LOCUS       NM_001368372            6428 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ARV1 homolog, fatty acid homeostasis modulator (Arv1),
            transcript variant 2, mRNA.
ACCESSION   NM_001368372 XM_006531338
VERSION     NM_001368372.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6428)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6428)
  AUTHORS   Gallo-Ebert,C., Francisco,J., Liu,H.Y., Draper,R., Modi,K.,
            Hayward,M.D., Jones,B.K., Buiakova,O., McDonough,V. and
            Nickels,J.T. Jr.
  TITLE     Mice lacking ARV1 have reduced signs of metabolic syndrome and
            non-alcoholic fatty liver disease
  JOURNAL   J Biol Chem 293 (16), 5956-5974 (2018)
   PUBMED   29491146
  REMARK    GeneRIF: Arv1-/- animals fed a high-fat diet were resistant to
            diet-induced obesity, had lower blood cholesterol and triglyceride
            levels, and retained glucose tolerance and insulin sensitivity.
REFERENCE   3  (bases 1 to 6428)
  AUTHORS   Palmer,E.E., Jarrett,K.E., Sachdev,R.K., Al Zahrani,F.,
            Hashem,M.O., Ibrahim,N., Sampaio,H., Kandula,T., Macintosh,R.,
            Gupta,R., Conlon,D.M., Billheimer,J.T., Rader,D.J., Funato,K.,
            Walkey,C.J., Lee,C.S., Loo,C., Brammah,S., Elakis,G., Zhu,Y.,
            Buckley,M., Kirk,E.P., Bye,A., Alkuraya,F.S., Roscioli,T. and
            Lagor,W.R.
  TITLE     Neuronal deficiency of ARV1 causes an autosomal recessive epileptic
            encephalopathy
  JOURNAL   Hum Mol Genet 25 (14), 3042-3054 (2016)
   PUBMED   27270415
  REMARK    GeneRIF: In contrast to wild type human ARV1, neither variant
            expressed detectable levels of protein in mammalian cells. Mice
            with a neuronal deletion of Arv1 recapitulated the human phenotype,
            exhibiting seizures and a severe survival defect in adulthood. Our
            data support ARV1 deficiency as a cause of autosomal recessive
            epileptic encephalopathy
REFERENCE   4  (bases 1 to 6428)
  AUTHORS   Lagor,W.R., Tong,F., Jarrett,K.E., Lin,W., Conlon,D.M., Smith,M.,
            Wang,M.Y., Yenilmez,B.O., McCoy,M.G., Fields,D.W., O'Neill,S.M.,
            Gupta,R., Kumaravel,A., Redon,V., Ahima,R.S., Sturley,S.L.,
            Billheimer,J.T. and Rader,D.J.
  TITLE     Deletion of murine Arv1 results in a lean phenotype with increased
            energy expenditure
  JOURNAL   Nutr Diabetes 5 (10), e181 (2015)
   PUBMED   26479315
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6428)
  AUTHORS   Ruggles,K.V., Garbarino,J., Liu,Y., Moon,J., Schneider,K.,
            Henneberry,A., Billheimer,J., Millar,J.S., Marchadier,D.,
            Valasek,M.A., Joblin-Mills,A., Gulati,S., Munkacsi,A.B., Repa,J.J.,
            Rader,D. and Sturley,S.L.
  TITLE     A functional, genome-wide evaluation of liposensitive yeast
            identifies the 'ARE2 required for viability' (ARV1) gene product as
            a major component of eukaryotic fatty acid resistance
  JOURNAL   J Biol Chem 289 (7), 4417-4431 (2014)
   PUBMED   24273168
  REMARK    GeneRIF: These results implicate ARV1 as a protective factor in
            lipotoxic diseases due to modulation of fatty acid metabolism.
REFERENCE   6  (bases 1 to 6428)
  AUTHORS   Tong,F., Billheimer,J., Shechtman,C.F., Liu,Y., Crooke,R.,
            Graham,M., Cohen,D.E., Sturley,S.L. and Rader,D.J.
