LOCUS       NP_001357520             371 aa            linear   ROD 01-JUN-2024
DEFINITION  ecto-ADP-ribosyltransferase 3 isoform 4 precursor [Mus musculus].
ACCESSION   NP_001357520 XP_006534780
VERSION     NP_001357520.1
DBSOURCE    REFSEQ: accession NM_001370591.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 371)
  AUTHORS   Martinez,M.E., Pinz,I., Preda,M., Norton,C.R., Gridley,T. and
            Hernandez,A.
  TITLE     DIO3 protects against thyrotoxicosis-derived cranio-encephalic and
            cardiac congenital abnormalities
  JOURNAL   JCI Insight 7 (21), e161214 (2022)
   PUBMED   36166296
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 371)
  AUTHORS   Abe,K., Yamamoto,R., Franke,V., Cao,M., Suzuki,Y., Suzuki,M.G.,
            Vlahovicek,K., Svoboda,P., Schultz,R.M. and Aoki,F.
  TITLE     The first murine zygotic transcription is promiscuous and uncoupled
            from splicing and 3' processing
  JOURNAL   EMBO J 34 (11), 1523-1537 (2015)
   PUBMED   25896510
REFERENCE   3  (residues 1 to 371)
  AUTHORS   Friedrich,M., Grahnert,A., Klein,C., Tschop,K., Engeland,K. and
            Hauschildt,S.
  TITLE     Genomic organization and expression of the human
            mono-ADP-ribosyltransferase ART3 gene
  JOURNAL   Biochim Biophys Acta 1759 (6), 270-280 (2006)
   PUBMED   16934346
REFERENCE   4  (residues 1 to 371)
  AUTHORS   Seedorf,H., Springer,I.N., Grundner-Culemann,E., Albers,H.K.,
            Reis,A., Fuchs,H., Hrabe de Angelis,M. and Acil,Y.
  TITLE     Amelogenesis imperfecta in a new animal model--a mutation in
            chromosome 5 (human 4q21)
  JOURNAL   J Dent Res 83 (8), 608-612 (2004)
   PUBMED   15271968
REFERENCE   5  (residues 1 to 371)
  AUTHORS   Glowacki,G., Braren,R., Firner,K., Nissen,M., Kuhl,M., Reche,P.,
            Bazan,F., Cetkovic-Cvrlje,M., Leiter,E., Haag,F. and Koch-Nolte,F.
  TITLE     The family of toxin-related ecto-ADP-ribosyltransferases in humans
            and the mouse
  JOURNAL   Protein Sci 11 (7), 1657-1670 (2002)
   PUBMED   12070318
REFERENCE   6  (residues 1 to 371)
  AUTHORS   Ohneda,O., Ohneda,K., Nomiyama,H., Zheng,Z., Gold,S.A., Arai,F.,
            Miyamoto,T., Taillon,B.E., McIndoe,R.A., Shimkets,R.A., Lewin,D.A.,
            Suda,T. and Lasky,L.A.
  TITLE     WECHE: a novel hematopoietic regulatory factor
  JOURNAL   Immunity 12 (2), 141-150 (2000)
   PUBMED   10714680
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122365.4.
            
            On May 14, 2019 this sequence version replaced XP_006534780.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189676.73831.1,
                                           SRR5189679.76533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 46.54 cM"
     Protein         1..371
                     /product="ecto-ADP-ribosyltransferase 3 isoform 4
                     precursor"
                     /EC_number="2.4.2.31"
                     /note="ecto-ADP-ribosyltransferase 3; ART3
                     mono(ADP-ribosyl)transferase; mono(ADP-ribosyl)transferase
                     3; NAD(P)(+)--arginine ADP-ribosyltransferase 3;
                     ADP-ribosyltransferase C2 and C3 toxin-like 3"
                     /calculated_mol_wt=39137
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2897
     mat_peptide     27..345
                     /product="Ecto-ADP-ribosyltransferase 3.
                     /id=PRO_0000019327"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2G4.2)"
                     /calculated_mol_wt=36493
     Region          29..251
                     /region_name="VIP2"
                     /note="A family of actin-ADP-ribosylating toxin. A member
                     of the Bacillus-prodiced vegetative insecticidal proteins
                     (VIPs) possesses high specificity against the major insect
                     pest, corn rootworms, and belongs to a classs of binary
                     toxins and regulators of...; cl00173"
                     /db_xref="CDD:469640"
     Region          306..346
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2G4.2)"
     CDS             1..371
                     /gene="Art3"
                     /gene_synonym="4930569O04Rik; ARTC3"
                     /coded_by="NM_001370591.1:115..1230"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4"
                     /db_xref="GeneID:109979"
                     /db_xref="MGI:MGI:1202729"
ORIGIN      
        1 mkmghfemvt tllaaavlmd ifqvkaevld maenafddey lkcksrmesk yipqmkreew
       61 andallrmvw dnaeiqwear kaqlflprnf kdtygialta yvneaqeqts fyhtfssavk
      121 maglsrrryi ynfpfkafhf ylvralqllr rpceksyktv vystspdisf tfgeqnqarl
      181 gnftlaysak petadnqrvl tiqtcfgvav gkflnkedds vvliplsevf qvsrkgtsnd
      241 lvlqsinstc syyecaflgg lktenciana eyidprylyn pdmdnqkled sgrnnldpdr
      301 mpeikvlqte enpllpdekp drsrgkannp tpglvpgpks hpsassgntl lpsvmastil
      361 lvasavnfie l
//
