LOCUS       NM_023049               2707 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ankyrin repeat and SOCS box-containing 2 (Asb2),
            transcript variant 1, mRNA.
ACCESSION   NM_023049 XM_977651 XM_977692 XM_977732 XM_977761
VERSION     NM_023049.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2707)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2707)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
REFERENCE   3  (bases 1 to 2707)
  AUTHORS   Min,K.D., Asakura,M., Shirai,M., Yamazaki,S., Ito,S., Fu,H.Y.,
            Asanuma,H., Asano,Y., Minamino,T., Takashima,S. and Kitakaze,M.
  TITLE     ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis
  JOURNAL   Sci Rep 11 (1), 23056 (2021)
   PUBMED   34845242
  REMARK    GeneRIF: ASB2 is a novel E3 ligase of SMAD9 required for
            cardiogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2707)
  AUTHORS   Tyser,R.C.V., Ibarra-Soria,X., McDole,K., Arcot Jayaram,S.,
            Godwin,J., van den Brand,T.A.H., Miranda,A.M.A., Scialdone,A.,
            Keller,P.J., Marioni,J.C. and Srinivas,S.
  TITLE     Characterization of a common progenitor pool of the epicardium and
            myocardium
  JOURNAL   Science 371 (6533) (2021)
   PUBMED   33414188
REFERENCE   5  (bases 1 to 2707)
  AUTHORS   Park,S.G., Kim,E.K., Nam,K.H., Lee,J.G., Baek,I.J., Lee,B.J. and
            Nam,S.Y.
  TITLE     Heart defects and embryonic lethality in Asb2 knock out mice
            correlate with placental defects
  JOURNAL   Cells Dev 165, 203663 (2021)
   PUBMED   33993984
  REMARK    GeneRIF: Heart defects and embryonic lethality in Asb2 knock out
            mice correlate with placental defects.
REFERENCE   6  (bases 1 to 2707)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   7  (bases 1 to 2707)
  AUTHORS   Terami,H., Hidaka,K., Shirai,M., Narumiya,H., Kuroyanagi,T.,
            Arai,Y., Aburatani,H. and Morisaki,T.
  TITLE     Efficient capture of cardiogenesis-associated genes expressed in ES
            cells
  JOURNAL   Biochem Biophys Res Commun 355 (1), 47-53 (2007)
   PUBMED   17286962
REFERENCE   8  (bases 1 to 2707)
  AUTHORS   Kile,B.T., Metcalf,D., Mifsud,S., DiRago,L., Nicola,N.A.,
            Hilton,D.J. and Alexander,W.S.
  TITLE     Functional analysis of Asb-1 using genetic modification in mice
  JOURNAL   Mol Cell Biol 21 (18), 6189-6197 (2001)
   PUBMED   11509662
REFERENCE   9  (bases 1 to 2707)
  AUTHORS   Kile,B.T., Viney,E.M., Willson,T.A., Brodnicki,T.C., Cancilla,M.R.,
            Herlihy,A.S., Croker,B.A., Baca,M., Nicola,N.A., Hilton,D.J. and
            Alexander,W.S.
  TITLE     Cloning and characterization of the genes encoding the ankyrin
            repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and
            Asb-4
  JOURNAL   Gene 258 (1-2), 31-41 (2000)
   PUBMED   11111040
REFERENCE   10 (bases 1 to 2707)
  AUTHORS   Roark,J.H., Kuntz,C.L., Nguyen,K.A., Caton,A.J. and Erikson,J.