  TITLE     Decreased expression of ARV1 results in cholesterol retention in
            the endoplasmic reticulum and abnormal bile acid metabolism
  JOURNAL   J Biol Chem 285 (44), 33632-33641 (2010)
   PUBMED   20663892
  REMARK    GeneRIF: Arv1p has a role in sterol movement from the ER and in the
            ensuing regulation of hepatic cholesterol and bile acid metabolism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151736.6.
            
            On Feb 8, 2019 this sequence version replaced XM_006531338.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.140090.1,
                                           SRR11927938.2819317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC151736.6         171720-171896       c
            178-297             AC151736.6         168687-168806       c
            298-451             AC151736.6         165580-165733       c
            452-676             AC151736.6         163046-163270       c
            677-821             AC151736.6         162121-162265       c
            822-6428            AC151736.6         155938-161544       c
FEATURES             Location/Qualifiers
     source          1..6428
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.81 cM"
     gene            1..6428
                     /gene="Arv1"
                     /gene_synonym="1110067L22Rik"
                     /note="ARV1 homolog, fatty acid homeostasis modulator"
                     /db_xref="GeneID:68865"
                     /db_xref="MGI:MGI:1916115"
     exon            1..177
                     /gene="Arv1"
                     /gene_synonym="1110067L22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..819
                     /gene="Arv1"
                     /gene_synonym="1110067L22Rik"
                     /codon_start=1
                     /product="protein ARV1"
                     /protein_id="NP_001355301.1"
                     /db_xref="CCDS:CCDS22774.1"
                     /db_xref="GeneID:68865"
                     /db_xref="MGI:MGI:1916115"
                     /translation="MGTGGRRGTRSGKGTEGAAATSSSCLYRCIECNREAQELYRDYS
                     HGVLKITICKSCQKPVDKYIEYDPVIILINAILCKTQAYRHILFNTKINIHGKLCMFC
                     LLCEAYLRWWQLQDSSQSPAPDDVIRYAKEWDFYRMFVIASFEQAAFLTGIFAFLWVQ
                     QPMTAKRAPDFVLLLKALLLSSYGKLLLIPAVIWEHDYTPLCLRLIKVFVLTSNFQAV
                     RVTLNTNRRLSLLVVLSGLLLESIVVFFFQRMEWDVSSDCALYKSQDF"
     exon            178..297
                     /gene="Arv1"
                     /gene_synonym="1110067L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            298..451
                     /gene="Arv1"
                     /gene_synonym="1110067L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            452..676
                     /gene="Arv1"
                     /gene_synonym="1110067L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            677..821
                     /gene="Arv1"
