LOCUS       NM_080847               4268 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus ankyrin repeat and SOCS box-containing 15 (Asb15),
            mRNA.
ACCESSION   NM_080847
VERSION     NM_080847.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4268)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4268)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   3  (bases 1 to 4268)
  AUTHORS   Lefebvre,J., Clarkson,M., Massa,F., Bradford,S.T., Charlet,A.,
            Buske,F., Lacas-Gervais,S., Schulz,H., Gimpel,C., Hata,Y.,
            Schaefer,F. and Schedl,A.
  TITLE     Alternatively spliced isoforms of WT1 control podocyte-specific
            gene expression
  JOURNAL   Kidney Int 88 (2), 321-331 (2015)
   PUBMED   25993318
REFERENCE   4  (bases 1 to 4268)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 4268)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   6  (bases 1 to 4268)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 4268)
  AUTHORS   McDaneld,T.G. and Spurlock,D.M.
  TITLE     Ankyrin repeat and suppressor of cytokine signaling (SOCS)
            box-containing protein (ASB) 15 alters differentiation of mouse
            C2C12 myoblasts and phosphorylation of mitogen-activated protein
            kinase and Akt
  JOURNAL   J Anim Sci 86 (11), 2897-2902 (2008)
   PUBMED   18641171
  REMARK    GeneRIF: ASB15 has a role in early myoblast differentiation and
            that its effects may be mediated in part by the PI3K/Akt signal
            transduction pathway
REFERENCE   8  (bases 1 to 4268)
  AUTHORS   McDaneld,T.G., Hannon,K. and Moody,D.E.
  TITLE     Ankyrin repeat and SOCS box protein 15 regulates protein synthesis
            in skeletal muscle
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 290 (6), R1672-R1682 (2006)
   PUBMED   16424087
  REMARK    GeneRIF: Results suggest ASB15 participates in the regulation of
            protein turnover and muscle cell development by stimulating protein
            synthesis and regulating differentiation of muscle cells.
REFERENCE   9  (bases 1 to 4268)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019556.1, AK029759.1, AK142748.1 and AK079418.1.
            
            On Nov 17, 2009 this sequence version replaced NM_080847.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF403043.1, AK019556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AK019556.1         2-69
            69-1919             AK029759.1         1-1851
            1920-3786           AK142748.1         122-1988
            3787-4268           AK079418.1         3894-4375
FEATURES             Location/Qualifiers
     source          1..4268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 11.28 cM"
     gene            1..4268
                     /gene="Asb15"
                     /gene_synonym="4930400E23Rik; Asb-15"
                     /note="ankyrin repeat and SOCS box-containing 15"
                     /db_xref="GeneID:78910"
                     /db_xref="MGI:MGI:1926160"
     exon            1..126
                     /gene="Asb15"
                     /gene_synonym="4930400E23Rik; Asb-15"
                     /inference="alignment:Splign:2.1.0"
     exon            127..235
                     /gene="Asb15"
                     /gene_synonym="4930400E23Rik; Asb-15"
                     /inference="alignment:Splign:2.1.0"
     exon            236..288
                     /gene="Asb15"
                     /gene_synonym="4930400E23Rik; Asb-15"
