LOCUS       NM_001272029            4720 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus armadillo repeat gene deleted in velocardiofacial
            syndrome (Arvcf), transcript variant 3, mRNA.
ACCESSION   NM_001272029
VERSION     NM_001272029.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4720)
  AUTHORS   Shi,X., Wang,Y., Yang,Z., Yuan,W. and Li,M.D.
  TITLE     Identification and validation of a novel gene ARVCF associated with
            alcohol dependence among Chinese population
  JOURNAL   iScience 27 (10), 110976 (2024)
   PUBMED   39429782
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4720)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4720)
  AUTHORS   Martin,J.B., Herman,K., Houssin,N.S., Rich,W., Reilly,M.A. and
            Plageman,T.F. Jr.
  TITLE     Arvcf Dependent Adherens Junction Stability is Required to Prevent
            Age-Related Cortical Cataracts
  JOURNAL   Front Cell Dev Biol 10, 840129 (2022)
   PUBMED   35874813
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4720)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4720)
  AUTHORS   Maddala,R. and Rao,P.V.
  TITLE     Switching of alpha-Catenin From Epithelial to Neuronal Type During
            Lens Epithelial Cell Differentiation
  JOURNAL   Invest Ophthalmol Vis Sci 58 (9), 3445-3455 (2017)
   PUBMED   28692740
REFERENCE   6  (bases 1 to 4720)
  AUTHORS   Lund,J., Chen,F., Hua,A., Roe,B., Budarf,M., Emanuel,B.S. and
            Reeves,R.H.
  TITLE     Comparative sequence analysis of 634 kb of the mouse chromosome 16
            region of conserved synteny with the human velocardiofacial
            syndrome region on chromosome 22q11.2
  JOURNAL   Genomics 63 (3), 374-383 (2000)
   PUBMED   10704284
REFERENCE   7  (bases 1 to 4720)
  AUTHORS   Lund,J., Roe,B., Chen,F., Budarf,M., Galili,N., Riblet,R.,
            Miller,R.D., Emanuel,B.S. and Reeves,R.H.
  TITLE     Sequence-ready physical map of the mouse chromosome 16 region with
            conserved synteny to the human velocardiofacial syndrome region on
            22q11.2
  JOURNAL   Mamm Genome 10 (5), 438-443 (1999)
   PUBMED   10337614
REFERENCE   8  (bases 1 to 4720)
  AUTHORS   Sutherland,H.F., Kim,U.J. and Scambler,P.J.
  TITLE     Cloning and comparative mapping of the DiGeorge syndrome critical
            region in the mouse
  JOURNAL   Genomics 52 (1), 37-43 (1998)
   PUBMED   9740669
REFERENCE   9  (bases 1 to 4720)
  AUTHORS   Puech,A., Saint-Jore,B., Funke,B., Gilbert,D.J., Sirotkin,H.,
            Copeland,N.G., Jenkins,N.A., Kucherlapati,R., Morrow,B. and
            Skoultchi,A.I.
  TITLE     Comparative mapping of the human 22q11 chromosomal region and the
            orthologous region in mice reveals complex changes in gene
            organization
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14608-14613 (1997)
   PUBMED   9405660
REFERENCE   10 (bases 1 to 4720)
  AUTHORS   Sirotkin,H., O'Donnell,H., DasGupta,R., Halford,S., St Jore,B.,
            Puech,A., Parimoo,S., Morrow,B., Skoultchi,A., Weissman,S.M.,
            Scambler,P. and Kucherlapati,R.
  TITLE     Identification of a new human catenin gene family member (ARVCF)
            from the region deleted in velo-cardio-facial syndrome
  JOURNAL   Genomics 41 (1), 75-83 (1997)
   PUBMED   9126485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY273838.1 and BC052393.1.
