LOCUS       NM_019915               4001 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus ADP-ribosyltransferase 2b (Art2b), mRNA.
ACCESSION   NM_019915 XM_003946402
VERSION     NM_019915.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4001)
  AUTHORS   Leutert,M., Duan,Y., Winzer,R., Menzel,S., Tolosa,E., Magnus,T.,
            Hottiger,M.O., Koch-Nolte,F. and Rissiek,B.
  TITLE     Identification of the Mouse T Cell ADP-Ribosylome Uncovers ARTC2.2
            Mediated Regulation of CD73 by ADP-Ribosylation
  JOURNAL   Front Immunol 12, 703719 (2021)
   PUBMED   34504490
  REMARK    GeneRIF: Identification of the Mouse T Cell ADP-Ribosylome Uncovers
            ARTC2.2 Mediated Regulation of CD73 by ADP-Ribosylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4001)
  AUTHORS   Gonde,H., Demeules,M., Hardet,R., Scarpitta,A., Junge,M.,
            Pinto-Espinoza,C., Varin,R., Koch-Nolte,F., Boyer,O. and
            Adriouch,S.
  TITLE     A Methodological Approach Using rAAV Vectors Encoding
            Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo
  JOURNAL   Front Immunol 12, 704408 (2021)
   PUBMED   34489954
  REMARK    GeneRIF: A Methodological Approach Using rAAV Vectors Encoding
            Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4001)
  AUTHORS   Georgiev,H., Ravens,I., Papadogianni,G., Malissen,B., Forster,R.
            and Bernhardt,G.
  TITLE     Blocking the ART2.2/P2X7-system is essential to avoid a detrimental
            bias in functional CD4 T cell studies
  JOURNAL   Eur J Immunol 48 (6), 1078-1081 (2018)
   PUBMED   29508376
  REMARK    GeneRIF: this study shows that blocking the ART2.2/P2X7-system is
            essential to avoid a detrimental bias in functional CD4 T cell
            studies
REFERENCE   4  (bases 1 to 4001)
  AUTHORS   Garcia-Rodriguez,S., Rosal-Vela,A., Botta,D., Cumba Garcia,L.M.,
            Zumaquero,E., Prados-Maniviesa,V., Cerezo-Wallis,D., Lo Buono,N.,
            Robles-Guirado,J.A., Guerrero,S., Gonzalez-Paredes,E.,
            Andres-Leon,E., Corbi,A., Mack,M., Koch-Nolte,F., Merino,R.,
            Zubiaur,M., Lund,F.E. and Sancho,J.
  TITLE     CD38 promotes pristane-induced chronic inflammation and increases
            susceptibility to experimental lupus by an apoptosis-driven and
            TRPM2-dependent mechanism
  JOURNAL   Sci Rep 8 (1), 3357 (2018)
   PUBMED   29463868
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4001)
  AUTHORS   Menzel,S., Rissiek,B., Bannas,P., Jakoby,T., Miksiewicz,M.,
            Schwarz,N., Nissen,M., Haag,F., Tholey,A. and Koch-Nolte,F.
  TITLE     Nucleotide-Induced Membrane-Proximal Proteolysis Controls the
            Substrate Specificity of T Cell Ecto-ADP-Ribosyltransferase ARTC2.2
  JOURNAL   J Immunol 195 (5), 2057-2066 (2015)
   PUBMED   26209623
  REMARK    GeneRIF: Data show that shedding of T Cell
            Ecto-ADP-ribosyltransferase ARTC2.2 alters its substrate profile.
REFERENCE   6  (bases 1 to 4001)
  AUTHORS   Koch-Nolte,F., Kuhl,M., Haag,F., Cetkovic-Cvrlje,M., Leiter,E.H.
            and Thiele,H.G.
  TITLE     Assignment of the human and mouse genes for muscle ecto mono
            (ADPribosyl)transferase to a conserved linkage group on human
            chromosome 11p15 and mouse chromosome 7
  JOURNAL   Genomics 36 (1), 215-216 (1996)
   PUBMED   8812442
REFERENCE   7  (bases 1 to 4001)
  AUTHORS   Hollmann,C., Haag,F., Schlott,M., Damaske,A., Bertuleit,H.,
            Matthes,M., Kuhl,M., Thiele,H.G. and Koch-Nolte,F.
