LOCUS       NM_007491               1737 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus ADP-ribosyltransferase 5 (Art5), transcript variant 1,
            mRNA.
ACCESSION   NM_007491
VERSION     NM_007491.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1737)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   2  (bases 1 to 1737)
  AUTHORS   Glowacki,G., Braren,R., Firner,K., Nissen,M., Kuhl,M., Reche,P.,
            Bazan,F., Cetkovic-Cvrlje,M., Leiter,E., Haag,F. and Koch-Nolte,F.
  TITLE     The family of toxin-related ecto-ADP-ribosyltransferases in humans
            and the mouse
  JOURNAL   Protein Sci 11 (7), 1657-1670 (2002)
   PUBMED   12070318
REFERENCE   3  (bases 1 to 1737)
  AUTHORS   Glowacki,G., Braren,R., Cetkovic-Cvrlje,M., Leiter,E.H., Haag,F.
            and Koch-Nolte,F.
  TITLE     Structure, chromosomal localization, and expression of the gene for
            mouse ecto-mono(ADP-ribosyl)transferase ART5
  JOURNAL   Gene 275 (2), 267-277 (2001)
   PUBMED   11587854
REFERENCE   4  (bases 1 to 1737)
  AUTHORS   Okazaki,I.J., Kim,H.J. and Moss,J.
  TITLE     Cloning and characterization of a novel membrane-associated
            lymphocyte NAD:arginine ADP-ribosyltransferase
  JOURNAL   J Biol Chem 271 (36), 22052-22057 (1996)
   PUBMED   8703012
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132297.4.
            
            On Sep 13, 2022 this sequence version replaced NM_007491.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1, 2, and 4 all encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132854.1, BC116823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-422               AC132297.4         140941-141362       c
            423-632             AC132297.4         140544-140753       c
            633-1362            AC132297.4         138891-139620       c
            1363-1395           AC132297.4         138418-138450       c
            1396-1737           AC132297.4         137989-138330       c
FEATURES             Location/Qualifiers
     source          1..1737
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.71 cM"
     gene            1..1737
                     /gene="Art5"
                     /gene_synonym="ARTC5; Yac-2"
                     /note="ADP-ribosyltransferase 5"
                     /db_xref="GeneID:11875"
                     /db_xref="MGI:MGI:107948"
     exon            1..422
                     /gene="Art5"
                     /gene_synonym="ARTC5; Yac-2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..632
                     /gene="Art5"
                     /gene_synonym="ARTC5; Yac-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             573..1502
                     /gene="Art5"
                     /gene_synonym="ARTC5; Yac-2"
                     /EC_number="2.4.2.31"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; ecto-ADP-ribosyltransferase 5;
                     mono(ADP-ribosyl)transferase 5; NAD(P)(+)--arginine
                     ADP-ribosyltransferase 5; ADP-ribosyltransferase C2 and C3
                     toxin-like 5"
                     /codon_start=1
                     /product="ecto-ADP-ribosyltransferase 5 isoform a
                     precursor"
                     /protein_id="NP_031517.2"
                     /db_xref="CCDS:CCDS21525.1"
                     /db_xref="GeneID:11875"
                     /db_xref="MGI:MGI:107948"
