LOCUS       NM_009711               2179 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus artemin (Artn), transcript variant 4, mRNA.
ACCESSION   NM_009711
VERSION     NM_009711.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2179)
  AUTHORS   Edamitsu,T., Taguchi,K., Kobayashi,E.H., Okuyama,R. and Yamamoto,M.
  TITLE     Aryl Hydrocarbon Receptor Directly Regulates Artemin Gene
            Expression
  JOURNAL   Mol Cell Biol 39 (20), e00190-19 (2019)
   PUBMED   31358547
  REMARK    GeneRIF: results demonstrate that the Artn gene is indeed regulated
            by the distal XRE-containing enhancer, and alloknesis in AhR-CA
            mice is provoked by the AhR-mediated direct induction of the Artn
            gene7
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2179)
  AUTHORS   Han,Y., Liu,Q., Hou,J., Gu,Y., Zhang,Y., Chen,Z., Fan,J., Zhou,W.,
            Qiu,S., Zhang,Y., Dong,T., Li,N., Jiang,Z., Zhu,H., Zhang,Q.,
            Ma,Y., Zhang,L., Wang,Q., Yu,Y., Li,N. and Cao,X.
  TITLE     Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells
            Promotes Tumor Progression
  JOURNAL   Cell 173 (3), 634-648 (2018)
   PUBMED   29606356
  REMARK    Erratum:[Cell. 2021 Mar 4;184(5):1392. doi:
            10.1016/j.cell.2020.02.036.. PMID: 33667369]
REFERENCE   3  (bases 1 to 2179)
  AUTHORS   Schaller,S., Buttigieg,D., Alory,A., Jacquier,A., Barad,M.,
            Merchant,M., Gentien,D., de la Grange,P. and Haase,G.
  TITLE     Novel combinatorial screening identifies neurotrophic factors for
            selective classes of motor neurons
  JOURNAL   Proc Natl Acad Sci U S A 114 (12), E2486-E2493 (2017)
   PUBMED   28270618
  REMARK    GeneRIF: HGF supports hindlimb motor neurons through c-Met; CNTF
            supports subsets of axial motor neurons through CNTFRalpha; and
            Artemin acts as the first survival factor for parasympathetic
            preganglionic motor neurons through GFRalpha3/Syndecan-3
            activation.
REFERENCE   4  (bases 1 to 2179)
  AUTHORS   Furlan,A., La Manno,G., Lubke,M., Haring,M., Abdo,H.,
            Hochgerner,H., Kupari,J., Usoskin,D., Airaksinen,M.S., Oliver,G.,
            Linnarsson,S. and Ernfors,P.
  TITLE     Visceral motor neuron diversity delineates a cellular basis for
            nipple- and pilo-erection muscle control
  JOURNAL   Nat Neurosci 19 (10), 1331-1340 (2016)
   PUBMED   27571008
REFERENCE   5  (bases 1 to 2179)
  AUTHORS   Li,S., Bhave,D., Chow,J.M., Riera,T.V., Schlee,S., Rauch,S.,
            Atanasova,M., Cate,R.L. and Whitty,A.
  TITLE     Quantitative analysis of receptor tyrosine kinase-effector coupling
            at functionally relevant stimulus levels
  JOURNAL   J Biol Chem 290 (16), 10018-10036 (2015)
   PUBMED   25635057
  REMARK    GeneRIF: RET coupling to ERK and Akt depends strongly on artemin
            concentration, and it is highest at the low (~100 pM) artemin
            levels required for neurite outgrowth.
REFERENCE   6  (bases 1 to 2179)
  AUTHORS   Andres,R., Forgie,A., Wyatt,S., Chen,Q., de Sauvage,F.J. and
            Davies,A.M.
  TITLE     Multiple effects of artemin on sympathetic neurone generation,
            survival and growth
  JOURNAL   Development 128 (19), 3685-3695 (2001)
   PUBMED   11585795
REFERENCE   7  (bases 1 to 2179)
  AUTHORS   Baudet,C., Mikaels,A., Westphal,H., Johansen,J., Johansen,T.E. and
            Ernfors,P.
