LOCUS       NM_026639               2384 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ADP-ribosyltransferase 4 (Art4), mRNA.
ACCESSION   NM_026639
VERSION     NM_026639.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2384)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2384)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (bases 1 to 2384)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2384)
  AUTHORS   Glowacki,G., Braren,R., Firner,K., Nissen,M., Kuhl,M., Reche,P.,
            Bazan,F., Cetkovic-Cvrlje,M., Leiter,E., Haag,F. and Koch-Nolte,F.
  TITLE     The family of toxin-related ecto-ADP-ribosyltransferases in humans
            and the mouse
  JOURNAL   Protein Sci 11 (7), 1657-1670 (2002)
   PUBMED   12070318
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019467.1.
            
            On Apr 6, 2007 this sequence version replaced NM_026639.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019467.1, BC046306.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2384              AK019467.1         2-2385
FEATURES             Location/Qualifiers
     source          1..2384
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 66.72 cM"
     gene            1..2384
                     /gene="Art4"
                     /gene_synonym="4432404K01Rik; ARTC4; DO; DOK1"
                     /note="ADP-ribosyltransferase 4"
                     /db_xref="GeneID:109978"
                     /db_xref="MGI:MGI:1202710"
     exon            1..438
                     /gene="Art4"
                     /gene_synonym="4432404K01Rik; ARTC4; DO; DOK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..1260
                     /gene="Art4"
                     /gene_synonym="4432404K01Rik; ARTC4; DO; DOK1"
                     /EC_number="2.4.2.31"
                     /note="mono(ADP-ribosyl)transferase 4; NAD(P)(+)--arginine
                     ADP-ribosyltransferase 4; ecto-ADP-ribosyltransferase 4;
                     ADP-ribosyltransferase C2 and C3 toxin-like 4"
                     /codon_start=1
                     /product="ecto-ADP-ribosyltransferase 4 precursor"
                     /protein_id="NP_080915.1"
                     /db_xref="CCDS:CCDS20658.1"
                     /db_xref="GeneID:109978"
                     /db_xref="MGI:MGI:1202710"
                     /translation="MALWLPGGQLTLLLLLWVQQTPAGSTEAPLKVDVDLTPDSFDDQ
                     YQGCSEQMVEELNQGDYFIKEVDTHKYYSRAWQKAHLTWLNQAKALPESMTPVHAVAI
                     VVFTLNLNVSSDLAKAMARAAGSPGQYSQSFHFKYLHYYLTSAIQLLRKDSSTKNGSL
                     CYKVYHGMKDVSIGANVGSTIRFGQFLSASLLKEETRVSGNQTLFTIFTCLGASVQDF
                     SLRKEVLIPPYELFEVVSKSGSPKGDLINLRSAGNMSTYNCQLLKACSKKCAPAPVVI
                     GCLFLVTVVISSKSRAQRNLLAPF"
     exon            439..1147
                     /gene="Art4"
                     /gene_synonym="4432404K01Rik; ARTC4; DO; DOK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..2384
                     /gene="Art4"
                     /gene_synonym="4432404K01Rik; ARTC4; DO; DOK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2362..2367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Art4"
                     /gene_synonym="4432404K01Rik; ARTC4; DO; DOK1"