                     /translation="MILEDLLMVLSCLSLHALWKVRAVPILPLSLVPDTFDDAYVGCS
                     EEMEEKAGLLLKEEMARHALLRESWEAAQEAWAHRRHKLTLPPGFKAQHGVAIMVYTN
                     SSNTLYWELNQAVRTGGGSRELYMRHFPFKALHFYLTRALQLLRGSGGCSRGPGEVVF
                     RGVGSLHFEPKRLGDSVRLGQFTSSSVDERVARRFGNATFFNLRTCFGAPIQALSVFP
                     EEREVLIPPHEVFLVTGFSQDGAQSIVTLWSYDQTCSHFNCAYLGGEKRRGCVSSRAV
                     GQPEAPSTEALALQSGKTLLLDPRKLQLSRAGP"
     exon            633..1362
                     /gene="Art5"
                     /gene_synonym="ARTC5; Yac-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1395
                     /gene="Art5"
                     /gene_synonym="ARTC5; Yac-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1737
                     /gene="Art5"
                     /gene_synonym="ARTC5; Yac-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1715..1720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Art5"
                     /gene_synonym="ARTC5; Yac-2"
                     /note="hexamer: ATTAAA"
     polyA_site      1737
                     /gene="Art5"
                     /gene_synonym="ARTC5; Yac-2"
                     /note="major polyA site"
ORIGIN      
        1 agatttggcg acttaactag cgtaatgaac aaggagagat cctcgtgggg cttcgtggcc
       61 tgggggtctg agggccatgg cccggcccag ggccaccgga gaagagacca agtctcacag
      121 gtctctcccc caactttgac ttagttcaga tcttacagaa agaacctatc atccaaacga
      181 aggagagttt tgcccctcaa tcacccaagg actctgccag ttcagctccc acgcccctgt
      241 ctgttgttgg ggaagatagg tgtcgggtta ccagtccagg ggctatagtt agccccgggg
      301 actttgtcca gctgtttgtt caggatctgc gatctgcgag cgcctgccgg cacttcagct
      361 ccagtcagcc gcaaagaacc atagccctgg gccgggccgc tctctgtctc aacttcttcc
      421 agcttcaccc ctcatccctc ctgagttcca gtccttgact aaggaccctc ctaggctgaa
      481 ggaaggaagg tcctggagcc catccaagcc agcactcccc tccactggct tcatcatcat
      541 cagggtcctg ctgtctcggg actcgtccta ggatgattct ggaggatctg ctgatggtcc
      601 tcagctgcct cagcttgcac gccctctgga aggttcgagc tgttcctatc ctgcccctga
      661 gcctggttcc agataccttt gatgatgcct atgtgggctg ctctgaggag atggaggaga
      721 aagcaggcct gctgctaaag gaagagatgg cacgccatgc cctgctgcgg gaatcctggg
      781 aagcagcaca agaggcctgg gcacaccggc gtcacaagct cactctacct cctggcttca
      841 aagcccagca cggagtagcg attatggtgt acaccaactc atccaacacc ttgtactggg
      901 agctgaacca ggccgtacgg acaggaggtg gctcccggga gctctacatg aggcacttcc
      961 ccttcaaggc cctgcatttc tacttgaccc gggctctgca gctgctgcgg ggctctggag
     1021 ggtgcagtag gggacctggg gaggtggtgt tccgaggtgt gggcagtctt cactttgaac
     1081 ccaagaggct gggggactct gtccgattag gacagtttac ctccagctct gtggatgaga
     1141 gagtggctcg caggtttggg aatgccacct tcttcaatct aaggacttgt tttggggctc
     1201 ctatccaggc gttgtctgtc ttccctgagg agcgtgaggt gctgataccc ccacacgaag
     1261 tcttcttggt cactgggttc tcccaggatg gagcccagag catagtgact ctctggagtt
     1321 atgatcagac ctgcagccac tttaactgcg cctatttggg tggggagaag agacgtggct
     1381 gtgtgtcctc aagagcagtc gggcagccag aggcaccctc cacagaggct ctggctctgc
     1441 aatcaggaaa gacactgctc ttggacccaa ggaagctgca gctctccaga gctggaccct
     1501 gaaagcctct taggactctt gggaactaat gaccttacta tgaagaaggg gctttgaacg
     1561 gctgcaggaa gcaggagtgt ggttctggtt ccagtcctag gagccacctg tccaaccaga
     1621 gttggagatc tgaggccatg gcagggttga gggaacccca cagtgtggtg ggaacttcct
     1681 aggacatgca aggtaaagac tggatggcta ctcaattaaa cagagttgtg gtgtgga
//
