LOCUS       NM_001039126            5971 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ankyrin repeat and SOCS box-containing 1 (Asb1),
            transcript variant 1, mRNA.
ACCESSION   NM_001039126
VERSION     NM_001039126.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5971)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5971)
  AUTHORS   Hou,P., Jia,P., Yang,K., Li,Z., Tian,T., Lin,Y., Zeng,W., Xing,F.,
            Chen,Y., Li,C., Liu,Y. and Guo,D.
  TITLE     An unconventional role of an ASB family protein in NF-kappaB
            activation and inflammatory response during microbial infection and
            colitis
  JOURNAL   Proc Natl Acad Sci U S A 118 (3) (2021)
   PUBMED   33431678
  REMARK    GeneRIF: An unconventional role of an ASB family protein in
            NF-kappaB activation and inflammatory response during microbial
            infection and colitis.
REFERENCE   3  (bases 1 to 5971)
  AUTHORS   Emeny,R.T., Baumert,J., Zannas,A.S., Kunze,S., Wahl,S., Iurato,S.,
            Arloth,J., Erhardt,A., Balsevich,G., Schmidt,M.V., Weber,P.,
            Kretschmer,A., Pfeiffer,L., Kruse,J., Strauch,K., Roden,M.,
            Herder,C., Koenig,W., Gieger,C., Waldenberger,M., Peters,A.,
            Binder,E.B. and Ladwig,K.H.
  TITLE     Anxiety Associated Increased CpG Methylation in the Promoter of
            Asb1: A Translational Approach Evidenced by Epidemiological and
            Clinical Studies and a Murine Model
  JOURNAL   Neuropsychopharmacology 43 (2), 342-353 (2018)
   PUBMED   28540928
  REMARK    GeneRIF: In murine acute social defeat stress, Asb1 gene expression
            is significantly upregulated in a tissue-specific manner (p=0.006),
            which correlates with upregulation of the neuroimmunomodulating
            cytokine interleukin 1 beta.
REFERENCE   4  (bases 1 to 5971)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   5  (bases 1 to 5971)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   6  (bases 1 to 5971)
  AUTHORS   de Ledesma,A.M., Desai,A.N., Bolivar,V.J., Symula,D.J. and
            Flaherty,L.
  TITLE     Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1:
            Congenic strains and candidate gene identification studies
  JOURNAL   Mamm Genome 17 (2), 111-118 (2006)
   PUBMED   16465591
REFERENCE   7  (bases 1 to 5971)
  AUTHORS   Peters,J. and Beechey,C.
  TITLE     Identification and characterisation of imprinted genes in the mouse
  JOURNAL   Brief Funct Genomic Proteomic 2 (4), 320-333 (2004)
   PUBMED   15163367
  REMARK    Review article
REFERENCE   8  (bases 1 to 5971)
  AUTHORS   Kile,B.T., Metcalf,D., Mifsud,S., DiRago,L., Nicola,N.A.,
            Hilton,D.J. and Alexander,W.S.
  TITLE     Functional analysis of Asb-1 using genetic modification in mice
  JOURNAL   Mol Cell Biol 21 (18), 6189-6197 (2001)
   PUBMED   11509662
REFERENCE   9  (bases 1 to 5971)
  AUTHORS   Kile,B.T., Viney,E.M., Willson,T.A., Brodnicki,T.C., Cancilla,M.R.,
            Herlihy,A.S., Croker,B.A., Baca,M., Nicola,N.A., Hilton,D.J. and
            Alexander,W.S.
  TITLE     Cloning and characterization of the genes encoding the ankyrin
            repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and
            Asb-4
  JOURNAL   Gene 258 (1-2), 31-41 (2000)
   PUBMED   11111040
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153774.1, BY231875.1 and AC109199.10.