                     /gene_synonym="1110067L22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            822..6428
                     /gene="Arv1"
                     /gene_synonym="1110067L22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2393..2398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arv1"
                     /gene_synonym="1110067L22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2429
                     /gene="Arv1"
                     /gene_synonym="1110067L22Rik"
                     /note="major polyA site"
     regulatory      6405..6410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arv1"
                     /gene_synonym="1110067L22Rik"
                     /note="hexamer: AACAAA"
     polyA_site      6428
                     /gene="Arv1"
                     /gene_synonym="1110067L22Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggagcccta gagtggccat ggggaccggc gggcgtaggg ggacgcggtc cgggaaaggc
       61 acggaaggcg cagcggcgac ttcttcctct tgcctgtatc gttgtatcga gtgcaaccga
      121 gaggctcagg agctgtaccg ggactacagc cacggcgtgc tcaagataac catctgcaaa
      181 tcctgccaga aaccagtaga caaatacatc gaatacgacc ctgttattat cttgattaat
      241 gccattttat gcaaaactca ggcctacagg catattcttt tcaacactaa aataaatatc
      301 catgggaaac tctgcatgtt ttgtttgctt tgtgaagcat acctgcggtg gtggcagctg
      361 caggactcga gccagagtcc agcccccgat gacgtgatcc ggtacgccaa ggagtgggac
      421 ttctacagga tgtttgtgat cgcttctttc gaacaagctg cctttcttac tggcatattt
      481 gctttcctgt gggtacagca acccatgaca gcaaaaagag cacccgactt tgttctgctg
      541 ctgaaagcac tgttgctgtc cagctacggg aagctcctgc taatcccggc cgtcatctgg
      601 gaacatgact acacacctct gtgtctcagg ctcattaaag tgtttgtcct gacctcaaat
      661 ttccaggcag tcagagtgac cctgaacaca aaccggaggc tctccctgtt ggtcgtgcta
      721 agtggcttac tgctggagag cattgtggtc ttcttcttcc agaggatgga gtgggatgtg
      781 agcagtgact gtgcgctcta caagtctcag gacttctgaa gacgctgaag gaagctgcgg
      841 gtggctctgt caggcctcta acatgcttcc tgccttccac ctgctgtgtc tacacaaggt
      901 tcaagattct tgactaggag ctctctgctg gtcgtgtcat ctcggcagga ctcagtggcc
      961 tctgagaaca cttctgtctg aggagggtgc ttctcctcag ccacactgcc tccctgtgcc
     1021 cagcgctcag tgctacagct tccttctgtt tgttcttcat ctgtcattca tggtgttcct
     1081 tccttctctg ctgtgtggag ctccctcctg tgcctccctg tctggcctat gggctccttc
     1141 ctccacctga ggaagcagga tcctagggtg aagaaatgca ggaggaccca cagcaggaga
     1201 gggagccata ctcaggctca tgtcgtcttc agtatgtcac cttgggtgtg gagcgctcca
     1261 ctcctcacat gccctgtggt gtagccctgt ttgctgctgt gctgtgagcc agcccagctt
     1321 ccttcctcct gggcctttgg gggtgtggct gctggagctg gcctccctcc tcagtgtacg
     1381 tgtatggctc ctcattctgg gcgttccgtc tgagctgctg cgtccctgac ttcccctttg
     1441 tggaccccct ttccatgccc tgggtccaca gtgcgaaact tcacagagct gctgcagctc
     1501 tgtcaaaatg ttcccgttgg tgctggaatt ctagccccac ccccttcctt ccttcacgtg
     1561 aaagggtggg tgggcctgtt cttcccagat ccctctcctg gccagtgctg cgtcctgtcc
     1621 cctgcctgat acttggtgta tgcaagagta ttgccctccg tccgatatgc ccacactcca
