LOCUS       NM_009710               1420 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ADP-ribosyltransferase 1 (Art1), transcript variant 1,
            mRNA.
ACCESSION   NM_009710
VERSION     NM_009710.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Lin,T., Zhang,S., Tang,Y., Xiao,M., Li,M., Gong,H., Xie,H. and
            Wang,Y.
  TITLE     ART1 knockdown decreases the IL-6-induced proliferation of
            colorectal cancer cells
  JOURNAL   BMC Cancer 24 (1), 354 (2024)
   PUBMED   38504172
  REMARK    GeneRIF: ART1 knockdown decreases the IL-6-induced proliferation of
            colorectal cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Chen,W., Xie,H., Xiao,M., Li,M., Tang,Y., Zhang,S., Li,X. and
            Wang,Y.
  TITLE     High Norepinephrine State Induces Growth of Colorectal Cancer Cells
            via ADP-Ribosyltransferase 1 in Type 2 Diabetes Mellitus
  JOURNAL   Front Biosci (Landmark Ed) 28 (11), 295 (2023)
   PUBMED   38062812
  REMARK    GeneRIF: High Norepinephrine State Induces Growth of Colorectal
            Cancer Cells via ADP-Ribosyltransferase 1 in Type 2 Diabetes
            Mellitus.
REFERENCE   4  (bases 1 to 1420)
  AUTHORS   Long,W.B., Pu,X., Tang,Y., Li,M., Liu,Y., She,Q., Wang,Y.L. and
            Guo,Q.X.
  TITLE     Arginine ADP-ribosyltransferase 1 Regulates Glycolysis in
            Colorectal Cancer via the PI3K/AKT/HIF1alpha Pathway
  JOURNAL   Curr Med Sci 42 (4), 733-741 (2022)
   PUBMED   35798928
  REMARK    GeneRIF: Arginine ADP-ribosyltransferase 1 Regulates Glycolysis in
            Colorectal Cancer via the PI3K/AKT/HIF1alpha Pathway.
REFERENCE   5  (bases 1 to 1420)
  AUTHORS   Leutert,M., Menzel,S., Braren,R., Rissiek,B., Hopp,A.K., Nowak,K.,
            Bisceglie,L., Gehrig,P., Li,H., Zolkiewska,A., Koch-Nolte,F. and
            Hottiger,M.O.
  TITLE     Proteomic Characterization of the Heart and Skeletal Muscle Reveals
            Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme
  JOURNAL   Cell Rep 24 (7), 1916-1929 (2018)
   PUBMED   30110646
  REMARK    GeneRIF: Proteomic characterization of the heart and skeletal
            muscle reveals widespread arginine ADP-ribosylation by the ARTC1
            ectoenzyme with hemopexin being its target protein.
REFERENCE   6  (bases 1 to 1420)
  AUTHORS   Perez-Stable,C., Altman,N.H., Mehta,P.P., Deftos,L.J. and Roos,B.A.
  TITLE     Prostate cancer progression, metastasis, and gene expression in
            transgenic mice
  JOURNAL   Cancer Res 57 (5), 900-906 (1997)
   PUBMED   9041192
REFERENCE   7  (bases 1 to 1420)
  AUTHORS   Yu,Y., Okamoto,S., Nemoto,E. and Dennert,G.
  TITLE     Molecular cloning of a functional murine arginine-specific
            mono-ADP-ribosyltransferase and its expression in lymphoid cells
  JOURNAL   DNA Cell Biol 16 (2), 235-244 (1997)
   PUBMED   9052744
REFERENCE   8  (bases 1 to 1420)
  AUTHORS   Okazaki,I.J., Kim,H.J. and Moss,J.
  TITLE     Cloning and characterization of a novel membrane-associated
            lymphocyte NAD:arginine ADP-ribosyltransferase
  JOURNAL   J Biol Chem 271 (36), 22052-22057 (1996)
   PUBMED   8703012
REFERENCE   9  (bases 1 to 1420)
  AUTHORS   Koch-Nolte,F., Kuhl,M., Haag,F., Cetkovic-Cvrlje,M., Leiter,E.H.
            and Thiele,H.G.
  TITLE     Assignment of the human and mouse genes for muscle ecto mono
            (ADPribosyl)transferase to a conserved linkage group on human
            chromosome 11p15 and mouse chromosome 7
  JOURNAL   Genomics 36 (1), 215-216 (1996)
   PUBMED   8812442
REFERENCE   10 (bases 1 to 1420)
  AUTHORS   Okazaki,I.J., Kim,H.J., McElvaney,N.G., Lesma,E. and Moss,J.
  TITLE     Molecular characterization of a glycosylphosphatidylinositol-linked
            ADP-ribosyltransferase from lymphocytes
  JOURNAL   Blood 88 (3), 915-921 (1996)
   PUBMED   8704249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132297.4.