            
            Transcript Variant: This variant (3) lacks an exon in the coding
            region but maintains reading frame, compared to variant 1. The
            encoded isoform (2) is shorter, compared to isoform 1. Both
            variants 3 and 4 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052393.1, AK084886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                BY273838.1         1-81
            82-4720             BC052393.1         1-4639
FEATURES             Location/Qualifiers
     source          1..4720
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.37 cM"
     gene            1..4720
                     /gene="Arvcf"
                     /note="armadillo repeat gene deleted in velocardiofacial
                     syndrome"
                     /db_xref="GeneID:11877"
                     /db_xref="MGI:MGI:109620"
     exon            1..275
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            276..327
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            328..558
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..3216
                     /gene="Arvcf"
                     /note="isoform 2 is encoded by transcript variant 3;
                     armadillo repeat protein deleted in velo-cardio-facial
                     syndrome homolog; armadillo repeat gene deleted in
                     velo-cardio-facial syndrome; splicing regulator ARVCF"
                     /codon_start=1
                     /product="splicing regulator ARVCF isoform 2"
                     /protein_id="NP_001258958.1"
                     /db_xref="CCDS:CCDS70693.1"
                     /db_xref="GeneID:11877"
                     /db_xref="MGI:MGI:109620"
                     /translation="MEDCNVHSAASILASVKEQEARFERLTRALEQERRHVALQLERA
                     QQPGMSSGGMVGSGQPLPMAWQQLVLQEQSPGSQASLATMPEAPEVLEETVTVEEDPG
                     TPTSHVSIVTSEDGTTRRTETKVTKTVKTVTTRTVRQVPLGPDGLPLLDGGPPLGSFA
                     DGPLDRHYLLRGGGGPAATLSRTYHSSGGGFPDGPESRDIPSYGSLSRGLGVRPPRTG
                     LLGPGPGDGCFTLPGRREAFPMGSESGPPSGRSLPEHFQAEPYGLEDDTRSLAADDEG
                     GPDLEPDYSTATRRRPEYGRGLRARAFEDTADDAGELIEERPPFPAATAPLAQPERGS
                     LGSLDRVVRRSPSVDSTRKEPRWRDPELPEVLAMLRHPVDPVKANAAAYLQHLCFENE
                     GIKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSYGRDTDNKAAIRDCGGVPAL
                     VRLLRAARDNEVRELVTGTLWNLSSYEPLKMVIIDHGLQTLTHEVIVPHSGWEREPNE
                     DSKPRDAEWTTVFKNTSGCLRNVSSDGAEARRRLRECEGLVDALLHALQSAVGRKDTD
                     NKSVENCVCIMRNLSYHVHKEVPGADRYQEAEPGIPGSTTSQRRRKDDASCFGGKKAK
                     GKKDAEMDRNFDTLDLPKRTEAAKGFELLYQPEVVRLYLSLLTESRNFNTLEAAAGAL
                     QNLSAGNWTWATYIRATVRKERGLPVLVELLQSETDKVVRAVAIALRNLSLDQRNKDL
                     IGSYAMTELVRNVRNAQAPAHPSAHLEEDTVVAVLNTIHEIVSDSLDNARSLLQARGV
                     PALVALVASSQSVREAKAASHVLQTVWSYKELRGALQRDGWTKSRFQSASTAKGPKGT
                     PSSGGFDDSTLPLVDKSLDGEKSNTRDVIPMDTLGPDGYATVDRRERRTLGSDSTGDT
                     SEKELLRPDPGRKAPPPGPSRPSVRLVDAVGDTKPQPVDSWV"
     exon            559..717
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            718..1247
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1747
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1931
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2049
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2218
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2290
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2418