  TITLE     Positive and negative interactions of GDNF, NTN and ART in
            developing sensory neuron subpopulations, and their collaboration
            with neurotrophins
  JOURNAL   Development 127 (20), 4335-4344 (2000)
   PUBMED   11003834
REFERENCE   8  (bases 1 to 2179)
  AUTHORS   Rosenblad,C., Gronborg,M., Hansen,C., Blom,N., Meyer,M.,
            Johansen,J., Dago,L., Kirik,D., Patel,U.A., Lundberg,C., Trono,D.,
            Bjorklund,A. and Johansen,T.E.
  TITLE     In vivo protection of nigral dopamine neurons by lentiviral gene
            transfer of the novel GDNF-family member neublastin/artemin
  JOURNAL   Mol Cell Neurosci 15 (2), 199-214 (2000)
   PUBMED   10673327
  REMARK    Erratum:[Mol Cell Neurosci 2001 Sep;18(3):332-3]
REFERENCE   9  (bases 1 to 2179)
  AUTHORS   Nishino,J., Mochida,K., Ohfuji,Y., Shimazaki,T., Meno,C.,
            Ohishi,S., Matsuda,Y., Fujii,H., Saijoh,Y. and Hamada,H.
  TITLE     GFR alpha3, a component of the artemin receptor, is required for
            migration and survival of the superior cervical ganglion
  JOURNAL   Neuron 23 (4), 725-736 (1999)
   PUBMED   10482239
REFERENCE   10 (bases 1 to 2179)
  AUTHORS   Baloh,R.H., Tansey,M.G., Lampe,P.A., Fahrner,T.J., Enomoto,H.,
            Simburger,K.S., Leitner,M.L., Araki,T., Johnson,E.M. Jr. and
            Milbrandt,J.
  TITLE     Artemin, a novel member of the GDNF ligand family, supports
            peripheral and central neurons and signals through the
            GFRalpha3-RET receptor complex
  JOURNAL   Neuron 21 (6), 1291-1302 (1998)
   PUBMED   9883723
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK053914.1 and AL627128.16.
            
            On Sep 26, 2013 this sequence version replaced NM_009711.3.
            
            Summary: This gene encodes a secreted ligand of the glial cell
            line-derived neurotrophic factor (GDNF) subfamily and TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein signals through the RET
            receptor and GFR alpha 3 coreceptor, and supports the survival of a
            number of peripheral neuron populations and at least one population
            of dopaminergic CNS neurons. Mice lacking a functional copy of this
            gene exhibit ptosis and impaired development of the sympathetic
            nervous system. [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3 encode the same protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053914.1, SRR13948564.5470971.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2177              AK053914.1         2-2178
            2178-2179           AL627128.16        164992-164993       c
FEATURES             Location/Qualifiers
     source          1..2179
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.83 cM"
     gene            1..2179
                     /gene="Artn"
                     /gene_synonym="neublastin"
                     /note="artemin"
                     /db_xref="GeneID:11876"
                     /db_xref="MGI:MGI:1333791"
     exon            1..378
                     /gene="Artn"
                     /gene_synonym="neublastin"
                     /inference="alignment:Splign:2.1.0"
     exon            379..612
                     /gene="Artn"
                     /gene_synonym="neublastin"
                     /inference="alignment:Splign:2.1.0"
     exon            613..1131
                     /gene="Artn"
                     /gene_synonym="neublastin"
                     /inference="alignment:Splign:2.1.0"
     CDS             1072..1746
                     /gene="Artn"
                     /gene_synonym="neublastin"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 4"
                     /codon_start=1
                     /product="artemin isoform 1 preproprotein"