            
            On Sep 13, 2022 this sequence version replaced NM_009710.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003107.1, BC063760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC132297.4         142853-142901
            50-155              AC132297.4         147370-147475
            156-921             AC132297.4         147777-148542
            922-963             AC132297.4         149837-149878
            964-1420            AC132297.4         151805-152261
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.71 cM"
     gene            1..1420
                     /gene="Art1"
                     /gene_synonym="ADPRT; ARTC1; Yac-1"
                     /note="ADP-ribosyltransferase 1"
                     /db_xref="GeneID:11870"
                     /db_xref="MGI:MGI:107511"
     exon            1..49
                     /gene="Art1"
                     /gene_synonym="ADPRT; ARTC1; Yac-1"
                     /inference="alignment:Splign:2.1.0"
     exon            50..155
                     /gene="Art1"
                     /gene_synonym="ADPRT; ARTC1; Yac-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1070
                     /gene="Art1"
                     /gene_synonym="ADPRT; ARTC1; Yac-1"
                     /EC_number="2.4.2.31"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; GPI-linked NAD(P)(+)--arginine
                     ADP-ribosyltransferase 1; mono(ADP-ribosyl)transferase 1;
                     ADP-ribosyltransferase C2 and C3 toxin-like 1"
                     /codon_start=1
                     /product="GPI-linked NAD(P)(+)--arginine
                     ADP-ribosyltransferase 1 isoform 1 precursor"
                     /protein_id="NP_033840.2"
                     /db_xref="CCDS:CCDS21526.1"
                     /db_xref="GeneID:11870"
                     /db_xref="MGI:MGI:107511"
                     /translation="MKIPAMMSLLLVSVGLRDGVQVQSYSISQLDIFSQETPLDMAPA
                     SFDDQYAGCLADMTAALPDLNHSEFQANKVYADGWAQANNQWQERRAWGSVWGSLPPS
                     PPGFRDEHGVALLAYTANSPLHKEFNAAVREAGRSRAHYLHHFSFKTLHFLLTEALQL
                     LRSHRSRGCQQVYRGVHGLRFRPAGPGATVRLGGFASASLKNVAAQQFGEDTFFGIWT
                     CLGAPIRGYSFFPEEEEVLIPPFETFQVINTSRPTQGPARIYLRALGKRSTYNCEYIK
                     EKKCRSGPCWLGSSAPGSISASCSLLLLLLFLVLSALPENPGLQQLTRC"
     exon            156..921
                     /gene="Art1"
                     /gene_synonym="ADPRT; ARTC1; Yac-1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..963
                     /gene="Art1"
                     /gene_synonym="ADPRT; ARTC1; Yac-1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1420
                     /gene="Art1"
                     /gene_synonym="ADPRT; ARTC1; Yac-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1398..1403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Art1"
                     /gene_synonym="ADPRT; ARTC1; Yac-1"
                     /note="hexamer: AATAAA"
     polyA_site      1420
                     /gene="Art1"
                     /gene_synonym="ADPRT; ARTC1; Yac-1"
                     /note="major polyA site"
ORIGIN      
        1 gtctatccca ggagaccagg tcagctttgc ccgccatgga gaaggctaga tgaggaaaaa
       61 gagacagcag cttgcccgag gtcacctcca ccatgaagat tcctgctatg atgtctctcc
      121 tactggtgtc tgtgggtctc agggatggag ttcaggttca aagttactcc atctcacaac
      181 tagacatctt ttctcaagaa acacccctgg acatggcccc agcgtccttt gatgaccagt
      241 atgctggctg cctggcagac atgacagcgg ccctgccaga tctcaaccac tcagagtttc
      301 aggccaacaa agtatacgcg gatggctggg ctcaggccaa caatcagtgg caggagcgca
      361 gggcctgggg gtccgtgtgg ggctccttgc ccccatcacc gccgggcttc cgggatgagc
      421 acggggtggc gctgctggcc tacaccgcca acagccccct gcacaaggag ttcaacgcag
      481 ctgtgcgtga ggcgggacgt tctcgggccc attacctcca ccacttctcc ttcaagaccc
      541 tccacttcct gctcaccgag gccctgcaac tgctccggag ccaccgatct cgcgggtgcc
      601 agcaggtgta caggggggtg cacggcctgc gctttcggcc agcggggcct ggcgccaccg
      661 ttaggctggg gggctttgct tctgcgtccc tcaagaacgt tgccgcccaa caatttggcg
      721 aggacacctt cttcggtatc tggacctgcc ttggggcccc catcaggggc tactcctttt
      781 tccctgaaga ggaggaggtg ctgatccctc ctttcgaaac tttccaggtg atcaatacaa
      841 gccgacccac ccagggtccc gcacgcatct acctccgcgc tctgggcaaa cgcagtacat
      901 acaactgtga atacatcaaa gaaaagaagt gcaggtctgg gccctgctgg ctgggtagct
      961 cagccccagg ctccatttct gcttcctgct ctcttctgct gctgctcttg ttccttgtgc
     1021 tgagcgccct tccagagaat ccaggtctcc agcaacttac ccgatgttga ccggccctga
     1081 ctgaagaagg ctggtcaact gtgcgccttc agtgtagcag gatcctggtg aatcagtcca
     1141 tctacaggga actctgggac cgtctatggc aattgccaga cacatcgata gagacagaga
     1201 agagaatttg gagactgaac ctcatccagg gatgtaggga cgggactgag gacaagcaga
     1261 ggactcgagg acaggcagag actcaacttg gagccaggag acttcaactc attgtgcgtg
     1321 acacacacac atgaccgtgg gccaagctgg agtcacttaa ttgcctctca taaaggtatg
     1381 agtggtagta ccaggctaat aaatgtgatt tttaaagaga
//