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2569
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2768
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2880
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..2968
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3022
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3108
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3228
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..4698
                     /gene="Arvcf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3904..3909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arvcf"
                     /note="hexamer: ATTAAA"
     polyA_site      3925
                     /gene="Arvcf"
     regulatory      3968..3973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arvcf"
                     /note="hexamer: ATTAAA"
     polyA_site      3987
                     /gene="Arvcf"
                     /note="major polyA site"
     regulatory      4669..4674
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arvcf"
                     /note="hexamer: ATTAAA"
     polyA_site      4698
                     /gene="Arvcf"
                     /note="major polyA site"
ORIGIN      
        1 agttggatgg ggcggggcgg aggcctcgtc tccggccagg tccgctttgc gcacgggcag
       61 cgggaggggt aggagggcta gcctgcttgc tggctgctcc agtaggggag gaggagtgtt
      121 ccccccctca cctcctcaca agcacaagtt gtggccccgg gagccacttt cggtgctggg
      181 cgctggagag gccgctcccc gcgcaccggg ggacctgggg acgcctgtct tgggggcgga
      241 ggccgcgctg cggagccgcc cacgccgcgc gccaggaaca gagtccacaa gatgggtgtt
      301 aggacatgct gagatccccc gaaataggct gctggcaccc tggtcatgga ggactgcaac
      361 gtgcattcgg ccgccagcat tttggcctcg gtgaaggaac aggaggcccg tttcgagcgg
      421 ctgacacggg cactagaaca agaacggcgc catgttgccc tgcagctgga gcgtgcccag
      481 cagcctggca tgagcagtgg tggtatggtg ggcagtgggc agcccctgcc aatggcctgg
      541 cagcagctgg ttctgcagga gcagagcccg ggtagccagg catcgctggc cacgatgcca
      601 gaggcacccg aggtactgga ggagacagtg actgtggagg aagaccctgg cacccccacc
      661 tctcacgtgt ccatcgtcac atcagaagat ggtacaaccc ggcggactga gactaaggtc
      721 actaagacgg tcaagactgt gaccacaagg acagtacgcc aggtgccttt gggcccagat
      781 ggactcccct tgctggacgg cggccctcca cttggctctt ttgctgacgg gcccctggac
      841 cggcattacc tacttcgtgg tggtggtggt ccagcagcca cactctcccg aacctaccac
      901 agcagtggag gtggctttcc cgatggcccc gagtcccgtg atattccaag ctatggcagc
      961 ttgtcccgag ggctcggggt acggccacca cgtactggcc tcctgggccc aggacctggt
     1021 gatggctgtt tcacactgcc tggccgccga gaagccttcc ccatgggctc tgaatccgga
     1081 ccaccaagcg gccgctctct gcctgagcat ttccaagctg aaccatatgg cctggaggat
     1141 gatacacgga gcctggctgc ggatgatgag ggtggccccg acctggagcc tgactatagc
     1201 acggcaaccc ggagaagacc tgagtacggg cggggccttc gtgccagggc ctttgaagac
     1261 acagcagatg atgctggtga gctgatagaa gagcgtcccc catttccagc agcaacagcc
     1321 cctctggccc agcctgagag gggcagcctg ggcagcttgg accgagtagt gcggcgctca
     1381 ccttcagtgg atagcacccg caaggagcca cgctggcggg accccgagct gccagaggtg
     1441 ttggccatgc tgcggcaccc tgtggaccct gtgaaagcca atgctgcagc ctacctgcag
     1501 cacctctgct ttgagaacga gggtattaag cggcgagtgc ggcagctgcg tgggctcccc
     1561 ctgcttgtgg cattactaga tcaccctcgg gctgaggtgc ggcgccgggc ctgtggggca
     1621 ctgcgcaacc tctcctatgg ccgggatact gacaacaagg ccgccatccg ggactgcggg
     1681 ggcgtgccag ccctggtgcg cctactgcgg gcggcccgtg acaatgaggt ccgtgagctg
     1741 gtcactggca cactctggaa cctgtcatcc tacgagcccc tgaagatggt catcattgac
     1801 cacggcttac agactctgac ccatgaggtc atcgtgcccc attccggctg ggagcgagag