            
            On May 27, 2006 this sequence version replaced NM_001039126.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153774.1, AF155352.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK153774.1         23-36
            15-360              BY231875.1         13-358
            361-2469            AK153774.1         383-2491
            2470-5971           AC109199.10        159431-162932
FEATURES             Location/Qualifiers
     source          1..5971
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.19 cM"
     gene            1..5971
                     /gene="Asb1"
                     /gene_synonym="1700029O08Rik; 1700054C17Rik; mKIAA1146"
                     /note="ankyrin repeat and SOCS box-containing 1"
                     /db_xref="GeneID:65247"
                     /db_xref="MGI:MGI:1929735"
     exon            1..300
                     /gene="Asb1"
                     /gene_synonym="1700029O08Rik; 1700054C17Rik; mKIAA1146"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1259
                     /gene="Asb1"
                     /gene_synonym="1700029O08Rik; 1700054C17Rik; mKIAA1146"
                     /note="isoform a is encoded by transcript variant 1;
                     ankyrin repeat and SOCS box protein 1; ASB-1; ankyrin
                     repeat-containing SOCS box protein 1; ankyrin repeat and
                     SOCS box-containing protein 1"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 1 isoform a"
                     /protein_id="NP_001034215.1"
                     /db_xref="CCDS:CCDS35665.1"
                     /db_xref="GeneID:65247"
                     /db_xref="MGI:MGI:1929735"
                     /translation="MAEGGTGPDGRAGPGPAGPNLKEWLREQFCDHPLEHCDDTRLHD
                     AAYVGDLQTLRNLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGNCVDFLIRKG
                     AEVDLVDVKGQTALYVAVVNGHLESTEILLEAGADPNGSRHHRSTPVYHASRVGRDDI
                     LKALIRYGADVDVNHHLTPDTRPPFSRRLTSLVVCPLYISAAYHNLQCFRLLLQAGAN
                     PDFNCNGPVNTQEFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPEA
                     RGRRKMDPEALQVFKEARSIPRTLLSLCRVAVRRALGKYRLHLVPSLPLPDPIKKFLL
                     YE"
     exon            301..442
                     /gene="Asb1"
                     /gene_synonym="1700029O08Rik; 1700054C17Rik; mKIAA1146"
                     /inference="alignment:Splign:2.1.0"
     exon            443..745
                     /gene="Asb1"
                     /gene_synonym="1700029O08Rik; 1700054C17Rik; mKIAA1146"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1131
                     /gene="Asb1"
                     /gene_synonym="1700029O08Rik; 1700054C17Rik; mKIAA1146"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..5971
                     /gene="Asb1"
                     /gene_synonym="1700029O08Rik; 1700054C17Rik; mKIAA1146"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5319..5324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asb1"
                     /gene_synonym="1700029O08Rik; 1700054C17Rik; mKIAA1146"
                     /note="hexamer: AATAAA"
     polyA_site      5342
                     /gene="Asb1"
                     /gene_synonym="1700029O08Rik; 1700054C17Rik; mKIAA1146"
     regulatory      5947..5952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Asb1"
                     /gene_synonym="1700029O08Rik; 1700054C17Rik; mKIAA1146"
                     /note="hexamer: AATAAA"
     polyA_site      5971
                     /gene="Asb1"
                     /gene_synonym="1700029O08Rik; 1700054C17Rik; mKIAA1146"
                     /note="major polyA site"
ORIGIN      
        1 gcagtttggt caaccccgct aatcagcaat caagtccgtt agccaggccg gaagtggaga
