LOCUS       NM_001170748            1935 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus ankyrin repeat and SOCS box-containing 14 (Asb14),
            transcript variant 1, mRNA.
ACCESSION   NM_001170748
VERSION     NM_001170748.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Yang,Y., Ma,D., Liu,B., Sun,X., Fu,W., Lv,F. and Qiu,C.
  TITLE     E3 Ubiquitin Ligase ASB14 Inhibits Cardiomyocyte Proliferation by
            Regulating MAPRE2 Ubiquitination
  JOURNAL   Cell Biochem Biophys 82 (2), 715-727 (2024)
   PUBMED   38319584
  REMARK    GeneRIF: E3 Ubiquitin Ligase ASB14 Inhibits Cardiomyocyte
            Proliferation by Regulating MAPRE2 Ubiquitination.
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   3  (bases 1 to 1935)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052884.1 and BC145002.1.
            
            On May 17, 2019 this sequence version replaced NM_001170748.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-604               AK052884.1         13-616
            605-1935            BC145002.1         1-1331
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 16.09 cM"
     gene            1..1935
                     /gene="Asb14"
                     /gene_synonym="Asb-14"
                     /note="ankyrin repeat and SOCS box-containing 14"
                     /db_xref="GeneID:142687"
                     /db_xref="MGI:MGI:2655107"
     exon            1..59
                     /gene="Asb14"
                     /gene_synonym="Asb-14"
                     /inference="alignment:Splign:2.1.0"
     exon            60..256
                     /gene="Asb14"
                     /gene_synonym="Asb-14"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1898
                     /gene="Asb14"
                     /gene_synonym="Asb-14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat and SOCS box-containing protein 14; ankyrin
                     repeat and SOCS box protein 14; ankyrin repeat
                     domain-containing SOCS box protein 14"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 14 isoform
                     1"
                     /protein_id="NP_001164219.2"
                     /db_xref="CCDS:CCDS49431.2"
                     /db_xref="GeneID:142687"
                     /db_xref="MGI:MGI:2655107"
                     /translation="MDPSGSDEDADADFDTQVIIQQSLLDVYKPGIAQHTPEAARLHS
                     FPSDDYKKIAEAIETGKEDALAGFAKYHPAFDEANGNGWLPLHKAAVQLNKNILEITM
                     NASEPSTWERTTHNGETALFLAVSSSLLENAHFLLLKGCNPNAKTSEGNSPLLTAVLK
                     DAYDMATLLISHGADVNLRCANERTALHEAAKLGRLDMVKLMLASGAYPDARSSYGFT
                     PLALAAQGGHTGIMQLLLQKGADVHSQASDSSSVLLEAVRGGNPEAVSLLLEYGADAN
                     IPKSSGHLPIHVAADKGHFLALKVLVPVTDIAAIKKSGISPVHCAAAGAHPHCLELLI
                     QAGFDVNFMLDQRIRKHYDDQRKSALYFAVSNGDLPSVKLLLSAGALPNQDPVNCLQI
                     ALRMGNYELISLLLRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERC
                     FDCPHGERVHRFCTFEGWTSTVIKDTMFCEVITLSWLQHLSGKVVRVMLDYVDQVQIC
                     SKLKAVLEKQRLWPEIHFILTNPRSLQHLCRLKIRKCMGRLRLRCPVFMSFLPLPNLL
                     KAYVLYKEYDLFGQERSTGTW"
     exon            257..312
                     /gene="Asb14"
                     /gene_synonym="Asb-14"
                     /inference="alignment:Splign:2.1.0"
     exon            313..444
                     /gene="Asb14"
