LOCUS       NM_001370591            1492 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus ADP-ribosyltransferase 3 (Art3), transcript variant 4,
            mRNA.
ACCESSION   NM_001370591 XM_006534717
VERSION     NM_001370591.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1492)
  AUTHORS   Martinez,M.E., Pinz,I., Preda,M., Norton,C.R., Gridley,T. and
            Hernandez,A.
  TITLE     DIO3 protects against thyrotoxicosis-derived cranio-encephalic and
            cardiac congenital abnormalities
  JOURNAL   JCI Insight 7 (21), e161214 (2022)
   PUBMED   36166296
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1492)
  AUTHORS   Abe,K., Yamamoto,R., Franke,V., Cao,M., Suzuki,Y., Suzuki,M.G.,
            Vlahovicek,K., Svoboda,P., Schultz,R.M. and Aoki,F.
  TITLE     The first murine zygotic transcription is promiscuous and uncoupled
            from splicing and 3' processing
  JOURNAL   EMBO J 34 (11), 1523-1537 (2015)
   PUBMED   25896510
REFERENCE   3  (bases 1 to 1492)
  AUTHORS   Friedrich,M., Grahnert,A., Klein,C., Tschop,K., Engeland,K. and
            Hauschildt,S.
  TITLE     Genomic organization and expression of the human
            mono-ADP-ribosyltransferase ART3 gene
  JOURNAL   Biochim Biophys Acta 1759 (6), 270-280 (2006)
   PUBMED   16934346
REFERENCE   4  (bases 1 to 1492)
  AUTHORS   Seedorf,H., Springer,I.N., Grundner-Culemann,E., Albers,H.K.,
            Reis,A., Fuchs,H., Hrabe de Angelis,M. and Acil,Y.
  TITLE     Amelogenesis imperfecta in a new animal model--a mutation in
            chromosome 5 (human 4q21)
  JOURNAL   J Dent Res 83 (8), 608-612 (2004)
   PUBMED   15271968
REFERENCE   5  (bases 1 to 1492)
  AUTHORS   Glowacki,G., Braren,R., Firner,K., Nissen,M., Kuhl,M., Reche,P.,
            Bazan,F., Cetkovic-Cvrlje,M., Leiter,E., Haag,F. and Koch-Nolte,F.
  TITLE     The family of toxin-related ecto-ADP-ribosyltransferases in humans
            and the mouse
  JOURNAL   Protein Sci 11 (7), 1657-1670 (2002)
   PUBMED   12070318
REFERENCE   6  (bases 1 to 1492)
  AUTHORS   Ohneda,O., Ohneda,K., Nomiyama,H., Zheng,Z., Gold,S.A., Arai,F.,
            Miyamoto,T., Taillon,B.E., McIndoe,R.A., Shimkets,R.A., Lewin,D.A.,
            Suda,T. and Lasky,L.A.
  TITLE     WECHE: a novel hematopoietic regulatory factor
  JOURNAL   Immunity 12 (2), 141-150 (2000)
   PUBMED   10714680
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122365.4.