                     /protein_id="NP_033841.1"
                     /db_xref="CCDS:CCDS18543.1"
                     /db_xref="GeneID:11876"
                     /db_xref="MGI:MGI:1333791"
                     /translation="MELGLAEPTALSHCLRPRWQSAWWPTLAVLALLSCVTEASLDPM
                     SRSPAARDGPSPVLAPPTDHLPGGHTAHLCSERTLRPPPQSPQPAPPPPGPALQSPPA
                     ALRGARAARAGTRSSRARTTDARGCRLRSQLVPVSALGLGHSSDELIRFRFCSGSCRR
                     ARSQHDLSLASLLGAGALRSPPGSRPISQPCCRPTRYEAVSFMDVNSTWRTVDHLSAT
                     ACGCLG"
     exon            1132..1270
                     /gene="Artn"
                     /gene_synonym="neublastin"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..2179
                     /gene="Artn"
                     /gene_synonym="neublastin"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2178
                     /gene="Artn"
                     /gene_synonym="neublastin"
                     /note="major polyA site"
ORIGIN      
        1 ctttgcttga ctaccaactt cgaattccca gtttcagcgt ctcgctgcag cccgcgatct
       61 ctactctgcc tcctggggtc ttctccaaat gtctagcccc cacctagagg gacctagcct
      121 agccagcggg gaccggatcc ggagggtgga gcggccaggt gagccctgaa aggtggggcg
      181 gggcgggggc gctctgggcc ccaccccggg atctggtgac gccggggctg gaatttgaca
      241 ccggacggcg gcgggcagga ggctgctgag ggatggagtt gggctcggcc cccagatgcg
      301 gcccgcgggc tctgccagca acaagtccct cgggccccag ccctcgctgc gactggggct
      361 tggagccctg cacccaagcc cctccagttc ttgtcgctag cttcttggac tgtgttaacc
      421 ctcctggctg gctgtaatgt gaggctcccg ctgccgccac agggcacaga ccggctgcca
      481 aggccccact tttaactaaa agaggcgctg ccaggtgcac aactctgggc atgatccact
      541 tgagcttcgg gggaaagccc agcactggtc ccaggagagg cgcctagaag gacacggacc
      601 aggacccctt tggtatggag tgaacgctga gcatggagtg gaaggaactc aagttactac
      661 tttctccaac caccctggta ccttcagccc tgaagtacag agcagaaggg tcttagaaga
      721 caggaccaca gctgtgtgag tctcccccct gaggccttag acgatctctg agctcagctg
      781 agctttgttt gcccatctgg agaagtgagc cattgattga ccttgtggca tcgcgaagga
      841 acaggtcctg ccaagcacct aacacagaga gcaaggttct ccatcgcagc taccgctgct
      901 gagttgactc tagctactcc aacctcctgg gtcgcttcga gagactggag tggaaggagg
      961 aataccccaa aggataacta actcatcttt cagtttgcaa gctgccgcag gaagagggtg
     1021 gggaaacggg tccacgaagg cttctgatgg gagcttctgg agccgaaagc tatggaactg
     1081 ggacttgcag agcctactgc attgtcccac tgcctccggc ctaggtggca gtcagcctgg
     1141 tggccaaccc tagctgttct agccctgctg agctgcgtca cagaagcttc cctggaccca
     1201 atgtcccgca gccccgccgc tcgcgacggt ccctcaccgg tcttggcgcc ccccacggac
     1261 cacctgcctg ggggacacac tgcgcatttg tgcagcgaaa gaaccctgcg acccccgcct
     1321 cagtctcctc agcccgcacc cccgccgcct ggtcccgcgc tccagtctcc tcccgctgcg
     1381 ctccgcgggg cacgcgcggc gcgtgcagga acccggagca gccgcgcacg gaccacagat
     1441 gcgcgcggct gccgcctgcg ctcgcagctg gtgccggtga gtgcgctcgg cctaggccac
     1501 agctccgacg agctgatacg tttccgcttc tgcagcggct cgtgccgccg agcacgctcc
     1561 cagcacgatc tcagtctggc cagcctactg ggcgctgggg ccctacggtc gcctcccggg
     1621 tcccggccga tcagccagcc ctgctgccgg cccactcgct atgaggccgt ctccttcatg
     1681 gacgtgaaca gcacctggag gaccgtggac cacctctccg ccactgcctg cggctgtctg
     1741 ggctgaggat gatctatctc caagcctttg cacactagac ccatgtgttg ccctacctgg
     1801 aacagctcca ccgggcctca ctaaccagga gcctcaactc agcaggatat ggaggctgca
     1861 gagctcaggc cccaggccgg tgagtgacag acgtcgtcgg catgacagac agagtgaaag
     1921 atgtcggaac cactgaccaa cagtcccaag ttgttcatgg atcacagctc tacagacagg
     1981 agaaacctca gctaaagaga actcctctgg gagaatccag aaatggccct ctgtcctggg
     2041 gaatgaattt tgaagagata tatatacata tatacattgt agtcgcgttg ctggaccagc
     2101 ctgtgctgaa accagtcccg tgttcacttg tggaagccga agccctattt attatttcta
     2161 aattatttat ttactttgc
//
