LOCUS       NP_033841                224 aa            linear   ROD 10-FEB-2025
DEFINITION  artemin isoform 1 preproprotein [Mus musculus].
ACCESSION   NP_033841
VERSION     NP_033841.1
DBSOURCE    REFSEQ: accession NM_009711.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 224)
  AUTHORS   Edamitsu,T., Taguchi,K., Kobayashi,E.H., Okuyama,R. and Yamamoto,M.
  TITLE     Aryl Hydrocarbon Receptor Directly Regulates Artemin Gene
            Expression
  JOURNAL   Mol Cell Biol 39 (20), e00190-19 (2019)
   PUBMED   31358547
  REMARK    GeneRIF: results demonstrate that the Artn gene is indeed regulated
            by the distal XRE-containing enhancer, and alloknesis in AhR-CA
            mice is provoked by the AhR-mediated direct induction of the Artn
            gene7
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 224)
  AUTHORS   Han,Y., Liu,Q., Hou,J., Gu,Y., Zhang,Y., Chen,Z., Fan,J., Zhou,W.,
            Qiu,S., Zhang,Y., Dong,T., Li,N., Jiang,Z., Zhu,H., Zhang,Q.,
            Ma,Y., Zhang,L., Wang,Q., Yu,Y., Li,N. and Cao,X.
  TITLE     Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells
            Promotes Tumor Progression
  JOURNAL   Cell 173 (3), 634-648 (2018)
   PUBMED   29606356
  REMARK    Erratum:[Cell. 2021 Mar 4;184(5):1392. doi:
            10.1016/j.cell.2020.02.036.. PMID: 33667369]
REFERENCE   3  (residues 1 to 224)
  AUTHORS   Schaller,S., Buttigieg,D., Alory,A., Jacquier,A., Barad,M.,
            Merchant,M., Gentien,D., de la Grange,P. and Haase,G.
  TITLE     Novel combinatorial screening identifies neurotrophic factors for
            selective classes of motor neurons
  JOURNAL   Proc Natl Acad Sci U S A 114 (12), E2486-E2493 (2017)
   PUBMED   28270618
  REMARK    GeneRIF: HGF supports hindlimb motor neurons through c-Met; CNTF
            supports subsets of axial motor neurons through CNTFRalpha; and
            Artemin acts as the first survival factor for parasympathetic
            preganglionic motor neurons through GFRalpha3/Syndecan-3
            activation.
REFERENCE   4  (residues 1 to 224)
  AUTHORS   Furlan,A., La Manno,G., Lubke,M., Haring,M., Abdo,H.,
            Hochgerner,H., Kupari,J., Usoskin,D., Airaksinen,M.S., Oliver,G.,
            Linnarsson,S. and Ernfors,P.
  TITLE     Visceral motor neuron diversity delineates a cellular basis for
            nipple- and pilo-erection muscle control
  JOURNAL   Nat Neurosci 19 (10), 1331-1340 (2016)
   PUBMED   27571008
REFERENCE   5  (residues 1 to 224)
  AUTHORS   Li,S., Bhave,D., Chow,J.M., Riera,T.V., Schlee,S., Rauch,S.,
            Atanasova,M., Cate,R.L. and Whitty,A.
  TITLE     Quantitative analysis of receptor tyrosine kinase-effector coupling
            at functionally relevant stimulus levels
  JOURNAL   J Biol Chem 290 (16), 10018-10036 (2015)
   PUBMED   25635057
  REMARK    GeneRIF: RET coupling to ERK and Akt depends strongly on artemin
            concentration, and it is highest at the low (~100 pM) artemin
            levels required for neurite outgrowth.
REFERENCE   6  (residues 1 to 224)
  AUTHORS   Andres,R., Forgie,A., Wyatt,S., Chen,Q., de Sauvage,F.J. and
            Davies,A.M.
  TITLE     Multiple effects of artemin on sympathetic neurone generation,
            survival and growth
  JOURNAL   Development 128 (19), 3685-3695 (2001)
   PUBMED   11585795
REFERENCE   7  (residues 1 to 224)
  AUTHORS   Baudet,C., Mikaels,A., Westphal,H., Johansen,J., Johansen,T.E. and
            Ernfors,P.