                     /note="hexamer: AATAAA"
     polyA_site      2382
                     /gene="Art4"
                     /gene_synonym="4432404K01Rik; ARTC4; DO; DOK1"
                     /note="major polyA site"
ORIGIN      
        1 attcccctgc atgccgacta gacagagaga cggtttttgc cttctttaca ctgaaaacca
       61 ttctgtgccg cgcacatctg gccctttcgc ggagacttca acactgcaaa ggcgctagac
      121 ttctaccttg gaggaaactg tcggttgttg aggttgttga tattcaacag aagtcacagt
      181 tgcggcagga gcagaacctc agacacagcc ggaaaagaaa atgccaaagg aggactctag
      241 agcgtattct gggacgaggc tttcagaata aagaagtgtt gctgacacaa accaccaagc
      301 tgcccactga ccagtagatc taagagaacg tgtctaccaa gtgctacaga caggaggatg
      361 gcgctgtggc ttccaggagg gcagctcacc ctgctgctac tgctctgggt ccagcagaca
      421 cccgcgggga gcactgaggc tcctcttaag gtcgacgtgg acttgacacc tgattccttt
      481 gatgatcaat accaaggctg tagcgaacag atggtggagg agctaaatca aggagactat
      541 ttcataaagg aagtagatac tcataagtat tactccagag catggcaaaa agcccaccta
      601 acctggctga accaggcaaa ggccctcccg gagagcatga ccccggtgca tgctgtggcc
      661 attgtggttt tcaccctgaa tctcaatgtg agctctgact tggccaaggc catggccagg
      721 gctgcgggat ctcctgggca gtacagtcag tcattccact tcaagtatct gcactactac
      781 ctcacctcag ccatccagct gctgaggaaa gacagctcta caaagaacgg cagtctgtgt
      841 tacaaggtgt accacgggat gaaggatgtg agcattggag ccaacgtagg ttccaccatt
      901 cgattcggcc agttcctctc tgcctccctg ctaaaggaag agacacgggt gtctggaaac
      961 caaaccctgt ttaccatttt cacttgtctg ggtgcctctg tgcaagactt ctctctcagg
     1021 aaggaagtct tgatcccccc ctatgagtta tttgaagtcg taagtaagag cggcagcccc
     1081 aaaggagatt tgataaactt gcggtctgct gggaacatga gcacgtataa ctgccagctg
     1141 ctaaaagctt gcagcaagaa gtgcgcccct gctccagtgg ttatcggctg cctctttttg
     1201 gtcactgttg ttatctcgtc caaaagcaga gcgcaaagga atctactggc tcctttttaa
     1261 aggagctgct taaatttgat gctcctattt gtgttaccaa agtctgaggc ccacacttcc
     1321 cacaatacca cagaagatgt gcaagaaaag ttcatggggg gggagagggg gcggggacaa
     1381 ccctaagttc aaatctaggc ctaaataagg cagaagactg tcagaaatcc ctgcctaaaa
     1441 ggatttaggc tactttttcc tgttgctgtc agcaaaacca atcacagaag ctcaaacaaa
     1501 gttcaggatg aaagctttgc ttccacttat aaacttacag aacatcgtag accagaagtg
     1561 tttggtccca gcagcaccag gcactacaga agcagatacc aggcagacta tcaaatctca
     1621 aggcctgccc cttgtgactc acttcctcca gcaaggctcc acctccggaa gactctacag
     1681 ccacgaaaaa taacaccacc agaaggagac aaagatctca acacatgagg cacatttaac
     1741 cttcaaacca cagcaaggtc ttagtgttca gcgctctctt ccaggagagg agatgggagt
     1801 cctgacagac aagggcagaa catccctgct ctgtgaaggt ttttcctacc cagacccgtc
     1861 tttgctctgc cctcctcagg aacctcacaa aggaccactc tcctgcagcc agccaaccag
     1921 aactgaaaag ggccttcagc acactgctac tgaaagccat gcatggcgtc ttccttgcct
     1981 gtccatttgc ccttcccagt ctcagggcct tggtcttatt cagtgaagac acccaaggat
     2041 accacttgcc cattacttgg ccagagatcc atgacaaaat gacaatcttg tggcagcata
     2101 tgagacagaa ttaggatacg ttttctagat tagttttggg agcgcagcat tcagaatcta
     2161 ttgtgagtga ttataaaagc tgagcacatg gcacgctgcg ttgcctgtag ctgcctcgcc
     2221 accaagagat aagaatttgc ctccctaaga aactaattca gtggaggcag tgctaagaaa
     2281 cagagagaag ataggcaaga tgagcctcta gcgccaaact gggcctgaac cagatagtca
     2341 gcttcatcat tttcatggat taataaatga tatctgtgct aacg
//