  TITLE     Molecular characterization of mouse T-cell
            ecto-ADP-ribosyltransferase Rt6: cloning of a second functional
            gene and identification of the Rt6 gene products
  JOURNAL   Mol Immunol 33 (9), 807-817 (1996)
   PUBMED   8811076
REFERENCE   8  (bases 1 to 4001)
  AUTHORS   Koch-Nolte,F., Petersen,D., Balasubramanian,S., Haag,F., Kahlke,D.,
            Willer,T., Kastelein,R., Bazan,F. and Thiele,H.G.
  TITLE     Mouse T cell membrane proteins Rt6-1 and Rt6-2 are arginine/protein
            mono(ADPribosyl)transferases and share secondary structure motifs
            with ADP-ribosylating bacterial toxins
  JOURNAL   J Biol Chem 271 (13), 7686-7693 (1996)
   PUBMED   8631807
REFERENCE   9  (bases 1 to 4001)
  AUTHORS   Koch-Nolte,F., Klein,J., Hollmann,C., Kuhl,M., Haag,F.,
            Gaskins,H.R., Leiter,E. and Thiele,H.G.
  TITLE     Defects in the structure and expression of the genes for the T cell
            marker Rt6 in NZW and (NZB x NZW)F1 mice
  JOURNAL   Int Immunol 7 (5), 883-890 (1995)
   PUBMED   7547715
REFERENCE   10 (bases 1 to 4001)
  AUTHORS   Prochazka,M., Gaskins,H.R., Leiter,E.H., Koch-Nolte,F., Haag,F. and
            Thiele,H.G.
  TITLE     Chromosomal localization, DNA polymorphism, and expression of Rt-6,
            the mouse homologue of rat T-lymphocyte differentiation marker RT6
  JOURNAL   Immunogenetics 33 (2), 152-156 (1991)
   PUBMED   1671854
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF016465.1 and AC129609.3.
            
            On Mar 28, 2018 this sequence version replaced NM_019915.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF016465.1, AF016463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AF016465.1         1-3
            4-14                AC129609.3         133540-133550       c
            15-865              AF016465.1         15-865
            866-4001            AC129609.3         128121-131256       c
FEATURES             Location/Qualifiers
     source          1..4001
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.61 cM"
     gene            1..4001
                     /gene="Art2b"
                     /gene_synonym="Art; ART2.2; ARTC2; Ly92b; Rt-6; Rt6;
                     Rt6-2"
                     /note="ADP-ribosyltransferase 2b"
                     /db_xref="GeneID:11872"
                     /db_xref="MGI:MGI:107545"
     CDS             1..870
                     /gene="Art2b"
                     /gene_synonym="Art; ART2.2; ARTC2; Ly92b; Rt-6; Rt6;
                     Rt6-2"
                     /EC_number="2.4.2.31"
                     /EC_number="3.2.2.5"
                     /note="T-cell ecto-ADP-ribosyltransferase 2;
                     ADP-ribosyltransferase C2 and C3 toxin-like 2;
                     mono(ADP-ribosyl)transferase 2B; T-cell
                     mono(ADP-ribosyl)transferase 2; T-cell differentiation
                     marker Rt6 homolog 2; T-cell NAD(P)(+)--arginine
                     ADP-ribosyltransferase 2; NAD(+) glycohydrolase"
                     /codon_start=1
                     /product="T-cell ecto-ADP-ribosyltransferase 2 precursor"
                     /protein_id="NP_064299.2"
                     /db_xref="CCDS:CCDS21512.1"
                     /db_xref="GeneID:11872"
                     /db_xref="MGI:MGI:107545"
                     /translation="MTSKIFKFFLTWWLTQQVTGLAVPFMLDMAPNAFDDQYESCVED
                     MEKKAPQLLQEDFNMNEELKLEWEKAEINWKEIKNSTSYPAGFHDFHGTALVAYTGNL
                     AIDFNRAVRDFKKSPDNFHYKAFHYYLTRAVQLLNDQGCSLVYRGTKVMFEYTGKGSV