       61 ccccagcacc ctccgtccgg agcaggaagt acgaaaagga ggctcatact ccccggaagc
      121 cgagccctgg acacgcccac ctgccggaaa cgccggcggt gcttctctga cagcgttgct
      181 ctctgacagg attgctgcgg aggtggacag gcggcggggt cagggcggag gctgaggacc
      241 aagtaggcat ggcggagggc gggaccggcc ccgatggacg ggccggcccg ggacccgcag
      301 gtcctaatct gaaggagtgg ctgagggagc agttctgtga ccatccactg gagcactgtg
      361 acgatacaag actccatgat gcagcctatg taggggacct ccagaccctc aggaacctac
      421 tgcaagagga gagctaccgg agccgcatca atgagaagtc tgtctggtgc tgcggctggc
      481 ttccctgcac accactgagg atcgcagcca ctgcaggcca tgggaactgt gtggacttcc
      541 tcatacgcaa aggggccgag gtggacctgg tggatgtcaa ggggcagact gccctgtatg
      601 tggctgtagt gaacgggcac ttggagagca ctgagatcct tttggaagct ggtgctgatc
      661 ccaacggcag ccggcaccac cgcagcactc ctgtgtacca tgcctctcgt gtgggtaggg
      721 acgacatcct gaaggctctt atcaggtatg gggcagatgt tgatgtcaac catcatctga
      781 ctcctgacac ccggccccct ttttcacggc ggctaacctc cttggtggtc tgtcctctat
      841 acatcagtgc tgcctaccat aaccttcagt gcttcaggct gctcttgcag gctggggcaa
      901 atcctgactt caattgcaat ggccctgtca acacccagga gttctacagg ggatcccctg
      961 ggtgtgtcat ggatgctgtc ctgcgccatg gctgtgaagc agccttcgtg agtctgttgg
     1021 tagagtttgg agccaacctg aacctggtga agtgggaatc cctgggccca gaggcaagag
     1081 gcagaagaaa gatggatcct gaggccttgc aggtctttaa agaggccaga agtattccca
     1141 ggaccttgct gagtttgtgc cgggtggctg tgagaagagc tcttggcaaa taccgactgc
     1201 atctggttcc ctcgctgccg ctgccagacc ccataaagaa gtttttgctt tatgagtagc
     1261 attcacatgc agtgctgact gcaatgtgga agccgatcac ctgcagtgaa aactgacaca
     1321 gactctggca tcctgggaac catggcctgt gctgccagct tgatccttgg ctgtcagtga
     1381 agaagaaacg gctgtgttct cttggactgt gattctatct caggtgcttg ggccatcgaa
     1441 cgctccttga gtcattgtca actgagaggc acatacaaac ttaattttgt tcctcttcag
     1501 tctctctgtt ttggattctt cctggcaatg tgtgcagcat gggctgagcc tggtgattgc
     1561 cctagtgggg aaggcttttt tctccaggct atgcatctat ttatgttcct actttgcaat
     1621 ttattgttct tttaaggctt gatatcaaaa cagaaagagg tttgttaaga aaagatatag
     1681 ggagaaggaa ttcggttcgt gcacttgcta gcctgctttc ttgcctgggt ttgtctgtct
     1741 atgctgcctg gtgcacatcc cttctctttg ctgccactgt tctattttgg gagttgtctt
     1801 ccgtctaaga tggcttctgg ggttctatct tattgcacag aggtcccaga acagtgttca
     1861 tagggcacca tctgctctgc caagggtttt ctgatgtctt accctgggga tcttcagaca
     1921 gtggttacct ttaggagacc cacctggaac taaccattaa gtgactgccc acattcagat
     1981 cagggaccat cttaatagta ctcactgcca gtcctcacaa gagaagatga cacgggtgct
     2041 ctcttcagac actcccatac aggaagtgga aaatgtcttg gtcacctggg tggttccagg
     2101 ctacaacttc ttggtgtcca ctagacagga tatctaggtg ttgggtgact gttcctccca
     2161 ctttctgacc caatgccttt gtgggtgctt ctagaggtct ttccctgtcc tgcccagggc
     2221 tgttggtggg tgagagagat gagcttattg caggattgca ggtttgttta actcttgagt
     2281 ggtgagtgtc acagcaggtg ggcccataac cacggccttg agcatcctta ggttgctcct
     2341 gtttcagtga agtcaccttt tgtcattctg aagcctgtta ggattactgt gtggaccttg
     2401 ctgattatag acttgagaat atttgggaca agcaggtaat aaatctgttt agacttttgg
     2461 ccataaaggg gatttaactt gttaatactt tcctagtgta ccattttgtg ttttagctga
     2521 ccagtcaggc agttggtagc cttgggattc tgtggatgga gttccaaacc ccaccccagt
     2581 gcctcaggaa ggcccaaggc agcaacacca agctggtcca aatgtactac atgagttttg
     2641 atgagccttg cccagtcctg gacagtgagt cctgtgtctg gggcaggaat gagctggcca
     2701 gagcctgtcc ctgtctcccc acagctgttc tgtgtggccc cagcacagct cttcacttgg
     2761 acttgagtag ctttccctgt ctcaaaccag ttttcagaac ctttcaatca cttcaaggtt
     2821 ctgcatgttc agaatttcca gccggtaact ctgaatgtga cacagcatcg gcatggactg
     2881 agggcacttc cccttgtcgc cagtatgcta tgaaggcact gcatgtcatt gctgtcaagg
     2941 atgaggtacg gggtaagaag caccccaggt tcatgagagg taccatagga agttgatgtg