     1861 cctaacgaag actcgaagcc ccgggatgcc gagtggacaa cagtcttcaa gaacacatca
     1921 ggctgcctga ggaatgtgag ctcagatggt gcagaggccc ggcggcgact ccgtgagtgc
     1981 gaagggctgg tggacgctct cctacatgcc ctgcagtcag ctgtgggcag gaaagacaca
     2041 gataataagt cagtagagaa ctgtgtgtgc atcatgcgga acctgtccta ccacgtgcac
     2101 aaagaagttc caggggctga caggtaccag gaggcagagc ctgggatccc gggcagcaca
     2161 acctcccagc gacggaggaa ggatgacgcc agctgctttg gtggcaagaa agcaaaaggg
     2221 aagaaggatg cagagatgga ccggaacttt gacacactgg acctgcctaa acgaacggag
     2281 gctgcaaaag gcttcgagct gctgtaccag ccggaggtgg tacgtctcta cctctcactc
     2341 cttacggaga gccggaactt caacaccctg gaagctgcag ccggtgccct gcaaaacctc
     2401 agtgctggca actggacgtg ggccacgtac atccgtgcca cagtgcgcaa ggaacgtggg
     2461 ctgccagtac tggtggaact gctacagtct gagaccgaca aggtggtgcg cgctgtagcc
     2521 atcgcgctgc gcaacctctc actagaccag cggaacaaag acctcatcgg gagctatgcc
     2581 atgacagagc tggttcggaa tgttcgcaat gcacaggctc ccgctcaccc cagtgcccac
     2641 ctggaggagg atactgtggt tgccgtgctc aacaccatcc atgagatcgt gtccgacagc
     2701 ctggacaatg ctcgctccct cctgcaggcc cgtggtgtgc ctgccctggt agcacttgtg
     2761 gcctccagcc agtcagtgcg ggaggccaag gcagcatcac acgtgctaca gactgtatgg
     2821 agctacaagg agctgcgtgg agccctgcag agggatggct ggacgaagtc acgcttccag
     2881 tctgctagca ctgccaaagg acccaaaggg acaccaagtt ctggcggctt tgatgacagc
     2941 acactgccac tggtagacaa gagccttgat ggggagaagt caaacacccg ggatgtgatc
     3001 cccatggata cccttggtcc agatggttac gccacagttg accggaggga gaggaggaca
     3061 ctgggcagtg actccacagg ggacacctct gagaaagaac tattgagacc cgatcctggc
     3121 aggaaggccc ctccgcctgg gcccagcagg ccctcggtca ggctggtgga cgccgtgggg
     3181 gacactaagc ctcagcctgt tgactcctgg gtctagcttg catgcctggg ccctggccca
     3241 gctgtttgtt cttagggatc gcatcgaggt agctggaaga gggccagagg gcccgccatc
     3301 ttgagcagaa ccagtcttgg agccaggagc cccaccctgc tgtggcaggg tggccaagcc
     3361 tcttgtccta ccttacccta ccctcttctc tactcttctg ctctaactct ccaggtctga
     3421 gttagctgtt tactgacatg gtgctgtgtg gtaggagagg aggctggggg gaggtcccca
     3481 tgcacagcca cagaggagca aatacaagcc tggattggag gtcctggagc aggcaatggg
     3541 acaagtaggg ggccttggaa aagaacttgg gctcccaagg gtggctggag tactacactg
     3601 catgtaggct gaccacaggg agggctgctc taaaagagtc cagacaggga agtttaggag
     3661 gcagccagat tgggggtagt ggcaagctgt gcttgtcacc agcaccccca tccttggatt
     3721 cctggaacac cttccctctg cagcatactc ctcctaagct gcctgtggct ggggccaccc
     3781 tggctgttgc atctgcctag aacctcaagt aacctcgggg cctgactgcc ggcagcagtg
     3841 gggggaactg ctgttcagtg cctgctgttt gtgactttaa aatgaagaaa actgacaaaa
     3901 tgcattaaaa atgaaaccaa aataagacta tcaacaaaaa ttgaaatttt tgtaagaaaa
     3961 tttaaagatt aaaaaagcag caaagaactg cctgtcttct gccttggctc accaggagag
     4021 ggcacagtcc tgtgctagct gagccaccac tgccccctgg tgaagataca gttccctcaa
     4081 gtcccattgc agggaggggg tggaaggggt atgggggttg tgctctgccc ctggcctcag
     4141 gcacgtccca ctgctgtcac tcctggctcc tgtgtgccgg ctgaccaata tgggcatatg
     4201 tgggagcaga caagatggag ctgacctttg tttctagtct aggaaatggg cccctactga
     4261 ggccttgagg agcctcttga aagagatggg ggctagggtg actcttaagc ttgggttggc
     4321 acttcctcag aatctgggtg cctggcagac atgcctcaat ggtgtgaact ggagagactg
     4381 tttatcccag agacatcggg gacagcgtgg ccccatgcct gtttagtcag agatgagtac
     4441 aaaggctgtt ctgcgccaag taagagcagt gtggtagctg aaaagaataa ctcagtgaat
     4501 ttcttatatc caaatattta gatctttaat ttcttttata atataaaaga gattatgact
     4561 ttttttttca aagtatttct atgtagccct ggctgtcctg gaactcactg tgtagaccag
     4621 gctggcacag aactcagatc catctgcctc tgcctcctgg attctgggat taaaggcatg
     4681 cgccatcata cctgaaaaaa aaaaaaaaaa aaaaaaaaaa
//
