LOCUS       NM_020577               1736 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus arsenite methyltransferase (As3mt), mRNA.
ACCESSION   NM_020577
VERSION     NM_020577.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1736)
  AUTHORS   Barguilla,I., Peremarti,J., Bach,J., Marcos,R. and Hernandez,A.
  TITLE     Role of As3mt and Mth1 in the genotoxic and carcinogenic effects
            induced by long-term exposures to arsenic in MEF cells
  JOURNAL   Toxicol Appl Pharmacol 409, 115303 (2020)
   PUBMED   33141059
  REMARK    GeneRIF: Role of As3mt and Mth1 in the genotoxic and carcinogenic
            effects induced by long-term exposures to arsenic in MEF cells.
REFERENCE   2  (bases 1 to 1736)
  AUTHORS   Coryell,M., McAlpine,M., Pinkham,N.V., McDermott,T.R. and Walk,S.T.
  TITLE     The gut microbiome is required for full protection against acute
            arsenic toxicity in mouse models
  JOURNAL   Nat Commun 9 (1), 5424 (2018)
   PUBMED   30575732
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1736)
  AUTHORS   Douillet,C., Huang,M.C., Saunders,R.J., Dover,E.N., Zhang,C. and
            Styblo,M.
  TITLE     Knockout of arsenic (+3 oxidation state) methyltransferase is
            associated with adverse metabolic phenotype in mice: the role of
            sex and arsenic exposure
  JOURNAL   Arch Toxicol 91 (7), 2617-2627 (2017)
   PUBMED   27847981
  REMARK    GeneRIF: As3mt role in obesity and insulin resistance
REFERENCE   4  (bases 1 to 1736)
  AUTHORS   Huang,M.C., Douillet,C., Su,M., Zhou,K., Wu,T., Chen,W.,
            Galanko,J.A., Drobna,Z., Saunders,R.J., Martin,E., Fry,R.C., Jia,W.
            and Styblo,M.
  TITLE     Metabolomic profiles of arsenic (+3 oxidation state)
            methyltransferase knockout mice: effect of sex and arsenic exposure
  JOURNAL   Arch Toxicol 91 (1), 189-202 (2017)
   PUBMED   26883664
  REMARK    GeneRIF: Data, including date from studies in knockout mice,
            suggest that As3mt is involved in energy metabolism in a
            sex-specific manner, independent of inorganic arsenic poisoning;
            thus, As3mt may be involved in cellular processes beyond
            methylation of inorganic arsenic.
REFERENCE   5  (bases 1 to 1736)
  AUTHORS   Bach,J., Peremarti,J., Annangi,B., Marcos,R. and Hernandez,A.
  TITLE     Reduced cellular DNA repair capacity after environmentally relevant
            arsenic exposure. Influence of Ogg1 deficiency
  JOURNAL   Mutat Res 779, 144-151 (2015)
   PUBMED   26210637
  REMARK    GeneRIF: Oxidative damage and Ogg1 deficient background exacerbate
            repair deficiencies..  Overexpression of the arsenic metabolizing
            enzyme As3mt acts as adaptive mechanism.
REFERENCE   6  (bases 1 to 1736)
  AUTHORS   Hughes,M.F., Edwards,B.C., Herbin-Davis,K.M., Saunders,J.,
            Styblo,M. and Thomas,D.J.
  TITLE     Arsenic (+3 oxidation state) methyltransferase genotype affects
            steady-state distribution and clearance of arsenic in
            arsenate-treated mice
  JOURNAL   Toxicol Appl Pharmacol 249 (3), 217-223 (2010)
   PUBMED   20887743
REFERENCE   7  (bases 1 to 1736)
  AUTHORS   Yokohira,M., Arnold,L.L., Pennington,K.L., Suzuki,S.,
            Kakiuchi-Kiyota,S., Herbin-Davis,K., Thomas,D.J. and Cohen,S.M.
  TITLE     Severe systemic toxicity and urinary bladder cytotoxicity and
            regenerative hyperplasia induced by arsenite in arsenic (+3
            oxidation state) methyltransferase knockout mice. A preliminary
            report
  JOURNAL   Toxicol Appl Pharmacol 246 (1-2), 1-7 (2010)
   PUBMED   20423714
REFERENCE   8  (bases 1 to 1736)
  AUTHORS   Drobna,Z., Naranmandura,H., Kubachka,K.M., Edwards,B.C.,
            Herbin-Davis,K., Styblo,M., Le,X.C., Creed,J.T., Maeda,N.,
            Hughes,M.F. and Thomas,D.J.