     3001 acttcggtga ggactgaccc tctactcagc agacttctga gctctggtta cctgtgtcct
     3061 tcctagcatg gggatgtggg tgtctgatga acctactgcc ttctggctga actggcccta
     3121 gcagaagagc ttagtggtcc agaggaagga gcctgagggt tgtcccagct catcaaaggg
     3181 gtatttgtgg ggttgttgct gttactgggg cagccacttg atttaagtga agacttgtgt
     3241 agtggaatct tggctaggca ggttggaacc agtgatgatc cctcagaatt tatcttttca
     3301 gtattgggct tttagacata tgtccagaaa cctgccaagg caatgccata cattttgtag
     3361 ctattttact tgtgatgtct atctgtctgt ctgtctgtct gtctatctat ctatctatta
     3421 atctattatc tacttatcat ctatgtattt atgtatttat ttgtttatat atttttgtat
     3481 ttatttattt attcatattc tttttccata agaggactta agctggagag tcttattttg
     3541 ttttgacagt agattggtaa agtagataat tggcattttt caaatattga ccagtactga
     3601 tgtcaggctt aaggaccatt atttcagagt ttcccctttt cactttcatg aatgaatttt
     3661 tagataaaaa tttcctgaaa gataaagtcc tgactgtggg ccagagcgga gggaagttct
     3721 tcatgcctga gagctgctct ggcctgtgct cagccagttc ctggagcagt gtctgctctg
     3781 cagcagacag gaagagctct tcctgtgcct ttccagggac cctgctgagg tcctgtgaag
     3841 tgccgaggct gcagacactt tgtttgggag gggtctctgt cctgagaaaa ctgcttccta
     3901 gtggaagtgc acttacggtg gtcacagtgc tgagagccca cagtctggat ttgggattga
     3961 ccttgtgggg cggttggatc atcttgaccc acagtgcagc accaacagag agccattcga
     4021 gcaaaagggt aagggtggct tgtagtactt gaggaaatca aatttcctca gctgactgga
     4081 ctgcctttta ttcttcagtc atgtcattcc tgacaacaga aggcttgctg gaaagggatg
     4141 gtatggggct atggctttgc atgtaaaaca cttttgattg ggatccacag cagtgttctt
     4201 ttcacctctg cctgctgctg tcctggcaca gtctgattgt agtggatgct acatattaat
     4261 gaggaagttt tagatcctaa gtagcattcc tggtggtgaa aggcattgtg gctttcccat
     4321 ggcctggggt ctaagtgtaa gctggaggac cactgtgcgc gacctgagga gtctagacat
     4381 gcttttgaag cgcctctacc accccagatc catgaggtca ccacagaaag tgtggccttt
     4441 ttggtaagac ttgcttgtcc ttcactcagg ccttgggaac cagtggcacc taggatgctg
     4501 gtgatgatgt caccagtggt ggtctgctgg tacctgtgtc tccttggtgc ctgcacaccg
     4561 ggcacttgga gactaatcct gccctgcagg gatcagatga ctttccatcc gcacagagat
     4621 tcctggaagt gcctcttgac ttgggagctt ctttctttcc cttgctcatt ttcacctcgt
     4681 tgctctcctt cccagagttc cttggtgtgc aataaagtag taggtataac tggttaggga
     4741 ctcttagtca tctcaggaaa gtcccacaga tgggtacatg caagctttga agtgggcagt
     4801 gatctgtgga atttactata cactccagcc tgacatagga caatggagtg aggagaatgc
     4861 ggggaactgc cgtagcctta acagacaccc aatacccagt gtcaatgatg catggggatc
     4921 caaccagatc ctgtgcatgt aagacaagca ctcgaccact gagctgtatc ttctgcctct
     4981 ttatgtctta ggtaaatgaa gcaatggaag ggtttttgta aatctcactt gagattgcca
     5041 tttatgaacc taattgtctt ggacatgcaa tgtcagtgcc ctgttctctc ctgcagtgtc
     5101 tgcatggcgt ccactacttc tgttggtgtt gggcgtgtgt agtgtcccgt gcactggggc
     5161 ctgtgtgctt gtgctgaagt cgtgctcact gcagccctct agttcctgtt tgaggatgaa
     5221 tgagtgcttg tttgcagtgc cctggactga cttgcttttg cccttgtgcc tagttaagag
     5281 atttcaaaag gtcaatgact ttttttatac attgttataa taaatgcttt attgccctct
     5341 gatttccttc ccacatgcct taattttgtg gcccgtgtct cactgaatag aagcttcctc
     5401 tgtgtacagt ctcttattta cattagttca tcattcattc attcattcat tcattcattc
     5461 attcatgtgt gatgtgtgtg tcatcttgta tctgcgctca catataagct atggtgtgga
     5521 tgtggagatc aaaggacagt gtttgggagt tggttctccc aagagccgag cctcttatag
     5581 cctccccgtg cagctgtgtg cacagttcaa gtgggagggg ctggctcctg gatagcttcc
     5641 tatggctgga gagaaggttc taaagcagga gtctgtagct gttcagtgga tcttggggtt
     5701 gcagggagaa atctagtctt ttgcccagga ttaaactatt tagtgttgct tggttcactt
     5761 tgtggctctg gttccagaac tgaagagagt tccttctcac agccttcctt cagtaacatt
     5821 gcacagcatt ctgtggtgtg gggacatgag ggacactgcc atttgtgccc catgtgatat
     5881 gtgacttatt ttgccagttg aaggtaaaat ctggcaattt gggataagcg tggagtgact
     5941 gaactgaata aaagttattt cttcatcttg a
//
