"
                     /gene_synonym="2400011J03Rik; Asb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1426
                     /gene="Asb3"
                     /gene_synonym="2400011J03Rik; Asb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1557
                     /gene="Asb3"
                     /gene_synonym="2400011J03Rik; Asb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..3225
                     /gene="Asb3"
                     /gene_synonym="2400011J03Rik; Asb-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1975..1980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asb3"
                     /gene_synonym="2400011J03Rik; Asb-3"
                     /note="hexamer: AATAAA"
     polyA_site      1992
                     /gene="Asb3"
                     /gene_synonym="2400011J03Rik; Asb-3"
                     /note="major polyA site"
ORIGIN      
        1 acatcaacat ccggggttgt tgagtcggtg gcctacggaa gcccgcgctt gggtcgcgtt
       61 gcattgcgtt gctgctgtag catcctagcg gttggactca aacgcagagg cccgggactg
      121 acgccggttg aacgggtctg gagacggcgc ttggacgaag cggcccggcc agactgatca
      181 aaaggatgga ttttacagag gcttactcag acacgtgttc tacggttgga cttgctgcca
      241 gagaaggcaa tgttaaaatt ctaaggaaat tgctcaaaaa aggccgaagt gtggatgtcg
      301 ctgataacag gggatggatg ccgattcatg aagcagctta tcacaatgct gtagagtgtt
      361 tgcagatgct aattcataca gattcatctg aaaactacat taaggcaaag acgtttgagg
      421 gcttctgtgc attgcatctt gctgtgagtc aaggacattg gaaaatcaca cagattcttt
      481 tggaagctgg agctgatcct aatgaaacca ctttagaaga aactacacca ttgtttttag
      541 ctgttgaaag tggacggata gatgtattaa agctgttgct tcaacatgga gcaaatgtca
      601 atggatccca ttctatgagt ggatggaatt ccttgcacca ggcttctttc cagggaaatg
      661 ctgagactat aagattgctt cttaaacaag gagcagacag agaatgccaa gatgactttg
      721 gaatcacacc tctgtttgtg gctgctcagt atgggaagct agagagcatg agcatactta
      781 tttcatctgg tgcaaatgtc aattgccaag ccttggataa agctactcct ttgtttattg
      841 ctgcacaaga gggtcataca aaatgtgtgg aacttttgct gtccagtggg gcggatcctg
      901 acctttattg taatgaagac aattggcaat tacctattca tgctgctgca caaatgggcc
      961 atacagagac cttggacttg ttaataccac gtactaaccg ggcttgtgac actggaccag
     1021 acaaagtgag ccctgtttat tctgcagtgt ttggaggacg ggaagagtgc ctggaaatgt
     1081 tactgcagaa tggctatagc ccagatgcac aaatgtgctt ggtatttgga ttcagttccc
     1141 ctctgtgcat ggctttccaa aaggactgtg atttttctgg aattgtgaat attcttttga
     1201 agtatggagc ccagttaaat gaacttcact tggcatactg cctcaagtat gagaagtttt
     1261 caatgttttg ctcttttttg aagaaaggtt ccctgatggt accttggaat catacatctg
     1321 aattcataag ttatgcagtt aaagcacaaa caaaatacaa ggcatggttg ccacatctcc
     1381 tgcttgctgg atttgaccca ttgattctgc tgtgcagcag ctcttgggtt gattcagcca
     1441 gtgatgacat ccttatcttt actttggaat tttctaattg gaagagactt ccttcagctg
     1501 ttgaaaagat gctctctgtt cgtgcaaact cctcttgggc tcttcaacaa catttggcct
     1561 ctgttccaag cctaacccat ctttgtcgtt tggaaattcg ggccagtcta aaagcagagc
     1621 accttcactc tgacattttc atccatcagt tgccacttcc cagaagtctg cagaactatt
     1681 tgctctatga agaggtttta agaatgaatg agattctaga accagcagct aatcaggatg
     1741 gagaaaccag caaggccacc tgacacaggt cctttaattc tgtttagtca caaaagacgg
     1801 cttgtgtgac tgtttggatt tggtgatcaa atgtccatgt ttacagttgc ttttcccagt
     1861 ttgtgtcttt cccaatattg tgaaccttat ccatcttgcc ttactcagtt ttatttctag
     1921 tgcactttgt tgtgtattat ttgtttacct gaccattttc tactttattc tgctaataaa
     1981 ctgtaattct gatgtggtgc tggatgtgac ttctttctac ttaggattca tgttcacctg
     2041 tgctagaatc taaggataga atccataaat ttccccagaa gaatttataa catctgtcct
     2101 tttgaattat atttcattat tattttactt agggatgaat atcttcaatg tttattaaga
     2161 ggaaactttc ctccatgtta taatctgttc tcagtcctta attcaaacat ttttgtgagg
     2221 tgttgatact cttgcatttt cacatgtaaa atcaggagtc ctttaaaaaa aaaaaaaaga
     2281 acataaaaag tcagtcatat tgttgatctc tcgcccccta ggttcattct ttctttatac
     2341 ttttggcaaa agatacctga tttttagttt gcaaagacaa gaacacatct aaactcaaag
     2401 tcatacacag cataaactat tttatgtcat ctttagaagt attttactgc acttagaata
     2461 ttaataaaga aacctgaaaa ggacattcat acagcactat ctatagggaa agaatgcaca
     2521 ctttattaat ttaatgctaa atataatagc caggcttcat tcagctccag aataagagag
     2581 cagctttgtt cctgttagtc accaatagtc aattatatca catcaatata atgtttttct
     2641 taatgtctgg atgtattttc agatcgtgga tgaaatatgg acctcagaat actactgcct
     2701 tgtgaatttt tacaactatt ttatttaaac ctcgagtcaa gaaaaatcaa acatgatcaa
     2761 atcagttatt tagggaattg gaaactagcc ttaagaaggt actagagtgt tgctgtcaat
     2821 atagacagaa caggctggtt tctaaaggag gcaagccttc atctcttgcc agcaacctga
     2881 gactgggtag atcagctggt cgcattttga taagcccttg aaagaagcat aatgtcttac
     2941 tgataactga ttgggaagac aagctcatct ttacattcaa gtcttgtttt gtgaggatat
     3001 aaagttaggt attgaaaagt aggcagaaat tctgatagtt ctggttaata aagatattcc
     3061 aaacttttaa aattttattt ttaaaataat gtgactttta tttttcaaac tctgtatcag
     3121 gttttgtttt tgcttatggc caagtgtata tagagtgctt taaaagagtt taccttttaa
     3181 tgtattttgt tcatgtccaa atgtattata aaaccctgat ttccc
//