     1681 gctgctactg gttccctcct atagaaagct gccacgttca ctcctgagaa ggacatctct
     1741 ccacactcca ccctggtgct tctacccagt tggcacctca atagcagctg ccttccaaat
     1801 tcctaccgca ggccacccag gtctgtgttc cctctggtgc gtctgtatgt ctggctgtct
     1861 gctgtaattc ataggaaaat caactcacca gtcttcagaa cccactacag agccagtggc
     1921 ctactgtgtg atcttgtgct ttgttctgtc ttcttaaaat tacactgagg agagaccctg
     1981 cctcccgctc ccctgtgtcc tccgtggctc ccagccagcc ttggaagcag ggcttctgtg
     2041 gtgatcagaa caggccccac aaagtagtct tgctctgctg tctacagctt tattcttcac
     2101 tctctggcag gaccagctac ctcaaaagag aaggcacaaa agaacccaag gtctctgctt
     2161 tctgtgagtg aagccaagac tggggatttc tgaacgtacc cagacacccc agaagatctg
     2221 aaccacctat accaaggctg aacgctctca ggcagcactg tggttccctt ataggaatga
     2281 tagctctgag ctccatcctt cctgctcttt agtgtaatat tttattacac tggtggcttt
     2341 aaccctgtat tttgtgtctt tctgacagaa gcactttgaa gttatctttc agaataaatc
     2401 aagcttttta tacatttcca gttcagtaac taaggttgtc ttttgaatta cctcagccag
     2461 aaatagccaa gataatcatt gtagttctct ctgtaatggt atgataaaga ctctacaact
     2521 agggtacttt ataaaagaaa gtgtttcgtt cagcttatgg tttcagaggg ttagagcgct
     2581 tggcagccta tagagagttc acatcttgat ccacaagcag gaggcacagt gagcactggg
     2641 aaccacagga gtgtttgaac ctcaaagccc accccagtgc cacacctcaa ggtcactcct
     2701 tgtaatcctt cccaaacagt tccaccagct gggaaccagc agttcaaata gatgggccta
     2761 atacatggtg gctcgctctt tttaagcact ctgtgagttc aaggccagcc tagtctgcaa
     2821 agctaggaca gccagggcta cacagagaaa ccctgtcttg taaaacttat atacatgtat
     2881 ttctatggga cccactctca tttaagccat gaaaatcata aaatccctga atgccacagc
     2941 ctagagatga attatatccc agttgagctg ctagagatgg atacagcagt aacatcggcc
     3001 taacccctgt gcccatttta gatacggttt cactgtctca tccataccag gcttctgagg
     3061 agctgagagt ggtactcaaa gaaactacac aagaaatcag ccagctgtga cggtgcacac
     3121 tgtaatcccg gcttctctag gcagaagcgt ctgggcagca cggtgaggtg gttgtgctag
     3181 ggaaaagtta gtgatctaga gaagcacaca caggagccca tctgaagcga ctcacagcag
     3241 ggtctttatt ctctttgagc tggcttgggg cccccaatgc accaccatca tgcaggatgt
     3301 ttttggtagt ggggaagcct cgaatgtcta tcagggcaaa actttttagt aagcagcaaa
     3361 cagggaatac aattgcaggg gatgcaagca tctaattgga aatctgctgt ggcctttaac
     3421 ataattggct gatgctggga gtcacttaac ttctgctcct ctcttcatgt ggtcattagg
     3481 caaggggtgg gcttgtaacc tcggatgcag gtttgttggg gaaatgacct ggagacactg
     3541 gtcttgttag gggtgtaacc tggaaactct gctcttggga ttagcctaga ctggagctag
     3601 gctcaggttc tgttgggggg aacttggaac taatgctata ttagcctgtt agtctgcctg
     3661 agttcaaact taggtcagat tatctaaaat ggagtctgaa tttaaaagat ttggcatctc
     3721 aaggtcaagg tcagtcttag cttagcagaa tctaaaaggc tgggcagtat agtgagactc
     3781 tgggccgctt tattgggtgt tttactgacc tcccttcttc agtcttacac cctgccccca
     3841 acactaggga ggtaagaaag gctagagggg aggggcgtca gcatcattag actagagagg
     3901 aggggcgtca gcatcattaa actagagagg aggggcatca gcatcttaga ctacttcctg
     3961 ctgattaggg gcatcaggtt ccttgggaca agactgggta tctccaagct gcaaacagca
     4021 acagcaggct cttatcttca gctgacacaa tcacacccct gccagagcat gagacaaatc
