LOCUS       NM_080858               1260 bp    mRNA    linear   ROD 22-DEC-2024
DEFINITION  Mus musculus ankyrin repeat and SOCS box-containing 12 (Asb12),
            transcript variant 2, mRNA.
ACCESSION   NM_080858
VERSION     NM_080858.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1260)
  AUTHORS   Zhang,R., Xu,J., Shen,C., Zhang,X., Li,S., Lv,J., Xu,D., Huang,X.,
            Zheng,B., Liu,M. and Wu,Y.
  TITLE     Testis-enriched Asb12 is not required for spermatogenesis and
            fertility in mice
  JOURNAL   Transl Androl Urol 11 (2), 168-178 (2022)
   PUBMED   35280661
REFERENCE   2  (bases 1 to 1260)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   3  (bases 1 to 1260)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671765.6.
            
            On May 1, 2007 this sequence version replaced NM_080858.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF403040.1, AK009644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AL671765.6         97451-97593         c
            144-992             AL671765.6         90327-91175         c
            993-1260            AL671765.6         89663-89930         c
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 41.99 cM"
     gene            1..1260
                     /gene="Asb12"
                     /gene_synonym="2310036C05Rik; Asb-12"
                     /note="ankyrin repeat and SOCS box-containing 12"
                     /db_xref="GeneID:70392"
                     /db_xref="MGI:MGI:1917642"
     exon            1..143
                     /gene="Asb12"
                     /gene_synonym="2310036C05Rik; Asb-12"
                     /inference="alignment:Splign:2.1.0"
     exon            144..992
                     /gene="Asb12"
                     /gene_synonym="2310036C05Rik; Asb-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1123
                     /gene="Asb12"
                     /gene_synonym="2310036C05Rik; Asb-12"
                     /EC_number="3.1.3.95"
                     /note="ankyrin repeat and SOCS box-containing protein 12;
                     ankyrin repeat domain-containing SOCS box protein 12"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 12"
                     /protein_id="NP_543134.1"
                     /db_xref="CCDS:CCDS30283.1"
                     /db_xref="GeneID:70392"
                     /db_xref="MGI:MGI:1917642"
                     /translation="MNLMDIAKIFSLLQPEKEEEDTGTGEKQALNQAVYDNDSCTLDH
                     LLHQERYKRFINSRSGWGIPGTPLRLAASYGHLNCVKVLLEHGADVDSLDVKAQTPLF
                     TAVSHGHLECVRMLLEAGACPSGSIYNNCSPVLTASRDGAFAILQELLGHGAEANVKA
                     KLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLYGADPDYNCTDQGLLSRVPQPRTLL
                     EICLHHNCEPEYIQLLIDFGANIYLPSLPVDPTSQDDKGIKLLLQARATPRSLLSQTR
                     LVIRRSLCRANQSQATDQLDIPPVLISYLKHQ"
     exon            993..1260
                     /gene="Asb12"
                     /gene_synonym="2310036C05Rik; Asb-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1169..1174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asb12"
                     /gene_synonym="2310036C05Rik; Asb-12"
                     /note="hexamer: AATAAA"
     regulatory      1200..1205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asb12"
                     /gene_synonym="2310036C05Rik; Asb-12"
                     /note="hexamer: AATAAT"
     polyA_site      1213
                     /gene="Asb12"
                     /gene_synonym="2310036C05Rik; Asb-12"
                     /note="major polyA site"
     polyA_site      1218
                     /gene="Asb12"
                     /gene_synonym="2310036C05Rik; Asb-12"
ORIGIN      
        1 ctttctactg ggaacagagg tcccaaagag ctctagcctg gggtggtagt tgttttctga
       61 ggagggccca ccaggacctt tgagcttcac agagagacta gaactgcaac tctccattga
      121 gcgcgggctc cagctgaagt cctatctgga atttcctcct ccttgcaatg agatagtgct
      181 attcgaataa accagaatga acctcatgga tatcgccaag atcttctctc ttctgcaacc
      241 tgaaaaggag gaggaggaca ctggcaccgg ggaaaaacag gctctcaatc aagctgtata
      301 tgacaatgac tcctgtaccc tggaccacct tctacaccag gaacgttata aacggttcat
      361 caacagcagg agtggctggg gtatacctgg aacacccttg cgtttggcag cttcttatgg
      421 tcacttaaat tgtgtgaagg tcctcctgga acatggtgct gatgttgata gcttggatgt
      481 caaagcacaa acaccacttt tcactgctgt gagccacggt catctggagt gcgtgagaat
      541 gcttttagaa gctggtgcct gtcctagtgg tagcatctac aacaattgct ctcctgttct
      601 cactgcctca cgtgatgggg cttttgccat cttacaggag ctcctagggc atggtgccga
      661 ggctaatgtc aaagctaaac taccagtctg ggcgtcaaat atagcttcat gttctggccc
      721 cctctatctg gctgcagtct atgggcacct tgattgtttc cgcctgcttt tgctctatgg
      781 ggcagatcct gattacaact gcactgacca gggcctttta agtcgtgttc cacagcctcg
      841 cacactcctt gaaatctgcc ttcatcataa ttgtgagcca gagtacatcc agcttttaat
      901 agattttgga gctaacatct accttccatc tctccctgtg gacccaactt cacaagatga
      961 taaaggcatc aaattgctgc tacaagcccg agccactcca cggtcactcc tgtcccagac
     1021 ccgtttagtt atccgcagat ccctctgccg ggcgaaccag tcacaagcca ccgaccagct
     1081 ggatatcccc cctgtgttga ttagctacct caaacatcaa tgataagttt tcaactttct
     1141 caggaaccta atgcatgata cctccaaaaa taaacctggt aacccaggtt acttgagtga
     1201 ataatacacc tcataacatt tctggcgtat tattttccac aacaaaatcc tcagcacagt
//