                     /gene_synonym="Asb-14"
                     /inference="alignment:Splign:2.1.0"
     exon            445..603
                     /gene="Asb14"
                     /gene_synonym="Asb-14"
                     /inference="alignment:Splign:2.1.0"
     exon            604..849
                     /gene="Asb14"
                     /gene_synonym="Asb-14"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1021
                     /gene="Asb14"
                     /gene_synonym="Asb-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1565
                     /gene="Asb14"
                     /gene_synonym="Asb-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1719
                     /gene="Asb14"
                     /gene_synonym="Asb-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1935
                     /gene="Asb14"
                     /gene_synonym="Asb-14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccagat aaccctgcaa catggaaact tcagagcagc cctagaggat atgaaaaagt
       61 tgaaaaagcc ttttcacaac tggaaaaata ttttaattcc ttctgacttg gaaatcaacc
      121 tatccaagct tcgtatggat ccctccggca gtgacgagga tgcagatgcc gactttgaca
      181 cccaggtcat catccaacag agtctgctgg atgtttacaa gccagggata gctcagcaca
      241 cgccagaagc ggcgagactc cattccttcc caagtgatga ttataagaag atagctgaag
      301 ccatcgagac aggtaaggaa gatgcattgg caggctttgc caagtaccat ccagcctttg
      361 atgaagccaa tgggaatggc tggcttcctc tgcataaggc agcagtgcag ttaaacaaga
      421 acatcttaga aataaccatg aacgcttccg aacccagtac gtgggaacga accactcaca
      481 acggtgaaac agcacttttt ttggctgtca gcagtagcct cctggaaaac gcccactttc
      541 tccttctcaa aggctgtaat ccaaacgcta aaacttctga aggcaattct cctcttctta
      601 cagctgttct gaaagacgcc tacgacatgg ccaccttgct gatcagccat ggagcagatg
      661 tcaatctccg atgtgccaat gagaggacag ctctccatga agctgccaag ctgggcagac
      721 tggacatggt aaaactgatg ctggcttctg gagcataccc agatgcacgg agctcctacg
      781 gattcacgcc ccttgccctc gctgctcaag gtggacacac tgggatcatg caactactac
      841 tgcagaaagg agctgacgtt cacagtcagg cctctgactc gtcctctgtg ttacttgaag
      901 ctgttagagg agggaatccg gaagctgtga gtctgttgtt agagtatgga gctgatgcca
      961 acattcctaa gagttcaggc cacctgccca tccacgtggc agctgacaaa ggccatttcc
     1021 tagctctaaa ggtattggtc ccagtcacag acatcgcagc catcaagaag agcgggatca
     1081 gtccggttca ctgcgcagca gctggggcgc acccccactg cctggaactt ctcattcagg
     1141 ctggatttga tgtgaatttc atgctggatc agagaatccg taaacattat gatgatcaac
     1201 ggaagtcagc cttgtatttt gctgtttcaa acggtgacct cccttcagtt aagctgcttc
     1261 tgagtgctgg agctctaccc aatcaagacc cagtcaactg cctacagata gctcttagga
     1321 tgggcaacta tgagctcata agtctattac tgaggcacgg ggccaacgtc aactacttct
     1381 gccgcgttaa ccctttgcat ttcccatcag cgctacaata cacattgaaa gatgaagtca
     1441 tgctcaggat gctgttgaat tatggctatg acactgagcg atgttttgat tgtcctcatg
     1501 gagaaagggt tcatcggttt tgtacttttg aaggctggac atctacagtt attaaagata
     1561 ctatgttttg tgaagtcata actttgtcat ggctacagca tctctctggg aaagttgttc
     1621 gtgtgatgct tgattatgtt gatcaagttc aaatctgttc aaaattgaaa gctgtgctgg
     1681 aaaaacaaag gctctggcca gaaatacatt ttatcttgac caacccccgt tctctacaac
     1741 atttgtgccg ccttaagatc cggaagtgta tgggacggtt acgtttgcgc tgccccgtct
     1801 tcatgtcgtt tcttccgctg cccaatctct taaaagcgta cgtcctttac aaagaatatg
     1861 acctttttgg acaagaacgt tctacaggaa catggtaact aagctcgtct agagggcaag
     1921 gtataatctg cagca
//