            
            On May 14, 2019 this sequence version replaced XM_006534717.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189676.73831.1,
                                           SRR5189679.76533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC122365.4         134958-135062
            106-183             AC122365.4         136205-136282
            184-892             AC122365.4         140540-141248
            893-925             AC122365.4         150067-150099
            926-958             AC122365.4         151666-151698
            959-988             AC122365.4         152908-152937
            989-1021            AC122365.4         157341-157373
            1022-1075           AC122365.4         159213-159266
            1076-1105           AC122365.4         160236-160265
            1106-1492           AC122365.4         162313-162699
FEATURES             Location/Qualifiers
     source          1..1492
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 46.54 cM"
     gene            1..1492
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /note="ADP-ribosyltransferase 3"
                     /db_xref="GeneID:109979"
                     /db_xref="MGI:MGI:1202729"
     exon            1..105
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            106..183
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1230
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /EC_number="2.4.2.31"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; ecto-ADP-ribosyltransferase 3; ART3
                     mono(ADP-ribosyl)transferase; mono(ADP-ribosyl)transferase
                     3; NAD(P)(+)--arginine ADP-ribosyltransferase 3;
                     ADP-ribosyltransferase C2 and C3 toxin-like 3"
                     /codon_start=1
                     /product="ecto-ADP-ribosyltransferase 3 isoform 4
                     precursor"
                     /protein_id="NP_001357520.1"
                     /db_xref="GeneID:109979"
                     /db_xref="MGI:MGI:1202729"
                     /translation="MKMGHFEMVTTLLAAAVLMDIFQVKAEVLDMAENAFDDEYLKCK
                     SRMESKYIPQMKREEWANDALLRMVWDNAEIQWEARKAQLFLPRNFKDTYGIALTAYV
                     NEAQEQTSFYHTFSSAVKMAGLSRRRYIYNFPFKAFHFYLVRALQLLRRPCEKSYKTV
                     VYSTSPDISFTFGEQNQARLGNFTLAYSAKPETADNQRVLTIQTCFGVAVGKFLNKED
                     DSVVLIPLSEVFQVSRKGTSNDLVLQSINSTCSYYECAFLGGLKTENCIANAEYIDPR
                     YLYNPDMDNQKLEDSGRNNLDPDRMPEIKVLQTEENPLLPDEKPDRSRGKANNPTPGL
                     VPGPKSHPSASSGNTLLPSVMASTILLVASAVNFIEL"
     exon            184..892
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            893..925
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            926..958
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            959..988
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1021
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1075
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1105
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1492
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1469..1474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /note="hexamer: AATAAA"
     polyA_site      1487
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /note="major polyA site"
ORIGIN      
        1 actgtcaaca acatcctatc ctggagggaa gttctccaca gcagagtggg aatccggtgt
       61 gagacagggc atcatttaaa cttcctgcag aggcacaaac gccagacgtg aaaaatgaag
      121 atgggacatt ttgaaatggt caccacgctg ctggcagccg cagttctaat ggacatcttc
      181 caggtgaagg cggaagtgtt agacatggca gagaacgcgt ttgacgacga atacctgaag
      241 tgcaaaagca gaatggaatc gaagtatatt ccgcagatga agagggagga gtgggcaaac
      301 gatgcgctcc tgcggatggt gtgggacaat gcggagatcc agtgggaagc gcggaaggct
      361 cagctcttcc tccctagaaa cttcaaggac acctatggca tagctctgac ggcctacgtg
      421 aatgaggctc aagagcagac ttccttctac cacacattca gcagcgctgt gaagatggcc
      481 ggcctgtccc gaagacggta catctataac ttcccgttca aggcttttca tttttacttg
      541 gtgagagccc tgcagctgct gagacgacct tgcgagaaaa gttacaaaac tgtggtgtac
      601 agcacaagcc cagacatttc attcacattc ggagagcaaa accaagccag gctgggtaac
      661 ttcacgttgg cgtattcagc caaaccggag acagccgaca accaacgggt gctaaccatc
      721 cagacctgct ttggagtcgc cgtgggaaag tttcttaata aagaagacga cagcgttgtt
      781 ttaatacctc tgagtgaggt ttttcaagtg tcgaggaaag gaactagcaa cgaccttgtc
      841 cttcagagca taaacagtac ctgcagctac tacgagtgcg cattcctcgg gggtctgaaa
      901 acagaaaatt gtatcgcgaa cgcagaatat attgacccta ggtatctcta caacccagat
      961 atggacaatc agaagcttga agactctggt aggaacaacc ttgaccctga cagaatgcca
     1021 gaaattaaag tgctacaaac agaggaaaat cctctcctgc cggatgaaaa gcctgacaga
     1081 agtcgaggaa aggccaacaa tcctactcca ggtctggttc caggtccgaa atcccatccc
     1141 tctgcatcct ctggcaatac gctccttcca tcagtcatgg catccaccat tttactcgtt
     1201 gcttctgctg taaacttcat cgagctatag cttgaaacgc tatcttaatc tttatctgaa
     1261 agactgctat ggggatccca caggaagtca agagaaaaaa atgtagtttt ccttggacag
     1321 acttgactgt ataaaagaac tgtatatttg ttcctcattt tacaatttaa aaagctggtc
     1381 cagatagtat catagaatta acttttcatt tctgtattaa ttttaggact gcaaaaatcc
     1441 caaagctata tactttttga tcggattcaa taaaaacttt aagtttacta aa
//