                     RFGQFSSSSLTKRVALSSNFFSNHGTLFIIRTCLGVNIKEFSSFPREEEVLIPGYEVY
                     HKVTAQNDNGYNEIFLDSPERKKSNFNCFYNGSAQTVNIDFSISGSRESCVSLFLVVL
                     LGLLVQQLTLAEL"
     exon            1..51
                     /gene="Art2b"
                     /gene_synonym="Art; ART2.2; ARTC2; Ly92b; Rt-6; Rt6;
                     Rt6-2"
                     /inference="alignment:Splign:2.1.0"
     exon            52..787
                     /gene="Art2b"
                     /gene_synonym="Art; ART2.2; ARTC2; Ly92b; Rt-6; Rt6;
                     Rt6-2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..4001
                     /gene="Art2b"
                     /gene_synonym="Art; ART2.2; ARTC2; Ly92b; Rt-6; Rt6;
                     Rt6-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1312..1317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Art2b"
                     /gene_synonym="Art; ART2.2; ARTC2; Ly92b; Rt-6; Rt6;
                     Rt6-2"
                     /note="hexamer: AATAAA"
     polyA_site      1331
                     /gene="Art2b"
                     /gene_synonym="Art; ART2.2; ARTC2; Ly92b; Rt-6; Rt6;
                     Rt6-2"
                     /note="major polyA site"
     regulatory      2743..2748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Art2b"
                     /gene_synonym="Art; ART2.2; ARTC2; Ly92b; Rt-6; Rt6;
                     Rt6-2"
                     /note="hexamer: ATTACA"
     polyA_site      2761
                     /gene="Art2b"
                     /gene_synonym="Art; ART2.2; ARTC2; Ly92b; Rt-6; Rt6;
                     Rt6-2"
                     /note="major polyA site"
     regulatory      3981..3986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Art2b"
                     /gene_synonym="Art; ART2.2; ARTC2; Ly92b; Rt-6; Rt6;
                     Rt6-2"
                     /note="hexamer: ATTAAA"
     polyA_site      4001
                     /gene="Art2b"
                     /gene_synonym="Art; ART2.2; ARTC2; Ly92b; Rt-6; Rt6;
                     Rt6-2"
ORIGIN      
        1 atgacatcaa aaattttcaa gttcttccta acttggtggc taacccagca ggtgactggc
       61 cttgcagtgc ctttcatgct agacatggct cctaatgcat ttgatgatca gtatgagagc
      121 tgtgtcgaag acatggagaa aaaggcaccc cagctgttac aagaagactt caacatgaat
      181 gaggaattaa aacttgagtg ggaaaaagca gagataaatt ggaaagagat caaaaacagt
      241 acgagttatc cggcaggttt ccatgatttc catgggacag ctttagttgc ctacactggg
      301 aacctcgcta tagattttaa cagagctgtt agagacttca agaaaagtcc ggataacttc
      361 cactacaagg ccttccatta ctacttaaca agagctgttc agcttttgaa tgaccagggt
      421 tgtagtttag tttaccgagg tactaaagtc atgtttgaat acactgggaa gggctctgtg
      481 cgatttgggc agttcagttc ttcatcttta acaaagagag tagctctttc ttcaaatttt
      541 ttcagtaatc atgggacact atttatcatc agaacctgct tgggggttaa tatcaaagaa
      601 ttctcctcat tccctcgtga agaggaggtg ttaattccag gctatgaagt atatcacaaa
      661 gtcacagcac aaaatgataa tgggtataat gaaatatttc tggactcccc agaaaggaag
      721 aagagcaact tcaattgctt ctataatggt tctgctcaaa cagtcaacat tgatttcagt
      781 atatcaggat ccagagagag ctgtgtatcc ctgttccttg tggttctcct cggtcttctg
      841 gtccagcagc ttactcttgc tgagctgtag ccctctcctg tgtgcagtct gtgggctgag
      901 tgttgaaggg aggctaaggg gcaagcactt gattggttgt ttaagagcta tagaaggggg
      961 gaggtgggat cctttcaggg gaggtctgct ttagcattca tgacttccat aagcgtccta
     1021 gcaacccact gggtcagtcc ttaaaattta cacctgactt taattttact atccctttac
     1081 agttttctac gatcaaaaag caatgtatgt ctgtacggtc agcagtaaga ggtttttgtt