                     /inference="alignment:Splign:2.1.0"
     exon            289..420
                     /gene="Asb15"
                     /gene_synonym="4930400E23Rik; Asb-15"
                     /inference="alignment:Splign:2.1.0"
     exon            421..579
                     /gene="Asb15"
                     /gene_synonym="4930400E23Rik; Asb-15"
                     /inference="alignment:Splign:2.1.0"
     exon            580..825
                     /gene="Asb15"
                     /gene_synonym="4930400E23Rik; Asb-15"
                     /inference="alignment:Splign:2.1.0"
     exon            826..997
                     /gene="Asb15"
                     /gene_synonym="4930400E23Rik; Asb-15"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1568
                     /gene="Asb15"
                     /gene_synonym="4930400E23Rik; Asb-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1722
                     /gene="Asb15"
                     /gene_synonym="4930400E23Rik; Asb-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..4268
                     /gene="Asb15"
                     /gene_synonym="4930400E23Rik; Asb-15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1889..1894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asb15"
                     /gene_synonym="4930400E23Rik; Asb-15"
                     /note="hexamer: AATATA"
     polyA_site      1921
                     /gene="Asb15"
                     /gene_synonym="4930400E23Rik; Asb-15"
                     /note="major polyA site"
ORIGIN      
        1 agaatgtgga atcatggctt tataaaagat gcatgtgttc tttgtaactt tggattcaag
       61 cgtctgcatg gcagtatttg ctaaagacat cgagagtaga cagacttgac tgatccaggc
      121 tatgagatat ggatattaat gatgattcta acgatgacca tcttgcaagt tatgacatcc
      181 agctctgtat tcaggaatcc attgaagcga gccaggctat atttcatcct aaaagattgg
      241 tacaactaag tgatcaaaac agaaagcttg tggaggccat aaggcaaggt cgcatttttg
      301 agctccagga gtatgtgcaa tataaatatg cactggaaga agcagatgag aaaggatggt
      361 tcccattgca tgaagctgta gttcaaccca ttcaacagat acttgagacg gttctggatg
      421 catcctataa gacactctgg gagttcaaga cctgtgatgg agaaacaccc ttgaccctgg
      481 cagtcaaagc tggtctggtg gaaaatgtca agacgttgct agacaaaggg gtctggccca
      541 acaccaaaaa tgacaaagga gagacacctc ttctgattgc tataaagagg ggctcctatg
      601 acatggtctc tgcactgatt aaatacaaca ccagccttga ccagccctgt gtcaaacgat
      661 ggtcagcaat gcatgaggca gctaagcaag gtcgcaaaga tattatcacg ctgctattga
      721 atcacagagg caacgtccac ttgagagacg gattcggagt cacaccctta ggagttgctg
      781 ctgagtatgg ccactgtgac gtgttagaac atcttattca caaaggtggt gatgtgtttg
      841 ctttggcgga tgatggggca tctgtgctat tcgaggcagc aggaggagga aaccctgact
      901 gcatctccct cctgctgaag tacggaggaa gcggcaatgt gcccaacaga gcagggcatc
      961 ttcccataca ccgagctgcc tatgagggac attatcttgc tctgaaatac cttatcccag
     1021 taacatccaa acatgcaatt cagaaaagcg gcctcactcc aattcactca gcagcagagg
     1081 gacaaaacgc ccagtgcctt gaattgctca ttgagaatgg ttttgatgtt aatgccctgc
     1141 ttgccgacca catttcccag agttacgatg atgagagaaa gactgcgcta tacttcgccg
     1201 tctccaataa tgatatccac tgcacagaag tccttctggc tgcaggtgca gaccccaact
     1261 tggatcccct caactgtctc cttgtggcgg tgagggccaa tcgacatgaa atcgtccggc
     1321 tgcttctctc ctatggggct aacgtcaatt gttattttat gcatgtgaat gacactcgct
     1381 tccccagtgc cattcagtat gccctaaatg atgagattat gctgaggctc ctgctgaata
     1441 atggttacca agtggagcta tgttttgact gcatgcacgg aaacatcttt gggaattcat