  TITLE     Positive and negative interactions of GDNF, NTN and ART in
            developing sensory neuron subpopulations, and their collaboration
            with neurotrophins
  JOURNAL   Development 127 (20), 4335-4344 (2000)
   PUBMED   11003834
REFERENCE   8  (residues 1 to 224)
  AUTHORS   Rosenblad,C., Gronborg,M., Hansen,C., Blom,N., Meyer,M.,
            Johansen,J., Dago,L., Kirik,D., Patel,U.A., Lundberg,C., Trono,D.,
            Bjorklund,A. and Johansen,T.E.
  TITLE     In vivo protection of nigral dopamine neurons by lentiviral gene
            transfer of the novel GDNF-family member neublastin/artemin
  JOURNAL   Mol Cell Neurosci 15 (2), 199-214 (2000)
   PUBMED   10673327
  REMARK    Erratum:[Mol Cell Neurosci 2001 Sep;18(3):332-3]
REFERENCE   9  (residues 1 to 224)
  AUTHORS   Nishino,J., Mochida,K., Ohfuji,Y., Shimazaki,T., Meno,C.,
            Ohishi,S., Matsuda,Y., Fujii,H., Saijoh,Y. and Hamada,H.
  TITLE     GFR alpha3, a component of the artemin receptor, is required for
            migration and survival of the superior cervical ganglion
  JOURNAL   Neuron 23 (4), 725-736 (1999)
   PUBMED   10482239
REFERENCE   10 (residues 1 to 224)
  AUTHORS   Baloh,R.H., Tansey,M.G., Lampe,P.A., Fahrner,T.J., Enomoto,H.,
            Simburger,K.S., Leitner,M.L., Araki,T., Johnson,E.M. Jr. and
            Milbrandt,J.
  TITLE     Artemin, a novel member of the GDNF ligand family, supports
            peripheral and central neurons and signals through the
            GFRalpha3-RET receptor complex
  JOURNAL   Neuron 21 (6), 1291-1302 (1998)
   PUBMED   9883723
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK053914.1 and AL627128.16.
            
            Summary: This gene encodes a secreted ligand of the glial cell
            line-derived neurotrophic factor (GDNF) subfamily and TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein signals through the RET
            receptor and GFR alpha 3 coreceptor, and supports the survival of a
            number of peripheral neuron populations and at least one population
            of dopaminergic CNS neurons. Mice lacking a functional copy of this
            gene exhibit ptosis and impaired development of the sympathetic
            nervous system. [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3 encode the same protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053914.1, SRR13948564.5470971.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..224
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.83 cM"
     Protein         1..224
                     /product="artemin isoform 1 preproprotein"
                     /calculated_mol_wt=19422
     sig_peptide     1..39
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=4322
     Region          43..124
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0L2.1)"
     mat_peptide     112..224
                     /product="Artemin. /evidence=ECO:0000305|PubMed:15204970.
                     /id=PRO_0000240289"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0L2.1)"
                     /calculated_mol_wt=12108
     Region          126..223
                     /region_name="TGF_beta_Artemin"
                     /note="transforming growth factor beta (TGF-beta) like
                     domain found in Artemin and similar proteins; cd19381"
                     /db_xref="CDD:381651"
     Site            order(130,132..134,138..141,146..148,150..157,164..166,
                     168,171..172,177..179,181..182,186..187,189..191,193..194,
                     197,199,201,203,206..207,209..211,214..217,223)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:381651"
     Site            order(130,132,134,138..141,151..157,164..166,168..169,
                     171..172,177..179,181..182,186..191,193,197,214..217)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:381651"
     Site            206
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z0L2.1)"
     CDS             1..224
                     /gene="Artn"
                     /gene_synonym="neublastin"
                     /coded_by="NM_009711.4:1072..1746"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 4"
                     /db_xref="CCDS:CCDS18543.1"
                     /db_xref="GeneID:11876"
                     /db_xref="MGI:MGI:1333791"
ORIGIN      
        1 melglaepta lshclrprwq sawwptlavl allscvteas ldpmsrspaa rdgpspvlap
       61 ptdhlpgght ahlcsertlr pppqspqpap pppgpalqsp paalrgaraa ragtrssrar
      121 ttdargcrlr sqlvpvsalg lghssdelir frfcsgscrr arsqhdlsla sllgagalrs
      181 ppgsrpisqp ccrptryeav sfmdvnstwr tvdhlsatac gclg
//
