LOCUS       NM_029847               3334 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus arylsulfatase K (Arsk), transcript variant 1, mRNA.
ACCESSION   NM_029847 XM_909354
VERSION     NM_029847.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3334)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3334)
  AUTHORS   Trabszo,C., Ramms,B., Chopra,P., Lullmann-Rauch,R., Stroobants,S.,
            Spross,J., Jeschke,A., Schinke,T., Boons,G.J., Esko,J.D., Lubke,T.
            and Dierks,T.
  TITLE     Arylsulfatase K inactivation causes mucopolysaccharidosis due to
            deficient glucuronate desulfation of heparan and chondroitin
            sulfate
  JOURNAL   Biochem J 477 (17), 3433-3451 (2020)
   PUBMED   32856704
  REMARK    GeneRIF: Arylsulfatase K inactivation causes mucopolysaccharidosis
            due to deficient glucuronate desulfation of heparan and chondroitin
            sulfate.
REFERENCE   3  (bases 1 to 3334)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3334)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3334)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 3334)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3334)
  AUTHORS   Ratzka,A., Mundlos,S. and Vortkamp,A.
  TITLE     Expression patterns of sulfatase genes in the developing mouse
            embryo
  JOURNAL   Dev Dyn 239 (6), 1779-1788 (2010)
   PUBMED   20503373
REFERENCE   8  (bases 1 to 3334)
  AUTHORS   Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
  TITLE     Sulfatases and sulfatase modifying factors: an exclusive and
            promiscuous relationship
  JOURNAL   Hum Mol Genet 14 (21), 3203-3217 (2005)
   PUBMED   16174644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122242.2.
            
            On Apr 15, 2022 this sequence version replaced NM_029847.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032812.1, AK019515.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-252               AC122242.2         23678-23929
            253-382             AC122242.2         28286-28415
            383-542             AC122242.2         30486-30645
            543-819             AC122242.2         47252-47528
            820-991             AC122242.2         50032-50203
            992-1216            AC122242.2         55444-55668
            1217-1441           AC122242.2         56799-57023
            1442-3334           AC122242.2         59701-61593
FEATURES             Location/Qualifiers
     source          1..3334
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.95 cM"
     gene            1..3334
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /note="arylsulfatase K"
                     /db_xref="GeneID:77041"
                     /db_xref="MGI:MGI:1924291"
     exon            1..252
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1788
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /EC_number="3.1.6.1"
                     /EC_number="3.1.6.18"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; glucuronate-2-sulfatase"
                     /codon_start=1
                     /product="arylsulfatase K isoform 1 precursor"
                     /protein_id="NP_084123.3"
                     /db_xref="CCDS:CCDS49315.1"
                     /db_xref="GeneID:77041"
                     /db_xref="MGI:MGI:1924291"
                     /translation="MLLLLVSVVAALALAAPAPRTQKKRMQVNQAPNVVLVASDSFDG
                     RLTFQPGSQVVKLPFINFMRAHGTTFLNAYTNSPICCPSRAAMWSGLFTHLTESWNNF
                     KGLDPNYTTWMDIMEKHGYQTQKFGKVDYTSGHHSISNRVEAWTRDVAFLLRQEGRPI
                     INLIPDKNRRRVMTKDWQNTDKAIEWLRQVNYTKPFVLYLGLNLPHPYPSPSSGENFG
                     SSTFHTSLYWLEKVAYDAIKIPKWLTLSQMHPVDFYSSYTKNCTGKFTENEIKNIRAF
                     YYAMCAETDAMLGEIILALHKLDLLQKTIVIYTSDHGEMAMEHRQFYKMSMYEASVHV
                     PLLMMGPGIKANLQVPSVVSLVDIYPTMLDIAGIALPPNLSGYSLLTLLSNASANEQA
                     FKFHRPPWILSEFHGCNANASTYMLRTGQWKYIAYADGASVQPQLFDLSLDPDELTNI
                     ATEFPEITYSLDQKLRSIVNYPKVSASVHQYNKEQFIMWKQSVGQNYSNVIAHLRWHQ
                     DWQRDPRKYENAIQHWLTAHSSPLASSPTQSTSGSQPTLPQSTSG"
     exon            253..382
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /inference="alignment:Splign:2.1.0"
     exon            383..542
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /inference="alignment:Splign:2.1.0"
     exon            543..819
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /inference="alignment:Splign:2.1.0"
     exon            820..991
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1216
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1441
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..3334
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1909..1914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /note="hexamer: AATAAA"
     polyA_site      1928
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /note="major polyA site"
     regulatory      1976..1981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /note="hexamer: ATTAAA"