  TITLE     Disruption of the arsenic (+3 oxidation state) methyltransferase
            gene in the mouse alters the phenotype for methylation of arsenic
            and affects distribution and retention of orally administered
            arsenate
  JOURNAL   Chem Res Toxicol 22 (10), 1713-1720 (2009)
   PUBMED   19691357
REFERENCE   9  (bases 1 to 1736)
  AUTHORS   Li,J., Waters,S.B., Drobna,Z., Devesa,V., Styblo,M. and Thomas,D.J.
  TITLE     Arsenic (+3 oxidation state) methyltransferase and the inorganic
            arsenic methylation phenotype
  JOURNAL   Toxicol Appl Pharmacol 204 (2), 164-169 (2005)
   PUBMED   15808521
  REMARK    GeneRIF: Rat, mouse and human are efficient methylators of
            inorganic arsenic. Findings suggest a role for AS3MT in the
            methylation of inorganic arsenic.
REFERENCE   10 (bases 1 to 1736)
  AUTHORS   Thomas,D.J., Waters,S.B. and Styblo,M.
  TITLE     Elucidating the pathway for arsenic methylation
  JOURNAL   Toxicol Appl Pharmacol 198 (3), 319-326 (2004)
   PUBMED   15276411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161865.4.
            
            On Aug 13, 2018 this sequence version replaced NM_020577.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006571.1, AK002801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC161865.4         143627-143705       c
            80-123              AC161865.4         143364-143407       c
            124-251             AC161865.4         142966-143093       c
            252-402             AC161865.4         142045-142195       c
            403-539             AC161865.4         141480-141616       c
            540-609             AC161865.4         138873-138942       c
            610-691             AC161865.4         135893-135974       c
            692-823             AC161865.4         131143-131274       c
            824-966             AC161865.4         130707-130849       c
            967-1101            AC161865.4         126125-126259       c
            1102-1736           AC161865.4         110068-110702       c
FEATURES             Location/Qualifiers
     source          1..1736
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.97 cM"
     gene            1..1736
                     /gene="As3mt"
                     /gene_synonym="2310045H08Rik; Cyt19"
                     /note="arsenite methyltransferase"
                     /db_xref="GeneID:57344"
                     /db_xref="MGI:MGI:1929882"
     exon            1..79
                     /gene="As3mt"
                     /gene_synonym="2310045H08Rik; Cyt19"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1209
                     /gene="As3mt"
                     /gene_synonym="2310045H08Rik; Cyt19"
                     /EC_number="2.1.1.137"
                     /note="S-adenosylmethionine:arsenic (III)
                     methyltransferase; methylarsonite methyltransferase;
                     S-adenosyl-L-methionine:arsenic(III) methyltransferase;
                     methyltransferase Cyt19; arsenic (+3 oxidation state)
                     methyltransferase"
                     /codon_start=1
                     /product="arsenite methyltransferase"
                     /protein_id="NP_065602.2"
                     /db_xref="CCDS:CCDS50458.1"
                     /db_xref="GeneID:57344"
                     /db_xref="MGI:MGI:1929882"
                     /translation="MAASRDADEIHKDVQNYYGNVLKTSADLQTNACVTRAKPVPSYI
                     RESLQNVHEDVSSRYYGCGLTVPERLENCRILDLGSGSGRDCYVLSQLVGEKGHVTGI
                     DMTEVQVEVAKTYLEHHMEKFGFQAPNVTFLHGRIEKLAEAGIQSESYDIVISNCVIN
                     LVPDKQQVLQEVYRVLKHGGELYFSDVYASLEVPEDIKSHKVLWGECLGGALYWKDLA
                     IIAQKIGFCPPRLVTADIITVENKELEGVLGDCRFVSATFRLFKLPKTEPAERCRVVY
                     NGGIKGHEKELIFDANFTFKEGEAVAVDEETAAVLKNSRFAPDFLFTPVDASLPAPQG