  TITLE     Breakdown of B cell tolerance in a mouse model of systemic lupus
            erythematosus
  JOURNAL   J Exp Med 181 (3), 1157-1167 (1995)
   PUBMED   7532679
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC031161.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_977761.1, XM_977732.1, XM_977651.1, XM_977692.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031161.1, SRR17784644.774119.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2707
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 52.9 cM"
     gene            1..2707
                     /gene="Asb2"
                     /gene_synonym="1110008E15Rik"
                     /note="ankyrin repeat and SOCS box-containing 2"
                     /db_xref="GeneID:65256"
                     /db_xref="MGI:MGI:1929743"
     exon            1..318
                     /gene="Asb2"
                     /gene_synonym="1110008E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            319..595
                     /gene="Asb2"
                     /gene_synonym="1110008E15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..2294
                     /gene="Asb2"
                     /gene_synonym="1110008E15Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat and SOCS box protein 2; ASB-2; ankyrin
                     repeat-containing SOCS box protein 2; ankyrin repeat and
                     SOCS box-containing protein 2"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 2 isoform 1"
                     /protein_id="NP_075536.1"
                     /db_xref="CCDS:CCDS26128.1"
                     /db_xref="GeneID:65256"
                     /db_xref="MGI:MGI:1929743"
                     /translation="MATEISTRGRQRAIGHEEYSLYSSLSEEELLQMAIEQSLADKTR
                     GPTPAEASASSQTNHQPGHFHPWTRSPSSPENPPARAPLGLFQGVMQKYSSNLFKTSQ
                     MAAMDPVLKAIKEGDEEALKIMIQDGKNLAEPNKEGWLPLHEAAYYGQLGCLKVLQQA
                     YPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNA
                     EAVRILVRYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLF
                     VAAQSGQLEALRFLAKHGADINTQASDSASALYEASKNEHEDVVEFLLSQGADANKAN
                     KDGLLPLHVASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNHDAVLEALLAAR
                     FDVNAPLAPERARLYEDRRSSALYFAVVNNNVYATELLLLAGADPNRDVISPLLVAIR
                     HGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSC
                     LYGNGPHPPAPRPGRFHDAPVDDKAPSVVQFCEFLSAPEVSRWAGPIIDVLLDYVGNV
                     QLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRL
                     IRYLKYENTQ"
     exon            596..700
                     /gene="Asb2"
                     /gene_synonym="1110008E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            701..867
                     /gene="Asb2"
                     /gene_synonym="1110008E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1023
                     /gene="Asb2"
                     /gene_synonym="1110008E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1269
                     /gene="Asb2"
                     /gene_synonym="1110008E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1441
                     /gene="Asb2"
                     /gene_synonym="1110008E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..2003
                     /gene="Asb2"
                     /gene_synonym="1110008E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2157
                     /gene="Asb2"
                     /gene_synonym="1110008E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2690
                     /gene="Asb2"
                     /gene_synonym="1110008E15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2671..2676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asb2"