     polyA_site      2000
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
     regulatory      3147..3152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /note="hexamer: AATAAA"
     regulatory      3166..3171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /note="hexamer: ATTAAA"
     polyA_site      3172
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
     polyA_site      3188
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
     regulatory      3309..3314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
                     /note="hexamer: ATTAAA"
     polyA_site      3334
                     /gene="Arsk"
                     /gene_synonym="2810429K17Rik; 4833414G15Rik; ASK"
ORIGIN      
        1 atatttactt ctgtatttgt aagccaaact tctagtcttg tccctagagt ccggcccctg
       61 ctcatgactg gagagcaggc tacaggagac ccgctcagca gccgcttctg aacggccatg
      121 cccgcgatgc tgttgctgtt ggtgtcggtg gtcgcagcgt tagcactcgc agcaccggcc
      181 cccagaacac agaagaaaag gatgcaagtg aaccaggcgc ccaacgtggt gctggtcgcc
      241 agtgactcct tcgatggaag actaacattt caaccaggaa gtcaggtagt aaaacttccc
      301 ttcattaact tcatgagagc acatggcacc accttcctaa atgcctacac taattcaccc
      361 atctgctgtc catcacgtgc agcaatgtgg agtggcctct tcactcactt gacagaatct
      421 tggaataatt ttaagggtct ggatccaaat tatacgacat ggatggacat catggagaag
      481 catggctatc agacacagaa atttggaaaa gtggactata cttcaggaca tcattccatt
      541 agtaaccgtg tggaagcatg gacaagagat gttgcattct tgctccgaca agaaggcaga
      601 cccataatta atcttatccc tgataagaat agaaggagag tgatgaccaa ggactggcag
      661 aatacagaca aagcaatcga atggctaaga caggttaact acaccaagcc atttgtcctt
      721 tacttgggat tgaatttgcc acacccttac ccttcaccat cttcaggaga aaactttggc
      781 tcttctacgt ttcacacttc cctttactgg cttgaaaagg tagcttatga tgcaatcaaa
      841 atcccaaagt ggttgacttt gtcacaaatg caccctgtgg atttttactc ctcctataca
      901 aaaaactgca ctgggaaatt tactgaaaat gaaattaaga acattagagc attttattat
      961 gctatgtgtg ctgagacaga tgccatgcta ggtgaaatta ttttggctct tcacaagtta
     1021 gatcttcttc agaaaactat tgttatatat acctcagacc atggagagat ggctatggaa
     1081 caccgccagt tttataaaat gagtatgtat gaagctagtg tccatgttcc tcttctgatg
     1141 atgggaccag gaattaaggc caacctacaa gtaccaagtg ttgtttctct tgtggatatc
     1201 taccctacta tgcttgacat tgctgggatt gctctgcctc caaatctgag tggatactcc
     1261 ttgttgacgc tgttgtcaaa tgcatctgca aatgaacagg cattcaaatt ccaccgtcca
     1321 ccttggattc tgagtgaatt ccatggatgc aatgcaaatg cttctaccta catgctacga
     1381 actggccagt ggaagtacat agcctacgct gatggtgctt ccgtgcagcc tcagctcttc
     1441 gatctttcct tggatccgga tgagctaaca aacattgcta cagaatttcc agaaattact
     1501 tattctttgg accagaagct tcgttctatt gtaaactacc ctaaagtgtc tgcttctgtc
     1561 catcagtaca ataaagaaca gtttatcatg tggaagcaaa gcgtagggca aaattactca
     1621 aacgttatag cacacctcag atggcatcaa gattggcaga gagatccaag gaagtatgaa
     1681 aatgcaatcc aacattggct cacagcccac tccagtccac tggctagcag cccaacccag
     1741 tccaccagtg gctcacagcc cactcttccc cagtccacca gtggctagca gcctactcca
     1801 gtgaccagtg actcatagcc cactcttctc cagtccacca gtggttagca tcccacttca
     1861 atccaccagt agctcacagc ctactcttct ccagtagcag tagacaataa taaaactttc
     1921 tcaagctata tgtgaatatg ttggtacata ctaaactgaa tcagccttaa caattattaa
     1981 aattacttat tttcaaaata tgtactatat attacttgcc aatgaataca gaattcatat
     2041 tttcaaaact agttatacta agaccttatt gttgcagacc tctgacagtt taacgtcaga
     2101 agtatttaaa gaatagaagc aagcattctt actgtttccc tggataatac agaatatgaa
     2161 atattttaac aactatcagt tgttatttat gaatcatgat gtctcgtgac tgactagttt
     2221 tttggtaaaa ctctttggaa gtatttgatg tgttagaact atttaatggg acatagactc
     2281 tgaatatagt tgattttact ttctgttgtt taaaaaaaga aaaaaaagaa tatgaagtcc
     2341 ccttcctttc ctggttaact tccttcaaag ggcaaccaca atctccttgc ttgtatctta
     2401 ttgtgaacaa gctatagtca ccaaccaaat ggatatattc tttacacatg catgcaggca
     2461 tatacacaat tgataatgtg ctatatagta tttcttttgg cacattgtgt tctggctgtt
     2521 attttctagt tccaattaac aatagatgct gaggagtaaa attgctgaac cagaatctat
     2581 aaaaatgtct gtagattttc ccaagttgtt tctaaagaag tgccagctgt tggcattccc
     2641 accaataggt agcaaatatt ttatttttac ttattgtgag tactgaaatt ttttttcata
     2701 gatctaataa ccactaaaat ttgcatcaaa acgactccca ctatgtctgt tggccatttt
     2761 ctctgtaggt tgttagcatt gttttgtttt gtttttttct gtcatacata tgtttttaga
     2821 tactaacctt ttgaaaagca aaagagaaaa aaaggacttg ctactcatca gaggactaag
     2881 atccaagtat tggcacccac acagtggctc acaacttgtg tgtaactcca attcagggga
     2941 gccagtgctc ttttctggcc tccaaggatg ccaggtaaac atgtagtaca cagacaaaat
     3001 gcagtcagga cactcattca tatacaattt aaaaaataat aaacaaatat atttttaaaa
     3061 atactggaaa taatattttt ctagcttgtc ttttgatatt gacctggagg aaatgtgtat
     3121 tttcttaatt ataaatcttt gtatcaaata aatatgattt ttaaaattaa aatattcttt
     3181 aaaatgttta tcaatctcta ttttgtgcct tttagaatct gtgtcctatt agaaagttct
     3241 tctctctgat cttcataaag ttttggtttt agcccttaga tctttgatcc atgtagaata
     3301 tttttcatat taaacatcta actttagttt tcaa
//