     1141 gttgttgttt tgttttttaa acatctgagt gtttgtgtgt gtgtgtgagt ttaatatcat
     1201 gtgccccaga cccactcatc ttcctgtccc ttcatatcca ccacacacac acacacacac
     1261 acacacacac acacacacac acacacacac acaaaacaaa caaagaagga aaataaagaa
     1321 cgcaaaacat agaatccgtc tcatggagga agcgctgcta tgtaggtggt atgtgtccca
     1381 caggattctc ctctgaccac acatcttcaa tgcaatgagc tattgagctg gatccaggtc
     1441 tctggaccct gcgacaccat ccatattgga tccttaccag gactcctcct ggtaatcctg
     1501 tttttgccca gtgacctgaa gctttgatac agcaggactg gccctttcag catcctaaca
     1561 gttcacagat aatgtagatt ttgggttgga ccaactcgaa gccctgcagc tgtgtctggg
     1621 tgattgctga gctggtcagc ccactgctct cccttatcca taccatcagg gcaatctcct
     1681 caagtacttc tctggttagg ccacccagtg ctgtcactgg caggaggcag ggtctcctct
     1741 cctgccctca tgcccttagg gcaacttacc tgcacccata acttcagagc tagctccact
     1801 gtgcttccca gttgaggtgc agggcccaga agtcattgag ggctgggaca gctgtcttgc
     1861 tctcacacca tcgggccatc taccctacac cctaatcact agtgcccgct ctactatgct
     1921 tgccaggcaa ggcaggggga gtggtgccac tctcccaagt tcttcagcca gcaagggaca
     1981 gaacttgctt ttccagctca cttgctctag tgaccccgtc gagtcagctc tccccactac
     2041 ctcaaggtgg caaggggtga tggggcagag gccatcatac ccctgcttag gccacacagg
     2101 agatgagtgg tggggttact ccccctagtg cttcagccag ggaggggtca gaggcagctc
     2161 tctgctctca agacctctgc ccacctcccc ccacctggtg ctgtggcaag ctgctgcagg
     2221 tggtgaaggg tgagttgggg tagggcatca ccccagtggc catgccacct catggcctca
     2281 tggcagatgt gtgggtggtg gtggtcagct ttgccataat cagcctctgg acctgttaac
     2341 caggcaacat gtagggccaa ctctaaaggt ctctcctaac tgctgctgct catgggcaag
     2401 aggaggaacc aactctccag agccagttag gggcaaggac agttctgcac aggcccttgg
     2461 acatccatat ggtgctaggg aggctgctgc ccagacccag gaccttccca tgtgccacac
     2521 ccactccagt ggagcctctg tgacaagtcc aaaagctgat ttttttatcc caggtgtaaa
     2581 cactgatttt tatcccagtt gtaaacactg cctggtttct gcttgctttt atgtacattt
     2641 ttctgttttg tgtaaatagt cattatgcat tggataacct taatgtatca cctaacttcc
     2701 ttgttttctt ctgtaatata agtctgatgc tcgcattgag aaattacatt cagatccagc
     2761 actcccttgt gttcgtgtct gtcactcaca gaccccttgc ccacctgagt actgggaccc
     2821 tgatttttcc cccggattga gggaccaact gaatccagcc cgtggcactt gtgctggtgt
     2881 atatttccag ggaactcggt ttcccagatc ctacaagtga gaaacctaac ttcgttcctc
     2941 ctcttatttc ccttccctca ttcctccctt ccttctcctc ctgctgctgt ttctccttat
     3001 ctttctcatc cttctttttg gtgacagggc cttgctatgt tgttctcaag cctcctcagt
     3061 ggctgagacg aaaataccat tgctcctggc tctaactctc cctttgctct agatctatgt
     3121 aacaatcttg attcagcagg ctttactgcc ttggcttgcc ctaacaccat tttactgttc
     3181 catactttta tattgaacag aacatatcat tgtatgtttc ttatgactga cattgaacga
     3241 gaggcatgaa atcctaatgc caacctgaaa tctgtgcaag tgttcccagg tgtggtgact
     3301 tatatgtctg taacccatca cttgtgaagt gaaggcaggt agatcaggag ttcaagaaca
     3361 gtcttgccta catagcatgt ttgagatcag cctggactac ataagaccct atctaaaaaa
     3421 aatattttaa aaataggaag gatgttaaga aaggctactg tagcatgaag atgctcaaag
     3481 cctaaatcgg aaaactctca ggggcagaat agacaaaacc ttcatatgcc agggtgtgag
     3541 gaagaagaag gtgtctgtaa aaaggaggtg acaaaaagtc ttgagagagt ttagaactca
     3601 acatactgta tcacacacat cttaactgat gatgggagcc agcgacacgg tgggtgatta
     3661 ggtgcataag tggagtttag gtatgtggtg gtttgagtta gaaaggctcc tataggttca
     3721 tacatttaca tcttggtcac cagaaagtgg cactatttgc aaggattatt aggtgatgtc
     3781 tgtttggagg ggaagtatcg cttggagtgg gcattgagat tgcaaaaagc ccattcctca
     3841 cccagaggct ctttcttact gctacccgtg gatatgggtg tagacctctc agctacctct
     3901 ccgggaccct ctctgtctga gttctaacat gcttcctgcc atgccgataa tgcactaagt
     3961 ctctgatact gtgagtccca attaaatgct ttcttttata a
//