                     /gene_synonym="1110008E15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2690
                     /gene="Asb2"
                     /gene_synonym="1110008E15Rik"
                     /note="major polyA site"
ORIGIN      
        1 tgctctctga agcgggagcc tgtctcccgt gccctcggag gagtggaggg cggaatcacg
       61 gcttccttag tgcgatcttc agaagggaaa tctgagagtc ataacgtctt atagcttggc
      121 ttgacatccg tggtcatgcg gtgggccaga aataaactcc ctgcttcaaa ggagagtgtt
      181 tcagagctgc ctggcacaac agctggaagc tcagggccag cacaggaggc aaactcagag
      241 agcatgttct gaattcagac agtcaagaaa aaatctcttt gttgcccaga cctgtgcccc
      301 tgccgcagag ccttgcaggg atttgtcacc tgctgtgtgc tggctactgc tgagtccctc
      361 ttctggaagc tggaggagag gtggccgaga tggcgactga gatctccact cggggcagac
      421 aacgtgccat cggacatgag gaatacagcc tatacagcag cctgagcgag gaggagctgc
      481 tccagatggc catcgagcag agcctggcag acaagactcg gggcccgacc cctgctgagg
      541 cctccgcgtc ctctcagacc aaccaccagc caggacattt ccacccatgg accaggtccc
      601 cttcgtctcc cgagaaccca ccggcccgcg cacccctggg tctgttccaa ggggtcatgc
      661 agaagtatag cagcaacctg ttcaagacct cccagatggc ggctatggac cccgtgctga
      721 aggccatcaa ggaaggggat gaagaggcct tgaagatcat gatccaggat gggaagaatc
      781 ttgcagagcc caacaaggag ggctggctgc cgctccacga ggctgcctac tatggccagc
      841 tgggctgcct gaaagtcctg cagcaagcct acccagggac cattgaccaa cgcacactgc
      901 aggaagagac agcattatac ctggccacat gcagagaaca cctggattgc ctcctgtcgc
      961 tgctccaggc gggggcagag cctgacatct ctaacaaatc cagggagact ccactttaca
     1021 aagcctgtga gcgcaagaac gcggaggcgg tgaggatatt ggtgcgatac aacgcagacg
     1081 ccaaccaccg ctgtaacagg ggctggaccg cactgcacga gtctgtctcc cgcaatgacc
     1141 tggaggtcat ggagatccta gtgagtggcg gggccaaggt ggaggccaag aatgtctaca
     1201 gcatcacccc tttgtttgtg gctgcccaga gtgggcagct ggaggccctg aggttcctgg
     1261 ccaagcatgg tgcagacatc aacacgcagg ccagtgacag tgcatcagcc ctctacgagg
     1321 ccagcaagaa tgagcatgaa gacgtggtag agtttcttct ctctcagggc gccgatgcta
     1381 acaaagccaa caaggacggc ctgctccccc tgcatgttgc ctccaagaag ggcaactata
     1441 gaatagtgca gatgctgctg cctgtgacca gccgcacgcg cgtgcgccgt agcggcatca
     1501 gcccgctgca cctagcggcc gagcgcaacc acgacgcggt gctggaggcg ctgctggccg
     1561 cgcgcttcga cgtgaacgca cctctggctc ccgagcgcgc ccgcctctac gaggaccgcc
     1621 gcagttctgc gctctacttc gctgtggtca acaacaatgt gtacgccacc gagctgttgc
     1681 tgctggcggg cgcggacccc aaccgcgatg tcatcagccc tctgctcgtg gccatccgcc
     1741 acggctgcct gcgcaccatg cagctgctgt tggaccatgg cgccaacatc gacgcctaca
     1801 tcgccactca ccccaccgcc tttccagcca ccatcatgtt tgccatgaag tgcctgtcgt
     1861 tactcaagtt ccttatggac ctcggctgcg atggcgagcc ctgcttctcc tgcctgtacg
     1921 gcaacgggcc gcacccaccc gccccgcgac ctggccgctt ccacgacgca cccgtggacg
     1981 acaaggcacc tagcgtggtg cagttctgtg agttcctgtc ggccccggaa gtgagccgct
     2041 gggcgggacc catcatcgat gtcctcctgg actatgtggg caacgtgcag ctgtgctccc
     2101 ggctgaagga gcacatcgac agctttgagg actgggctgt catcaaggag aaggcagaac
     2161 ctccgagacc tctggctcac ctctgccggc tgcgggttcg gaaggccata ggaaaatacc
     2221 ggataaaact cctggacaca ctgccgcttc ccggcaggct aatcagatac ctgaaatatg
     2281 agaatacaca gtaaccagcc tggagaggag atgtggcctt cagactgttt ccgggacgcc
     2341 ccaggtggcc tgcatccagg accccctggg gtcagaacag gtgtgacctt gctggttctt
     2401 tgctggagct tcacccaaag tgagaacctg atgtggggag tggacgtgga acctctgctt
     2461 tcacactgtc agcggatcgc agacccgctc tgcttctggc catagccaga gaccttcaac
     2521 ctggggccag gggagagctg gtctgggcaa ggtggcccag gcaggaatcc tggccttaag
     2581 ctggagaact tgtaggaatc cctcactgga ccctcagctt tcaggctgcg agggagacgc
     2641 ccagcccaag tattttattt cactgagcac aataaacgtt gtatacagaa aaaaaaaaaa
     2701 aaaaaaa
//