     4081 acagtcagcc tctgtggacc atccaaagca gcccctatat cccacacctg ggattaaaac
     4141 attcacataa aattttgtgc ttttaaagaa accaaaattc tcactagagg gttgtagctt
     4201 actgttggac tcttccctgg tgtgtgtgaa gtctgttggt ccaacctcat caaaaaaaca
     4261 gtcttcttag gattaagact gtaagagtga acagtggttg gcccctccag ctaccagtga
     4321 gccgagaggc tttccccacg cagacccaga ggctggtcca tgcatccaat aaaagtccct
     4381 acagttccta gaattttaac taaaagtctc tgaacgatca gtaacgttgg caagtcctag
     4441 tgaaaatgca cagtgcacac ctgtcctgtc gctgtaatac ggttgttact gccatttcac
     4501 tctgaccctt agtatgtttg gtttgaattt gttggctggt tttgtgtgtg tacacgtgtt
     4561 tgcagtcctg ggttgagcac aaggacttga atgtagttta ttaaaacaga catttggtga
     4621 gatggctcag ggggtaaagc ccatgacaca gagcctgacc agccgcattc gctcctcaag
     4681 gcccacgtgt tggaaggaga gaaccagctt ctgcaggttg tccccggaca cacacgcaca
     4741 cacacacaca caggcatgca cacagagtat taattgagaa caaggaaatg cacaggcaca
     4801 ccagccatgg tagaaagcct gcctcgtgac cacactgata aacgggctga agccaggtgt
     4861 tgtattccct gtaatcctgg cacccaggag gtgaggcagg aggatggaga gtttgaaatc
     4921 accctggcca tatagaatgg ccttttcaaa ggagaaacct tcagtgctga cagctgactg
     4981 cccactcgtg ttttcaatgc ccagagagca tgctgcttta agtgctgcag acagcacgct
     5041 cccagtgagc agggacaggt gctctgtgtc ctagtatctg agccctttgg gccaaactgg
     5101 ggagacagta tagtgcgtgg gagccaagaa ggatatttgt atatatttgc aaggtcaaat
     5161 tgatcagaaa gcttaacagt aagattgaaa ccacaaaatg gctaatggga gtgtttagga
     5221 tcacacagga gatgtgatga gactgagtcc tcctcctctt cctcctcctc ttcctcctcc
     5281 tcttcttcct cctcctcctc ctcctcctcc tcctcctctg tctgatgagc agcccctgtg
     5341 tatctgagtg cctagtggca ggtctctgga ggtccatatt tctttgttag gaaagagact
     5401 agtttaccac ccttcagata cacttgcagg gaagcgagac cagacgtttg ttaagtagag
     5461 cgctcggatg actagaacca ggcttcagtc tgtgtctctg aaggaagcat tgatgaaggg
     5521 aagagaacat cccagggacc ccacagtggt aactgtctga ctgctgcacg gccacagacc
     5581 tcattataaa gtgagagatc tactgtaaag agaaaccctt ccagcttaaa gccaaaatag
     5641 ccctggcttc tgcagcatca ccagagaagg tgcgccaaag ccagagcctc aagtatgaca
     5701 caggatcccc taccccatgt cttgttgggt gtggctcttg ggatgagctg tccgagaaag
     5761 catggaagtg cctaatagtc tgcaccaggg gcctgcagct aggaggctta gaatgtgctc
     5821 agtcctgaac agggaaggca gacagagagc ctggaggtgg gtttgtgtgt gccccaagct
     5881 gcgctccccc tggaagtgtg tccctacaca ctgttttagg gacagctgct gtgtacactc
     5941 cctggcctat cactggccag catcaccata gtctccatct aatcaagtgt ccccctcccc
     6001 tcctgtggga accaccagtg gcattaccca cctagggcgt cagtgctcac tgccaaaggg
     6061 agtagagctc tcacctgtgg gtgtagggca agaagctcta agcacctcac cactgagccg
     6121 catggccagc tctgaggcca gcagtgtggg gtgtactcca ttctgaccaa aaggtttcca
     6181 ctgccacctg cttcctgcac tctgcaggag tcacccagtg gggacacaat tggcaggaaa
     6241 cagacaggca cctgctccgc attggagtca aagtcagagc tgccttgagt atcttaaaac
     6301 aagcaggatt ccttatcttc cccaccgagg ctgttttcca aagtctggtt tcattcagtc
     6361 tgcccagcct ttgtcctgac ttatgaaccc acccacttaa aaaaaacaaa aactgcacta
     6421 aaaagcca
//