     1501 ttgtgtggtc agagactgag gaggagggac tgccagggtg gacatcatgc ataataaaag
     1561 ataatccgtt ctgtgagttt attacagttc cgtggatgaa gcacctggtg ggcggcattg
     1621 tccgcatact gatagattac atggattacg tccctctgtg tgcaaaactg aagtctgtgc
     1681 tagaagtaca gagagaatgg ccagaaatac gccaaataat agagaatcct tgctccctaa
     1741 agcatctgtg ccgattaaaa attcgccgag ttatgggact gcagcgactc tgccagccag
     1801 cctccataca gatgcttcct ctcccggcgg cgatgcgaag atacttatta tttaaagagt
     1861 ttgacctcta cggacagtag ctaaagttaa tataacttta aaattatatt ttaaaatgtg
     1921 attcttaaag catttttttt taactgtgat tcccctagag aagtcactgg aatcattttg
     1981 tattcttatt ttgtattctt aagtgtattt taacaccact gagaatctcg tagctatgtc
     2041 gtgtccctat gggaagatca tgtacactct taaagacttt taggctgcta agataagtaa
     2101 tatgctgtat tttcatttct attgattgtc ctcagttgtt acgagtcttc atattctccc
     2161 tatcaactga atatcaatat tgagagtcta ggcttaaaag gtaaataacc agtttctcac
     2221 caccaccacc cctgccccac aaacatgcca gctgctgccc tacctattat tagaacccct
     2281 gctctagaag agctcattta tgcatgcaga ttcaccctgt aagccagcct ctccagcgct
     2341 ccttggctca gtccctaaca acttccttgc ggctaaattc tataaacaac tttcgctccc
     2401 cttcctgttg attcttgcgg cactaactca gtttcctgtt agtcctcagg ttttaccata
     2461 ctgataggct gctcttttcc ctctccgtcc tccccctcaa cctccctgcc tctgcttctc
     2521 taggctgctc ctcttcctgc aggcctctag agacaggtcc tctgtccttt tctgatacgc
     2581 tgtgttctct ggaaaattcc attcactagc cttggttgtg atcagtctgc tggggaccat
     2641 gatgtttaca gctgaagttc aactttttgt ctcctatgct tcagacctgt tcgacattga
     2701 cgtaatacat ttctaaacat aaaggtatct gtagttcaac gcgtcctcaa atccttcctt
     2761 cacaaaacac ttgtctctta cattctgcag ttcagtacta gcacaggcaa ttctgtttcc
     2821 aagtgaaaaa gacttggcat aagtctcgac acataccccc acccctattt tctcacccag
     2881 catgccaact cagcaaatgc caccgagttt ctctcttaaa tccaccgttt cctgctcagt
     2941 cccacaaatt ccactgtaca tctgactgtg ttcttcctcc tactgagaca atacagtgcc
     3001 gcttccccga cttgctctcc tagcctttct ttttcccagt tccttacaga gtccacacac
     3061 agcacttcag aatgaacttt cagagacttt aatatagctc attcccttgc tgaaaatcac
     3121 tccctattat tttgggataa acatctcaaa ttctcccaag acctccacgc tttaactgcc
     3181 ctacccatat cctctgtagc ctatctgcat atcccctccc ccttttggca acgtcattgc
     3241 tacacatctt ctacagcaat tcccagactt tatggtttta taagaccaga ggttttcatt
     3301 ttattattat tattattatt attattatta ttattattat ggtcctcttt ctaaaggata
     3361 ccacctgtta tcaacagttc agttttaaag ggggttagtc cttaaaatgc tagaaagcaa
     3421 gacatggtaa gctcactcat ttaaatggat tgactttagt tttgaaaaga tggaccatgc
     3481 tattatctct tcactgacaa gcaaaacttc actgtgctcc acaagaatct gagtctctta
     3541 gatgggaacc attgtgaacc tcaggacctt tacatttcct tcaccctctc catctgaagc
     3601 gctctttcct ctcctttacg cctctctccc actgattagc tgacccctta cgctgcggat
     3661 cctgattcag ctgttgcttc ctccggatgg aggtcactgc ggacagccgc tcacgtggta
     3721 ttgtagtact ctatgtcaca ctagactgga agccccacgg gggcaggatc gtgtctgctt
     3781 tatttcccag tatgtcgtca aagccaaaca cacgccctag aatgtgaatg ttatataaga
     3841 accagactaa aataatcagt gacttggtgg taatatgata ggttagagtt tcgacttggt
     3901 gtgtaaaccc agtaatatac gtattaaaat tgcttgttct ttcatttttt tgacattttt
     3961 atcataagag taaatattct tttggtagta atatcttgtt tgtaaatttt gttagtttgt
     4021 aaattttctg agttacattt actttcagtt atctttgaaa gataaataag tctggaaaaa
     4081 aattatataa tcaggattat ggtttcaatg tatctccttg aggatttttt aaaatacaaa
     4141 ttataccata atgtatttaa ctcgaactgt catgttttat gtacaatata tcataattct
     4201 tgtgttgctt tctttattgt gcctaaagtc cttgcttata aatgttgctc taaataaata
     4261 aaaaatag
//