                     RSELETKVLIRDPFKLAEDSDKMKPRHAPEGTGGCCGKRKNC"
     exon            80..123
                     /gene="As3mt"
                     /gene_synonym="2310045H08Rik; Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            124..251
                     /gene="As3mt"
                     /gene_synonym="2310045H08Rik; Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            252..402
                     /gene="As3mt"
                     /gene_synonym="2310045H08Rik; Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            403..539
                     /gene="As3mt"
                     /gene_synonym="2310045H08Rik; Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            540..609
                     /gene="As3mt"
                     /gene_synonym="2310045H08Rik; Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            610..691
                     /gene="As3mt"
                     /gene_synonym="2310045H08Rik; Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            692..823
                     /gene="As3mt"
                     /gene_synonym="2310045H08Rik; Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            824..966
                     /gene="As3mt"
                     /gene_synonym="2310045H08Rik; Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1101
                     /gene="As3mt"
                     /gene_synonym="2310045H08Rik; Cyt19"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1736
                     /gene="As3mt"
                     /gene_synonym="2310045H08Rik; Cyt19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcctcgg cgatctcttc gaaagccggg ctgaggggaa tcctggacag ggaatcctgg
       61 acgtggagat cgtgagtcat ggctgcttcc cgagacgctg atgagatcca caaggacgtt
      121 cagaactact atgggaatgt actgaagaca tctgcagacc tccagactaa tgcttgtgtc
      181 acgcgagcca agccggtccc cagctacatc cgggaaagtc tgcagaatgt acacgaagac
      241 gttagttcga ggtattatgg ctgtggtctg actgttcctg agcggctgga aaactgccga
      301 attttggatc tgggtagtgg gagtggcagg gattgctatg tgcttagcca gctggttggt
      361 gagaagggac atgtcaccgg aatagacatg actgaggtcc aggtcgaagt ggctaaaacc
      421 tatcttgaac accacatgga aaaatttggt ttccaggcac ccaatgtgac ttttctccac
      481 ggccgcatcg agaagttggc agaggctggg atccagagtg agagctatga tattgtcata
      541 tccaactgtg ttatcaacct tgttcctgat aaacaacaag tcctccagga ggtctatcga
      601 gtgctgaagc acggcgggga gctctatttc agtgacgtct atgccagcct tgaagtgcca
      661 gaagacatca agtcgcacaa agttttatgg ggggaatgcc tgggaggcgc tctgtactgg
      721 aaggatcttg ccatcattgc ccaaaagatt gggttctgcc ctccacgttt ggtcactgcc
      781 gatatcatta ctgttgaaaa caaggagctc gaaggggttc ttggtgactg tcgctttgtg
      841 tctgccacat ttcgcctctt caaactccct aagacagagc cagccgaaag atgccgagtt
      901 gtttacaatg gaggaatcaa gggacatgaa aaggaactaa ttttcgatgc aaatttcaca
      961 ttcaaggaag gcgaagctgt tgcagtggat gaggagacgg cagctgtcct gaagaactca
     1021 cgttttgctc cggattttct cttcacacct gttgacgcct cgctgccagc tccccagggc
     1081 cgttctgagt tagagacaaa ggttctaatc agagatccat tcaagcttgc agaggactct
     1141 gacaagatga agcccagaca tgcacctgaa ggcacgggag gctgctgtgg caagaggaaa
     1201 aactgctaga tctacagcca gcgcggagcc caccgggctc aagagggtgg ctaaaggaca
     1261 gtcacagagg cttcttagcc tgctcttcgc cagtgcacag attatgtgaa ggtggcaaag
     1321 ccaccacaag ctagaccact gctaagaata agagtgactt ttagaggatg ttaattgaag
     1381 gttcacagca aatcgcctgc ttttctattt ctctatctca gagttctggt gccacctagt
     1441 ggtcagaagt agaacttgga agcccaaggt ttactcaaag ggccaaaggc atcatcaacg
     1501 ttgtgagaat tatcttcctt ctggcctacc acaggacacc tctgggttct tctctgtggt
     1561 taccaggaag cacagtactt actaaattta tgctaaccat gacaaaagat tgtcaactca
     1621 aatttgctag gagtattctt taggttgctg tctgcaattt ttttctctgt aactgaatga
     1681 aaaagaaaac aaataaaaaa taaatttgac ttcagttcac cttgataatt gatacc
//
